HUP0200418A2 - Új citokin zalpha 11 ligandum - Google Patents
Új citokin zalpha 11 ligandumInfo
- Publication number
- HUP0200418A2 HUP0200418A2 HU0200418A HUP0200418A HUP0200418A2 HU P0200418 A2 HUP0200418 A2 HU P0200418A2 HU 0200418 A HU0200418 A HU 0200418A HU P0200418 A HUP0200418 A HU P0200418A HU P0200418 A2 HUP0200418 A2 HU P0200418A2
- Authority
- HU
- Hungary
- Prior art keywords
- ligand
- human cytokine
- zalpha
- receptor
- protein
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány tárgyát zalpha11 ligandum polinukleotid és polipeptidmolekulák képezik. A zalpha11 ligandum egy új citokin. Apolipeptideket hematopoietikus sejtek in vitro és in vivoszaporodásának és/vagy fejlődésének stimulálására használjuk. Atalálmány tárgát képezik továbbá a fehérje előállítási módszerei, afehérje használata és az ellene készített ellenanyagok. Ó
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26490899A | 1999-03-09 | 1999-03-09 | |
US26599299A | 1999-03-11 | 1999-03-11 | |
US14201399P | 1999-07-01 | 1999-07-01 | |
PCT/US2000/006067 WO2000053761A2 (en) | 1999-03-09 | 2000-03-09 | Human cytokine as ligand of the zalpha receptor and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0200418A2 true HUP0200418A2 (hu) | 2002-05-29 |
HUP0200418A3 HUP0200418A3 (en) | 2003-12-29 |
HU229148B1 HU229148B1 (en) | 2013-09-30 |
Family
ID=27385745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0200418A HU229148B1 (en) | 1999-03-09 | 2000-03-09 | Human cytokine as ligand of the zalpha receptor and uses thereof |
Country Status (23)
Country | Link |
---|---|
EP (3) | EP1165791B1 (hu) |
JP (1) | JP4405686B2 (hu) |
KR (1) | KR100743640B1 (hu) |
CN (5) | CN101575377B (hu) |
AT (1) | ATE377076T1 (hu) |
AU (2) | AU777842B2 (hu) |
BR (1) | BR0008772B1 (hu) |
CA (1) | CA2366921C (hu) |
CZ (1) | CZ302921B6 (hu) |
DE (1) | DE60036930T2 (hu) |
DK (1) | DK1165791T3 (hu) |
ES (1) | ES2295019T3 (hu) |
HU (1) | HU229148B1 (hu) |
IL (5) | IL145288A0 (hu) |
MX (1) | MXPA01009074A (hu) |
NO (2) | NO331551B1 (hu) |
NZ (1) | NZ514708A (hu) |
PL (1) | PL207350B1 (hu) |
PT (1) | PT1165791E (hu) |
RU (1) | RU2346951C2 (hu) |
UA (1) | UA84387C2 (hu) |
WO (1) | WO2000053761A2 (hu) |
ZA (1) | ZA017370B (hu) |
Families Citing this family (36)
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US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
US7189400B2 (en) | 1998-03-17 | 2007-03-13 | Genetics Institute, Llc | Methods of treatment with antagonists of MU-1 |
WO2000053761A2 (en) * | 1999-03-09 | 2000-09-14 | Zymogenetics, Inc. | Human cytokine as ligand of the zalpha receptor and uses thereof |
EP1432431B1 (en) * | 2001-10-04 | 2017-05-10 | Genetics Institute LLC | Methods and compositions for modulating interleukin-21 activity |
AU2002336676A1 (en) | 2001-11-05 | 2003-05-19 | Zymogenetics, Inc | Il-21 antagonists |
JP2006514601A (ja) * | 2002-06-07 | 2006-05-11 | ザイモジェネティクス インコーポレイティッド | ガンおよびその他の治療用途におけるil−21の使用方法 |
CA2491320A1 (en) | 2002-07-15 | 2004-01-22 | Wyeth | Methods and compositions for modulating t helper (th) cell development and function |
EP1782823A3 (en) * | 2002-10-11 | 2007-05-16 | Novo Nordisk A/S | IL-21 peptides and nucleic acids |
CA2501807A1 (en) * | 2002-10-11 | 2004-04-22 | Novo Nordisk A/S | Treatment of allergic conditions by use of il 21 |
US7250274B2 (en) * | 2002-12-13 | 2007-07-31 | Zymogenetics, Inc. | IL-21 production in prokaryotic hosts |
NZ542306A (en) | 2003-03-14 | 2008-04-30 | Wyeth Corp | Antibodies against human IL-21 receptor and uses therefor |
CA2529520A1 (en) * | 2003-06-19 | 2004-12-29 | Centocor, Inc. | Interleukin-21 analogs |
DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
DK1648931T3 (da) | 2003-07-21 | 2011-03-07 | Transgene Sa | Multifunktionelle cytokiner |
AU2004275871A1 (en) * | 2003-09-25 | 2005-04-07 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using IL-21 |
US20060228331A1 (en) * | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
CN1867581B (zh) * | 2003-10-10 | 2012-02-01 | 诺沃挪第克公司 | Il-21衍生物 |
ES2428358T3 (es) | 2003-10-17 | 2013-11-07 | Novo Nordisk A/S | Terapia de combinación |
EP1708737A2 (en) * | 2004-01-15 | 2006-10-11 | Novo Nordisk A/S | Use of interleukin-21 for the treatment of autoimmune diseases and allograft rejection |
DK2842576T3 (en) | 2004-01-21 | 2017-10-16 | Novo Nordisk Healthcare Ag | Transglutaminase-mediated peptide conjugation |
GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
BRPI0609079A2 (pt) | 2005-04-18 | 2010-11-16 | Novo Nordisk As | peptìdeo, composição farmacêutica, método para o tratamento de cáncer, uso de um peptìdeo construto de ácido nucleico, vetor, hospedeiro, e, anticorpo |
JP5322653B2 (ja) | 2005-11-28 | 2013-10-23 | ザイモジェネティクス, インコーポレイテッド | Il−21アンタゴニスト |
EP2091968A2 (en) | 2006-10-26 | 2009-08-26 | Novo Nordisk A/S | Il-21 variants |
CA2671665A1 (en) | 2006-12-21 | 2008-06-26 | Novo-Nordisk A/S | Interleukin-21 variants with altered binding to the il-21 receptor |
CN102027011B (zh) | 2007-12-07 | 2014-09-03 | 津莫吉尼蒂克斯公司 | 抗人il-21单克隆抗体 |
AR071885A1 (es) | 2008-05-23 | 2010-07-21 | Wyeth Corp | Proteinas de union al receptor de interleuquina 21 |
RU2010152689A (ru) | 2008-05-23 | 2012-06-27 | УАЙТ ЭлЭлСи (US) | Способы лечения с применением белков, связывающих рецептор интерлейкина-21 |
EP2344180A2 (en) | 2008-09-23 | 2011-07-20 | Wyeth LLC | Methods for predicting production of activating signals by cross-linked binding proteins |
CN102021196B (zh) * | 2009-11-20 | 2013-06-26 | 上海杰隆生物工程股份有限公司 | 毕赤酵母生产重组人白细胞介素21的方法 |
IN2015KN00073A (hu) | 2012-06-27 | 2015-07-31 | Univ Rutgers | |
WO2015110930A1 (en) | 2014-01-24 | 2015-07-30 | Pfizer Inc. | Modified interleukin 21 receptor proteins |
EP2982693A1 (en) * | 2014-08-07 | 2016-02-10 | Affimed Therapeutics AG | CD3 binding domain |
US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
CN112662694A (zh) * | 2020-12-25 | 2021-04-16 | 康九生物科技(长春)有限公司 | 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用 |
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-
2000
- 2000-03-09 WO PCT/US2000/006067 patent/WO2000053761A2/en active Application Filing
- 2000-03-09 CN CN2009101354816A patent/CN101575377B/zh not_active Expired - Fee Related
- 2000-03-09 IL IL14528800A patent/IL145288A0/xx unknown
- 2000-03-09 CN CN2011103037822A patent/CN102406937A/zh active Pending
- 2000-03-09 PT PT00916164T patent/PT1165791E/pt unknown
- 2000-03-09 DE DE60036930T patent/DE60036930T2/de not_active Expired - Lifetime
- 2000-03-09 AU AU37312/00A patent/AU777842B2/en not_active Ceased
- 2000-03-09 CN CNA2005101141968A patent/CN1827639A/zh active Pending
- 2000-03-09 NZ NZ514708A patent/NZ514708A/en not_active IP Right Cessation
- 2000-03-09 HU HU0200418A patent/HU229148B1/hu not_active IP Right Cessation
- 2000-03-09 CZ CZ20013184A patent/CZ302921B6/cs not_active IP Right Cessation
- 2000-03-09 CA CA2366921A patent/CA2366921C/en not_active Expired - Fee Related
- 2000-03-09 JP JP2000603382A patent/JP4405686B2/ja not_active Expired - Fee Related
- 2000-03-09 EP EP00916164A patent/EP1165791B1/en not_active Expired - Lifetime
- 2000-03-09 UA UA2001106769A patent/UA84387C2/ru unknown
- 2000-03-09 BR BRPI0008772-6A patent/BR0008772B1/pt not_active IP Right Cessation
- 2000-03-09 DK DK00916164T patent/DK1165791T3/da active
- 2000-03-09 ES ES00916164T patent/ES2295019T3/es not_active Expired - Lifetime
- 2000-03-09 RU RU2004126135/13A patent/RU2346951C2/ru not_active IP Right Cessation
- 2000-03-09 CN CNB008068747A patent/CN100500846C/zh not_active Expired - Fee Related
- 2000-03-09 KR KR1020017011499A patent/KR100743640B1/ko not_active IP Right Cessation
- 2000-03-09 CN CN2006101031515A patent/CN1927883B/zh not_active Expired - Fee Related
- 2000-03-09 MX MXPA01009074A patent/MXPA01009074A/es active IP Right Grant
- 2000-03-09 EP EP20100185147 patent/EP2295577A3/en not_active Withdrawn
- 2000-03-09 PL PL351160A patent/PL207350B1/pl unknown
- 2000-03-09 EP EP07017344A patent/EP1881070B1/en not_active Expired - Lifetime
- 2000-03-09 AT AT00916164T patent/ATE377076T1/de active
-
2001
- 2001-09-05 IL IL145288A patent/IL145288A/en not_active IP Right Cessation
- 2001-09-06 ZA ZA2001/07370A patent/ZA017370B/en unknown
- 2001-09-07 NO NO20014364A patent/NO331551B1/no not_active IP Right Cessation
-
2005
- 2005-01-20 AU AU2005200240A patent/AU2005200240A1/en not_active Abandoned
-
2008
- 2008-12-04 IL IL195713A patent/IL195713A/en not_active IP Right Cessation
-
2010
- 2010-08-04 IL IL207403A patent/IL207403A/en not_active IP Right Cessation
- 2010-08-05 IL IL207424A patent/IL207424A/en not_active IP Right Cessation
-
2011
- 2011-07-29 NO NO20111085A patent/NO20111085L/no unknown
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