DE69734596D1 - "smoothened" proteine aus wirbeltieren - Google Patents

"smoothened" proteine aus wirbeltieren

Info

Publication number
DE69734596D1
DE69734596D1 DE69734596T DE69734596T DE69734596D1 DE 69734596 D1 DE69734596 D1 DE 69734596D1 DE 69734596 T DE69734596 T DE 69734596T DE 69734596 T DE69734596 T DE 69734596T DE 69734596 D1 DE69734596 D1 DE 69734596D1
Authority
DE
Germany
Prior art keywords
smoothened
vertebrate
swiveling
proteins
chimeras
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69734596T
Other languages
English (en)
Other versions
DE69734596T2 (de
Inventor
Sauvage J De
Arnon Rosenthal
M Stone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24894172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69734596(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69734596D1 publication Critical patent/DE69734596D1/de
Publication of DE69734596T2 publication Critical patent/DE69734596T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69734596T 1996-09-30 1997-09-29 "smoothened" proteine aus wirbeltieren Revoked DE69734596T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/720,484 US5990281A (en) 1996-09-30 1996-09-30 Vertebrate smoothened proteins
US720484 1996-09-30
PCT/US1997/017433 WO1998014475A1 (en) 1996-09-30 1997-09-29 Vertebrate smoothened proteins

Publications (2)

Publication Number Publication Date
DE69734596D1 true DE69734596D1 (de) 2005-12-15
DE69734596T2 DE69734596T2 (de) 2006-07-20

Family

ID=24894172

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69734596T Revoked DE69734596T2 (de) 1996-09-30 1997-09-29 "smoothened" proteine aus wirbeltieren

Country Status (12)

Country Link
US (2) US5990281A (de)
EP (1) EP0939769B1 (de)
JP (1) JP4671371B2 (de)
AT (1) ATE309270T1 (de)
AU (1) AU725701B2 (de)
CA (1) CA2267181A1 (de)
DE (1) DE69734596T2 (de)
DK (1) DK0939769T3 (de)
ES (1) ES2252795T3 (de)
IL (1) IL129139A (de)
WO (1) WO1998014475A1 (de)
ZA (1) ZA978503B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000117A2 (en) 1997-06-27 1999-01-07 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
EP1037982A1 (de) 1997-12-08 2000-09-27 Ontogeny, Inc. Menschliche patched gene und proteine, und entsprechende verwendungen
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
US20080118518A1 (en) * 2006-09-07 2008-05-22 Cirrito Thomas P Cancer stem cell-targeted cancer therapy
JP5887270B2 (ja) 2009-09-02 2016-03-16 ジェネンテック， インコーポレイテッド 突然変異体ｓｍｏｏｔｈｅｎｅｄおよびその使用方法
JP7438560B2 (ja) * 2018-07-11 2024-02-27 ヘッジホッグ，インコーポレイテッド Ｓｍｏタンパク質の特異的エピトープ、これを認知する抗体及びこれを含む組成物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) * 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4342566A (en) * 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
WO1981002798A1 (en) 1980-03-21 1981-10-01 Concurrent Processing Systems Computer system and interface therefor
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) * 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4870009A (en) * 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4601978A (en) * 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
AU2353384A (en) * 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) * 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
JPS63502716A (ja) * 1986-03-07 1988-10-13 マサチューセッツ・インステチュート・オブ・テクノロジー 糖タンパク安定性の強化方法
GB8724885D0 (en) * 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
US5169770A (en) * 1987-12-21 1992-12-08 The University Of Toledo Agrobacterium mediated transformation of germinating plant seeds
ES2096590T3 (es) * 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
DK168302B1 (da) * 1989-06-29 1994-03-07 Danisco Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
WO1992020373A1 (en) * 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1993008829A1 (en) * 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP0656064B1 (de) * 1992-08-17 1997-03-05 Genentech, Inc. Bispezifische immunoadhesine
ES2108460T3 (es) * 1993-06-03 1997-12-16 Therapeutic Antibodies Inc Fragmentos de anticuerpos en terapeutica.
US6136958A (en) * 1996-09-30 2000-10-24 Genentech, Inc. Antibodies to vertebrate smoothened proteins

Also Published As

Publication number Publication date
ZA978503B (en) 1999-03-23
US6407216B1 (en) 2002-06-18
JP4671371B2 (ja) 2011-04-13
US5990281A (en) 1999-11-23
AU4600597A (en) 1998-04-24
AU725701B2 (en) 2000-10-19
DE69734596T2 (de) 2006-07-20
DK0939769T3 (da) 2006-03-13
CA2267181A1 (en) 1998-04-09
ES2252795T3 (es) 2006-05-16
ATE309270T1 (de) 2005-11-15
EP0939769A1 (de) 1999-09-08
IL129139A0 (en) 2000-02-17
EP0939769B1 (de) 2005-11-09
IL129139A (en) 2007-12-03
JP2001501476A (ja) 2001-02-06
WO1998014475A1 (en) 1998-04-09

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation