DK1658302T3 - Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C - Google Patents
Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis CInfo
- Publication number
- DK1658302T3 DK1658302T3 DK04744307.2T DK04744307T DK1658302T3 DK 1658302 T3 DK1658302 T3 DK 1658302T3 DK 04744307 T DK04744307 T DK 04744307T DK 1658302 T3 DK1658302 T3 DK 1658302T3
- Authority
- DK
- Denmark
- Prior art keywords
- flavirividae
- treatment
- diseases caused
- purine nucleoside
- nucleoside analogues
- Prior art date
Links
- 208000005176 Hepatitis C Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000003834 purine nucleoside derivatives Chemical class 0.000 title 1
- XZLIYCQRASOFQM-UHFFFAOYSA-N 5h-imidazo[4,5-d]triazine Chemical class N1=NC=C2NC=NC2=N1 XZLIYCQRASOFQM-UHFFFAOYSA-N 0.000 abstract 1
- 241000710831 Flavivirus Species 0.000 abstract 1
- 241000710778 Pestivirus Species 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49021603P | 2003-07-25 | 2003-07-25 | |
| PCT/IB2004/002703 WO2005009418A2 (en) | 2003-07-25 | 2004-07-26 | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1658302T3 true DK1658302T3 (da) | 2010-11-22 |
Family
ID=34102969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04744307.2T DK1658302T3 (da) | 2003-07-25 | 2004-07-26 | Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20050075309A1 (enExample) |
| EP (1) | EP1658302B1 (enExample) |
| JP (1) | JP2007501185A (enExample) |
| KR (1) | KR20060084845A (enExample) |
| CN (1) | CN1852915A (enExample) |
| AT (1) | ATE478886T1 (enExample) |
| AU (1) | AU2004258750A1 (enExample) |
| BR (1) | BRPI0412849A (enExample) |
| CA (1) | CA2533367C (enExample) |
| DE (1) | DE602004028841D1 (enExample) |
| DK (1) | DK1658302T3 (enExample) |
| ES (1) | ES2351603T3 (enExample) |
| NO (1) | NO20060914L (enExample) |
| PL (1) | PL1658302T3 (enExample) |
| PT (1) | PT1658302E (enExample) |
| RU (1) | RU2006105640A (enExample) |
| WO (1) | WO2005009418A2 (enExample) |
Families Citing this family (78)
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| CA2568379A1 (en) | 2004-06-15 | 2005-12-29 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
| CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| JP5001842B2 (ja) | 2004-09-14 | 2012-08-15 | ギリアド ファーマセット エルエルシー | ２’−フルオロ−２’−アルキル−置換又は他の置換されていてもよいリボフラノシルピリミジン類及びプリン類並びにそれらの誘導体の製造 |
| CA2600359A1 (en) * | 2005-03-09 | 2006-09-09 | Idenix (Cayman) Limited | Nucleosides with non-natural bases as anti-viral agents |
| WO2007041775A1 (en) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
| CN101336247B (zh) | 2005-12-09 | 2013-01-23 | 豪夫迈·罗氏有限公司 | 抗病毒核苷 |
| JP2009532411A (ja) | 2006-04-04 | 2009-09-10 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈｃｖ治療のための３’，５’−ジ−ｏ−アシル化ヌクレオシド |
| CA2659461A1 (en) * | 2006-08-25 | 2008-02-28 | Wyeth | Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto |
| EP2084174B1 (en) | 2006-10-10 | 2013-07-31 | Gilead Pharmasset LLC | Preparation of nucleosides ribofuranosyl pyrimidines |
| ES2367455T3 (es) | 2006-11-09 | 2011-11-03 | F. Hoffmann-La Roche Ag | Arilamidas sustituidas por tiazol u oxazol. |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TW200936146A (en) * | 2007-11-29 | 2009-09-01 | Metabasis Therapeutics Inc | Antiviral nucleoside compounds |
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| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
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| KR101848099B1 (ko) | 2009-09-21 | 2018-04-11 | 길리애드 사이언시즈, 인코포레이티드 | 1'-치환된 카바-뉴클레오사이드 유사체의 제조를 위한 방법 및 중간체 |
| JP2013511030A (ja) | 2009-11-14 | 2013-03-28 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈｃｖ治療の迅速な反応を予測するためのバイオマーカー |
| RU2012127201A (ru) | 2009-12-02 | 2014-01-20 | Ф.Хоффманн-Ля Рош Аг | Биомаркеры для прогнозирования устойчивого ответа на лечение вируса гепатита с |
| CN102858790A (zh) | 2010-03-31 | 2013-01-02 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| KR20200052384A (ko) | 2010-07-19 | 2020-05-14 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
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| EA027929B1 (ru) | 2012-05-25 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Нуклеозиды на основе урацила и спирооксетана |
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| RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
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- 2004-07-26 JP JP2006520940A patent/JP2007501185A/ja active Pending
- 2004-07-26 DE DE602004028841T patent/DE602004028841D1/de not_active Expired - Lifetime
- 2004-07-26 AT AT04744307T patent/ATE478886T1/de active
- 2004-07-26 DK DK04744307.2T patent/DK1658302T3/da active
- 2004-07-26 AU AU2004258750A patent/AU2004258750A1/en not_active Abandoned
- 2004-07-26 PL PL04744307T patent/PL1658302T3/pl unknown
- 2004-07-26 EP EP04744307A patent/EP1658302B1/en not_active Expired - Lifetime
- 2004-07-26 US US10/900,008 patent/US20050075309A1/en not_active Abandoned
- 2004-07-26 WO PCT/IB2004/002703 patent/WO2005009418A2/en not_active Ceased
- 2004-07-26 ES ES04744307T patent/ES2351603T3/es not_active Expired - Lifetime
- 2004-07-26 PT PT04744307T patent/PT1658302E/pt unknown
- 2004-07-26 CN CNA2004800270217A patent/CN1852915A/zh active Pending
- 2004-07-26 BR BRPI0412849-4A patent/BRPI0412849A/pt not_active IP Right Cessation
- 2004-07-26 CA CA2533367A patent/CA2533367C/en not_active Expired - Fee Related
- 2004-07-26 KR KR1020067001534A patent/KR20060084845A/ko not_active Withdrawn
- 2004-07-26 RU RU2006105640/04A patent/RU2006105640A/ru not_active Application Discontinuation
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2006
- 2006-02-24 NO NO20060914A patent/NO20060914L/no not_active Application Discontinuation
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2008
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2014
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| PL1658302T3 (pl) | 2011-03-31 |
| WO2005009418A3 (en) | 2005-04-07 |
| ATE478886T1 (de) | 2010-09-15 |
| CA2533367A1 (en) | 2005-02-03 |
| US20090169507A1 (en) | 2009-07-02 |
| NO20060914L (no) | 2006-04-25 |
| US20050075309A1 (en) | 2005-04-07 |
| CN1852915A (zh) | 2006-10-25 |
| JP2007501185A (ja) | 2007-01-25 |
| ES2351603T3 (es) | 2011-02-08 |
| EP1658302A2 (en) | 2006-05-24 |
| DE602004028841D1 (de) | 2010-10-07 |
| US8742101B2 (en) | 2014-06-03 |
| EP1658302B1 (en) | 2010-08-25 |
| RU2006105640A (ru) | 2007-09-10 |
| CA2533367C (en) | 2013-10-01 |
| AU2004258750A1 (en) | 2005-02-03 |
| KR20060084845A (ko) | 2006-07-25 |
| US20140234251A1 (en) | 2014-08-21 |
| BRPI0412849A (pt) | 2006-09-26 |
| PT1658302E (pt) | 2010-10-25 |
| WO2005009418A2 (en) | 2005-02-03 |
| US9186369B2 (en) | 2015-11-17 |
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