DK1658302T3 - Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C - Google Patents
Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis CInfo
- Publication number
- DK1658302T3 DK1658302T3 DK04744307.2T DK04744307T DK1658302T3 DK 1658302 T3 DK1658302 T3 DK 1658302T3 DK 04744307 T DK04744307 T DK 04744307T DK 1658302 T3 DK1658302 T3 DK 1658302T3
- Authority
- DK
- Denmark
- Prior art keywords
- flavirividae
- treatment
- diseases caused
- purine nucleoside
- nucleoside analogues
- Prior art date
Links
- 208000005176 Hepatitis C Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000003834 purine nucleoside derivatives Chemical class 0.000 title 1
- XZLIYCQRASOFQM-UHFFFAOYSA-N 5h-imidazo[4,5-d]triazine Chemical class N1=NC=C2NC=NC2=N1 XZLIYCQRASOFQM-UHFFFAOYSA-N 0.000 abstract 1
- 241000710831 Flavivirus Species 0.000 abstract 1
- 241000710778 Pestivirus Species 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49021603P | 2003-07-25 | 2003-07-25 | |
| PCT/IB2004/002703 WO2005009418A2 (en) | 2003-07-25 | 2004-07-26 | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1658302T3 true DK1658302T3 (da) | 2010-11-22 |
Family
ID=34102969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04744307.2T DK1658302T3 (da) | 2003-07-25 | 2004-07-26 | Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20050075309A1 (enExample) |
| EP (1) | EP1658302B1 (enExample) |
| JP (1) | JP2007501185A (enExample) |
| KR (1) | KR20060084845A (enExample) |
| CN (1) | CN1852915A (enExample) |
| AT (1) | ATE478886T1 (enExample) |
| AU (1) | AU2004258750A1 (enExample) |
| BR (1) | BRPI0412849A (enExample) |
| CA (1) | CA2533367C (enExample) |
| DE (1) | DE602004028841D1 (enExample) |
| DK (1) | DK1658302T3 (enExample) |
| ES (1) | ES2351603T3 (enExample) |
| NO (1) | NO20060914L (enExample) |
| PL (1) | PL1658302T3 (enExample) |
| PT (1) | PT1658302E (enExample) |
| RU (1) | RU2006105640A (enExample) |
| WO (1) | WO2005009418A2 (enExample) |
Families Citing this family (78)
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| EP1758453B1 (en) | 2004-06-15 | 2014-07-16 | Merck Sharp & Dohme Corp. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
| CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| WO2006031725A2 (en) | 2004-09-14 | 2006-03-23 | Pharmasset, Inc. | Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| CA2600359A1 (en) * | 2005-03-09 | 2006-09-09 | Idenix (Cayman) Limited | Nucleosides with non-natural bases as anti-viral agents |
| WO2007041775A1 (en) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
| EP1957510A1 (en) | 2005-12-09 | 2008-08-20 | F.Hoffmann-La Roche Ag | Antiviral nucleosides |
| CA2647276A1 (en) | 2006-04-04 | 2007-10-11 | F. Hoffmann-La Roche Ag | 3',5'-di-o-acylated nucleosides for hcv treatment |
| US20080182895A1 (en) * | 2006-08-25 | 2008-07-31 | Howe Anita Y M | Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto |
| ES2429290T3 (es) | 2006-10-10 | 2013-11-14 | Gilead Pharmasset Llc | Preparación de nucleósidos de ribofuranosilpirimidinas |
| AU2007316681B2 (en) | 2006-11-09 | 2013-01-24 | F. Hoffmann-La Roche Ag | Thiazole and oxazole-substituted arylamides |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TW200936146A (en) * | 2007-11-29 | 2009-09-01 | Metabasis Therapeutics Inc | Antiviral nucleoside compounds |
| EP2225213B1 (en) | 2007-12-17 | 2015-04-29 | F. Hoffmann-La Roche AG | Triazole-substituted arylamide derivatives and their use as p2x3 and /or p2x2/3 purinergic receptor antagonists |
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| BRPI0820838B8 (pt) | 2007-12-17 | 2021-05-25 | Hoffmann La Roche | derivados de arilamida substituídos por tetrazol, composição farmacêutica que os compreende e seu uso como antagonistas do receptor purinérgico p2x3 e/ou p2x2/3 |
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| CN102438989B (zh) | 2009-06-22 | 2015-05-27 | 霍夫曼-拉罗奇有限公司 | 噁唑酮和吡咯烷酮取代的芳基酰胺 |
| CN102574778B (zh) | 2009-06-22 | 2015-01-07 | 弗·哈夫曼-拉罗切有限公司 | 新的联苯基和苯基-吡啶酰胺类化合物 |
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| BR112012011393A2 (pt) | 2009-12-02 | 2017-06-20 | Hoffmann La Roche | biomarcadores para a previsão da resposta sustentada ao tratamento de hcv |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| LT2609923T (lt) | 2010-03-31 | 2017-09-11 | Gilead Pharmasset Llc | (s)-izopropilo 2-(((s)-(perfluorfenoksi)(fenoksi)fosforil)amino)-propanoato kristalinimo būdas |
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-
2004
- 2004-07-26 RU RU2006105640/04A patent/RU2006105640A/ru not_active Application Discontinuation
- 2004-07-26 BR BRPI0412849-4A patent/BRPI0412849A/pt not_active IP Right Cessation
- 2004-07-26 JP JP2006520940A patent/JP2007501185A/ja active Pending
- 2004-07-26 PL PL04744307T patent/PL1658302T3/pl unknown
- 2004-07-26 DE DE602004028841T patent/DE602004028841D1/de not_active Expired - Lifetime
- 2004-07-26 AT AT04744307T patent/ATE478886T1/de active
- 2004-07-26 WO PCT/IB2004/002703 patent/WO2005009418A2/en not_active Ceased
- 2004-07-26 ES ES04744307T patent/ES2351603T3/es not_active Expired - Lifetime
- 2004-07-26 PT PT04744307T patent/PT1658302E/pt unknown
- 2004-07-26 AU AU2004258750A patent/AU2004258750A1/en not_active Abandoned
- 2004-07-26 US US10/900,008 patent/US20050075309A1/en not_active Abandoned
- 2004-07-26 CA CA2533367A patent/CA2533367C/en not_active Expired - Fee Related
- 2004-07-26 CN CNA2004800270217A patent/CN1852915A/zh active Pending
- 2004-07-26 EP EP04744307A patent/EP1658302B1/en not_active Expired - Lifetime
- 2004-07-26 KR KR1020067001534A patent/KR20060084845A/ko not_active Withdrawn
- 2004-07-26 DK DK04744307.2T patent/DK1658302T3/da active
-
2006
- 2006-02-24 NO NO20060914A patent/NO20060914L/no not_active Application Discontinuation
-
2008
- 2008-11-13 US US12/270,795 patent/US8742101B2/en not_active Expired - Lifetime
-
2014
- 2014-05-02 US US14/269,003 patent/US9186369B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060084845A (ko) | 2006-07-25 |
| AU2004258750A1 (en) | 2005-02-03 |
| US20140234251A1 (en) | 2014-08-21 |
| WO2005009418A3 (en) | 2005-04-07 |
| BRPI0412849A (pt) | 2006-09-26 |
| DE602004028841D1 (de) | 2010-10-07 |
| JP2007501185A (ja) | 2007-01-25 |
| CN1852915A (zh) | 2006-10-25 |
| ATE478886T1 (de) | 2010-09-15 |
| US8742101B2 (en) | 2014-06-03 |
| PL1658302T3 (pl) | 2011-03-31 |
| CA2533367C (en) | 2013-10-01 |
| US20090169507A1 (en) | 2009-07-02 |
| NO20060914L (no) | 2006-04-25 |
| WO2005009418A2 (en) | 2005-02-03 |
| RU2006105640A (ru) | 2007-09-10 |
| EP1658302A2 (en) | 2006-05-24 |
| CA2533367A1 (en) | 2005-02-03 |
| ES2351603T3 (es) | 2011-02-08 |
| EP1658302B1 (en) | 2010-08-25 |
| US20050075309A1 (en) | 2005-04-07 |
| PT1658302E (pt) | 2010-10-25 |
| US9186369B2 (en) | 2015-11-17 |
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