DE68929019D1 - Optische schnittstelle - Google Patents

Optische schnittstelle

Info

Publication number
DE68929019D1
DE68929019D1 DE68929019T DE68929019T DE68929019D1 DE 68929019 D1 DE68929019 D1 DE 68929019D1 DE 68929019 T DE68929019 T DE 68929019T DE 68929019 T DE68929019 T DE 68929019T DE 68929019 D1 DE68929019 D1 DE 68929019D1
Authority
DE
Germany
Prior art keywords
pct
light
date
sensing surfaces
biosensor system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68929019T
Other languages
English (en)
Other versions
DE68929019T2 (de
Inventor
Hakan Sjoedin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Biacore AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore AB filed Critical Biacore AB
Application granted granted Critical
Publication of DE68929019D1 publication Critical patent/DE68929019D1/de
Publication of DE68929019T2 publication Critical patent/DE68929019T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • G01N21/553Attenuated total reflection and using surface plasmons
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24Coupling light guides
    • G02B6/26Optical coupling means
    • G02B6/34Optical coupling means utilising prism or grating
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21Polarisation-affecting properties
    • G01N21/211Ellipsometry
    • G01N2021/212Arrangement with total internal reflection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity
    • G01N21/5907Densitometers
    • G01N2021/5957Densitometers using an image detector type detector, e.g. CCD
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/0332Cuvette constructions with temperature control
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Glass Compositions (AREA)
  • Optical Communication System (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Optical Measuring Cells (AREA)
DE68929019T 1988-11-10 1989-11-09 Optische schnittstelle Expired - Lifetime DE68929019T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8804075A SE462408B (sv) 1988-11-10 1988-11-10 Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
PCT/SE1989/000645 WO1990005317A1 (en) 1988-11-10 1989-11-09 Optical interface means

Publications (2)

Publication Number Publication Date
DE68929019D1 true DE68929019D1 (de) 1999-07-22
DE68929019T2 DE68929019T2 (de) 1999-10-07

Family

ID=20373909

Family Applications (2)

Application Number Title Priority Date Filing Date
DE89912281T Expired - Lifetime DE68912343T2 (de) 1988-11-10 1989-11-09 Optisches biosensorsystem.
DE68929019T Expired - Lifetime DE68929019T2 (de) 1988-11-10 1989-11-09 Optische schnittstelle

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE89912281T Expired - Lifetime DE68912343T2 (de) 1988-11-10 1989-11-09 Optisches biosensorsystem.

Country Status (7)

Country Link
US (2) US5313264A (de)
EP (2) EP0534941B1 (de)
JP (2) JP3294605B2 (de)
AT (1) ATE181423T1 (de)
DE (2) DE68912343T2 (de)
SE (1) SE462408B (de)
WO (2) WO1990005295A1 (de)

Families Citing this family (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100392D0 (sv) * 1991-02-08 1991-02-08 Pharmacia Biosensor Ab A method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means
SE9200917D0 (sv) * 1991-08-20 1992-03-25 Pharmacia Biosensor Ab Assay method
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
GB9200564D0 (en) * 1992-01-11 1992-03-11 Fisons Plc Analytical device with variable angle of incidence
SE470147B (sv) * 1992-04-16 1993-11-15 Ericsson Telefon Ab L M Inkapsling för optisk vågledare
SE9201984D0 (sv) * 1992-06-29 1992-06-29 Pharmacia Biosensor Ab Improvement in optical assays
US5656504A (en) * 1992-10-26 1997-08-12 Pharmacia Biosensor Ab Method of preventing undesired binding in solid phase assays
US5576220A (en) * 1993-02-19 1996-11-19 Arris Pharmaceutical Corporation Thin film HPMP matrix systems and methods for constructing and displaying ligands
US5432607A (en) * 1993-02-22 1995-07-11 International Business Machines Corporation Method and apparatus for inspecting patterned thin films using diffracted beam ellipsometry
DE4315211A1 (de) * 1993-05-07 1994-02-03 Gunnar Brink Vorrichtung und Verfahren zum Nachweis der Adsorption von Molekülen mittels Nahinfrarot-Oberflächenplasmonenresonanz
SE501713C2 (sv) * 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler
US5521702A (en) * 1994-06-14 1996-05-28 Salamon; Zdzislaw Reusable biocompatible interface for immobilization of materials on a solid support
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
EP0712011A1 (de) * 1994-11-09 1996-05-15 Hewlett-Packard Company Optisches Brechungsindex-Anpassungs-System
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
SE9502258D0 (sv) * 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US5606633A (en) * 1995-06-26 1997-02-25 American Research Corporation Of Virginia Chemical detector employing surface plasmon resonance excited using an optical waveguide configured as an asymmetric waveguide coupler
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
SE9503028D0 (sv) * 1995-09-01 1995-09-01 Pharmacia Biosensor Ab Method of analysing chemical and physical interactions at a sensor surface
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
AU7526496A (en) * 1995-10-25 1997-05-15 University Of Washington Surface plasmon resonance electrode as chemical sensor
WO1997015821A1 (en) * 1995-10-25 1997-05-01 University Of Washington Surface plasmon resonance probe systems based on a folded planar lightpipe
SE9504206D0 (sv) * 1995-11-24 1995-11-24 Pharmacia Ab Optical coupling device and method for its production
US5986268A (en) * 1996-01-11 1999-11-16 The Trustees Of Princeton University Organic luminescent coating for light detectors
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
JP3090692B2 (ja) * 1996-02-28 2000-09-25 株式会社分子バイオホトニクス研究所 酵素反応測定方法及びその測定装置
DE19615366B4 (de) * 1996-04-19 2006-02-09 Carl Zeiss Jena Gmbh Verfahren und Einrichtung zum Nachweis physikalischer, chemischer, biologischer oder biochemischer Reaktionen und Wechselwirkungen
US5955379A (en) * 1996-04-25 1999-09-21 Mcgill University Biosensor device and method
US6107080A (en) * 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
US6130037A (en) * 1996-04-25 2000-10-10 Pence And Mcgill University Biosensor device and method
US5917607A (en) * 1996-04-25 1999-06-29 Fuji Photo Film Co., Ltd. Surface plasmon sensor for multiple channel analysis
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
JPH09292334A (ja) * 1996-04-30 1997-11-11 Fuji Photo Film Co Ltd 表面プラズモンセンサー
EP1650547B1 (de) * 1996-04-30 2011-10-19 FUJIFILM Corporation Oberflächenplasmonensensor
US6232124B1 (en) 1996-05-06 2001-05-15 Verification Technologies, Inc. Automated fingerprint methods and chemistry for product authentication and monitoring
ATE408824T1 (de) * 1996-05-30 2008-10-15 Cellomics Inc Miniaturisierte zellenanordnung und verfahren und vorrichtung zum screening mittels zellen
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US20060141539A1 (en) * 1996-05-30 2006-06-29 Taylor D L Miniaturized cell array methods and apparatus for cell-based screening
DE19628002C1 (de) 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
JPH10132784A (ja) * 1996-11-05 1998-05-22 Hitachi Electron Eng Co Ltd Dna塩基配列決定装置
GB9623820D0 (en) * 1996-11-16 1997-01-08 Secr Defence Surface plasma resonance sensor
ATE308039T1 (de) 1996-11-18 2005-11-15 Novartis Ag Messvorrichtung mit einem planaren optischen wellenleiter
EP0843173A1 (de) * 1996-11-18 1998-05-20 Novartis AG Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
US5846843A (en) * 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
US6458547B1 (en) * 1996-12-12 2002-10-01 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
AU742417B2 (en) * 1997-02-04 2002-01-03 Ge Healthcare Bio-Sciences Ab Analytical method and apparatus
SE9700384D0 (sv) * 1997-02-04 1997-02-04 Biacore Ab Analytical method and apparatus
EP0863395B1 (de) * 1997-02-07 2005-06-15 Fuji Photo Film Co., Ltd. Oberflächen-Plasmonen-Sensor
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
CA2282658C (en) 1997-02-27 2003-02-25 Cellomics, Inc. A system for cell-based screening
US6686208B2 (en) * 1997-03-18 2004-02-03 Institut Fur Chemo- Und Biosensorik Munster E.V. Device and method for carrying out fluoresence immunotests
DE19711281C1 (de) * 1997-03-18 1998-04-16 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
JP3739537B2 (ja) * 1997-03-26 2006-01-25 大日本印刷株式会社 光学的分析装置用測定チップ
AU7011898A (en) 1997-04-22 1998-11-13 Thomas Schalkhammer Reinforced cluster optical sensors
AU1060099A (en) * 1997-06-10 1999-01-25 American Research Corporation Of Virginia Detection of chemical agent materials using a sorbent polymer and fluores cent probe
US6141100A (en) * 1997-08-15 2000-10-31 Bio-Rad Laboratories, Inc. Imaging ATR spectrometer
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
US6091984A (en) * 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
WO1999030135A1 (en) 1997-12-12 1999-06-17 The Perkin-Elmer Corporation Optical resonance analysis system
US6200814B1 (en) * 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
DE19805809C2 (de) * 1998-02-12 2000-02-17 Biotul Bio Instr Gmbh Bestimmung der Oberflächenplasmonen-Resonanz mit Hilfe von örtlich oder zeitlich modifizierten Schichten
JP3086674B2 (ja) * 1998-02-20 2000-09-11 アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー 指度校正を可能にする有機物質検出装置及びそれを用いた有機物質監視システム
DE19814811C1 (de) * 1998-04-02 1999-08-05 Inst Physikalische Hochtech Ev Anordnung für die Oberflächenplasmonen-Resonanz-Spektroskopie
DE19815932C2 (de) * 1998-04-09 2000-06-21 Glukomeditech Ag Verfahren zur Miniaturisierung eines Polarimeters zur Analyse niedrig konzentrierter Komponenten im flüssigen Meßgut auf optischer Basis sowie Vorrichtung zu seiner Durchführung
DE19817470B4 (de) * 1998-04-20 2008-10-30 Hofmann, Andreas Vorrichtung zur Oberflächenplasmonenresonanzmessung
EP1080365A1 (de) * 1998-05-20 2001-03-07 Graffinity Pharmaceuticals Aktiengesellschaft Spr-sensor zur gleichzeitigen erfassung einer vielzahl von in fluider form vorliegenden proben
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
EP0971226A1 (de) * 1998-07-06 2000-01-12 Suzuki Motor Corporation SPR Sensorzelle und diese verwendende Vorrichtung für Immunoassay
US6432364B1 (en) 1998-07-06 2002-08-13 Suzuki Motor Corporation SPR sensor cell and immunoassay apparatus using the same
GB2339615B (en) * 1998-07-14 2001-02-07 Cozart Bioscience Ltd Screening device and method of screening an immunoassay test
US6111652A (en) * 1998-07-14 2000-08-29 Texas Instruments Incorporated High throughput surface plasmon resonance analysis system
US6052187A (en) * 1998-08-31 2000-04-18 Containerless Research, Inc. Hyperspectral polarization profiler for remote sensing
US6937341B1 (en) 1998-09-29 2005-08-30 J. A. Woollam Co. Inc. System and method enabling simultaneous investigation of sample with two beams of electromagnetic radiation
US6326612B1 (en) * 1998-10-13 2001-12-04 Texas Instruments Incorporated System and method for optical sensing utilizing a portable, detachable sensor cartridge
US6300638B1 (en) 1998-11-12 2001-10-09 Calspan Srl Corporation Modular probe for total internal reflection fluorescence spectroscopy
AU1524500A (en) 1998-11-13 2000-06-05 Leica Microsystems Inc. Refractometer and method for qualitative and quantitative measurements
EP1131618B1 (de) * 1998-11-20 2005-10-12 Graffinity Pharmaceutical Design GmbH Messanordnung und messmethode zum parallelen auslesen von spr-sensoren
JP2000162124A (ja) * 1998-12-01 2000-06-16 Nippon Laser Denshi Kk 表面プラズモン共鳴角検出装置のセンサーチップ
US6490030B1 (en) 1999-01-18 2002-12-03 Verification Technologies, Inc. Portable product authentication device
US6404497B1 (en) 1999-01-25 2002-06-11 Massachusetts Institute Of Technology Polarized light scattering spectroscopy of tissue
NZ513843A (en) * 1999-02-01 2002-07-26 Vir As A surface plasmon resonance sensor
US6738141B1 (en) 1999-02-01 2004-05-18 Vir A/S Surface plasmon resonance sensor
EP1031828B1 (de) * 1999-02-25 2006-09-13 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
US6787368B1 (en) 1999-03-02 2004-09-07 Helix Biopharma Corporation Biosensor method for detecting analytes in a liquid
US6008893A (en) * 1999-03-22 1999-12-28 Biacore Ab Reversible-flow conduit system
US6897072B1 (en) 1999-04-27 2005-05-24 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
US6480282B1 (en) * 1999-05-06 2002-11-12 University Of Washington Capillary surface plasmon resonance sensors and multisensors
US6784999B1 (en) * 1999-05-17 2004-08-31 The Florida International University Board Of Trustees Surface plasmon resonance detection with high angular resolution and fast response time
ATE295541T1 (de) * 1999-06-18 2005-05-15 Biacore Ab Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
WO2001002839A1 (en) 1999-07-05 2001-01-11 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6692697B1 (en) 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
EP1072881A3 (de) * 1999-07-30 2002-04-24 Texas Instruments Incorporated Ein integrierter optischer Sensor
WO2001029537A2 (en) * 1999-10-15 2001-04-26 Glaxo Group Limited Method and apparatus for monitoring solid phase chemical reactions
US6512580B1 (en) 1999-10-27 2003-01-28 Verification Technologies, Inc. Method and apparatus for portable product authentication
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
WO2001042786A2 (en) 1999-12-09 2001-06-14 Cellomics, Inc. System for cell based screening : cell spreading
US6594018B1 (en) 2000-02-01 2003-07-15 Texas Instruments Incorporated Miniature integrated multiple channel surface plasmon resonance liquid sensor
DE10006083B4 (de) 2000-02-11 2004-01-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zur quantitativen und/oder qualitativen Bestimmung von Schichtdicken sowie ein Mikroreaktionsgefäß und eine Titerplatte
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US20020164643A1 (en) * 2000-02-18 2002-11-07 Aspira Biosystems, Inc. Compositions and methods for surface imprinting
US7349092B1 (en) 2000-02-22 2008-03-25 J.A. Woollam Co., Inc System for reducing stress induced effects during determination of fluid optical constants
DE10008006C2 (de) * 2000-02-22 2003-10-16 Graffinity Pharm Design Gmbh SPR-Sensor und SPR-Sensoranordnung
ATE353438T1 (de) * 2000-02-22 2007-02-15 Santhera Pharmaceuticals Deuts Spr-sensorsystem
EP1186881A4 (de) * 2000-03-16 2006-04-19 Fuji Photo Film Co Ltd Messverfahren und vorrichtung mit verwendung der abgeschwächten totalreflektion
JP4188538B2 (ja) * 2000-04-12 2008-11-26 浜松ホトニクス株式会社 免疫クロマト試験片の測定装置
US20040000787A1 (en) * 2000-04-24 2004-01-01 Rakesh Vig Authentication mark for a product or product package
US20030112423A1 (en) * 2000-04-24 2003-06-19 Rakesh Vig On-line verification of an authentication mark applied to products or product packaging
AU6114501A (en) * 2000-05-03 2001-11-12 Jen Gau Jr Biological identification system with integrated sensor chip
DE10023363C1 (de) * 2000-05-12 2001-12-20 Jandratek Gmbh Plasmonenresonanzsensor
US6638593B2 (en) * 2000-06-30 2003-10-28 Verification Technologies, Inc. Copy-protected optical media and method of manufacture thereof
AU2001259033A1 (en) 2000-06-30 2002-01-14 Verification Technologies, Inc. Copy-protected optical media and method of manufacture thereof
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6833920B2 (en) * 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US20020093654A1 (en) * 2000-07-11 2002-07-18 Lieberman Robert A. Apparatus and method for imaging
JP2004505291A (ja) 2000-07-21 2004-02-19 ビール アクティーゼルスカブ 表面プラズモン共振センサのための結合素子
US7660415B2 (en) * 2000-08-03 2010-02-09 Selinfreund Richard H Method and apparatus for controlling access to storage media
EP2275802A1 (de) * 2000-08-09 2011-01-19 Artificial Sensing Instruments ASI AG Wellenleitergitterstruktur und optische Messanordnung
AU2002212904B2 (en) * 2000-11-02 2006-01-12 Ge Healthcare Bio-Sciences Ab Valve integrally associated with microfluidic liquid transport assembly
EP1343973B2 (de) 2000-11-16 2020-09-16 California Institute Of Technology Vorrichtung und verfahren zur durchführung von assays und screening mit hohem durchsatz
FR2817963B1 (fr) * 2000-12-13 2004-08-06 Inst Optique Theorique Et Appl Dispositif d'imagerie par plasmon d'une surface metallique et procede d'utilisation du dispositif
JP4173628B2 (ja) * 2000-12-14 2008-10-29 富士フイルム株式会社 表面プラズモン共鳴測定装置
EP1219954B1 (de) * 2000-12-27 2008-02-13 FUJIFILM Corporation Totalreflexion nutzender Sensor
US20020140940A1 (en) * 2001-02-28 2002-10-03 Bambot Shabbir B. System and method for measurement and analysis of a sample by absorption spectrophotometry
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
EP1243916A3 (de) * 2001-03-22 2004-04-14 Fuji Photo Film Co., Ltd. Messvorrichtung und Messchip
JP2003254905A (ja) * 2001-03-22 2003-09-10 Fuji Photo Film Co Ltd 測定装置
US7208322B2 (en) * 2001-04-02 2007-04-24 Agilent Technologies, Inc. Sensor surfaces for detecting analytes
AU2002258702A1 (en) * 2001-04-02 2002-10-15 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
WO2002086468A1 (en) * 2001-04-19 2002-10-31 Maven Technologies Llc. Imaging apparatus and method
US7189366B2 (en) * 2001-05-25 2007-03-13 The United States Of America As Represented By The Secretary Of The Interior Molecular tag reader
DE10126152C2 (de) * 2001-05-30 2003-12-24 Inst Mikrotechnik Mainz Gmbh Ortsaufgelöstes Ellipsometrie-Verfahren zur quantitativen und/oder qualitativen Bestimmung von Probenänderungen, Biochip und Meßanordnung
SE0102331D0 (sv) * 2001-06-29 2001-06-29 Biacore Ab Flow cell method
EP1422512A1 (de) * 2001-08-28 2004-05-26 Matsushita Electric Industrial Co., Ltd. Vorrichtung zur messung von informationen an einer teilchenkomponente
WO2003021231A2 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Method and apparatus for normalization and deconvolution of assay data
DE10146945A1 (de) * 2001-09-24 2003-04-10 Zeiss Carl Jena Gmbh Meßanordnung und Meßverfahren
DE10151312C2 (de) * 2001-10-17 2003-08-28 Vir As Taastrup Oberflächenplasmonen-Resonanz-Sensor
US6791691B2 (en) 2001-10-19 2004-09-14 Fuji Photo Film Co., Ltd. Measuring method and apparatus using attenuation in total internal reflection
SE526185C2 (sv) * 2001-11-07 2005-07-19 Prolight Diagnostics Ab Metod och anordning för immunanalys
US7187444B2 (en) 2001-11-12 2007-03-06 Fuji Photo Film Co., Ltd. Measuring method and apparatus using attenuation in total internal reflection
AU2002358520A1 (en) * 2001-11-28 2003-06-10 Graffinity Pharmaceuticals Ag Method for the selection and identification of peptide or protein molecules by means of phase display
EP1451558A1 (de) * 2001-11-28 2004-09-01 Graffinity Pharmaceuticals Aktiengesellschaft Spr-sensorflächenträger
US6943887B2 (en) * 2001-12-04 2005-09-13 Texas Instruments Incorporated Surface plasmon resonance sensor having real-time referencing
EP1324019B1 (de) * 2001-12-25 2006-07-12 Fuji Photo Film Co., Ltd. Sensorsystem mit evaneszenten Wellen
JP4173725B2 (ja) * 2001-12-25 2008-10-29 富士フイルム株式会社 エバネッセント波を利用したセンサー
FR2834340B1 (fr) * 2001-12-28 2004-07-16 Mauna Kea Technologies Appareillage de spectroscopie d'autofluorescence subsurfacique
EP1470401A4 (de) * 2002-01-12 2007-08-29 Maven Technologies Llc Vorrichtung und verfahren zur abbildung
DE10202466B4 (de) * 2002-01-23 2004-09-02 Carl Zeiss Jena Gmbh Objektträger für die Fluoreszenzmikroskopie
EP2368635A3 (de) 2002-02-12 2012-03-07 Cellectricon Ab Systeme und Verfahren zur schnellen Änderung der Lösungsumgebung um Sensoren
US7470518B2 (en) 2002-02-12 2008-12-30 Cellectricon Ab Systems and method for rapidly changing the solution environment around sensors
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
US6717663B2 (en) * 2002-03-08 2004-04-06 Reichert, Inc. Optical configuration and method for differential refractive index measurements
JP3878872B2 (ja) * 2002-03-25 2007-02-07 独立行政法人科学技術振興機構 表面プラズモン共鳴センサ
US20030194709A1 (en) * 2002-04-10 2003-10-16 Xing Yang Hydrophobic zone device
GB0208687D0 (en) * 2002-04-16 2002-05-29 Davis John B Elastomer-glass fluid control elements
DE10217098B4 (de) * 2002-04-17 2004-04-15 Carl Zeiss Jena Gmbh Auflicht-Beleuchtungsanordnung für ein Mikroskop
US20030207454A1 (en) * 2002-05-01 2003-11-06 Eyster Curt R. Devices and methods for analyte concentration determination
US6734956B2 (en) * 2002-05-06 2004-05-11 Reichert, Inc. Optical configuration and method for differential refractive index measurements
EP1509770B1 (de) * 2002-05-31 2014-07-09 GE Healthcare Bio-Sciences AB Verfahren zur kopplung von bindungsagentien an eine substratoberfläche
US20030228566A1 (en) * 2002-06-11 2003-12-11 Biotechplex Corporation Method of and apparatus for screening for drug candidates
JP4109022B2 (ja) * 2002-06-13 2008-06-25 富士フイルム株式会社 測定装置および該測定装置の使用方法
JP2004016609A (ja) * 2002-06-19 2004-01-22 Omron Healthcare Co Ltd 体液成分濃度測定方法及び体液成分濃度測定装置
US6816254B2 (en) * 2002-07-29 2004-11-09 Richert, Inc. Flow cell clamp
US20040023397A1 (en) * 2002-08-05 2004-02-05 Rakesh Vig Tamper-resistant authentication mark for use in product or product packaging authentication
JP3764711B2 (ja) * 2002-08-27 2006-04-12 株式会社東芝 管状バイオ検知システム
US6804007B2 (en) * 2002-09-10 2004-10-12 Reichert, Inc. Apparatus for multiplexing two surface plasma resonance channels onto a single linear scanned array
JP4380977B2 (ja) * 2002-10-28 2009-12-09 東洋紡績株式会社 表面プラズモン共鳴測定用フローセル
US7030989B2 (en) * 2002-10-28 2006-04-18 University Of Washington Wavelength tunable surface plasmon resonance sensor
AU2003283663A1 (en) * 2002-11-01 2004-05-25 Cellectricon Ab Computer programs,workstations, systems and methods for microfluidic substrates in cell
US6885455B2 (en) * 2002-11-22 2005-04-26 Dwight U. Bartholomew Self-calibration of an optical-based sensor using a total internal reflection (TIR) signature
CA2511934C (en) * 2002-12-25 2011-08-16 Proteoptics Ltd. Surface plasmon resonance sensor
GB0300001D0 (en) * 2003-01-02 2003-02-05 Polwart Neil Improved surface plasmon resonance sensor
US7265844B2 (en) * 2003-04-10 2007-09-04 Wisconsin Alumni Research Foundation Horizontal surface plasmon resonance instrument with improved light path
US7148968B2 (en) * 2003-04-10 2006-12-12 Wisconsin Alumni Research Foundation Portable surface plasmon resonance imaging instrument
JP4076962B2 (ja) * 2003-04-23 2008-04-16 独立行政法人科学技術振興機構 差動式表面プラズモン共鳴現象測定装置及びその測定方法
DE10320226B3 (de) * 2003-05-05 2004-12-16 Graffinity Pharmaceuticals Ag Vorrichtung und Verfahren zur optischen Kopplung
DE10324973B4 (de) * 2003-05-27 2006-04-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
JP2004354092A (ja) * 2003-05-27 2004-12-16 Aisin Seiki Co Ltd 表面プラズモン共鳴測定装置
US7373255B2 (en) 2003-06-06 2008-05-13 Biacore Ab Method and system for determination of molecular interaction parameters
DE10327399A1 (de) * 2003-06-18 2005-01-05 Carl Zeiss Jena Gmbh Verfahren und Messanordnung zur markierungsfreien Detektion von Bindungsereignissen zwischen Proteinen und oberflächengebundenen Antikörpern
US7057720B2 (en) * 2003-06-24 2006-06-06 Corning Incorporated Optical interrogation system and method for using same
US20050019216A1 (en) * 2003-07-24 2005-01-27 Hans-Heinrich Trutnau Apparatus for introducing a sample into a flowthrough analysis system
AU2004274866B2 (en) * 2003-08-01 2007-12-13 Ge Healthcare Bio-Science Ab Method and apparatus for quantitating surface-binding optical resonance profiles
US7223609B2 (en) * 2003-08-14 2007-05-29 Agilent Technologies, Inc. Arrays for multiplexed surface plasmon resonance detection of biological molecules
US7804592B2 (en) * 2003-10-16 2010-09-28 Nard Institute, Ltd. Method for measuring a surface plasmon resonance and noble metal compound used for the same
US7002688B2 (en) * 2003-10-16 2006-02-21 Pria Diagnostics, Inc. Multilens optical assembly for a diagnostic device
US7417737B2 (en) 2003-12-02 2008-08-26 Fujilfilm Corporation Method for measuring surface plasmon resonance
JP4593573B2 (ja) * 2004-01-08 2010-12-08 オスモペン, リミテッド ライアビリティ カンパニー 表面プラズモン共鳴型ナノリットル浸透圧計
JP2005257455A (ja) 2004-03-11 2005-09-22 Fuji Photo Film Co Ltd 測定装置および測定ユニット
US20050210996A1 (en) * 2004-03-12 2005-09-29 Quinn John G Flow channel structure and method
NZ528338A (en) * 2004-03-19 2006-10-27 Ind Res Ltd Biosensors for detecting bond rupture
JP4683538B2 (ja) * 2004-05-06 2011-05-18 セイコーインスツル株式会社 分析用マイクロチップを含む分析システムと分析方法
CN100595564C (zh) * 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
WO2006022277A1 (ja) 2004-08-24 2006-03-02 Fujifilm Corporation 表面プラズモン共鳴分析における解離定数の算出方法
JP4371954B2 (ja) * 2004-08-31 2009-11-25 富士フイルム株式会社 表面プラズモン共鳴分析による被験物質の解析方法
JP4420335B2 (ja) * 2004-09-10 2010-02-24 エヌ・ティ・ティ・アドバンステクノロジ株式会社 表面プラズモン測定装置および測定方法
JP2006090758A (ja) * 2004-09-21 2006-04-06 Fuji Photo Film Co Ltd 全反射減衰を利用した測定装置
ITMI20041801A1 (it) * 2004-09-21 2004-12-21 Solvay Solexis Spa Uso di lattici submicrometrici di perfluoropolimeri nella determinazione di interazione molecolari mediante laser light scattering (lls)
JP4460405B2 (ja) 2004-09-21 2010-05-12 富士フイルム株式会社 全反射減衰を利用した測定方法及び装置並びに固定装置
JP2006090718A (ja) * 2004-09-21 2006-04-06 Fuji Photo Film Co Ltd 全反射減衰を利用した測定装置
JP4363649B2 (ja) * 2004-09-30 2009-11-11 富士フイルム株式会社 全反射減衰を利用した測定装置及び方法
JP2006105610A (ja) 2004-09-30 2006-04-20 Fuji Photo Film Co Ltd 全反射減衰を利用した測定装置及び方法
JP2006098345A (ja) * 2004-09-30 2006-04-13 Fuji Photo Film Co Ltd センサの固定量測定装置及び方法
JP2006105911A (ja) * 2004-10-08 2006-04-20 Fuji Photo Film Co Ltd 1次元測定ユニット
JP2006112808A (ja) * 2004-10-12 2006-04-27 Fujikura Ltd 表面プラズモンセンサー
SE0402476D0 (sv) * 2004-10-13 2004-10-13 Biacore Ab Preparation and use of a reactive solid support surface
US7375813B2 (en) * 2004-10-21 2008-05-20 Eastman Kodak Company Method and system for diffusion attenuated total reflection based concentration sensing
US7285420B2 (en) * 2004-11-18 2007-10-23 Corning Incorporated System and method for self-referencing a sensor in a micron-sized deep flow chamber
JP4691044B2 (ja) * 2004-11-25 2011-06-01 古河電気工業株式会社 ファイバセンサ、ファイバセンサ装置
US7483140B1 (en) 2004-12-10 2009-01-27 University Of Central Florida Research Foundation, Inc. Micro integrated planar optical waveguide type SPR sensor
JP4485959B2 (ja) 2005-01-04 2010-06-23 富士フイルム株式会社 センサユニット
US8249682B2 (en) * 2005-01-07 2012-08-21 Lacrisciences, Llc Device for measuring concentrations of constituents of tear sample
JP4004505B2 (ja) * 2005-01-11 2007-11-07 富士フイルム株式会社 流路部材及びセンサユニット
JP4474290B2 (ja) * 2005-01-18 2010-06-02 富士フイルム株式会社 センサユニット
KR100668323B1 (ko) * 2005-01-19 2007-01-12 삼성전자주식회사 표면 플라즈몬 공명을 이용한 휴대용 바이오칩 스캐너
WO2006086682A2 (en) * 2005-02-11 2006-08-17 Swagelok Company Fluid concentration sensing arrangement
JP2006242916A (ja) * 2005-03-07 2006-09-14 Fuji Photo Film Co Ltd 全反射減衰を利用するセンサユニット及び測定方法
US7768638B2 (en) * 2005-03-18 2010-08-03 Illumina, Inc. Systems for and methods of facilitating focusing an optical scanner
US20060257290A1 (en) * 2005-04-13 2006-11-16 Fuji Photo Film Co., Ltd. Fluid dispenser, fluid dispensing method and assay apparatus for assay in utilizing attenuated total reflection
EP1767271B1 (de) 2005-04-13 2012-12-05 Fujifilm Corporation Untersuchungssystem mit einer Abgabevorrichtung für Fluide und einer Sensoreinheit
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
JP4516477B2 (ja) * 2005-05-19 2010-08-04 富士フイルム株式会社 全反射減衰を利用した測定装置及びその測定方法
JP4657803B2 (ja) 2005-05-19 2011-03-23 富士フイルム株式会社 送液システム及びその送液方法並びに流路ユニット。
US20070016378A1 (en) * 2005-06-13 2007-01-18 Biacore Ab Method and system for affinity analysis
JP4647415B2 (ja) * 2005-06-27 2011-03-09 富士フイルム株式会社 測定セル保持機構、及び、バイオセンサー
JP4607684B2 (ja) * 2005-06-29 2011-01-05 富士フイルム株式会社 流路ブロック、センサユニット、及び全反射減衰を利用した測定装置
CN104076162A (zh) 2005-07-20 2014-10-01 康宁股份有限公司 无标记高通量生物分子筛选系统和方法
WO2007024051A1 (en) * 2005-08-24 2007-03-01 Lg Chem, Ltd. Artificial marble containing transparent chip using co-extrusion and process for preparing the same
US8158377B2 (en) * 2005-08-31 2012-04-17 Ut-Battelle, Llc Biosensor method and system based on feature vector extraction
US8198075B2 (en) * 2005-08-31 2012-06-12 Ut-Battelle, Llc Method and apparatus for enhanced detection of toxic agents
US20070065954A1 (en) * 2005-09-15 2007-03-22 Minoru Taya Surface plasmon resonance biosensor system for detection of antigens and method for determining the presence of antigens
WO2007035527A2 (en) 2005-09-15 2007-03-29 Duke University Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
JP2007093395A (ja) * 2005-09-29 2007-04-12 Fujifilm Corp センサユニット及び全反射減衰を利用した測定方法
US20070202515A1 (en) * 2005-10-12 2007-08-30 Pathologica, Llc. Promac signature application
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
EP1790984B1 (de) 2005-11-25 2013-08-28 FUJIFILM Corporation Verfahren zur Herstellung eines Biosensors mit einer dünnen und kovalent verbundenen Polymerschicht
JP4768417B2 (ja) * 2005-11-28 2011-09-07 富士フイルム株式会社 バイオセンサー
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
JP2007163284A (ja) * 2005-12-13 2007-06-28 Fujifilm Corp スクリーニング方法、スクリーニングプログラム及びスクリーニング装置
US8812239B2 (en) * 2005-12-14 2014-08-19 Ut-Battelle, Llc Method and system for real-time analysis of biosensor data
JP4732905B2 (ja) * 2006-01-24 2011-07-27 富士フイルム株式会社 スクリーニング方法および装置
US20070176728A1 (en) * 2006-01-31 2007-08-02 Ranganath Tirumala R Tiled periodic metal film sensors
JP2007240501A (ja) * 2006-03-13 2007-09-20 Canon Inc 流速測定装置及び流速測定方法
ITMI20060480A1 (it) * 2006-03-16 2007-09-17 Solvay Solexis Spa Usom di perfluoropolimeri nella dtermibnazione della costante di legame recettore-ligando
JP4664221B2 (ja) * 2006-03-20 2011-04-06 富士フイルム株式会社 センサユニット及び全反射プリズム
JP2007271360A (ja) * 2006-03-30 2007-10-18 Fujifilm Corp 測定装置及びセンサユニットの保持方法
JP2009543055A (ja) * 2006-06-30 2009-12-03 コーニング インコーポレイテッド フロースルーアッセイ用の流体取扱システム
EP2450710B1 (de) 2006-07-14 2020-09-02 The Regents of The University of California Krebsbiomarker und Anwendungsverfahren dafür
DE102006041338B3 (de) * 2006-09-01 2007-11-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Plasmonenresonanzsensor
US8263415B2 (en) * 2006-09-14 2012-09-11 Ge Healthcare Bio-Sciences Ab Method of determining analyte concentration
US7976217B2 (en) * 2006-09-15 2011-07-12 Corning Incorporated Screening system and method for analyzing a plurality of biosensors
US7943092B2 (en) * 2006-10-10 2011-05-17 Oakland University Portable surface plasmon resonance biosensor
JP2007206056A (ja) * 2006-11-06 2007-08-16 Fujifilm Corp 全反射減衰を利用した測定方法および測定装置
US8202491B2 (en) 2006-11-21 2012-06-19 Bioscale, Inc. Apparatus for analyte processing
US20080118402A1 (en) * 2006-11-21 2008-05-22 David Brancazio Method and apparatus for analyte processing
GB2458855B (en) 2007-02-05 2011-06-08 Intelligent Bio Systems Inc A system for imaging treated bio-molecules in a flow-cell using a non-lasing light source
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US20080204881A1 (en) * 2007-02-28 2008-08-28 Agilent Technologies, Inc. Optical coupling system and an optical element
JP2008233027A (ja) * 2007-03-23 2008-10-02 Fujifilm Corp 液体タンク、及び、液循環装置
JP4843543B2 (ja) * 2007-03-28 2011-12-21 株式会社日立ハイテクノロジーズ 蛍光検出装置及び方法
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US8372476B2 (en) * 2007-05-02 2013-02-12 Sony Corporation Method of plasmonic crystal
JP4760873B2 (ja) * 2008-08-11 2011-08-31 ソニー株式会社 プラズモニック結晶の設計方法
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
EP2716656B1 (de) 2007-06-15 2016-10-12 Xiamen University An Hämagglutinin des Vogelgrippevirus Subtyp H5 bindende monoklonale Antikörper und Verwendung dafür
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
WO2008155716A1 (en) * 2007-06-21 2008-12-24 Koninklijke Philips Electronics N. V. Microelectronic sensor device for detecting label particles
WO2009014553A1 (en) * 2007-07-23 2009-01-29 Nomadics, Inc. Fluidic configuration for flow injection analysis system
US7817266B2 (en) * 2007-07-26 2010-10-19 J.A. Woollam Co., Inc. Small volume cell
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009033056A1 (en) 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
EP2208048A1 (de) * 2007-11-05 2010-07-21 Koninklijke Philips Electronics N.V. Biosensorkartusche
WO2009066236A1 (en) * 2007-11-22 2009-05-28 Koninklijke Philips Electronics N.V. Methods and systems for coupling a bio-cartridge with an optical reader
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
AU2009204461A1 (en) * 2008-01-10 2009-07-16 Pacific Biosciences Of California, Inc. Methods and systems for analysis of fluorescent reactions with modulated excitation
WO2009090985A1 (ja) 2008-01-16 2009-07-23 Nippon Telegraph And Telephone Corporation 流速測定装置、抗原濃度測定装置、フローセル、流速測定方法、抗原濃度測定方法
JP5542067B2 (ja) * 2008-02-04 2014-07-09 コーニンクレッカ フィリップス エヌ ヴェ エバネセント照射及び蛍光に基づく分子診断システム
US8735846B1 (en) * 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
WO2009120568A2 (en) * 2008-03-24 2009-10-01 Nanolambda, Inc. Multi-purpose plasmonic ambient light sensor and visual range proximity sensor
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
US8094316B1 (en) * 2008-05-12 2012-01-10 Institute Of Photonics And Electronics As Cr, V.V.I. Surface plasmon resonance coupler and disperser sensor
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
AU2009255776A1 (en) * 2008-06-02 2009-12-10 Ge Healthcare Bio-Sciences Ab Method for virus detection
US20090323073A1 (en) * 2008-06-30 2009-12-31 Reichert, Inc. Analytical Instrument Having Internal Reference Channel
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
EP2313777B1 (de) * 2008-08-22 2014-07-02 GE Healthcare Bio-Sciences AB Verfahren zur characterisierung von antikörpern
US8564781B2 (en) * 2008-09-01 2013-10-22 Hitachi Chemical Company, Ltd. SPR sensor
US8501115B2 (en) * 2008-10-24 2013-08-06 Statspin, Inc. Modular system for performing laboratory protocols and associated methods
JP5033820B2 (ja) * 2009-02-03 2012-09-26 株式会社日立ハイテクノロジーズ 全反射顕微鏡装置、及び蛍光試料分析方法
WO2010122547A1 (en) * 2009-04-20 2010-10-28 Bio-Rad Laboratories Inc. Non-scanning surface plasmon resonance ( spr) system
JP5669449B2 (ja) * 2009-06-26 2015-02-12 メトラー−トレド アクチェンゲゼルシャフト 屈折計
US20120182548A1 (en) * 2009-07-23 2012-07-19 Insight Nanofluidics Inc Nanofluidic cell
US9255883B2 (en) 2009-10-05 2016-02-09 Konica Minolta, Inc. Surface plasmon-enhanced fluorescence measuring apparatus
IT1396382B1 (it) 2009-10-30 2012-11-19 Bellini Metodo per la misurazione di interazioni molecolari mediante rilevazione di luce riflessa da multistrati dielettrici funzionalzzati.
US8743368B2 (en) * 2009-11-12 2014-06-03 General Electric Company Optical sensor system and method of sensing
KR101105328B1 (ko) * 2009-11-23 2012-01-16 한국표준과학연구원 분자 흡착 및 해리 동특성 측정장치 및 측정방법
CN102667448B (zh) 2009-11-30 2015-02-04 通用电气健康护理生物科学股份公司 用于相互作用分析的方法和系统
CN102667447B (zh) 2009-11-30 2016-03-23 通用电气健康护理生物科学股份公司 用于结合行为分析的方法和系统
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
JP5585138B2 (ja) * 2010-03-17 2014-09-10 オムロン株式会社 流路チップ及び治具
CN101825573B (zh) * 2010-04-26 2012-11-21 武士学 元素发射光谱激发装置
US20120003639A1 (en) 2010-04-27 2012-01-05 Prelude, Inc. Cancer biomarkers and methods of use thereof
US9274042B2 (en) * 2010-05-07 2016-03-01 Stc.Unm Spatially correlated light collection from multiple sample streams excited with a line focused light source
US9482664B2 (en) 2010-05-17 2016-11-01 Sentilus Holdco LLC Detection devices and related methods of use
WO2011155435A1 (ja) 2010-06-07 2011-12-15 コニカミノルタホールディングス株式会社 近接場増強蛍光センサチップ
EP2395356B1 (de) * 2010-06-09 2014-10-01 Konica Minolta Holdings, Inc. Versandsystem einer Mikrochip-Lösung
JP5459143B2 (ja) * 2010-08-13 2014-04-02 コニカミノルタ株式会社 Spfs(表面プラズモン励起増強蛍光分光法)により測定される蛍光シグナルの補正方法およびこれを用いたアッセイ方法、並びにこれらの方法に用いられる構造体および表面プラズモン共鳴センサー
WO2012045325A1 (en) * 2010-10-04 2012-04-12 Ibis Technologies Bv Surface plasmon resonance measuring system and a method for surface plasmon resonance measurement
JP5772612B2 (ja) 2011-01-27 2015-09-02 コニカミノルタ株式会社 表面プラズモン励起増強蛍光分光法を利用する蛍光測定装置用センサチップを用いたアッセイ方法、およびアッセイ用キット
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
JP2012233860A (ja) * 2011-05-09 2012-11-29 Kyoto Univ 生体試料中の分析対象物のアッセイ方法及びそれに用いたpoct装置
US9116122B2 (en) * 2011-06-06 2015-08-25 The United States Of America As Represented By The Secretary Of The Navy Surface plasmon resonance biosensor
JP6145096B2 (ja) 2011-09-28 2017-06-07 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 表面プラズモン共鳴バイオセンサシステム
WO2013055281A1 (en) * 2011-09-30 2013-04-18 Ge Healthcare Bio-Sciences Ab Multi-channel flowcell
FR2982028B1 (fr) 2011-10-26 2020-02-21 Aryballe Technologies Puce microstructuree comprenant des surfaces convexes pour analyse par resonance des plasmons de surface, dispositif d'analyse contenant ladite puce microstructuree et utilisation dudit dispositif
FR2982027B1 (fr) 2011-10-26 2014-01-03 Thibaut Mercey Puce microstructuree pour analyse par resonance des plasmons de surface, dispositif d'analyse comprenant ladite puce microstructuree et utilisation dudit dispositif
JP5988130B2 (ja) 2012-01-30 2016-09-07 株式会社エンプラス レンズアレイの製造方法およびこれに用いるフィルム担持基板およびフィルム貼着用治具
US9291556B2 (en) * 2012-02-22 2016-03-22 S.T. Japan, Inc. Objective optical system for ATR measurement, and ATR measurement device
US9791080B2 (en) 2012-03-12 2017-10-17 Idex Health & Science Llc Microfluidic interconnect
DE102012102983A1 (de) * 2012-04-05 2013-10-10 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zum Bestimmen eines kritischen Winkels eines Anregungslichtstrahls
WO2013186672A2 (en) 2012-06-10 2013-12-19 Bio-Rad Laboratories Inc. Optical detection system for liquid samples
EP2864762A4 (de) * 2012-06-21 2016-01-20 Stc Unm Räumlich korrelierte lichtsammlung aus mehreren mit einer leitungsfokussierten lichtquelle angeregten probenströmen
US8957374B2 (en) 2012-09-28 2015-02-17 Corning Incorporated Systems and methods for measuring birefringence in glass and glass-ceramics
JP6263884B2 (ja) * 2013-07-18 2018-01-24 コニカミノルタ株式会社 表面プラズモン増強蛍光測定装置および表面プラズモン増強蛍光測定方法
JP6263887B2 (ja) * 2013-07-22 2018-01-24 コニカミノルタ株式会社 表面プラズモン増強蛍光測定方法および表面プラズモン増強蛍光測定装置
US10156488B2 (en) 2013-08-29 2018-12-18 Corning Incorporated Prism-coupling systems and methods for characterizing curved parts
US9983064B2 (en) 2013-10-30 2018-05-29 Corning Incorporated Apparatus and methods for measuring mode spectra for ion-exchanged glasses having steep index region
US11022609B2 (en) 2013-11-19 2021-06-01 Ge Healthcare Bio-Sciences Ab Method for determining interaction kinetics with rapid dissociation
CN105813753B (zh) 2013-12-19 2018-03-30 通用电气健康护理生物科学股份公司 具有隔膜阀的分层微流体装置及其制造方法
JP6180924B2 (ja) * 2013-12-26 2017-08-16 東京エレクトロン株式会社 熱流束測定方法、基板処理システム及び熱流束測定用部材
CN103728280B (zh) * 2014-01-15 2016-01-20 中国科学院化学研究所 一种表面等离子体共振耦合光学元件
CN106471372B (zh) 2014-01-29 2019-10-11 通用电气健康护理生物科学股份公司 用于相互作用分析的方法和系统
FR3017956B1 (fr) 2014-02-21 2018-02-09 Horiba Jobin Yvon Sas Systeme et procede de transfert d'un echantillon fluidique dans une cellule fluidique
CN106471408B (zh) * 2014-04-23 2019-10-18 康宁股份有限公司 提高应力的棱镜耦合测量中的对比度的方法
US9261429B2 (en) * 2014-05-21 2016-02-16 Corning Incorporated Prism-coupling systems and methods for characterizing large depth-of-layer waveguides
JP6359348B2 (ja) * 2014-06-06 2018-07-18 キヤノンメディカルシステムズ株式会社 センサチップ及びセンサチップへの液体供給方法
CN107076671B (zh) 2014-06-24 2021-05-07 思拓凡瑞典有限公司 光学传感器表面上的质量传输性质的归一化
US9919958B2 (en) 2014-07-17 2018-03-20 Corning Incorporated Glass sheet and system and method for making glass sheet
US11255852B2 (en) 2014-10-30 2022-02-22 Cytiva Sweden Ab Method to determine solvent correction curves
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
US9534981B2 (en) 2014-12-23 2017-01-03 Corning Incorporated Prism-coupling systems and methods for characterizing ion-exchanged waveguides with large depth-of-layer
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
WO2016118812A1 (en) 2015-01-23 2016-07-28 Vanderbilt University A robust interferometer and methods of using same
EP3325966B1 (de) 2015-07-20 2021-01-20 Sentilus Holdco, LLC Chips, detektoren und verfahren zur herstellung und verwendung davon
US10915066B2 (en) 2015-12-22 2021-02-09 Covestro Deutschland Ag Device and method for the industrial production of volume reflection holograms with substrate-guided reconstruction beams
EP3408649B1 (de) 2016-01-29 2023-06-14 Vanderbilt University Interferometrie mit antwortfunktion in freier lösung
WO2017196891A1 (en) 2016-05-09 2017-11-16 Biodesy, Inc. Methods and devices for detection of peripheral membrane protein interactions using nonlinear optical techniques
CA3032040A1 (en) 2016-07-25 2018-02-01 Marmon Retail Store Equipment LLC Merchandiser and methods relating to same
FR3063147B1 (fr) * 2017-02-20 2023-08-25 Commissariat Energie Atomique Detecteur optique de particules
CN107356770A (zh) * 2017-05-26 2017-11-17 中国政法大学 一种全自动表面等离子体共振检测仪
US11099189B2 (en) * 2017-10-17 2021-08-24 Board Of Regents, The University Of Texas System Limulus amoebocyte lysate assay and method of same
US10481090B2 (en) 2018-03-12 2019-11-19 International Business Machines Corporation Plasmonic non-dispersive infrared gas sensors
US11513074B2 (en) 2018-07-11 2022-11-29 Ofek—Eshkolot Research And Development Ltd. Method and device for detecting extracellular vesicles
US20220187301A1 (en) 2018-09-14 2022-06-16 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
GB201917630D0 (en) 2019-12-03 2020-01-15 Ge Healthcare Bio Sciences Ab Method for determination of aggregates
GB202107754D0 (en) 2021-05-31 2021-07-14 Univ Newcastle Screening for the effects of complement protein changes
CN114720429A (zh) * 2022-04-12 2022-07-08 无锡简测生物科技有限公司 一种光学测量系统
CN114965378B (zh) * 2022-04-18 2023-10-31 北京英柏生物科技有限公司 被胶式spr导光棱镜
CN114813654B (zh) * 2022-04-18 2024-07-02 北京英柏生物科技有限公司 自黏贴片式spr传感芯片
WO2024006120A1 (en) * 2022-06-30 2024-01-04 Illumina, Inc. Sequencing system with curved image plane or object plane
WO2024041955A2 (en) 2022-08-25 2024-02-29 Cytiva Sweden Ab Sensor surface-based sample analysis
WO2024165605A1 (en) 2023-02-07 2024-08-15 Cytiva Sweden Ab Method and system for analyte-ligand interaction analysis

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865488A (en) * 1973-11-30 1975-02-11 Rca Corp Fingerprint display system utilizing a stored fingerprint
US3910678A (en) * 1974-11-22 1975-10-07 Itt Fiber optic tubular star connector
US3963323A (en) * 1974-12-23 1976-06-15 International Telephone And Telegraph Corporation Fiber optic connector with protective cable sleeves
US4120585A (en) * 1976-11-19 1978-10-17 Calspan Corporation Fingerprint identification system using a pliable optical prism
US4304257A (en) * 1980-07-01 1981-12-08 Instrumentation Laboratory Inc. Valve with flexible sheet member
US4428670A (en) * 1980-08-11 1984-01-31 Siemens Corporation Fingerprint sensing device for deriving an electric signal
US4385831A (en) * 1980-09-22 1983-05-31 Siemens Corporation Device for investigation of a finger relief
US4544267A (en) * 1980-11-25 1985-10-01 Fingermatrix, Inc. Finger identification
US4747652A (en) * 1981-04-27 1988-05-31 Raychem Corporation Optical fiber coupler
ATE30780T1 (de) * 1981-06-22 1987-11-15 Battelle Memorial Institute Verfahren zum bestimmen bioaktiver substanzen.
US4569080A (en) * 1982-07-09 1986-02-04 Fingermatrix, Inc. Fingerprint image refinement
FR2553200B1 (fr) * 1983-10-05 1985-12-06 Cabloptic Sa Procede pour positionner une fibre optique par rapport a un autre composant optique, et dispositif pour la mise en oeuvre de ce procede
GB2148024B (en) * 1983-10-11 1986-05-08 Vladimir Mikhailovic Zolotarev Optical element for attenuated total reflection, a method of spectroscopic analysis and a mould for making this element
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
US4759605A (en) * 1985-07-15 1988-07-26 Raychem Corporation Apparatus for coupling light between an optical fiber and a light element
GB8530715D0 (en) * 1985-12-13 1986-01-22 Unilever Plc Microchemical testing
JPS62274238A (ja) * 1986-05-22 1987-11-28 ベクトン・デイツキンソン・アンド・カンパニ− フロ−サイトメトリ−装置に用いる光学的結合用ゲル
JP2591750B2 (ja) * 1986-06-26 1997-03-19 オ−ソ・ダイアグノステイツク・システムズ・インコ−ポレ−テツド 免疫分析システム
GB8620193D0 (en) * 1986-08-19 1986-10-01 Emi Plc Thorn Chemical sensor
GB2197068B (en) * 1986-11-03 1990-08-08 Stc Plc Optical sensor device
GB2197065A (en) * 1986-11-03 1988-05-11 Stc Plc Optical sensor device
US4908508A (en) * 1987-02-12 1990-03-13 Akzo N.V. Process and apparatus for determining thicknesses of layers
NL8700851A (nl) * 1987-04-10 1988-11-01 Tno Werkwijze en inrichting voor het detecteren van zeer lage concentraties van een in een meetmedium aanwezige chemische component onder toepassing van oppervlakte-plasmonresonantie en elektrochemisch gestimuleerde adsorptie.
CA1321488C (en) * 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
US4848722A (en) * 1987-12-11 1989-07-18 Integrated Fluidics, Inc. Valve with flexible sheet member

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US5164589A (en) 1992-11-17
EP0442921A1 (de) 1991-08-28
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WO1990005317A1 (en) 1990-05-17
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