DE60041415D1 - Stabiles polymorph des n-(3-ehynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-chinazolin-hydrochlorids, utische anwendung - Google Patents

Stabiles polymorph des n-(3-ehynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-chinazolin-hydrochlorids, utische anwendung

Info

Publication number
DE60041415D1
DE60041415D1 DE60041415T DE60041415T DE60041415D1 DE 60041415 D1 DE60041415 D1 DE 60041415D1 DE 60041415 T DE60041415 T DE 60041415T DE 60041415 T DE60041415 T DE 60041415T DE 60041415 D1 DE60041415 D1 DE 60041415D1
Authority
DE
Germany
Prior art keywords
ehynylphenylamino
chinazoline
utical
methoxyethoxy
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041415T
Other languages
English (en)
Inventor
Richard D Connell
James D Moyer
Michael J Morin
Shama M Kajiji
Barbara A Foster
Karen J Ferrante
Timothy Norris
Jeffrey W Raggon
Sandra L Silberman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OSI Pharmaceuticals LLC
Original Assignee
OSI Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by OSI Pharmaceuticals LLC filed Critical OSI Pharmaceuticals LLC
Application granted granted Critical
Publication of DE60041415D1 publication Critical patent/DE60041415D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60041415T 1999-11-11 2000-11-09 Stabiles polymorph des n-(3-ehynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-chinazolin-hydrochlorids, utische anwendung Expired - Lifetime DE60041415D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16490799P 1999-11-11 1999-11-11
US19319100P 2000-03-30 2000-03-30
US20642000P 2000-05-23 2000-05-23
PCT/US2000/031009 WO2001034574A1 (en) 1999-11-11 2000-11-09 Stable polymorph of n-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof

Publications (1)

Publication Number Publication Date
DE60041415D1 true DE60041415D1 (de) 2009-03-05

Family

ID=27389075

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041415T Expired - Lifetime DE60041415D1 (de) 1999-11-11 2000-11-09 Stabiles polymorph des n-(3-ehynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-chinazolin-hydrochlorids, utische anwendung

Country Status (38)

Country Link
US (1) US6900221B1 (de)
EP (4) EP2292233A3 (de)
JP (1) JP4689916B2 (de)
KR (1) KR100769264B1 (de)
CN (1) CN100351241C (de)
AP (1) AP1434A (de)
AR (1) AR035563A1 (de)
AT (1) ATE420645T1 (de)
AU (3) AU784243B2 (de)
BG (1) BG65880B1 (de)
BR (1) BR0015544A (de)
CA (2) CA2389333C (de)
CL (1) CL2010000616A1 (de)
CY (1) CY1112671T1 (de)
CZ (1) CZ303897B6 (de)
DE (1) DE60041415D1 (de)
DK (1) DK1233948T3 (de)
EA (1) EA005318B1 (de)
ES (1) ES2320408T3 (de)
GE (1) GEP20053503B (de)
HK (1) HK1049663B (de)
HR (1) HRP20020388B1 (de)
HU (1) HU226857B1 (de)
IL (2) IL149222A0 (de)
IS (1) IS2612B (de)
MA (1) MA25570A1 (de)
ME (2) MEP36308A (de)
MY (1) MY129348A (de)
NO (1) NO327082B1 (de)
NZ (1) NZ518406A (de)
PL (1) PL223486B1 (de)
PT (1) PT1233948E (de)
RS (1) RS51198B (de)
SI (1) SI1233948T1 (de)
SK (1) SK286995B6 (de)
TW (1) TWI249528B (de)
UA (1) UA74803C2 (de)
WO (1) WO2001034574A1 (de)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
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AU2006201815A1 (en) 2006-05-25
EP1233948A1 (de) 2002-08-28
CN1414954A (zh) 2003-04-30
NO20021910L (no) 2002-07-01
IL177827A (en) 2014-01-30
KR20020063889A (ko) 2002-08-05
HK1049663A1 (en) 2003-05-23
MA25570A1 (fr) 2002-10-01
ME00328B (de) 2011-05-10

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