DK1233948T3 - Stabil polymorf af N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinaminhydrochlorid, fremgangsm der til fremstilling og farmaceutiske anvendelser deraf - Google Patents

Stabil polymorf af N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinaminhydrochlorid, fremgangsm der til fremstilling og farmaceutiske anvendelser deraf

Info

Publication number
DK1233948T3
DK1233948T3 DK00980346T DK00980346T DK1233948T3 DK 1233948 T3 DK1233948 T3 DK 1233948T3 DK 00980346 T DK00980346 T DK 00980346T DK 00980346 T DK00980346 T DK 00980346T DK 1233948 T3 DK1233948 T3 DK 1233948T3
Authority
DK
Denmark
Prior art keywords
ethynylphenylamino
methoxyethoxy
bis
preparation
methods
Prior art date
Application number
DK00980346T
Other languages
English (en)
Inventor
Jeffrey W Raggon
Shama M Kajiji
Timothy Norris
Richard D Connell
James D Moyer
Michael J Morin
Barbara A Foster
Karen J Ferrante
Sandra L Silberman
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1233948(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Application granted granted Critical
Publication of DK1233948T3 publication Critical patent/DK1233948T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK00980346T 1999-11-11 2000-11-09 Stabil polymorf af N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinaminhydrochlorid, fremgangsm der til fremstilling og farmaceutiske anvendelser deraf DK1233948T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16490799P 1999-11-11 1999-11-11
US19319100P 2000-03-30 2000-03-30
US20642000P 2000-05-23 2000-05-23
PCT/US2000/031009 WO2001034574A1 (en) 1999-11-11 2000-11-09 Stable polymorph of n-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof

Publications (1)

Publication Number Publication Date
DK1233948T3 true DK1233948T3 (da) 2009-04-27

Family

ID=27389075

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00980346T DK1233948T3 (da) 1999-11-11 2000-11-09 Stabil polymorf af N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinaminhydrochlorid, fremgangsm der til fremstilling og farmaceutiske anvendelser deraf

Country Status (38)

Country Link
US (1) US6900221B1 (da)
EP (4) EP1233948B1 (da)
JP (1) JP4689916B2 (da)
KR (1) KR100769264B1 (da)
CN (1) CN100351241C (da)
AP (1) AP1434A (da)
AR (1) AR035563A1 (da)
AT (1) ATE420645T1 (da)
AU (3) AU784243B2 (da)
BG (1) BG65880B1 (da)
BR (1) BR0015544A (da)
CA (2) CA2389333C (da)
CL (1) CL2010000616A1 (da)
CY (1) CY1112671T1 (da)
CZ (1) CZ303897B6 (da)
DE (1) DE60041415D1 (da)
DK (1) DK1233948T3 (da)
EA (1) EA005318B1 (da)
ES (1) ES2320408T3 (da)
GE (1) GEP20053503B (da)
HK (1) HK1049663B (da)
HR (1) HRP20020388B1 (da)
HU (1) HU226857B1 (da)
IL (2) IL149222A0 (da)
IS (1) IS2612B (da)
MA (1) MA25570A1 (da)
ME (2) ME00328B (da)
MY (1) MY129348A (da)
NO (1) NO327082B1 (da)
NZ (1) NZ518406A (da)
PL (1) PL223486B1 (da)
PT (1) PT1233948E (da)
RS (1) RS51198B (da)
SI (1) SI1233948T1 (da)
SK (1) SK286995B6 (da)
TW (1) TWI249528B (da)
UA (1) UA74803C2 (da)
WO (1) WO2001034574A1 (da)

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* Cited by examiner, † Cited by third party
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