PT1233948E - Polimorfos estáveis de cloridrato de n-(3- etinilfenilamino)-6,7-bis(2-metoxietoxi)-4-quinazolinamida. métodos de produção e suas utilizações farmacêuticas - Google Patents

Polimorfos estáveis de cloridrato de n-(3- etinilfenilamino)-6,7-bis(2-metoxietoxi)-4-quinazolinamida. métodos de produção e suas utilizações farmacêuticas Download PDF

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Publication number
PT1233948E
PT1233948E PT00980346T PT00980346T PT1233948E PT 1233948 E PT1233948 E PT 1233948E PT 00980346 T PT00980346 T PT 00980346T PT 00980346 T PT00980346 T PT 00980346T PT 1233948 E PT1233948 E PT 1233948E
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PT
Portugal
Prior art keywords
ethynylphenylamino
methoxyethoxy
bis
production
methods
Prior art date
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PT00980346T
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English (en)
Inventor
Richard D Connell
Shama Mohammed Kajiji
Sandra Leta Silberman
James D Moyer
Michael J Morin
Barbara A Foster
Karen J Ferrante
Timothy Norris
Jeffrey W Raggon
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Osi Pharm Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1233948(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Publication of PT1233948E publication Critical patent/PT1233948E/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT00980346T 1999-11-11 2000-11-09 Polimorfos estáveis de cloridrato de n-(3- etinilfenilamino)-6,7-bis(2-metoxietoxi)-4-quinazolinamida. métodos de produção e suas utilizações farmacêuticas PT1233948E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16490799P 1999-11-11 1999-11-11
US19319100P 2000-03-30 2000-03-30
US20642000P 2000-05-23 2000-05-23

Publications (1)

Publication Number Publication Date
PT1233948E true PT1233948E (pt) 2009-04-16

Family

ID=27389075

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00980346T PT1233948E (pt) 1999-11-11 2000-11-09 Polimorfos estáveis de cloridrato de n-(3- etinilfenilamino)-6,7-bis(2-metoxietoxi)-4-quinazolinamida. métodos de produção e suas utilizações farmacêuticas

Country Status (38)

Country Link
US (1) US6900221B1 (pt)
EP (4) EP2168581A3 (pt)
JP (1) JP4689916B2 (pt)
KR (1) KR100769264B1 (pt)
CN (1) CN100351241C (pt)
AP (1) AP1434A (pt)
AR (1) AR035563A1 (pt)
AT (1) ATE420645T1 (pt)
AU (3) AU784243B2 (pt)
BG (1) BG65880B1 (pt)
BR (1) BR0015544A (pt)
CA (2) CA2389333C (pt)
CL (1) CL2010000616A1 (pt)
CY (1) CY1112671T1 (pt)
CZ (1) CZ303897B6 (pt)
DE (1) DE60041415D1 (pt)
DK (1) DK1233948T3 (pt)
EA (1) EA005318B1 (pt)
ES (1) ES2320408T3 (pt)
GE (1) GEP20053503B (pt)
HK (1) HK1049663B (pt)
HR (1) HRP20020388B1 (pt)
HU (1) HU226857B1 (pt)
IL (2) IL149222A0 (pt)
IS (1) IS2612B (pt)
MA (1) MA25570A1 (pt)
ME (2) ME00328B (pt)
MY (1) MY129348A (pt)
NO (1) NO327082B1 (pt)
NZ (1) NZ518406A (pt)
PL (1) PL223486B1 (pt)
PT (1) PT1233948E (pt)
RS (1) RS51198B (pt)
SI (1) SI1233948T1 (pt)
SK (1) SK286995B6 (pt)
TW (1) TWI249528B (pt)
UA (1) UA74803C2 (pt)
WO (1) WO2001034574A1 (pt)

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