CY2007002I2 - Ω-καρβοξυαρυλυποκατεστημενες διφαινυλουριες σαν αναστολεις της raf κινασης - Google Patents
Ω-καρβοξυαρυλυποκατεστημενες διφαινυλουριες σαν αναστολεις της raf κινασηςInfo
- Publication number
- CY2007002I2 CY2007002I2 CY200700002C CY2007002C CY2007002I2 CY 2007002 I2 CY2007002 I2 CY 2007002I2 CY 200700002 C CY200700002 C CY 200700002C CY 2007002 C CY2007002 C CY 2007002C CY 2007002 I2 CY2007002 I2 CY 2007002I2
- Authority
- CY
- Cyprus
- Prior art keywords
- carboxyarylyposubstituted
- binylureas
- kinase inhibitors
- raf kinase
- raf
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 102000009929 raf Kinases Human genes 0.000 title 1
- 108010077182 raf Kinases Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
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- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11587799P | 1999-01-13 | 1999-01-13 | |
US42522899A | 1999-10-22 | 1999-10-22 | |
PCT/US2000/000648 WO2000042012A1 (en) | 1999-01-13 | 2000-01-12 | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
Publications (2)
Publication Number | Publication Date |
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CY2007002I1 CY2007002I1 (el) | 2009-11-04 |
CY2007002I2 true CY2007002I2 (el) | 2009-11-04 |
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CY20061100668T CY1105286T1 (el) | 1999-01-13 | 2006-05-23 | Ω-καρβοξυαρυλυποκατεστημενες διφαινυλουριες σαν αναστολεις της raf κινασης |
CY200700002C CY2007002I2 (el) | 1999-01-13 | 2007-01-18 | Ω-καρβοξυαρυλυποκατεστημενες διφαινυλουριες σαν αναστολεις της raf κινασης |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CY20061100668T CY1105286T1 (el) | 1999-01-13 | 2006-05-23 | Ω-καρβοξυαρυλυποκατεστημενες διφαινυλουριες σαν αναστολεις της raf κινασης |
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US (8) | US20010011136A1 (el) |
EP (1) | EP1140840B1 (el) |
CY (2) | CY1105286T1 (el) |
FR (1) | FR06C0034I2 (el) |
WO (1) | WO2000042012A1 (el) |
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-
2000
- 2000-01-12 EP EP00903239A patent/EP1140840B1/en not_active Expired - Lifetime
- 2000-01-12 WO PCT/US2000/000648 patent/WO2000042012A1/en active Search and Examination
-
2001
- 2001-02-02 US US09/773,675 patent/US20010011136A1/en not_active Abandoned
- 2001-02-02 US US09/773,672 patent/US20010016659A1/en not_active Abandoned
- 2001-02-02 US US09/773,659 patent/US20010011135A1/en not_active Abandoned
- 2001-02-02 US US09/773,604 patent/US20010034447A1/en not_active Abandoned
- 2001-02-02 US US09/773,658 patent/US20010027202A1/en not_active Abandoned
- 2001-09-10 US US09/948,915 patent/US20020042517A1/en not_active Abandoned
-
2002
- 2002-02-11 US US10/071,248 patent/US7528255B2/en not_active Expired - Fee Related
-
2006
- 2006-05-23 CY CY20061100668T patent/CY1105286T1/el unknown
- 2006-10-27 FR FR06C0034C patent/FR06C0034I2/fr active Active
-
2007
- 2007-01-18 CY CY200700002C patent/CY2007002I2/el unknown
- 2007-08-27 US US11/845,595 patent/US20080032979A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20010034447A1 (en) | 2001-10-25 |
CY2007002I1 (el) | 2009-11-04 |
EP1140840A1 (en) | 2001-10-10 |
WO2000042012A1 (en) | 2000-07-20 |
US20020042517A1 (en) | 2002-04-11 |
FR06C0034I2 (fr) | 2007-04-27 |
FR06C0034I1 (el) | 2006-08-12 |
US20010016659A1 (en) | 2001-08-23 |
CY1105286T1 (el) | 2010-03-03 |
EP1140840B1 (en) | 2006-03-22 |
US20010011135A1 (en) | 2001-08-02 |
US20010011136A1 (en) | 2001-08-02 |
EP1140840A4 (en) | 2002-09-18 |
US7528255B2 (en) | 2009-05-05 |
US20080032979A1 (en) | 2008-02-07 |
US20010027202A1 (en) | 2001-10-04 |
US20030139605A1 (en) | 2003-07-24 |
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