FR06C0034I2 - Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf - Google Patents

Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf

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Publication number
FR06C0034I2
FR06C0034I2 FR06C0034C FR06C0034C FR06C0034I2 FR 06C0034 I2 FR06C0034 I2 FR 06C0034I2 FR 06C0034 C FR06C0034 C FR 06C0034C FR 06C0034 C FR06C0034 C FR 06C0034C FR 06C0034 I2 FR06C0034 I2 FR 06C0034I2
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Prior art keywords
diphenylureas
carboxyaryl
substituted
kinase inhibitors
raf kinase
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FR06C0034C
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Bayer Pharmaceuticals Corp
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Bayer Pharmaceuticals Corp
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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FR06C0034C 1999-01-13 2006-10-27 Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf Active FR06C0034I2 (fr)

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US11587799P 1999-01-13 1999-01-13
US42522899A 1999-10-22 1999-10-22
PCT/US2000/000648 WO2000042012A1 (fr) 1999-01-13 2000-01-12 DIPHENYLUREES A SUBSTITUANTS φ-CARBOXYARYLES, INHIBITRICES DE KINASE RAF

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US20080032979A1 (en) 2008-02-07
US20020042517A1 (en) 2002-04-11
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CY2007002I2 (el) 2009-11-04
CY2007002I1 (el) 2009-11-04
US20010034447A1 (en) 2001-10-25
FR06C0034I1 (fr) 2006-08-12
US20010011136A1 (en) 2001-08-02
EP1140840B1 (fr) 2006-03-22
US7528255B2 (en) 2009-05-05
US20010027202A1 (en) 2001-10-04
EP1140840A1 (fr) 2001-10-10
EP1140840A4 (fr) 2002-09-18
WO2000042012A1 (fr) 2000-07-20
CY1105286T1 (el) 2010-03-03
US20010011135A1 (en) 2001-08-02

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