CN1089232C - 将微水溶性药物转化为非晶态的方法 - Google Patents

将微水溶性药物转化为非晶态的方法 Download PDF

Info

Publication number
CN1089232C
CN1089232C CN96196203A CN96196203A CN1089232C CN 1089232 C CN1089232 C CN 1089232C CN 96196203 A CN96196203 A CN 96196203A CN 96196203 A CN96196203 A CN 96196203A CN 1089232 C CN1089232 C CN 1089232C
Authority
CN
China
Prior art keywords
salt
amorphous state
acid
slightly water
soluble medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96196203A
Other languages
English (en)
Chinese (zh)
Other versions
CN1192677A (zh
Inventor
宫本操
织田寿久
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Publication of CN1192677A publication Critical patent/CN1192677A/zh
Application granted granted Critical
Publication of CN1089232C publication Critical patent/CN1089232C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Sludge (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN96196203A 1995-08-11 1996-08-08 将微水溶性药物转化为非晶态的方法 Expired - Fee Related CN1089232C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP20593695 1995-08-11
JP205936/95 1995-08-11
JP31040195 1995-11-29
JP310401/95 1995-11-29
JP31040095 1995-11-29
JP310400/95 1995-11-29

Publications (2)

Publication Number Publication Date
CN1192677A CN1192677A (zh) 1998-09-09
CN1089232C true CN1089232C (zh) 2002-08-21

Family

ID=27328563

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196203A Expired - Fee Related CN1089232C (zh) 1995-08-11 1996-08-08 将微水溶性药物转化为非晶态的方法

Country Status (14)

Country Link
US (1) US6462093B1 (enExample)
EP (2) EP1356807A3 (enExample)
KR (1) KR100498813B1 (enExample)
CN (1) CN1089232C (enExample)
AT (1) ATE255405T1 (enExample)
AU (1) AU702088B2 (enExample)
CA (1) CA2228907A1 (enExample)
CZ (1) CZ296072B6 (enExample)
DE (1) DE69630964T2 (enExample)
MX (1) MX9800717A (enExample)
NO (1) NO320486B1 (enExample)
NZ (1) NZ315089A (enExample)
TW (1) TW487582B (enExample)
WO (1) WO1997006781A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106793821A (zh) * 2014-08-29 2017-05-31 花王株式会社 含有难溶性多酚类的固体分散体的制造方法

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1745774A3 (en) * 1997-08-11 2007-04-11 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
EP0901786B1 (en) 1997-08-11 2007-06-13 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
JPH11130698A (ja) * 1997-10-31 1999-05-18 Freunt Ind Co Ltd アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法
IE980115A1 (en) * 1998-02-16 2000-02-09 Biovail Internat Ltd Solubilizing delivery systems and method of manufacture
EP1027885B1 (en) 1999-02-09 2008-07-09 Pfizer Products Inc. Basic drug compositions with enhanced bioavailability
EP1027887B1 (en) * 1999-02-10 2008-08-13 Pfizer Products Inc. Matrix controlled release device
CA2362728C (en) 1999-03-24 2009-06-23 Fmc Corporation Improved aqueous solubility pharmaceutical formulations
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
ATE329579T1 (de) 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
OA12124A (en) 1999-12-23 2006-05-05 Pfizer Prod Inc Pharmmaceutical compositions providing enhanced drug concentrations.
DE10013289A1 (de) * 2000-03-17 2001-09-20 Knoll Ag Torasemid enthaltende pharmazeutische Zubereitungen
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US7115279B2 (en) 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
US20030086972A1 (en) * 2000-08-09 2003-05-08 Appel Leah E. Hydrogel-driven drug dosage form
EP1308156A4 (en) * 2000-08-11 2009-07-15 Eisai R&D Man Co Ltd AGGREGATE SOLID DISPERSION WITH IMPROVED SOLUBILITY
KR20020014570A (ko) * 2000-08-18 2002-02-25 김충섭 고체분산화시킨 무정형 이프리플라본의 제조방법
WO2002024168A1 (fr) * 2000-09-25 2002-03-28 Nippon Shinyaku Co., Ltd. Procede de production d'une dispersion solide medicinale
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
EP1340496A4 (en) * 2000-11-07 2004-04-14 Hisamitsu Pharmaceutical Co PHARMACEUTICAL PREPARATION OF THE PERCUTANEOUS ABSORPTION TYPE
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
WO2002083101A1 (de) * 2001-04-11 2002-10-24 Bayer Aktiengesellschaft Nimodipin-tablette mit kontrollierter freisetzung und verfahren zu deren herstellung
WO2003000235A1 (en) 2001-06-22 2003-01-03 Pfizer Products Inc. Pharmaceutical compositions of dispersions of drugs and neutral polymers
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
ITMI20012749A1 (it) 2001-12-21 2003-06-21 Chiesi Farma Spa Procedimento per la preparazione mediante trattamento con microonde di composti di inclusione tra farmaco e ciclodestrine e prodotti ottenut
AU2003223158B2 (en) 2002-01-09 2008-01-17 Emisphere Technologies, Inc. Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate
ATE395044T1 (de) 2002-02-01 2008-05-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
MY128945A (en) * 2002-04-16 2007-03-30 Kowa Co Solid dispersion composition
DE10224170A1 (de) * 2002-05-31 2003-12-11 Desitin Arzneimittel Gmbh Pharmazeutische Zusammensetzung mit verzögerter Wirkstofffreisetzung
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
ITMI20022748A1 (it) * 2002-12-23 2004-06-24 Eurand Int Dispersioni solide stabilizzate di farmaco in un carrier organico e procedimento per la loro preparazione.
MXPA06001417A (es) 2003-08-04 2006-05-15 Pfizer Prod Inc Composiciones farmaceuticas de adsorbatos de farmacos amorfos y materiales que forman microfases lipofilas.
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
KR101138219B1 (ko) * 2003-11-14 2012-04-24 아지노모토 가부시키가이샤 페닐알라닌 유도체의 고체 분산체 또는 고체 분산체 의약 제제
US8535716B2 (en) * 2004-04-01 2013-09-17 Tsrl, Inc. Methods and composition of extended delivery of water insoluble drugs
CA2561124A1 (en) * 2004-04-08 2005-10-27 Wyeth Bazedoxifene acetate solid dispersion formulations
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
ZA200700030B (en) * 2004-06-08 2009-06-24 Vertex Pharma Pharmaceutical compositions
JP2006028130A (ja) * 2004-07-21 2006-02-02 Toa Eiyo Ltd ピモベンダン経口投与製剤
US7576216B2 (en) 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
FR2875409B1 (fr) * 2004-09-17 2010-05-07 Sanofi Aventis Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose
CN101068546A (zh) * 2004-10-06 2007-11-07 卫材R&D管理有限公司 医药组合物及其制造方法以及医药组合物中的二氢吡啶类化合物的稳定化方法
CA2858733C (en) * 2004-12-31 2017-12-19 Iceutica Pty Ltd Nanoparticle compositions and methods for synthesis thereof
KR20070100820A (ko) 2005-01-31 2007-10-11 가부시키가이샤 바이오세렌택 경피 흡수 제제, 경피 흡수 제제 유지 시트 및 경피 흡수제제 유지 용구
HRP20120502T1 (hr) * 2005-04-11 2012-07-31 Abbott@Laboratories Farmaceutske smjese s poboljšanim profilom otapanja za slabo topljive lijekove
US9205046B2 (en) * 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Enhanced stability of inverse thermal gelling composite hydrogels
US9205047B2 (en) * 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix
WO2006118210A1 (ja) * 2005-04-28 2006-11-09 Eisai R & D Management Co., Ltd. ジヒドロピリジン系化合物の分解を防止する方法
WO2006128288A1 (en) * 2005-06-02 2006-12-07 Thallion Pharmaceuticals Inc. Formulation comprising farnesyl dibenzodiazepinone and a pharmaceutically acceptable surfactant
WO2007016435A2 (en) * 2005-07-28 2007-02-08 Isp Investments Inc. Method to improve characteristics of spray dried powders and granulated materials, and the products thereby produced
JP4974018B2 (ja) * 2005-08-24 2012-07-11 オリンパステルモバイオマテリアル株式会社 生体材料とその製造方法
PT1926476E (pt) * 2005-08-29 2013-07-10 Sanofi Aventis Us Llc Dispersões sólidas amorfas de 7-cloro-n,n,5-trimetil-4-oxo-3- fenil-3,5-di-hidro-4h-piridazino[4,5-b]indole-1-acetamida
EP2000152A4 (en) 2006-03-23 2013-01-23 Shionogi & Co SOLID PREPARATION WITH IMPROVED SOLUBILITY
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
WO2008092046A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Amorphous oxcarbazepine and the production thereof
WO2008092057A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Formulation process method to produce spray dried products
KR20100016093A (ko) * 2007-03-30 2010-02-12 아지노모토 가부시키가이샤 고체 분산체 제제
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
EP2162120B1 (en) 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
KR101443826B1 (ko) 2007-06-14 2014-09-23 가부시키가이샤 폴라 파마 의약조성물
EP2030613A1 (en) 2007-08-17 2009-03-04 Abbott GmbH & Co. KG Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics
JPWO2009038112A1 (ja) * 2007-09-21 2011-01-06 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗剤を含有する固形製剤
WO2009073216A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer
US9724362B2 (en) 2007-12-06 2017-08-08 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US20110065800A1 (en) 2008-05-14 2011-03-17 Haihong Fan Formulations for cathepsin k inhibitors
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
US20100160363A1 (en) * 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
CN102438623A (zh) * 2009-03-19 2012-05-02 盐野义制药株式会社 含有npyy5受体拮抗剂的固体制剂
MY159208A (en) 2009-04-24 2016-12-30 Iceutica Pty Ltd A novel formulation of indomethacin
CN101618012B (zh) * 2009-07-10 2012-07-04 东华大学 一种难溶性药物固体分散体制备方法
FR2954771B1 (fr) * 2010-04-23 2013-09-13 Mohamed Skiba Nouveau procede de synthese de copolymeres, terpolymeres et tetrapolymeres de cyclodextrines et leurs utilisations
ES2511145T3 (es) * 2010-10-14 2014-10-22 Abbott Gmbh & Co. Kg Formulación de dispersión sólida de curcuminoides
US20130237609A1 (en) * 2011-10-19 2013-09-12 Kevin J. Edgar Cellulose derivatives for enhancing bioavailability of flavonoids
JP5909796B2 (ja) * 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
KR20150038212A (ko) * 2012-07-23 2015-04-08 다우 글로벌 테크놀로지스 엘엘씨 경질 캡슐 쉘용 필름 조성물
KR101986683B1 (ko) * 2012-12-13 2019-06-10 한미약품 주식회사 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
CN103191077B (zh) * 2013-04-18 2014-08-20 广东彼迪药业有限公司 一种格列齐特片及其制备方法
EP2832723B1 (en) * 2013-07-29 2017-02-15 Zentiva, a.s. Stabilised amorphous forms of Saxagliptin
JP2015189677A (ja) * 2014-03-27 2015-11-02 テバ製薬株式会社 ソリフェナシン非晶質体を含有する医薬組成物
KR20170005007A (ko) 2014-05-15 2017-01-11 테라벨류스 코포레이션 경구 섭취용 조성물
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
EP3267977B1 (en) * 2015-03-12 2021-08-11 DuPont Nutrition USA, Inc. Solid dispersions
CN107920528A (zh) * 2015-09-04 2018-04-17 住友化学株式会社 组合物、组合物的制造方法和农药组合物
KR101912224B1 (ko) * 2017-02-20 2018-10-26 충남대학교산학협력단 타다라필 함유 고체 분산체, 이를 포함하는 약제학적 조성물 및 이의 제조방법
WO2019172420A1 (ja) * 2018-03-09 2019-09-12 協和発酵キリン株式会社 医薬組成物
CN111184692B (zh) * 2020-02-14 2021-10-26 南京大渊医美生物技术有限公司 一种白藜芦醇的制剂及其制备方法
CN111803447B (zh) * 2020-06-22 2022-08-09 三明学院 一种制备无定形药物的方法
WO2022090295A1 (en) * 2020-10-28 2022-05-05 Merck Patent Gmbh Method for producing an amorphous solid dispersion and pharmaceutical composition for stabilizing active pharmaceutical ingredients
CN113350309B (zh) * 2021-08-09 2021-11-12 北京五和博澳药业股份有限公司 一种难溶性药物渗透泵控释片剂及其制备方法
CN117257964B (zh) * 2023-10-25 2024-04-02 苏州大学 基于碳酸氢铵的微波诱导吲哚美辛原位无定形化增溶技术

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003023A1 (fr) * 1986-10-31 1988-05-05 Mitsubishi Chemical Industries Limited Composition de medicament contre les maladies du foie et procede de preparation
JPH02229A (ja) * 1987-12-16 1990-01-05 General Electric Co <Ge> オリゴマー組成物
JPH05306225A (ja) * 1992-04-27 1993-11-19 Taiyo Yakuhin Kogyo Kk 持続性製剤

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2373049A (en) * 1943-02-05 1945-04-03 Du Pont Stabilization of organic substances
US4083814A (en) * 1976-12-16 1978-04-11 General Electric Company Polycarbonate compositions plasticized with urea compounds
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS6038322A (ja) * 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd ジヒドロピリジンａ物質含有易溶性固形製剤
US4695591A (en) * 1985-03-29 1987-09-22 Schering Corporation Controlled release dosage forms comprising hydroxypropylmethylcellulose
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
CH668187A5 (de) * 1986-08-07 1988-12-15 Ciba Geigy Ag Therapeutisches system mit systemischer wirkung.
SE8604117D0 (sv) * 1986-09-29 1986-09-29 Kabivitrum Ab Composition
JPS63115815A (ja) 1986-10-31 1988-05-20 Mitsubishi Kasei Corp 肝疾患治療薬組成物
US5510115A (en) * 1987-11-16 1996-04-23 Baxter Travenol Laboratories, Inc. Method and composition for administration of beneficial agent by controlled dissolution
US5211957A (en) * 1988-03-25 1993-05-18 Ciba-Geigy Corporation Solid rapidly disintegrating dosage form
JP2528706B2 (ja) * 1988-05-30 1996-08-28 ゼリア新薬工業株式会社 ジヒドロピリジン化合物の製剤組成物
JPH01305616A (ja) * 1988-06-02 1989-12-08 Toshiba Corp 半導体集積回路の出力回路
JP2750130B2 (ja) 1988-08-31 1998-05-13 日清製粉株式会社 経口投与用組成物
ES2111065T5 (es) 1991-04-16 2005-06-16 Nippon Shinyaku Company, Limited Procedimiento para producir una dispersion solida.
US5326570A (en) * 1991-07-23 1994-07-05 Pharmavene, Inc. Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine
US5340591A (en) 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
ES2138070T3 (es) * 1992-12-23 2000-01-01 Saitec Srl Proceso para la preparacion de formas farmaceuticas de liberacion controlada y las formas obtenidas de esta manera.
DK19393D0 (da) 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
NO933375L (no) * 1993-02-24 1994-08-25 Marcus Kjemiske As Thor Vaskemiddelblanding
JPH0717866A (ja) * 1993-06-16 1995-01-20 Meiji Seika Kaisha Ltd 医薬組成物
DE69411276T2 (de) * 1993-09-23 1998-11-26 E.I. Du Pont De Nemours And Co., Wilmington, Del. Körnige wasserdispergierbare landwirtschaftliche zusammensetzung hergestellt durch strangpressen mit wärme
IL139728A (en) * 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
US5705190A (en) * 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003023A1 (fr) * 1986-10-31 1988-05-05 Mitsubishi Chemical Industries Limited Composition de medicament contre les maladies du foie et procede de preparation
JPH02229A (ja) * 1987-12-16 1990-01-05 General Electric Co <Ge> オリゴマー組成物
JPH05306225A (ja) * 1992-04-27 1993-11-19 Taiyo Yakuhin Kogyo Kk 持続性製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
《沈阳药学院学报》9(4) 1992.4.30 刘淑英等硝苯喧-水溶性材料-肠溶性材料固体分散物的研究 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106793821A (zh) * 2014-08-29 2017-05-31 花王株式会社 含有难溶性多酚类的固体分散体的制造方法
US10894058B2 (en) 2014-08-29 2021-01-19 Kao Corporation Method for producing solid dispersion containing hardly soluble polyphenol
CN106793821B (zh) * 2014-08-29 2021-05-07 花王株式会社 含有难溶性多酚类的固体分散体的制造方法

Also Published As

Publication number Publication date
NO980549D0 (no) 1998-02-09
DE69630964D1 (de) 2004-01-15
DE69630964T2 (de) 2004-10-28
JPWO9706781A1 (enExample) 1997-02-27
KR100498813B1 (ko) 2006-02-28
CZ32698A3 (cs) 1998-06-17
KR19990035836A (ko) 1999-05-25
MX9800717A (es) 1998-11-30
ATE255405T1 (de) 2003-12-15
WO1997006781A1 (en) 1997-02-27
EP0852140B1 (en) 2003-12-03
NO980549L (no) 1998-04-02
AU6669396A (en) 1997-03-12
EP0852140A1 (en) 1998-07-08
US6462093B1 (en) 2002-10-08
EP1356807A3 (en) 2004-01-28
AU702088B2 (en) 1999-02-11
CZ296072B6 (cs) 2006-01-11
NO320486B1 (no) 2005-12-12
CA2228907A1 (en) 1997-02-27
NZ315089A (en) 1999-06-29
TW487582B (en) 2002-05-21
CN1192677A (zh) 1998-09-09
EP0852140A4 (enExample) 1998-07-29
EP1356807A2 (en) 2003-10-29

Similar Documents

Publication Publication Date Title
CN1089232C (zh) 将微水溶性药物转化为非晶态的方法
KR102228157B1 (ko) 가열 용융 압출용 조성물 및 이것을 사용한 가열 용융 압출 성형물의 제조 방법
KR102315569B1 (ko) 히프로멜로오스 아세트산에스테르 숙신산에스테르를 사용한 스프레이 드라이용 용액 및 고체 분산체의 제조 방법
CN102188365A (zh) 一种难溶性药物共晶固体分散体及其制备方法
CN1309375C (zh) 制备直接制片制剂与辅料的方法
Appelgren et al. A Novel Method for The Granulation and Coating of Pharmacologically Active Substances.
RU2167649C2 (ru) Способ получения твердой дисперсии умеренно водорастворимого лекарственного вещества (варианты) и фармацевтическая композиция
Pandya et al. Solid dispersion adsorbate-a novel technique for dissolution enhancement of febuxostat
CN109730970A (zh) 德拉马尼速释制剂及其制备方法
WO2002013792A1 (fr) Dispersion solide médicamenteuse à solubilité accrue
JP2003116966A (ja) 直接錠剤化用調合物および補助剤の調合方法
EP2376061A1 (en) Aqueous coacervate composition comprising poorly water-soluble biologically-active agents
Sonawane et al. Preparation and characterization of microwave-assisted candesartan cilexetil solid dispersions
JPH09309834A (ja) 塩酸エホニジピン製剤の製造法
CN104042561A (zh) 一种卡马西平共晶固体分散体及其制备方法
PATRA et al. Solubility enhancement of rivaroxaban by solid dispersion with polyethylene glycol 4000
JP2024091760A (ja) 非晶質固体分散体を含む複合物
JPWO1997006781A1 (ja) 難溶性薬物の非晶質化法
CN102133203B (zh) 拉西地平分散片及其制备方法
JPH02167229A (ja) かわらたけ由来の蛋白多糖体の粒状製剤
Sakhare et al. Formulation aspects of Solid Dispersions of Simvastatin
CN113368069A (zh) 一种含有依折麦布的固体制剂及其制备方法
CN104188951A (zh) 一种二乙酰大黄酸组合物及其制备方法
Vyas et al. Preparation and characterization of solid dispersion of modafinil using PEG 6000 as hydrophilic carrier for improvement of dissolution profile
Patil et al. Application of 22 level factorial design in formulation and evaluation of spherical agglomerates by solvent change method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20020821

Termination date: 20130808