JP5508859B2 - 噴霧乾燥製品を製造するための調剤処理方法 - Google Patents
噴霧乾燥製品を製造するための調剤処理方法 Download PDFInfo
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- JP5508859B2 JP5508859B2 JP2009547436A JP2009547436A JP5508859B2 JP 5508859 B2 JP5508859 B2 JP 5508859B2 JP 2009547436 A JP2009547436 A JP 2009547436A JP 2009547436 A JP2009547436 A JP 2009547436A JP 5508859 B2 JP5508859 B2 JP 5508859B2
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/122—Pulverisation by spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
Description
本発明は、噴霧乾燥製品の製造方法に関する。より詳細には、本発明の一態様は、有機材料を含む供給原料を該有機材料用の非溶媒を含む組成物中で利用して噴霧乾燥組成物を製造し、ここで供給原料を周囲条件と比べて高めた温度及び/又は高めた圧力で供給する固体材料の調製方法に関するものである。発明の特定の実施形態によると、供給原料は、ポリマーと薬学的活性材料とを備える。
1.使用が困難な供給原料の溶媒の必要性を低減ないし排除する;
2.有毒な供給原料の溶媒の必要性を低減ないし排除する;
3.生産速度を高める;
4.処方の柔軟性を増す;
5.製品粉体中の残留溶媒濃度を低減する;
6.粒径に対する制御を改善する;
7.粒径分布に対する制御を改善する;
8.活性成分の放出速度を増す;
9.活性成分の放出量を増す;
10.固体状態の化学的性質を変える(有機材料の結晶性を低減する);
11.高度にひしゃげた及び/又はへこんだ粒子を創る;及び/又は
12.粉体の嵩密度及び/又はタップ密度を高める。
は分子鎖末端間の平均二乗距離であり、
は非摂動長である。
(
は、重心周りの旋回平均二乗径
及び対応する非摂動長
を用いて分岐ポリマーについて類似した方法で記述することができる。)ポリマーの溶解性は、αが1またはより大きい場合に得られ、この条件を満足する溶媒を「良溶媒」又は単に「溶媒」と呼ぶ。ポリマー−溶媒の引力がポリマー−ポリマーの引力より大きいため、溶媒はポリマー分子を真直ぐにする(又は膨張する)。光分散法(例えば、ビスコテック社製の3重検出器アレイ)を用いて
に書かれた変数を決定することができる。かかる概念が、マルコムP.ステーブンスによるポリマー化学、入門編のテキストに定義されており、ここに参照して援用する。
a)少なくとも約25%、特に少なくとも約100%、特定の実施態様によれば少なくとも約200%の初期の放出の増大
b)少なくとも約25%、特に少なくとも約100%、特定の実施態様によれば少なくとも約200%の放出量の増大
c)少なくとも約25%、特に少なくとも約100%、特定の実施態様によれば少なくとも約200%の最大血漿濃度の増大
d)少なくとも約25%、特に少なくとも約100%、特定の実施態様によれば少なくとも約200%のAUC0−24hの増大
A.ジクロロメタン10%、アセトン90%中で総固形分が10%となるように1:3のエファビレンツ(EFV):ポリビニルピロリドン(PVP)と2%のラウリル硫酸ナトリウム(SLS)とを含む分散液を作成した。周囲条件下PVP用の非溶媒であるアセトンを上記量で用いて真性溶液は形成されなかった。
(実施例2)
(実施例3)
Claims (21)
- (a)薬学的活性材料とポリマーを該ポリマー用の非溶媒を含有する溶媒系中に備える供給原料を準備し、該供給原料を40℃から200℃の温度及び1気圧(ゲージ圧)から20気圧(ゲージ圧)の圧力で供給し、
(b)前記供給原料を液滴またはフィルムのいずれかで分配し、
(c)前記溶媒系を供給原料から蒸発させる
ことを特徴とする固体材料を製造する方法。 - 前記供給原料が更に1以上の薬学的に許容し得る成分を含む請求項1に記載の方法。
- 前記ポリマーを、脂肪族ポリエステル、カルボキシアルキルセルロース、アルキルセルロース、ゼラチン、ヒドロキシアルキルセルロース、ヒドロキシアルキルアルキルセルロース、ヒドロキシアルキルアルキルセルロース誘導体、ポリアミン、ポリエチレングリコール、メタクリル酸ポリマー及びコポリマー、N−ビニルピロリドンのホモ及びコポリマー、ビニルラクタムのホモ及びコポリマー、澱粉、多糖類、ポリグリコール、ポリビニルエステル、精製/変性されたシェラック及びそれらの混合物からなる群から選択する請求項1に記載の方法。
- 前記ポリマーを、ポリビニルピロリドン、ヒドロキシプロピルメチルセルロースアセテートスクシネート、ポリビニルピロリドン−コビニルアセテート、ヒドロキシプロピルメチルセルロースフタレート及びそれらの混合物からなる群から選択する請求項1に記載の方法。
- 前記溶媒系が、5%の溶媒対95%の非溶媒から95%の溶媒対5%の非溶媒の比率で存在する少なくとも一つのポリマー用の溶媒と非溶媒の組合せを含む請求項1に記載の方法。
- 前記溶媒対非溶媒の比率が、ポリマーを供給原料に高めた温度及び/又は高めた圧力で溶解するように選択される請求項5に記載の方法。
- 前記供給原料中のポリマーの濃度が、1%から90%である請求項1に記載の方法。
- 前記薬学的活性材料が、非溶媒なしのポリマー系を用いて調製した対照組成物と比較して、増加した溶解速度を呈する請求項1に記載の方法。
- 前記薬学的活性材料が、非溶媒なしのポリマー系を用いて調製した対照組成物と比較して、増加した溶解量を呈する請求項1に記載の方法。
- 請求項1に記載の方法によって製造した粒子を含む組成物。
- 請求項10に記載の組成物を備える薬学組成物。
- 経口固体投与形態の形状である請求項11に記載の薬学組成物。
- (a)薬学的活性材料とポリマーとを該ポリマー用の溶媒と非溶媒との混合物中に含む供給原料を40℃から200℃の温度及び1気圧(ゲージ圧)から20気圧(ゲージ圧)の圧力で供給し、
(b)前記供給原料を噴霧乾燥して噴霧乾燥組成物を形成する
ことを特徴とする噴霧乾燥組成物を製造する方法。 - 前記噴霧乾燥組成物が、0.5μmから5000μmの平均粒径を有する粒子を含む請求項13に記載の方法。
- 前記噴霧乾燥組成物が少なくとも25重量%の薬学的活性材料を含む請求項13に記載の方法。
- 前記噴霧乾燥組成物が少なくとも75重量%の薬学的活性材料を含む請求項15に記載の方法。
- 前記噴霧乾燥組成物が、同一のポリマーと、非溶媒なしの同一溶媒から噴霧乾燥した活性物とを含む系から調製した対照組成物と比較して活性物の放出百分率が少なくとも25%大きい溶解性を示す請求項13に記載の方法。
- 前記噴霧乾燥組成物が、同一のポリマーと、非溶媒なしの同一の溶媒から噴霧乾燥した活性物とを含む系から調製した対照組成物と比較して活性物放出の初期速度が少なくとも25%大きい溶解性を示す請求項13に記載の方法。
- 前記噴霧乾燥組成物が、同一のポリマーと、非溶媒なしの同一の溶媒から噴霧乾燥した活性物とを含む系から調製した対照組成物と比較して活性物放出の百分率が少なくとも100%大きい溶解性を示す請求項13に記載の方法。
- 前記噴霧乾燥組成物が、同一のポリマーと、非溶媒なしの同一の溶媒から噴霧乾燥した活性物とを含む系から調製した対照組成物と比較して活性物放出の初期速度が少なくとも100%大きい溶解性を示す請求項13に記載の方法。
- 請求項13に記載の方法によって製造した噴霧乾燥組成物。
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Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2125938A2 (en) | 2007-01-26 | 2009-12-02 | Isp Investments Inc. | Formulation process method to produce spray dried products |
EP2332941A4 (en) * | 2008-09-17 | 2012-08-08 | Cj Cheiljedang Corp | STABILIZED SOLIDS DISPERSION FROM ADEFOVIR-DIPIVOXIL AND PROCESS FOR THE PRODUCTION THEREOF |
WO2010102245A1 (en) | 2009-03-05 | 2010-09-10 | Upsher-Smith Laboratories, Inc. | Solid dispersion comprising resveratrol |
WO2010102066A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Dextran polymer powder for inhalation administration of pharmaceuticals |
PT3130396T (pt) | 2009-03-27 | 2021-05-12 | Bend Res Inc | Processo de secagem por pulverização |
US20120178822A1 (en) * | 2009-04-28 | 2012-07-12 | Isp Investments Inc. | Co-Processed Excipient Compositions |
TR200904500A2 (tr) * | 2009-06-10 | 2009-10-21 | Öner Levent | Ezetimib nanokristallerinin hazırlanması için yöntem ve farmasötik formülasyonları. |
WO2012002547A1 (ja) * | 2010-07-02 | 2012-01-05 | 富士化学工業株式会社 | ボセンタン固体分散体 |
US9084944B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
PT2611529T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Método de secagem por pulverização |
US9248584B2 (en) | 2010-09-24 | 2016-02-02 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
US8623978B2 (en) | 2010-11-23 | 2014-01-07 | Basf Se | Process for the preparation of low-peroxide crosslinked vinyllactam polymer |
JP2014508027A (ja) * | 2010-12-21 | 2014-04-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 噴霧乾燥技術 |
ES2645769T3 (es) * | 2011-01-05 | 2017-12-07 | Hospira, Inc. | Secado por pulverización de la vancomicina |
CN103459480B (zh) | 2011-04-12 | 2017-02-22 | 巴斯夫欧洲公司 | 包含至少一种无机磷化合物的氧化敏感性低过氧化物聚合物 |
DE202011005055U1 (de) | 2011-04-12 | 2011-09-12 | Basf Se | Peroxidarmes Polymer enthaltend Phosphorverbindung |
EP2511331A1 (de) | 2011-04-12 | 2012-10-17 | Basf Se | Peroxidarmes Polymer enthaltend Phosphorverbindung |
US9023931B2 (en) | 2011-04-12 | 2015-05-05 | Basf Se | Oxidation-sensitive, low-peroxide polymer comprising at least one inorganic phosphorus compound |
US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
US20130172271A1 (en) * | 2012-01-04 | 2013-07-04 | Cynthia Fragale | Pharmaceutical Spray Drying |
CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
WO2016067132A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
US11793783B2 (en) | 2015-08-05 | 2023-10-24 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
US11684567B2 (en) | 2015-08-05 | 2023-06-27 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
EP3257574A1 (en) * | 2016-06-15 | 2017-12-20 | Clariant International Ltd | Method for producing a particle-shaped material |
EA201992178A1 (ru) * | 2017-03-15 | 2020-05-22 | Сересин Инк. | Фармацевтические композиции с высоким содержанием лекарственного средства из среднецепочечных триглицеридов и способы, связанные c ними |
CN109395424B (zh) * | 2018-10-30 | 2020-10-09 | 焦作中维特品药业股份有限公司 | 一种聚维酮干燥系统及干燥方法 |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
CN111871326A (zh) * | 2020-05-27 | 2020-11-03 | 常州道宁医药科技有限公司 | 一种定制α/β比例来制备无水乳糖微晶的设备及方法 |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB988122A (en) | 1962-08-13 | 1965-04-07 | Du Pont | Improvements in or relating to explosives |
GB1138180A (en) | 1966-11-23 | 1968-12-27 | Yarsley Res Lab Ltd | Process for the spray-drying of resins |
GB1201171A (en) | 1967-03-28 | 1970-08-05 | Atomic Energy Authority Uk | Improvements in or relating to the production of fine powders |
US3450494A (en) | 1967-07-18 | 1969-06-17 | Conrad J Gaiser | Amorphous sodium silicate having inherent binding properties and method of producing same |
US3981676A (en) | 1970-03-03 | 1976-09-21 | L'oreal | Lyophilized dyes and the use thereof to color keratinic fibers |
US4209912A (en) * | 1978-01-16 | 1980-07-01 | General Electric Company | Process and apparatus for the drying of resinous materials |
JPS5586501A (en) | 1978-12-25 | 1980-06-30 | Takasago Thermal Eng Co Lts | Method for atomization of high viscous fluid |
US4956386A (en) | 1980-04-25 | 1990-09-11 | Gist-Brocades N.V. | Pharmaceutical compositions and process for their preparation |
US4572915A (en) | 1984-05-01 | 1986-02-25 | Bioglan Laboratories | Clear micellized solutions of fat soluble essential nutrients |
US4826689A (en) | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
US5012975A (en) | 1990-02-21 | 1991-05-07 | Pfizer Inc. | Apparatus and method for mixing and spraying a slurry |
US5100679A (en) | 1990-10-03 | 1992-03-31 | Cargill B.V. | Method of making a modified proteinaceous product and composition thereof |
US5340591A (en) | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
JP3306600B2 (ja) * | 1992-08-05 | 2002-07-24 | 三菱電機株式会社 | 自動音量調整装置 |
US5663169A (en) | 1992-08-07 | 1997-09-02 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
IT1263840B (it) | 1993-03-30 | 1996-09-04 | Giuseppe Furiosi | Formulazioni orali di ubidecarenone in forma di capsule |
DE4327063A1 (de) | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
SI9400079B (sl) | 1994-02-15 | 2003-02-28 | Dr. Weidner Eckhard, Dipl. Ing. | Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom |
AU710504B2 (en) | 1994-03-15 | 1999-09-23 | Brown University Research Foundation | Polymeric gene delivery system |
ES2134282T3 (es) | 1994-04-02 | 1999-10-01 | Nestle Sa | Procedimiento de fabricacion de una composicion para bebida. |
US5958458A (en) | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
SE9501384D0 (sv) | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
CA2218074C (en) | 1995-04-14 | 2002-10-08 | Mohammed Eljamal | Powdered pharmaceutical formulations having improved dispersibility |
US6143211A (en) | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
TW487582B (en) | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
EP0862420A4 (en) | 1995-10-13 | 1999-11-03 | Penn State Res Found | SYNTHESIS OF DRUG SPRAY DRUG NANOPARTICLES |
IL117773A (en) | 1996-04-02 | 2000-10-31 | Pharmos Ltd | Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability |
US6056971A (en) | 1996-07-24 | 2000-05-02 | Biosytes Usa, Inc. | Method for enhancing dissolution properties of relatively insoluble dietary supplements and product incorporating same |
JP3889481B2 (ja) | 1996-08-16 | 2007-03-07 | 株式会社カネカ | 医薬組成物 |
IT1284604B1 (it) | 1996-09-27 | 1998-05-21 | Roberto Valducci | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
EP0913177A1 (de) | 1997-11-03 | 1999-05-06 | Roche Diagnostics GmbH | Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung |
UA72207C2 (uk) | 1998-04-07 | 2005-02-15 | Брістол- Майєрс Сквібб Фарма Компані | Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення |
GB9819272D0 (en) | 1998-09-03 | 1998-10-28 | Andaris Ltd | Microparticles |
JP2002534371A (ja) | 1999-01-06 | 2002-10-15 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | 水不溶性薬物を含む医薬的活性成分の製造方法及びそれを含む経口投与用医薬組成物 |
EP1027885B1 (en) | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
ATE400252T1 (de) | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6253463B1 (en) | 1999-04-26 | 2001-07-03 | Niro A/S | Method of spray drying |
GB9919693D0 (en) | 1999-08-19 | 1999-10-20 | Rhone Poulenc Rorer Ltd | Process |
US6503927B1 (en) | 1999-10-28 | 2003-01-07 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
US6761909B1 (en) * | 1999-12-21 | 2004-07-13 | Rxkinetix, Inc. | Particulate insulin-containing products and method of manufacture |
EE200200357A (et) | 1999-12-23 | 2003-10-15 | Pfizer Products Inc. | Ravimaine suurenenud kontsentratsioone andvad farmatseutilised kompositsioonid |
US6740338B1 (en) | 2000-01-20 | 2004-05-25 | Raj K. Chopra | Reduced form of Cenzyme Q in high bioavailability stable oral dosage form |
GB0008411D0 (en) | 2000-04-05 | 2000-05-24 | Vectura Ltd | Pharmaceutical preparations and their manufacture |
DE10021539C1 (de) | 2000-05-03 | 2002-02-28 | Henkel Kgaa | Vorrichtung zur Sprühtrocknung von lösungsmittelhaltigen Zusammensetzungen |
US20020045668A1 (en) | 2000-07-17 | 2002-04-18 | Wenbin Dang | Compositions for sustained release of analgesic agents, and methods of making and using the same |
US6579521B2 (en) | 2000-10-20 | 2003-06-17 | Chiron Corporation | Methods of therapy for HIV infection |
US6403116B1 (en) | 2000-11-03 | 2002-06-11 | Triarco Inductries, Inc. | Coenzyme Q10 formulation |
US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
US6300377B1 (en) | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
MXPA03008999A (es) * | 2001-04-02 | 2004-02-12 | Astrazeneca Ab | Composicion farmaceutica solida que comprende 4-ciano -trifluor-3 -(4-fluorfenilsulfonil) -2-hidroxi-2 -metilpropino -m-toluidida y pvp. |
KR100463167B1 (ko) | 2001-04-13 | 2004-12-23 | 주식회사 태평양 | 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물 |
WO2003000226A2 (en) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions containing polymer and drug assemblies |
CA2448864C (en) | 2001-06-22 | 2008-04-22 | Pfizer Products Inc. | Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer |
EP1404300B1 (en) | 2001-06-22 | 2009-09-30 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
TW586963B (en) * | 2001-07-20 | 2004-05-11 | Nektar Therapeutics Uk Ltd | Method and apparatus for preparing target substance in particulate form and fluid inlet assembly for said apparatus |
US20030044474A1 (en) | 2001-08-03 | 2003-03-06 | Shaklee Corporation | High molecular weight, lipophilic, orally ingestible bioactive agents in formulations having improved bioavailability |
JP2004537401A (ja) | 2001-08-08 | 2004-12-16 | ブラウン ユニバーシティ リサーチ ファウンデーション | 疎水性薬物の微粉砕方法 |
WO2003027170A1 (de) | 2001-09-15 | 2003-04-03 | Siemens Axiva Gmbh & Co. Kg | Verfahren zur herstellung feinster partikel aus schmelzbaren feststoffen |
US6723359B2 (en) | 2001-10-18 | 2004-04-20 | Firmenich Sa | Spray-dried compositions and method for their preparation |
SE0103838D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Pharmaceutical formulation & product |
EP1448170A4 (en) | 2001-11-27 | 2010-05-12 | Bristol Myers Squibb Co | EFAVIRENZ STAMP PREPARATIONS HAVING UNIQUE BIOPHARMACEUTICAL CHARACTERISTICS |
US20030147965A1 (en) | 2001-12-10 | 2003-08-07 | Spherics, Inc. | Methods and products useful in the formation and isolation of microparticles |
MXPA04007428A (es) | 2002-02-01 | 2004-10-11 | Pfizer Prod Inc | Formas de dosificacion de liberacion inmediata que contienen dispersiones de farmaco solido. |
RS61604A (en) | 2002-02-01 | 2006-10-27 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
RU2288703C2 (ru) | 2002-02-01 | 2006-12-10 | Пфайзер Продактс Инк. | Способ создания однородных высушенных распылением твердых аморфных лекарственных дисперсных систем с использованием распыляющих напорных форсунок (варианты) и продукт |
CN1633245A (zh) | 2002-02-14 | 2005-06-29 | Dsmip资产有限公司 | 水可分散的辅酶q10干粉 |
JP3974422B2 (ja) * | 2002-02-20 | 2007-09-12 | 富士フイルム株式会社 | 溶液製膜方法 |
DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
US6899470B2 (en) * | 2002-07-17 | 2005-05-31 | Fitel Usa Corp. | Systems and methods for fabricating low-loss, high-strength optical fiber transmission lines |
AU2003304108B2 (en) | 2002-10-30 | 2007-03-22 | Spherics, Inc. | Nanoparticulate bioactive agents |
US20040121003A1 (en) | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
EP1624862B1 (en) | 2003-05-08 | 2014-12-31 | Nektar Therapeutics | Particulate materials |
EP1635786A2 (en) | 2003-05-28 | 2006-03-22 | Nektar Therapeutics | Spray drying of an alcoholic aqueous solution for the manufacture of a water-insoluble active agent microparticle with a partial or complete amino acid and/or phospholipid coat |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US20050096365A1 (en) | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
DE10358387A1 (de) | 2003-12-13 | 2005-07-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung |
US20050133949A1 (en) | 2003-12-19 | 2005-06-23 | Pragtech, Inc. | Polymer solidification and coating process |
CN101039906A (zh) | 2004-10-18 | 2007-09-19 | 特瓦制药工业有限公司 | 通过将盐溶解于有机溶剂并除去该溶剂来制备无定形阿托伐他汀半钙的方法,所述有机溶剂为醇和酮和 /或酯的混合物 |
WO2006082500A1 (en) | 2005-02-03 | 2006-08-10 | Pfizer Products Inc. | Dosage forms providing controlled and immediate release of cholesteryl ester transfer protein inhibitors and immediate release of hmg-coa reductase inhibitors |
DE102005026755A1 (de) * | 2005-06-09 | 2006-12-14 | Basf Ag | Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung |
WO2006134610A1 (en) | 2005-06-16 | 2006-12-21 | Hetero Drugs Limited | Efavirenz pharmaceutical composition having enhanced dissolution profile |
EP2125938A2 (en) | 2007-01-26 | 2009-12-02 | Isp Investments Inc. | Formulation process method to produce spray dried products |
WO2011142283A1 (ja) * | 2010-05-10 | 2011-11-17 | 国立大学法人群馬大学 | ポリ乳酸微粒子の製造方法、ポリ乳酸微粒子、並びにこれを用いた結晶核剤、成形体、及び表面改質剤 |
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2008
- 2008-01-25 EP EP08728265A patent/EP2125938A2/en not_active Withdrawn
- 2008-01-25 US US12/019,889 patent/US10189957B2/en active Active
- 2008-01-25 JP JP2009547436A patent/JP5508859B2/ja active Active
- 2008-01-25 WO PCT/US2008/052003 patent/WO2008092057A2/en active Application Filing
- 2008-01-25 CN CN2008800063395A patent/CN101622302B/zh not_active Expired - Fee Related
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EP2125938A2 (en) | 2009-12-02 |
US10189957B2 (en) | 2019-01-29 |
JP2010516781A (ja) | 2010-05-20 |
WO2008092057A3 (en) | 2008-09-25 |
WO2008092057A2 (en) | 2008-07-31 |
CN101622302A (zh) | 2010-01-06 |
US20080181962A1 (en) | 2008-07-31 |
CN101622302B (zh) | 2013-01-23 |
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