EP0862420A4 - Synthesis of drug nanoparticles by spray drying - Google Patents

Synthesis of drug nanoparticles by spray drying

Info

Publication number
EP0862420A4
EP0862420A4 EP96939455A EP96939455A EP0862420A4 EP 0862420 A4 EP0862420 A4 EP 0862420A4 EP 96939455 A EP96939455 A EP 96939455A EP 96939455 A EP96939455 A EP 96939455A EP 0862420 A4 EP0862420 A4 EP 0862420A4
Authority
EP
European Patent Office
Prior art keywords
synthesis
spray drying
drug nanoparticles
nanoparticles
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96939455A
Other languages
German (de)
French (fr)
Other versions
EP0862420A1 (en
Inventor
Ulagaraj Selvaraj
Gary L Messing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penn State Research Foundation
Original Assignee
Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US519495P priority Critical
Priority to US5194P priority
Application filed by Penn State Research Foundation filed Critical Penn State Research Foundation
Priority to PCT/US1996/016417 priority patent/WO1997013503A1/en
Publication of EP0862420A1 publication Critical patent/EP0862420A1/en
Publication of EP0862420A4 publication Critical patent/EP0862420A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476Particles, beads, capsules, spheres
    • A61K49/0485Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
EP96939455A 1995-10-13 1996-10-11 Synthesis of drug nanoparticles by spray drying Withdrawn EP0862420A4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US519495P true 1995-10-13 1995-10-13
US5194P 1995-10-13
PCT/US1996/016417 WO1997013503A1 (en) 1995-10-13 1996-10-11 Synthesis of drug nanoparticles by spray drying

Publications (2)

Publication Number Publication Date
EP0862420A1 EP0862420A1 (en) 1998-09-09
EP0862420A4 true EP0862420A4 (en) 1999-11-03

Family

ID=21714643

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96939455A Withdrawn EP0862420A4 (en) 1995-10-13 1996-10-11 Synthesis of drug nanoparticles by spray drying

Country Status (2)

Country Link
EP (1) EP0862420A4 (en)
WO (1) WO1997013503A1 (en)

Families Citing this family (47)

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US5747001A (en) * 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
US20020039594A1 (en) * 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
GB9710604D0 (en) * 1997-05-22 1997-07-16 Nycomed Imaging As Contrast media
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
CA2217095A1 (en) * 1997-10-22 1999-04-22 Hydro-Quebec Activated interface nanocomposites prepared by mechanical grinding of magnesium hydrides and their use for hydrogen storage
DE19920555B4 (en) * 1999-05-05 2004-08-26 Cognis Deutschland Gmbh & Co. Kg Use of nanoscale metal soaps
US8771740B2 (en) 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
WO2001045677A1 (en) * 1999-12-20 2001-06-28 Kerkhof Nicholas J Process for producing nanometer particles by fluid bed spray-drying
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DE60135455D1 (en) 2000-05-16 2008-10-02 Univ Minnesota It a multi-nozzle assembly
DE10026698A1 (en) 2000-05-30 2001-12-06 Basf Ag Self-emulsifying drug formulation and use of this formulation
AU9124301A (en) * 2000-09-27 2002-04-08 Verion Inc Instant water dissolvable encapsulate and process
WO2002082900A1 (en) 2001-03-30 2002-10-24 Rhodia Inc. Aqeuous suspension of nanoparticles comprising an agrochemical active ingredient
KR100463167B1 (en) * 2001-04-13 2004-12-23 주식회사 태평양 Percutaneous Controlled Releasing Material Using Nano-sized Polymeric Particles and External Application Agent Containing the Same
WO2003032959A1 (en) * 2001-10-15 2003-04-24 Bosch William H Nanoparticulate compositions comprising inorganic cores
EP1446104B2 (en) 2001-11-01 2011-08-03 Novartis AG Spray drying methods
AT508735T (en) 2001-12-19 2011-05-15 Novartis Ag Pulmonary administration of aminoglycosides
GB0216700D0 (en) 2002-07-18 2002-08-28 Astrazeneca Ab Process
CA2496441C (en) 2002-08-12 2010-03-16 Pfizer Products Inc. Pharmaceutical compositions of semi-ordered drugs and polymers
GB0302673D0 (en) 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0310300D0 (en) * 2003-05-06 2003-06-11 Univ Belfast Nanocomposite drug delivery composition
JP2007500234A (en) 2003-05-28 2007-01-11 ネクター セラピューティクス Pharmaceutically molding containing insoluble active agents in water
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
DE10351004A1 (en) 2003-10-30 2005-05-25 Basf Ag Aqueous nanodispersion-forming formulations of active agents, especially plant protectants such as fungicides, comprise random copolymer of unsaturated sulfonic acid(s)
WO2006083326A2 (en) * 2004-08-07 2006-08-10 Cabot Corporation Gas dispersion manufacture of nanoparticulates and nanoparticulate-containing products and processing thereof
US7829000B2 (en) * 2005-02-25 2010-11-09 Hewlett-Packard Development Company, L.P. Core-shell solid freeform fabrication
MX2007011772A (en) 2005-03-23 2007-12-05 Elan Pharma Int Ltd Nanoparticulate corticosteroid and antihistamine formulations.
FR2891275B1 (en) * 2005-09-26 2007-11-16 Commissariat Energie Atomique Process for manufacturing compositions comprising nanoparticles of a chemical composed elememnt or dispersed in an organic matrix
US7951428B2 (en) 2006-01-31 2011-05-31 Regents Of The University Of Minnesota Electrospray coating of objects
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
EP1988941A2 (en) 2006-01-31 2008-11-12 Nanocopoeia, Inc. Nanoparticle coating of surfaces
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
WO2008034273A1 (en) 2006-09-22 2008-03-27 Mivital Ag Emulsions comprising rubber arabicum
US9040816B2 (en) 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
WO2008080037A2 (en) 2006-12-21 2008-07-03 Isp Investments Inc. Carotenoids of enhanced bioavailability
EP2125938A2 (en) 2007-01-26 2009-12-02 Isp Investments Inc. Formulation process method to produce spray dried products
US8703204B2 (en) * 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
EP2162120B1 (en) 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
WO2009073216A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer
US9724362B2 (en) 2007-12-06 2017-08-08 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2378869A2 (en) * 2008-12-18 2011-10-26 Basf Se Aqueous dispersion comprising pesticide particles and dissolved saccharide
WO2011031462A2 (en) * 2009-08-25 2011-03-17 Latitude Pharmaceuticals Incorporated Compositions for delivery of insoluble agents
IN2012DE00674A (en) 2012-03-07 2015-08-21 National Institute Of Pharmaceutical Education And Research (Niper) novel one step process for preparation of compositions comprising nanocrystalline solid dispersions
RU2561686C1 (en) * 2014-04-01 2015-08-27 Александр Александрович Кролевец Method of encapsulation aspirin in xanthan gum

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952402A (en) * 1984-10-30 1990-08-28 Elan Corporation, P.L.C. Controlled release powder and process for its preparation
WO1994009898A1 (en) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Method of manufacturing microcapsules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952402A (en) * 1984-10-30 1990-08-28 Elan Corporation, P.L.C. Controlled release powder and process for its preparation
US5354556A (en) * 1984-10-30 1994-10-11 Elan Corporation, Plc Controlled release powder and process for its preparation
WO1994009898A1 (en) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Method of manufacturing microcapsules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9713503A1 *

Also Published As

Publication number Publication date
EP0862420A1 (en) 1998-09-09
WO1997013503A1 (en) 1997-04-17

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RIC1 Classification (correction)

Free format text: 6A 61K 9/16 A, 6B 29B 9/00 B, 6B 29B 9/12 B, 6A 61K 9/51 B, 6A 61K 9/50 B

18W Withdrawn

Withdrawal date: 20011115