DK1163234T3 - Farmaceutiske formuleringer med forbedret vandoplöselighed - Google Patents

Farmaceutiske formuleringer med forbedret vandoplöselighed

Info

Publication number
DK1163234T3
DK1163234T3 DK00918139T DK00918139T DK1163234T3 DK 1163234 T3 DK1163234 T3 DK 1163234T3 DK 00918139 T DK00918139 T DK 00918139T DK 00918139 T DK00918139 T DK 00918139T DK 1163234 T3 DK1163234 T3 DK 1163234T3
Authority
DK
Denmark
Prior art keywords
active agent
stabilized
formulation
composition
water solubility
Prior art date
Application number
DK00918139T
Other languages
English (en)
Inventor
Ronald S Vladyka Jr
David F Erkoboni
Pamela R Stergios
Original Assignee
Scherer Technologies Inc R P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherer Technologies Inc R P filed Critical Scherer Technologies Inc R P
Application granted granted Critical
Publication of DK1163234T3 publication Critical patent/DK1163234T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
DK00918139T 1999-03-24 2000-03-20 Farmaceutiske formuleringer med forbedret vandoplöselighed DK1163234T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12591499P 1999-03-24 1999-03-24
US14968099P 1999-08-19 1999-08-19
US09/528,624 US6497905B1 (en) 1999-03-24 2000-03-20 Aqueous solubility pharmaceutical formulations

Publications (1)

Publication Number Publication Date
DK1163234T3 true DK1163234T3 (da) 2006-02-27

Family

ID=26824087

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00918139T DK1163234T3 (da) 1999-03-24 2000-03-20 Farmaceutiske formuleringer med forbedret vandoplöselighed

Country Status (14)

Country Link
US (3) US6497905B1 (da)
EP (1) EP1163234B1 (da)
JP (1) JP2003531099A (da)
CN (1) CN1156461C (da)
AT (1) ATE307808T1 (da)
AU (1) AU3900300A (da)
BR (1) BR0009176A (da)
CA (1) CA2362728C (da)
DE (1) DE60023465T2 (da)
DK (1) DK1163234T3 (da)
ES (1) ES2251985T3 (da)
IL (2) IL145140A0 (da)
TW (1) TWI245644B (da)
WO (1) WO2000056726A1 (da)

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Also Published As

Publication number Publication date
US20020012706A1 (en) 2002-01-31
DE60023465T2 (de) 2006-07-20
CA2362728C (en) 2009-06-23
CN1379768A (zh) 2002-11-13
JP2003531099A (ja) 2003-10-21
AU3900300A (en) 2000-10-09
IL145140A0 (en) 2002-06-30
EP1163234A4 (en) 2003-05-02
US6511681B2 (en) 2003-01-28
DE60023465D1 (de) 2005-12-01
CA2362728A1 (en) 2000-09-28
US20020037324A1 (en) 2002-03-28
EP1163234B1 (en) 2005-10-26
WO2000056726A1 (en) 2000-09-28
TWI245644B (en) 2005-12-21
US6379707B2 (en) 2002-04-30
US6497905B1 (en) 2002-12-24
BR0009176A (pt) 2001-12-18
EP1163234A1 (en) 2001-12-19
IL145140A (en) 2006-08-20
CN1156461C (zh) 2004-07-07
ATE307808T1 (de) 2005-11-15
ES2251985T3 (es) 2006-05-16

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