CA2228907A1 - Method for converting sparingly water-soluble medical substance to amorphous state - Google Patents
Method for converting sparingly water-soluble medical substance to amorphous state Download PDFInfo
- Publication number
- CA2228907A1 CA2228907A1 CA002228907A CA2228907A CA2228907A1 CA 2228907 A1 CA2228907 A1 CA 2228907A1 CA 002228907 A CA002228907 A CA 002228907A CA 2228907 A CA2228907 A CA 2228907A CA 2228907 A1 CA2228907 A1 CA 2228907A1
- Authority
- CA
- Canada
- Prior art keywords
- salt
- acid
- amorphous state
- medical substance
- sparingly water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000010438 heat treatment Methods 0.000 claims abstract description 56
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- 239000003381 stabilizer Substances 0.000 claims abstract description 35
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 28
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- 238000011282 treatment Methods 0.000 claims description 34
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 18
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Treatment Of Sludge (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20593695 | 1995-08-11 | ||
| JP7-205936 | 1995-08-11 | ||
| JP31040195 | 1995-11-29 | ||
| JP7-310400 | 1995-11-29 | ||
| JP7-310401 | 1995-11-29 | ||
| JP31040095 | 1995-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2228907A1 true CA2228907A1 (en) | 1997-02-27 |
Family
ID=27328563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002228907A Abandoned CA2228907A1 (en) | 1995-08-11 | 1996-08-08 | Method for converting sparingly water-soluble medical substance to amorphous state |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6462093B1 (enExample) |
| EP (2) | EP1356807A3 (enExample) |
| KR (1) | KR100498813B1 (enExample) |
| CN (1) | CN1089232C (enExample) |
| AT (1) | ATE255405T1 (enExample) |
| AU (1) | AU702088B2 (enExample) |
| CA (1) | CA2228907A1 (enExample) |
| CZ (1) | CZ296072B6 (enExample) |
| DE (1) | DE69630964T2 (enExample) |
| MX (1) | MX9800717A (enExample) |
| NO (1) | NO320486B1 (enExample) |
| NZ (1) | NZ315089A (enExample) |
| TW (1) | TW487582B (enExample) |
| WO (1) | WO1997006781A1 (enExample) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1745774A3 (en) * | 1997-08-11 | 2007-04-11 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
| EP0901786B1 (en) | 1997-08-11 | 2007-06-13 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
| JPH11130698A (ja) * | 1997-10-31 | 1999-05-18 | Freunt Ind Co Ltd | アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法 |
| IE980115A1 (en) * | 1998-02-16 | 2000-02-09 | Biovail Internat Ltd | Solubilizing delivery systems and method of manufacture |
| EP1027885B1 (en) | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
| EP1027887B1 (en) * | 1999-02-10 | 2008-08-13 | Pfizer Products Inc. | Matrix controlled release device |
| CA2362728C (en) | 1999-03-24 | 2009-06-23 | Fmc Corporation | Improved aqueous solubility pharmaceutical formulations |
| GB9920558D0 (en) * | 1999-08-31 | 1999-11-03 | Bradford Particle Design Ltd | Methods for particle formation and their products |
| ATE329579T1 (de) | 1999-11-12 | 2006-07-15 | Abbott Lab | Feste dispersion mit ritonavir, fenofibrat oder griseofulvin |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| OA12124A (en) | 1999-12-23 | 2006-05-05 | Pfizer Prod Inc | Pharmmaceutical compositions providing enhanced drug concentrations. |
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- 1996-08-07 TW TW085109577A patent/TW487582B/zh not_active IP Right Cessation
- 1996-08-08 DE DE69630964T patent/DE69630964T2/de not_active Expired - Lifetime
- 1996-08-08 NZ NZ315089A patent/NZ315089A/xx unknown
- 1996-08-08 CN CN96196203A patent/CN1089232C/zh not_active Expired - Fee Related
- 1996-08-08 EP EP03016608A patent/EP1356807A3/en not_active Withdrawn
- 1996-08-08 EP EP96926600A patent/EP0852140B1/en not_active Expired - Lifetime
- 1996-08-08 KR KR1019980700496A patent/KR100498813B1/ko not_active Expired - Fee Related
- 1996-08-08 WO PCT/JP1996/002246 patent/WO1997006781A1/ja not_active Ceased
- 1996-08-08 CA CA002228907A patent/CA2228907A1/en not_active Abandoned
- 1996-08-08 AT AT96926600T patent/ATE255405T1/de not_active IP Right Cessation
- 1996-08-08 US US09/011,060 patent/US6462093B1/en not_active Expired - Fee Related
- 1996-08-08 CZ CZ0032698A patent/CZ296072B6/cs not_active IP Right Cessation
- 1996-08-08 AU AU66693/96A patent/AU702088B2/en not_active Ceased
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1998
- 1998-01-26 MX MX9800717A patent/MX9800717A/es not_active IP Right Cessation
- 1998-02-09 NO NO19980549A patent/NO320486B1/no unknown
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|---|---|
| NO980549D0 (no) | 1998-02-09 |
| DE69630964D1 (de) | 2004-01-15 |
| DE69630964T2 (de) | 2004-10-28 |
| JPWO9706781A1 (enExample) | 1997-02-27 |
| KR100498813B1 (ko) | 2006-02-28 |
| CZ32698A3 (cs) | 1998-06-17 |
| KR19990035836A (ko) | 1999-05-25 |
| MX9800717A (es) | 1998-11-30 |
| ATE255405T1 (de) | 2003-12-15 |
| WO1997006781A1 (en) | 1997-02-27 |
| EP0852140B1 (en) | 2003-12-03 |
| NO980549L (no) | 1998-04-02 |
| AU6669396A (en) | 1997-03-12 |
| EP0852140A1 (en) | 1998-07-08 |
| US6462093B1 (en) | 2002-10-08 |
| EP1356807A3 (en) | 2004-01-28 |
| AU702088B2 (en) | 1999-02-11 |
| CZ296072B6 (cs) | 2006-01-11 |
| NO320486B1 (no) | 2005-12-12 |
| NZ315089A (en) | 1999-06-29 |
| TW487582B (en) | 2002-05-21 |
| CN1192677A (zh) | 1998-09-09 |
| CN1089232C (zh) | 2002-08-21 |
| EP0852140A4 (enExample) | 1998-07-29 |
| EP1356807A2 (en) | 2003-10-29 |
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