BRPI0413277A - composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas - Google Patents

composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas

Info

Publication number
BRPI0413277A
BRPI0413277A BRPI0413277-7A BRPI0413277A BRPI0413277A BR PI0413277 A BRPI0413277 A BR PI0413277A BR PI0413277 A BRPI0413277 A BR PI0413277A BR PI0413277 A BRPI0413277 A BR PI0413277A
Authority
BR
Brazil
Prior art keywords
lipophilic microphase
pharmaceutical compositions
forming materials
amorphous drug
microphase forming
Prior art date
Application number
BRPI0413277-7A
Other languages
English (en)
Inventor
Walter Christian Babcock
Dwayne Thomas Friesen
Ravi Mysore Shanker
Daniel Tod Smithey
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0413277A publication Critical patent/BRPI0413277A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçõES FARMACêUTICAS DE ADSORVATOS DE MEDICAMENTOS AMORFOS E MATERIAIS QUE FORMAM MICROFASES LIPOFìLICAS". Uma composição farmacêutica compreende um adsorvato sólido compreendendo um medicamento adsorvido em um substrato e um material que forma uma microfase lipofílica. O adsorvato sólido também pode ser co-administrado com um material que forma uma microfase lipofílica a um meio de utilização in vivo. As composições da presente invenção aumentam a concentração de medicamento no meio de utilização.
BRPI0413277-7A 2003-08-04 2004-07-23 composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas BRPI0413277A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49241003P 2003-08-04 2003-08-04
PCT/IB2004/002498 WO2005011635A2 (en) 2003-08-04 2004-07-23 Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials

Publications (1)

Publication Number Publication Date
BRPI0413277A true BRPI0413277A (pt) 2006-10-10

Family

ID=34115618

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413277-7A BRPI0413277A (pt) 2003-08-04 2004-07-23 composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas

Country Status (8)

Country Link
US (2) US9023393B2 (pt)
EP (1) EP1653927B1 (pt)
JP (1) JP2007501218A (pt)
AT (1) ATE540671T1 (pt)
BR (1) BRPI0413277A (pt)
CA (1) CA2532931A1 (pt)
MX (1) MXPA06001417A (pt)
WO (1) WO2005011635A2 (pt)

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US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
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USRE47033E1 (en) 2018-09-11
EP1653927B1 (en) 2012-01-11
WO2005011635A2 (en) 2005-02-10
WO2005011635A3 (en) 2005-03-17
ATE540671T1 (de) 2012-01-15
US9023393B2 (en) 2015-05-05
JP2007501218A (ja) 2007-01-25
US20050031693A1 (en) 2005-02-10
EP1653927A2 (en) 2006-05-10
MXPA06001417A (es) 2006-05-15

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