EA200301279A1 - Фармацевтические композиции адсорбатов аморфного лекарственного средства - Google Patents

Фармацевтические композиции адсорбатов аморфного лекарственного средства

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Publication number
EA200301279A1
EA200301279A1 EA200301279A EA200301279A EA200301279A1 EA 200301279 A1 EA200301279 A1 EA 200301279A1 EA 200301279 A EA200301279 A EA 200301279A EA 200301279 A EA200301279 A EA 200301279A EA 200301279 A1 EA200301279 A1 EA 200301279A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
adsorbates
amorphous
medicine
amorphous medicine
Prior art date
Application number
EA200301279A
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English (en)
Other versions
EA006777B1 (ru
Inventor
Уолтер Кристиан Бэбкок
Двэйн Томас Фризен
Рави Майсор Шенкер
Дэниел Тод Смити
Ральф Тэддэй
Original Assignee
Пфайзер Продактс Инк.
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Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200301279A1 publication Critical patent/EA200301279A1/ru
Publication of EA006777B1 publication Critical patent/EA006777B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)

Abstract

Фармацевтические композиции включают лекарственное средство, обладающее низкой растворимостью, адсорбированное на субстрате, обладающем большой площадью поверхности, для получения адсорбата. Композиции в некоторых вариантах осуществления настоящего изобретения включают полимер, повышающий концентрацию.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301279A 2001-06-22 2002-05-21 Фармацевтические композиции адсорбатов аморфного лекарственного средства EA006777B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30026001P 2001-06-22 2001-06-22
PCT/IB2002/001792 WO2003000238A1 (en) 2001-06-22 2002-05-21 Pharmaceutical compositions of adsorbates of amorphous drug

Publications (2)

Publication Number Publication Date
EA200301279A1 true EA200301279A1 (ru) 2004-06-24
EA006777B1 EA006777B1 (ru) 2006-04-28

Family

ID=23158346

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301279A EA006777B1 (ru) 2001-06-22 2002-05-21 Фармацевтические композиции адсорбатов аморфного лекарственного средства

Country Status (29)

Country Link
US (3) US20030054037A1 (ru)
EP (2) EP2275091A1 (ru)
JP (1) JP4547148B2 (ru)
KR (2) KR100768766B1 (ru)
CN (1) CN1523979A (ru)
AT (1) ATE486586T1 (ru)
AU (1) AU2002302903B2 (ru)
BG (1) BG108489A (ru)
BR (1) BR0210519A (ru)
CA (1) CA2448825C (ru)
CR (1) CR7167A (ru)
CZ (1) CZ20033456A3 (ru)
DE (1) DE60238193D1 (ru)
EA (1) EA006777B1 (ru)
EC (1) ECSP034895A (ru)
EE (1) EE200400034A (ru)
HU (1) HUP0400281A3 (ru)
IL (1) IL158771A0 (ru)
IS (1) IS7018A (ru)
MA (1) MA27038A1 (ru)
MX (1) MXPA03010165A (ru)
NO (1) NO20035498D0 (ru)
NZ (1) NZ529490A (ru)
OA (1) OA12625A (ru)
PL (1) PL367674A1 (ru)
SK (1) SK15742003A3 (ru)
TN (1) TNSN03138A1 (ru)
WO (1) WO2003000238A1 (ru)
ZA (1) ZA200308735B (ru)

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