TW487582B - Method for converting sparingly water-soluble medical substance to amorphous state - Google Patents

Method for converting sparingly water-soluble medical substance to amorphous state Download PDF

Info

Publication number
TW487582B
TW487582B TW085109577A TW85109577A TW487582B TW 487582 B TW487582 B TW 487582B TW 085109577 A TW085109577 A TW 085109577A TW 85109577 A TW85109577 A TW 85109577A TW 487582 B TW487582 B TW 487582B
Authority
TW
Taiwan
Prior art keywords
amorphous
poorly soluble
solid dispersion
acid
sparingly water
Prior art date
Application number
TW085109577A
Other languages
English (en)
Chinese (zh)
Inventor
Mijamoto Misao
Oda Tosikhisa
Original Assignee
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd
Application granted granted Critical
Publication of TW487582B publication Critical patent/TW487582B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Sludge (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW085109577A 1995-08-11 1996-08-07 Method for converting sparingly water-soluble medical substance to amorphous state TW487582B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20593695 1995-08-11
JP31040095 1995-11-29
JP31040195 1995-11-29

Publications (1)

Publication Number Publication Date
TW487582B true TW487582B (en) 2002-05-21

Family

ID=27328563

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085109577A TW487582B (en) 1995-08-11 1996-08-07 Method for converting sparingly water-soluble medical substance to amorphous state

Country Status (14)

Country Link
US (1) US6462093B1 (enExample)
EP (2) EP1356807A3 (enExample)
KR (1) KR100498813B1 (enExample)
CN (1) CN1089232C (enExample)
AT (1) ATE255405T1 (enExample)
AU (1) AU702088B2 (enExample)
CA (1) CA2228907A1 (enExample)
CZ (1) CZ296072B6 (enExample)
DE (1) DE69630964T2 (enExample)
MX (1) MX9800717A (enExample)
NO (1) NO320486B1 (enExample)
NZ (1) NZ315089A (enExample)
TW (1) TW487582B (enExample)
WO (1) WO1997006781A1 (enExample)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287971T3 (es) 1997-08-11 2007-12-16 Pfizer Products Inc. Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
EP1741424B1 (en) * 1997-08-11 2018-10-03 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailabilty
JPH11130698A (ja) * 1997-10-31 1999-05-18 Freunt Ind Co Ltd アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法
IE980115A1 (en) * 1998-02-16 2000-02-09 Biovail Internat Ltd Solubilizing delivery systems and method of manufacture
ATE400251T1 (de) 1999-02-09 2008-07-15 Pfizer Prod Inc Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit
ATE404178T1 (de) * 1999-02-10 2008-08-15 Pfizer Prod Inc Vorrichtung mit matrixgesteuerter wirkstofffreisetzung
ES2251985T3 (es) 1999-03-24 2006-05-16 R.P. Scherer Technologies, Inc. Particula granulada para mejorar la solubilidad acuosa de farmacos, y su procedimiento de preparacion.
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
EP1175205B1 (en) 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
CN1402629A (zh) 1999-12-23 2003-03-12 辉瑞产品公司 提供提高的药物浓度的药物组合物
DE10013289A1 (de) * 2000-03-17 2001-09-20 Knoll Ag Torasemid enthaltende pharmazeutische Zubereitungen
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
US20030086972A1 (en) * 2000-08-09 2003-05-08 Appel Leah E. Hydrogel-driven drug dosage form
CA2418490A1 (en) * 2000-08-11 2002-02-21 Eisai Co., Ltd. Drug-containing solid dispersion having improved solubility
KR20020014570A (ko) * 2000-08-18 2002-02-25 김충섭 고체분산화시킨 무정형 이프리플라본의 제조방법
WO2002024168A1 (fr) * 2000-09-25 2002-03-28 Nippon Shinyaku Co., Ltd. Procede de production d'une dispersion solide medicinale
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
JP4057418B2 (ja) * 2000-11-07 2008-03-05 久光製薬株式会社 経皮吸収型製剤
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
WO2002083101A1 (de) * 2001-04-11 2002-10-24 Bayer Aktiengesellschaft Nimodipin-tablette mit kontrollierter freisetzung und verfahren zu deren herstellung
JP2004534812A (ja) 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク 薬物および中性ポリマーの分散物の医薬組成物
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
ITMI20012749A1 (it) 2001-12-21 2003-06-21 Chiesi Farma Spa Procedimento per la preparazione mediante trattamento con microonde di composti di inclusione tra farmaco e ciclodestrine e prodotti ottenut
EP1469827B1 (en) * 2002-01-09 2017-12-27 Emisphere Technologies, Inc. Polymorphs of sodium 4- (4-chloro-2-hydroxybenzoyl)amino butanoate
DE60320940D1 (de) 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
MY128945A (en) * 2002-04-16 2007-03-30 Kowa Co Solid dispersion composition
DE10224170A1 (de) * 2002-05-31 2003-12-11 Desitin Arzneimittel Gmbh Pharmazeutische Zusammensetzung mit verzögerter Wirkstofffreisetzung
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
ITMI20022748A1 (it) * 2002-12-23 2004-06-24 Eurand Int Dispersioni solide stabilizzate di farmaco in un carrier organico e procedimento per la loro preparazione.
BRPI0413277A (pt) 2003-08-04 2006-10-10 Pfizer Prod Inc composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
CN100563658C (zh) * 2003-11-14 2009-12-02 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
US8535716B2 (en) * 2004-04-01 2013-09-17 Tsrl, Inc. Methods and composition of extended delivery of water insoluble drugs
BRPI0509381A (pt) * 2004-04-08 2007-09-18 Wyeth Corp dispersão sólida, métodos de preparar a dispersão sólida, de tratar um mamìfero tendo uma doença ou sìndrome associadas com a deficiência ou o excesso de estrogênio, uma doença ou distúrbio associados com a proliferação ou desenvolvimento anormal de tecidos endometrais, de tratar cáncer de mamas de um mamìfero, e uma mulher pós-menopáusica quanto a um ou mais distúrbios vasomotores, de reduzir colesterol, e de inibir perda óssea em um mamìfero, composição, forma de dosagem, e, uso de uma dispersão sólida
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
AR049297A1 (es) * 2004-06-08 2006-07-12 Vertex Pharma Una composicion farmaceutica y dispersiones solidas de vx-950 (inhibidor de la proteasa de hcv ns3/4a) y proceso de obtencion
JP2006028130A (ja) * 2004-07-21 2006-02-02 Toa Eiyo Ltd ピモベンダン経口投与製剤
US7576216B2 (en) 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
FR2875409B1 (fr) * 2004-09-17 2010-05-07 Sanofi Aventis Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose
US20080095841A1 (en) * 2004-10-06 2008-04-24 Eisai R&D Management Co., Ltd. Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition
EP1830824B1 (en) * 2004-12-31 2016-01-13 Iceutica Pty Ltd. Nanoparticle composition and methods for synthesis thereof
JP4913030B2 (ja) 2005-01-31 2012-04-11 株式会社バイオセレンタック 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
ES2384333T3 (es) * 2005-04-11 2012-07-03 Abbott Laboratories Composiciones farmacéuticas que tienen perfiles de disolución mejorados para fármacos poco solubles
US9205047B2 (en) * 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix
US9205046B2 (en) * 2005-04-25 2015-12-08 The Governing Council Of The University Of Toronto Enhanced stability of inverse thermal gelling composite hydrogels
WO2006118210A1 (ja) * 2005-04-28 2006-11-09 Eisai R & D Management Co., Ltd. ジヒドロピリジン系化合物の分解を防止する方法
AU2006254675A1 (en) * 2005-06-02 2006-12-07 Thallion Pharmaceuticals Inc. Formulation comprising farnesyl dibenzodiazepinone and a pharmaceutically acceptable surfactant
US20070026073A1 (en) * 2005-07-28 2007-02-01 Doney John A Amorphous efavirenz and the production thereof
JP4974018B2 (ja) * 2005-08-24 2012-07-11 オリンパステルモバイオマテリアル株式会社 生体材料とその製造方法
CN101272767B (zh) * 2005-08-29 2012-08-29 赛诺菲-安万特美国有限责任公司 7-氯-N,N,5-三甲基-4-氧-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体
WO2007108463A1 (ja) 2006-03-23 2007-09-27 Shionogi & Co., Ltd. 溶解性が改善された固形製剤
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
US20080152717A1 (en) * 2006-12-14 2008-06-26 Isp Investments, Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
WO2008092046A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Amorphous oxcarbazepine and the production thereof
JP5508859B2 (ja) * 2007-01-26 2014-06-04 アイエスピー インヴェストメンツ インコーポレイテッド 噴霧乾燥製品を製造するための調剤処理方法
WO2008120724A1 (ja) * 2007-03-30 2008-10-09 Ajinomoto Co., Inc. 固体分散体製剤
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
EP2162120B1 (en) 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
JP5325779B2 (ja) * 2007-06-14 2013-10-23 株式会社ポーラファルマ 医薬組成物
EP2030613A1 (en) 2007-08-17 2009-03-04 Abbott GmbH & Co. KG Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics
US20100240711A1 (en) * 2007-09-21 2010-09-23 Shionogi & Co., Ltd. Solid preparation comprising npyy5 receptor antagonist
EP2231169B1 (en) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
WO2009073216A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer
US20110065800A1 (en) 2008-05-14 2011-03-17 Haihong Fan Formulations for cathepsin k inhibitors
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
US20100160363A1 (en) * 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
JPWO2010107040A1 (ja) * 2009-03-19 2012-09-20 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗剤を含有する固形製剤
CN102438594A (zh) 2009-04-24 2012-05-02 伊休蒂卡有限公司 吲哚美辛的新剂型
CN101618012B (zh) * 2009-07-10 2012-07-04 东华大学 一种难溶性药物固体分散体制备方法
FR2954771B1 (fr) * 2010-04-23 2013-09-13 Mohamed Skiba Nouveau procede de synthese de copolymeres, terpolymeres et tetrapolymeres de cyclodextrines et leurs utilisations
JP2014503470A (ja) * 2010-10-14 2014-02-13 アボット ゲーエムベーハー ウント カンパニー カーゲー クルクミノイド固体分散製剤
WO2013058751A1 (en) * 2011-10-19 2013-04-25 Virginia Tech Intellectual Properties, Inc. Cellulose derivatives for enhancing bioavailability of flavonoids
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
EP2874613A1 (en) * 2012-07-23 2015-05-27 Dow Global Technologies, Inc. Film composition for hard capsule shells
KR101986683B1 (ko) * 2012-12-13 2019-06-10 한미약품 주식회사 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
CN103191077B (zh) * 2013-04-18 2014-08-20 广东彼迪药业有限公司 一种格列齐特片及其制备方法
EP2832723B1 (en) * 2013-07-29 2017-02-15 Zentiva, a.s. Stabilised amorphous forms of Saxagliptin
JP2015189677A (ja) * 2014-03-27 2015-11-02 テバ製薬株式会社 ソリフェナシン非晶質体を含有する医薬組成物
JPWO2015174475A1 (ja) 2014-05-15 2017-04-20 株式会社セラバリューズ 経口摂取用組成物
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
WO2016031651A1 (ja) * 2014-08-29 2016-03-03 花王株式会社 難溶解性ポリフェノール類を含有する固体分散体の製造方法
WO2016145132A1 (en) * 2015-03-12 2016-09-15 Fmc Corporation Solid dispersions
AR105887A1 (es) * 2015-09-04 2017-11-22 Sumitomo Chemical Co Composición, método de producción para la composición, y composición agroquímica
KR101912224B1 (ko) * 2017-02-20 2018-10-26 충남대학교산학협력단 타다라필 함유 고체 분산체, 이를 포함하는 약제학적 조성물 및 이의 제조방법
WO2019172420A1 (ja) * 2018-03-09 2019-09-12 協和発酵キリン株式会社 医薬組成物
CN111184692B (zh) * 2020-02-14 2021-10-26 南京大渊医美生物技术有限公司 一种白藜芦醇的制剂及其制备方法
CN111803447B (zh) * 2020-06-22 2022-08-09 三明学院 一种制备无定形药物的方法
WO2022090295A1 (en) * 2020-10-28 2022-05-05 Merck Patent Gmbh Method for producing an amorphous solid dispersion and pharmaceutical composition for stabilizing active pharmaceutical ingredients
CN113350309B (zh) * 2021-08-09 2021-11-12 北京五和博澳药业股份有限公司 一种难溶性药物渗透泵控释片剂及其制备方法
CN117257964B (zh) * 2023-10-25 2024-04-02 苏州大学 基于碳酸氢铵的微波诱导吲哚美辛原位无定形化增溶技术
CN121044616B (zh) * 2025-11-05 2026-02-13 北京大学 一种氨基酸介导的非晶态稀土氧化物的合成方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2373049A (en) * 1943-02-05 1945-04-03 Du Pont Stabilization of organic substances
US4083814A (en) * 1976-12-16 1978-04-11 General Electric Company Polycarbonate compositions plasticized with urea compounds
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS6038322A (ja) * 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd ジヒドロピリジンａ物質含有易溶性固形製剤
US4695591A (en) * 1985-03-29 1987-09-22 Schering Corporation Controlled release dosage forms comprising hydroxypropylmethylcellulose
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
CH668187A5 (de) * 1986-08-07 1988-12-15 Ciba Geigy Ag Therapeutisches system mit systemischer wirkung.
SE8604117D0 (sv) * 1986-09-29 1986-09-29 Kabivitrum Ab Composition
WO1988003023A1 (fr) * 1986-10-31 1988-05-05 Mitsubishi Chemical Industries Limited Composition de medicament contre les maladies du foie et procede de preparation
JPS63115815A (ja) * 1986-10-31 1988-05-20 Mitsubishi Kasei Corp 肝疾患治療薬組成物
US5510115A (en) * 1987-11-16 1996-04-23 Baxter Travenol Laboratories, Inc. Method and composition for administration of beneficial agent by controlled dissolution
US4855380A (en) * 1987-12-16 1989-08-08 General Electric Company Cyclopentadiene-containing cyclic polycarbonate oligomer
US5211957A (en) * 1988-03-25 1993-05-18 Ciba-Geigy Corporation Solid rapidly disintegrating dosage form
JP2528706B2 (ja) 1988-05-30 1996-08-28 ゼリア新薬工業株式会社 ジヒドロピリジン化合物の製剤組成物
JPH01305616A (ja) * 1988-06-02 1989-12-08 Toshiba Corp 半導体集積回路の出力回路
JP2750130B2 (ja) * 1988-08-31 1998-05-13 日清製粉株式会社 経口投与用組成物
WO1992018106A1 (fr) 1991-04-16 1992-10-29 Nippon Shinyaku Co., Ltd. Procede de production d'une dispersion solide
US5326570A (en) * 1991-07-23 1994-07-05 Pharmavene, Inc. Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine
US5340591A (en) 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
JP2516524B2 (ja) 1992-04-27 1996-07-24 大洋薬品工業株式会社 持続性製剤
DK0675710T3 (da) * 1992-12-23 2000-03-27 Saitec Srl Fremgangsmåde til fremstilling af farmaceutiske former med styret frigivelse samt de herved opnåede former
DK19393D0 (da) * 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
NO933375L (no) * 1993-02-24 1994-08-25 Marcus Kjemiske As Thor Vaskemiddelblanding
JPH0717866A (ja) * 1993-06-16 1995-01-20 Meiji Seika Kaisha Ltd 医薬組成物
EP0720427B1 (en) * 1993-09-23 1998-06-24 E.I. Du Pont De Nemours And Company Water-dispersible granular agricultural compositions made by heat extrusion
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5705190A (en) * 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs

Also Published As

Publication number Publication date
DE69630964D1 (de) 2004-01-15
MX9800717A (es) 1998-11-30
ATE255405T1 (de) 2003-12-15
CZ32698A3 (cs) 1998-06-17
KR19990035836A (ko) 1999-05-25
EP0852140B1 (en) 2003-12-03
AU702088B2 (en) 1999-02-11
NO980549L (no) 1998-04-02
NZ315089A (en) 1999-06-29
EP0852140A1 (en) 1998-07-08
EP1356807A2 (en) 2003-10-29
NO320486B1 (no) 2005-12-12
DE69630964T2 (de) 2004-10-28
CN1192677A (zh) 1998-09-09
CA2228907A1 (en) 1997-02-27
NO980549D0 (no) 1998-02-09
EP1356807A3 (en) 2004-01-28
AU6669396A (en) 1997-03-12
EP0852140A4 (enExample) 1998-07-29
KR100498813B1 (ko) 2006-02-28
US6462093B1 (en) 2002-10-08
WO1997006781A1 (en) 1997-02-27
CZ296072B6 (cs) 2006-01-11
CN1089232C (zh) 2002-08-21
JPWO9706781A1 (enExample) 1997-02-27

Similar Documents

Publication Publication Date Title
TW487582B (en) Method for converting sparingly water-soluble medical substance to amorphous state
TWI414321B (zh) Solid preparation of enteric solid dispersion and method for producing the same
KR102315569B1 (ko) 히프로멜로오스 아세트산에스테르 숙신산에스테르를 사용한 스프레이 드라이용 용액 및 고체 분산체의 제조 방법
KR101527254B1 (ko) 저치환도 히드록시프로필셀룰로오스 및 이것을 포함하는 고형 제제
KR102089112B1 (ko) 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법
KR20040091099A (ko) 속방성 약학적 과립 조성물 및 그것의 연속적 제조 방법
JPS6229514A (ja) 医薬活性物質の遅延放出形粒状物及びその製造方法
TW200825107A (en) Low-substituted hydroxypropylcellulose powder and method for producing the same
CN114796222B (zh) 用于口腔掩味的含氢溴酸沃替西汀的包衣颗粒、固体分散体和制剂
CN101939003A (zh) 生物利用度改善的恩他卡朋、左旋多巴与卡比多巴的药物组合物
CZ277897B6 (en) Process for preparing solid pharmaceutical preparation and the solid pharmaceutical preparation with a controlled release of nifedipine
WO2015032873A1 (en) High-load pharmaceutical compositions comprising abiraterone acetate
WO2012013088A1 (zh) 决奈达隆固体分散体及其制备方法
KR20170114949A (ko) 용해 상태가 우수한 히프로멜로오스 아세트산에스테르 숙신산에스테르 분말 및 그의 제조 방법, 및 고체 분산체용 조성물, 코팅용 조성물, 약물 함유 입자 및 고형 제제의 각 제조 방법
JPH08291063A (ja) 易吸収性製剤及びその製造法
WO2002013792A1 (fr) Dispersion solide médicamenteuse à solubilité accrue
RU2167649C2 (ru) Способ получения твердой дисперсии умеренно водорастворимого лекарственного вещества (варианты) и фармацевтическая композиция
JP3372242B2 (ja) 徐放性微粒子製剤及びその製造方法
CN108653218B (zh) 作为alk/fak/igf1r多激酶抑制剂的吡咯并嘧啶衍生物的药物制剂组合物及其制备方法
EP3216807B1 (en) Coating composition containing methyl cellulose, method for producing the same, and solid preparation
CN112516101B (zh) 一种含有富马酸喹硫平的片剂及其制备方法
Szabo-Revesz et al. Potato starch in pharmaceutical technology-A review
CN106913545B (zh) 一种格列美脲片剂及其制备方法
JP2024091760A (ja) 非晶質固体分散体を含む複合物
CN119158030A (zh) 一种应用于头孢地尼制剂中的组合辅料及其制备方法及应用

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent
MM4A Annulment or lapse of patent due to non-payment of fees