KR100498813B1 - 물에난용성인약물의비결정질화방법 - Google Patents

물에난용성인약물의비결정질화방법 Download PDF

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Publication number
KR100498813B1
KR100498813B1 KR1019980700496A KR19980700496A KR100498813B1 KR 100498813 B1 KR100498813 B1 KR 100498813B1 KR 1019980700496 A KR1019980700496 A KR 1019980700496A KR 19980700496 A KR19980700496 A KR 19980700496A KR 100498813 B1 KR100498813 B1 KR 100498813B1
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KR
South Korea
Prior art keywords
acid
amorphous state
salt
water
drug
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Expired - Fee Related
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KR1019980700496A
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English (en)
Korean (ko)
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KR19990035836A (ko
Inventor
미사오 미야모토
도시히사 오다
Original Assignee
닛산 가가쿠 고교 가부시키 가이샤
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Publication of KR19990035836A publication Critical patent/KR19990035836A/ko
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Publication of KR100498813B1 publication Critical patent/KR100498813B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Sludge (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Materials For Medical Uses (AREA)
KR1019980700496A 1995-08-11 1996-08-08 물에난용성인약물의비결정질화방법 Expired - Fee Related KR100498813B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP20593695 1995-08-11
JP95-205936 1995-08-11
JP95-310401 1995-11-29
JP31040095 1995-11-29
JP95-310400 1995-11-29
JP31040195 1995-11-29

Publications (2)

Publication Number Publication Date
KR19990035836A KR19990035836A (ko) 1999-05-25
KR100498813B1 true KR100498813B1 (ko) 2006-02-28

Family

ID=27328563

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980700496A Expired - Fee Related KR100498813B1 (ko) 1995-08-11 1996-08-08 물에난용성인약물의비결정질화방법

Country Status (14)

Country Link
US (1) US6462093B1 (enExample)
EP (2) EP1356807A3 (enExample)
KR (1) KR100498813B1 (enExample)
CN (1) CN1089232C (enExample)
AT (1) ATE255405T1 (enExample)
AU (1) AU702088B2 (enExample)
CA (1) CA2228907A1 (enExample)
CZ (1) CZ296072B6 (enExample)
DE (1) DE69630964T2 (enExample)
MX (1) MX9800717A (enExample)
NO (1) NO320486B1 (enExample)
NZ (1) NZ315089A (enExample)
TW (1) TW487582B (enExample)
WO (1) WO1997006781A1 (enExample)

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TW487582B (en) 2002-05-21
CN1089232C (zh) 2002-08-21
DE69630964D1 (de) 2004-01-15
AU6669396A (en) 1997-03-12
EP1356807A2 (en) 2003-10-29
DE69630964T2 (de) 2004-10-28
NO980549L (no) 1998-04-02
US6462093B1 (en) 2002-10-08
NZ315089A (en) 1999-06-29
EP0852140B1 (en) 2003-12-03
CZ32698A3 (cs) 1998-06-17
EP1356807A3 (en) 2004-01-28
EP0852140A1 (en) 1998-07-08
JPWO9706781A1 (enExample) 1997-02-27
NO320486B1 (no) 2005-12-12
CZ296072B6 (cs) 2006-01-11
ATE255405T1 (de) 2003-12-15
WO1997006781A1 (en) 1997-02-27
MX9800717A (es) 1998-11-30
CA2228907A1 (en) 1997-02-27
CN1192677A (zh) 1998-09-09
EP0852140A4 (enExample) 1998-07-29
AU702088B2 (en) 1999-02-11
KR19990035836A (ko) 1999-05-25

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