CN108430456B - 癌症疫苗 - Google Patents

癌症疫苗 Download PDF

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Publication number
CN108430456B
CN108430456B CN201680075024.0A CN201680075024A CN108430456B CN 108430456 B CN108430456 B CN 108430456B CN 201680075024 A CN201680075024 A CN 201680075024A CN 108430456 B CN108430456 B CN 108430456B
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cancer
vaccine
mrna
hla
methyl
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CN108430456A (zh
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尼古拉斯·瓦利安特
塔尔·扎克斯
埃里克·易-春·黄
朱塞佩·恰拉梅拉
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ModernaTx Inc
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ModernaTx Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111Immunoglobulin superfamily
    • A61K39/001114CD74, Ii, MHC class II invariant chain or MHC class II gamma chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588Adjuvants of undefined constitution

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201680075024.0A 2015-10-22 2016-10-21 癌症疫苗 Active CN108430456B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111635839.9A CN114404581A (zh) 2015-10-22 2016-10-21 癌症疫苗

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562245129P 2015-10-22 2015-10-22
US201562245031P 2015-10-22 2015-10-22
US62/245,031 2015-10-22
US62/245,129 2015-10-22
US201562247317P 2015-10-28 2015-10-28
US201562247472P 2015-10-28 2015-10-28
US62/247,472 2015-10-28
US62/247,317 2015-10-28
US201662368810P 2016-07-29 2016-07-29
US62/368,810 2016-07-29
PCT/US2016/058317 WO2017070618A1 (en) 2015-10-22 2016-10-21 Cancer vaccines

Related Child Applications (1)

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CN202111635839.9A Division CN114404581A (zh) 2015-10-22 2016-10-21 癌症疫苗

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CN108430456A CN108430456A (zh) 2018-08-21
CN108430456B true CN108430456B (zh) 2022-01-18

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CN201680075024.0A Active CN108430456B (zh) 2015-10-22 2016-10-21 癌症疫苗
CN202111635839.9A Pending CN114404581A (zh) 2015-10-22 2016-10-21 癌症疫苗

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US (1) US12582609B2 (enExample)
EP (1) EP3364949A4 (enExample)
JP (3) JP2018532777A (enExample)
CN (2) CN108430456B (enExample)
AU (3) AU2016341309A1 (enExample)
CA (1) CA3003090A1 (enExample)
MA (1) MA46255A (enExample)
WO (1) WO2017070618A1 (enExample)

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