MX2019004913A - Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm). - Google Patents

Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm).

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Publication number
MX2019004913A
MX2019004913A MX2019004913A MX2019004913A MX2019004913A MX 2019004913 A MX2019004913 A MX 2019004913A MX 2019004913 A MX2019004913 A MX 2019004913A MX 2019004913 A MX2019004913 A MX 2019004913A MX 2019004913 A MX2019004913 A MX 2019004913A
Authority
MX
Mexico
Prior art keywords
lipid nanoparticle
lipid
mrna vaccines
mrna
lipid nanoparticles
Prior art date
Application number
MX2019004913A
Other languages
English (en)
Inventor
Baumhof Patrick
Fotin-Mleczek Mariola
Heidenreich Regina
J Hope Michael
Jasny Edith
Lazzaro Sandra
Jia Ching LIN Paulo
Lutz Johannes
Mui Barbara
Petsch Benjamin
Rauch Susanne
Ellen Schwendt Kim
Tam Ying
Original Assignee
Curevac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curevac Ag filed Critical Curevac Ag
Publication of MX2019004913A publication Critical patent/MX2019004913A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
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    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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Abstract

La invención se refiere a nanopartículas lipídicas que comprenden ARNm y sus usos médicos. Las nanopartículas lipídicas de la presente invención comprenden un lípido catiónico según la fórmula (I), (II) o (III) y/o un lípido de PEG según la fórmula (IV), así como un compuesto de ARNm que comprende una secuencia de ARNm que codifica un péptido o proteína antigénico. La invención se refiere además al uso de las nanopartículas lipídicas como vacunas o medicamentos, en particular con respecto a vacunación de gripe o rabia.
MX2019004913A 2016-10-26 2017-10-26 Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm). MX2019004913A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP2016075843 2016-10-26
EP2016075929 2016-10-27
EP2017064066 2017-06-09
PCT/EP2017/077517 WO2018078053A1 (en) 2016-10-26 2017-10-26 Lipid nanoparticle mrna vaccines

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MX2019004913A true MX2019004913A (es) 2019-09-16

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MX2019004913A MX2019004913A (es) 2016-10-26 2017-10-26 Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm).

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US (2) US20200163878A1 (es)
EP (1) EP3532094A1 (es)
JP (2) JP7289265B2 (es)
KR (1) KR20190093816A (es)
CN (1) CN110352071A (es)
AU (2) AU2017350488B2 (es)
BR (1) BR112019008481A2 (es)
CA (1) CA3040337A1 (es)
IL (2) IL301800A (es)
MX (1) MX2019004913A (es)
SG (1) SG11201903460QA (es)
WO (1) WO2018078053A1 (es)

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KR20160044566A (ko) 2013-08-21 2016-04-25 큐어백 아게 호흡기 세포융합 바이러스
SG10201912038TA (en) 2014-04-23 2020-02-27 Modernatx Inc Nucleic acid vaccines
ES2931832T3 (es) 2014-06-25 2023-01-03 Acuitas Therapeutics Inc Lípidos y formulaciones de nanopartículas lipídicas novedosos para la entrega de ácidos nucleicos
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