EA201891124A2 - Новые мукозные адъюванты и системы доставки - Google Patents

Новые мукозные адъюванты и системы доставки

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Publication number
EA201891124A2
EA201891124A2 EA201891124A EA201891124A EA201891124A2 EA 201891124 A2 EA201891124 A2 EA 201891124A2 EA 201891124 A EA201891124 A EA 201891124A EA 201891124 A EA201891124 A EA 201891124A EA 201891124 A2 EA201891124 A2 EA 201891124A2
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Eurasian Patent Office
Prior art keywords
adjuvants
floured
new
delivery systems
methods
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EA201891124A
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English (en)
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EA201891124A3 (ru
EA039237B1 (ru
Inventor
Билли М. Харджис
Нейл Р. Памфорд
Марион Морган
Сричаитаня Шиварамаиах
Гильермо Теллес
Аманда Вулфенден
Original Assignee
Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Арканзас
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Application filed by Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Арканзас filed Critical Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Арканзас
Publication of EA201891124A2 publication Critical patent/EA201891124A2/ru
Publication of EA201891124A3 publication Critical patent/EA201891124A3/ru
Publication of EA039237B1 publication Critical patent/EA039237B1/ru

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Abstract

В настоящем документе представлены адъюванты, содержащие хитозан, поперечно-сшитый с применением альдегида, или маннозилированный хитозан. Также представлены способы создания адъювантов и способы комбинирования или соединения адъювантов с антигенами. Комбинации адъювант-антиген можно использовать в составах вакцин, и составы вакцин можно использовать в способах для вакцинации животных против источника антигена или для усиления иммунного ответа у индивидуума.
EA201891124A 2012-10-29 2013-10-29 Применение маннозилированного хитозана в качестве адъюванта в составе вакцин для пероральной или мукозной доставки EA039237B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261719713P 2012-10-29 2012-10-29

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EA201891124A2 true EA201891124A2 (ru) 2018-10-31
EA201891124A3 EA201891124A3 (ru) 2019-03-29
EA039237B1 EA039237B1 (ru) 2021-12-21

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA201590829A EA031234B1 (ru) 2012-10-29 2013-10-29 Вакцина с адъювантом на основе маннозилированного хитозана
EA201891124A EA039237B1 (ru) 2012-10-29 2013-10-29 Применение маннозилированного хитозана в качестве адъюванта в составе вакцин для пероральной или мукозной доставки

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EA201590829A EA031234B1 (ru) 2012-10-29 2013-10-29 Вакцина с адъювантом на основе маннозилированного хитозана

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US (4) US20150297714A1 (ru)
EP (1) EP2911676B1 (ru)
JP (1) JP6284537B2 (ru)
KR (1) KR102144602B1 (ru)
CN (2) CN104884069B (ru)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2214701T3 (pl) * 2007-11-01 2017-01-31 The Board Of Trustees Of The University Of Arkansas Kompozycje i sposoby wzmacniania odpowiedzi odpornościowych na Eimeria
NZ708065A (en) * 2012-10-29 2019-07-26 Univ Arkansas Novel mucosal adjuvants and delivery systems
NZ711019A (en) 2013-02-14 2019-07-26 Univ Arkansas Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
EP2968423A4 (en) 2013-03-15 2016-11-09 Univ Arkansas COMPOSITIONS AND METHODS FOR INCREASING IMMUNE REACTIONS AGAINST ENTERAL PATHOGENES
CN106659799B (zh) * 2014-07-25 2020-07-17 碧奥辛斯有限责任公司 用于制备针对因肠致病性细菌引起的感染的广谱疫苗的包含表达内置的多个表位的分子构建体的基本单元的糖缀合物疫苗
GB201522541D0 (en) * 2015-12-21 2016-02-03 Inst Research In Biomedicine Compositions
BR112018072592A2 (pt) 2016-05-03 2019-04-16 The Board Of Trustees Of The University Of Arkansas vetor de vacina de levedura que inclui polipeptídeos imunoestimulantes e antigênicos, e métodos de uso dos mesmos
WO2018225662A1 (ja) * 2017-06-07 2018-12-13 出光興産株式会社 自然免疫増強剤
CN111603566A (zh) * 2019-02-25 2020-09-01 河南农业大学 一种靶向呼吸道黏膜的递呈载体复合物及应用
WO2022256740A1 (en) 2021-06-04 2022-12-08 Curia Ip Holdings, Llc Polymeric fusion proteins and compositions for inducing an immune response against infection
CN114134167A (zh) * 2021-11-30 2022-03-04 山东邦盛达生物科技有限公司 具有粘膜免疫调节作用的重组枯草芽孢杆菌的制备方法及重组枯草芽孢杆菌和应用
CN114288401B (zh) * 2021-12-31 2023-10-03 四川农业大学 抗原蛋白的应用、引物组以及试剂盒
WO2023183080A1 (en) * 2022-03-21 2023-09-28 University Of Southern California Triple vaccine protects against bacterial and fungal pathogens via trained immunity

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501770A (en) * 1967-04-13 1970-03-17 Lilly Co Eli Shipping fever vaccine
AU6642390A (en) * 1989-10-27 1991-05-31 Arch Development Corporation Methods and compositions for promoting immunopotentiation
WO1996031237A2 (en) * 1995-04-04 1996-10-10 Wound Healing Of Oklahoma Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant
GB9725084D0 (en) * 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
AT410635B (de) * 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
FI20010118A (fi) * 2001-01-19 2002-07-20 Carbion Oy Uudet helicobacter pylori reseptorit ja niiden käyttö
NO317654B1 (no) * 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som inneholder en nukleinsyre og et kitosan, fremgangsmate for fremstilling av formuleringen, samt anvendelser derav.
WO2005077977A2 (en) 2004-02-11 2005-08-25 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Carcinoembryonic antigen fusions proteins and uses thereof
GB0405787D0 (en) * 2004-03-15 2004-04-21 Chiron Srl Low dose vaccines
UA5098U (ru) 2004-07-05 2005-02-15 Михайло Валерійович Бабкін Использование хитозана как адъюванта
US20060045912A1 (en) * 2004-08-30 2006-03-02 Peter Truog 4-phenylbutyric acid controlled-release formulations for therapeutic use
CA2580343A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics, Inc. Imidazoquinoline compounds
US20090028932A1 (en) * 2005-04-15 2009-01-29 Wilson Mary E Vaccine formulations for leishmania
EP1951299B1 (en) 2005-11-04 2012-01-04 Novartis Vaccines and Diagnostics S.r.l. Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
WO2008060617A2 (en) * 2006-11-15 2008-05-22 The Brigham And Women's Hospital, Inc. Therapeutic uses of tim-3 modulators
CN101903408B (zh) * 2007-10-30 2013-08-14 粘凝胶股份公司 壳聚糖组合物
US8778384B2 (en) * 2008-03-24 2014-07-15 Advanced Bionutrition Corporation Compositions and methods for encapsulating vaccines for the oral vaccination and boostering of fish and other animals
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
JP2010065027A (ja) * 2008-08-12 2010-03-25 Mie Univ 魚類のウイルス性出血性敗血症に対する不活化ワクチンとその処方
EP2364153B1 (en) * 2008-11-12 2015-05-06 Synedgen, Inc. Chitosan derivatives to optimize animal weight gain
EP2196196A1 (en) * 2008-12-10 2010-06-16 Medipol S.A. Compound, medicament, vaccine composition and nanocapsules
JP5292141B2 (ja) * 2009-03-17 2013-09-18 シチズンマシナリーミヤノ株式会社 タレット刃物台のクーラント供給構造
US9234047B2 (en) * 2009-11-06 2016-01-12 Pharmasan Labs, Inc. Preparing hapten-specific antibodies and their application for immunodiagnostics and research
EP2508212A1 (en) * 2011-04-05 2012-10-10 Universitätsklinikum Freiburg Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
NZ708065A (en) * 2012-10-29 2019-07-26 Univ Arkansas Novel mucosal adjuvants and delivery systems

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