ES2503516R1 - Complejo inmunogénico para vacunación y método de obtención - Google Patents
Complejo inmunogénico para vacunación y método de obtención Download PDFInfo
- Publication number
- ES2503516R1 ES2503516R1 ES201330474A ES201330474A ES2503516R1 ES 2503516 R1 ES2503516 R1 ES 2503516R1 ES 201330474 A ES201330474 A ES 201330474A ES 201330474 A ES201330474 A ES 201330474A ES 2503516 R1 ES2503516 R1 ES 2503516R1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- immunogenic complex
- vaccination
- mannan
- dialdehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000002255 vaccination Methods 0.000 title abstract 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 2
- 229920000057 Mannan Polymers 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Complejo inmunogénico para vacunación y método de obtención.#La presente invención se relaciona con un complejo inmunogénico que comprende un antígeno polimerizado, manano y un dialdehído, la composición que lo comprende, y el uso del mismo como estimulador de la respuesta inmune y vacuna, útil en el tratamiento de enfermedades infecciosas, neoplasias y alergias. Asimismo, la invención se relaciona con el método de obtención de dicho complejo inmunogénico, basado en la polimerización y conjugación simultánea del antígeno y el manano mediante el empleo de un dialdehído.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201330474A ES2503516B1 (es) | 2013-04-03 | 2013-04-03 | Complejo inmunogénico para vacunación y método de obtención |
| BR112015025257-5A BR112015025257B1 (pt) | 2013-04-03 | 2014-04-03 | Complexo imunogênico para uso em vacinação e método para a obtenção do mesmo |
| JP2016505868A JP6285012B2 (ja) | 2013-04-03 | 2014-04-03 | ワクチン接種における使用のための免疫原性複合体およびこれを得る方法 |
| ES14724497T ES2856690T3 (es) | 2013-04-03 | 2014-04-03 | Complejo inmunogénico para vacunación y método de obtención |
| EP14724497.4A EP2982381B1 (en) | 2013-04-03 | 2014-04-03 | Immunogenic complex for vaccination and method for the production thereof |
| PCT/ES2014/070263 WO2014162036A1 (es) | 2013-04-03 | 2014-04-03 | Complejo inmunogénico para vacunación y método de obtención |
| DK14724497.4T DK2982381T3 (da) | 2013-04-03 | 2014-04-03 | Immunogent kompleks til vaccination og fremgangsmåde til fremstilling deraf |
| MX2015014005A MX367780B (es) | 2013-04-03 | 2014-04-03 | Complejo inmunogénico para vacunación y método de obtención. |
| CN201480030171.7A CN105492022B (zh) | 2013-04-03 | 2014-04-03 | 用于接种疫苗的免疫原性络合物及其获得方法 |
| US14/781,733 US9901633B2 (en) | 2013-04-03 | 2014-04-03 | Immunogenic complex for vaccination and method for the production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201330474A ES2503516B1 (es) | 2013-04-03 | 2013-04-03 | Complejo inmunogénico para vacunación y método de obtención |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ES2503516A2 ES2503516A2 (es) | 2014-10-06 |
| ES2503516R1 true ES2503516R1 (es) | 2014-11-24 |
| ES2503516B1 ES2503516B1 (es) | 2015-09-09 |
Family
ID=50732211
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201330474A Active ES2503516B1 (es) | 2013-04-03 | 2013-04-03 | Complejo inmunogénico para vacunación y método de obtención |
| ES14724497T Active ES2856690T3 (es) | 2013-04-03 | 2014-04-03 | Complejo inmunogénico para vacunación y método de obtención |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14724497T Active ES2856690T3 (es) | 2013-04-03 | 2014-04-03 | Complejo inmunogénico para vacunación y método de obtención |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9901633B2 (es) |
| EP (1) | EP2982381B1 (es) |
| JP (1) | JP6285012B2 (es) |
| CN (1) | CN105492022B (es) |
| DK (1) | DK2982381T3 (es) |
| ES (2) | ES2503516B1 (es) |
| MX (1) | MX367780B (es) |
| WO (1) | WO2014162036A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046539B1 (fr) * | 2016-01-11 | 2018-01-12 | Societe Industrielle Limousine D'application Biologique | Principe actif de pichia heedii et utilisation cosmetique en particulier pour lutter contre les effets de la pollution sur la peau |
| BR112021014064A2 (pt) | 2019-01-17 | 2021-09-21 | LETI Pharma S.L. | Processo para produção de um extrato alergênico despigmentado, extrato alergênico despigmentado, extrato alergênico despigmentado polimerizado, composição farmacêutica, e vacina |
| JP2025510729A (ja) * | 2022-03-21 | 2025-04-15 | ユニバーシティ オブ サザン カリフォルニア | 三重ワクチンは、訓練免疫を介して細菌および真菌病原体に対して防御する |
| JPWO2024117232A1 (es) * | 2022-11-30 | 2024-06-06 | ||
| WO2024220928A2 (en) * | 2023-04-21 | 2024-10-24 | The Children's Medical Center Corporation | Polysaccharide adjuvants for use in protein-based or rna-based vaccines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0892297A (ja) * | 1994-09-21 | 1996-04-09 | Dai Ichi Pure Chem Co Ltd | μ−カルパイン８０ＫサブユニットのＮ末端ペプチドに対する抗体及びこれを用いる免疫測定方法及び測定試薬 |
| US8021667B2 (en) * | 1994-11-16 | 2011-09-20 | Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Compositions for immunotherapy and uses thereof |
| DK1409654T3 (da) | 1999-06-16 | 2008-12-08 | Boston Biomedical Res Inst | Immunologisk styring af beta-amyloid-niveauer in vivo |
| JP2004043332A (ja) * | 2002-07-09 | 2004-02-12 | Nof Corp | 経口用リポソーム製剤 |
| JP4334931B2 (ja) * | 2002-07-19 | 2009-09-30 | 独立行政法人科学技術振興機構 | 新規抗体酵素生産方法および新規抗体酵素 |
| MXPA05005528A (es) * | 2002-11-26 | 2006-04-05 | Alk Abello As | Producto farmaceutico de alergeno. |
| AU2011226992B2 (en) * | 2010-05-10 | 2012-03-22 | Ascend Biopharmaceuticals Pty Ltd | Immunostimulatory and vaccine compositions |
-
2013
- 2013-04-03 ES ES201330474A patent/ES2503516B1/es active Active
-
2014
- 2014-04-03 US US14/781,733 patent/US9901633B2/en active Active
- 2014-04-03 CN CN201480030171.7A patent/CN105492022B/zh active Active
- 2014-04-03 EP EP14724497.4A patent/EP2982381B1/en active Active
- 2014-04-03 DK DK14724497.4T patent/DK2982381T3/da active
- 2014-04-03 MX MX2015014005A patent/MX367780B/es active IP Right Grant
- 2014-04-03 ES ES14724497T patent/ES2856690T3/es active Active
- 2014-04-03 JP JP2016505868A patent/JP6285012B2/ja active Active
- 2014-04-03 WO PCT/ES2014/070263 patent/WO2014162036A1/es not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN105492022A (zh) | 2016-04-13 |
| ES2856690T3 (es) | 2021-09-28 |
| ES2503516B1 (es) | 2015-09-09 |
| ES2503516A2 (es) | 2014-10-06 |
| DK2982381T3 (da) | 2021-03-01 |
| EP2982381A1 (en) | 2016-02-10 |
| JP2016515603A (ja) | 2016-05-30 |
| MX2015014005A (es) | 2016-05-05 |
| WO2014162036A1 (es) | 2014-10-09 |
| EP2982381B1 (en) | 2020-12-02 |
| US20160058859A1 (en) | 2016-03-03 |
| CN105492022B (zh) | 2020-03-10 |
| JP6285012B2 (ja) | 2018-02-28 |
| MX367780B (es) | 2019-09-03 |
| US9901633B2 (en) | 2018-02-27 |
| BR112015025257A2 (pt) | 2017-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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