BR112018004242A2 - composições de vacina que possuem estabilidade e imunogenicidade aumentadas - Google Patents

composições de vacina que possuem estabilidade e imunogenicidade aumentadas

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Publication number
BR112018004242A2
BR112018004242A2 BR112018004242A BR112018004242A BR112018004242A2 BR 112018004242 A2 BR112018004242 A2 BR 112018004242A2 BR 112018004242 A BR112018004242 A BR 112018004242A BR 112018004242 A BR112018004242 A BR 112018004242A BR 112018004242 A2 BR112018004242 A2 BR 112018004242A2
Authority
BR
Brazil
Prior art keywords
increased stability
immunogenicity
vaccine compositions
nanoparticles
vaccines
Prior art date
Application number
BR112018004242A
Other languages
English (en)
Inventor
Oliver Cynthia
Shane Erica
Smith Gale
Glenn Gregory
tian Jing-hui
Massare Michael
Boddapati Sarathi
Liu Ye
Original Assignee
Novavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novavax Inc filed Critical Novavax Inc
Publication of BR112018004242A2 publication Critical patent/BR112018004242A2/pt

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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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Abstract

são reveladas nesse relatório descritivo nanopartículas adequadas para uso em vacinas. as nanopartículas apresentam antígenos de patógenos circundados e associados com um núcleo de detergente, resultando em estabilidade aumentada e boa imunogenicidade. dosagens, formulações e métodos para a preparação das vacinas e nanopartículas também são revelados.
BR112018004242A 2015-09-03 2016-09-06 composições de vacina que possuem estabilidade e imunogenicidade aumentadas BR112018004242A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562213947P 2015-09-03 2015-09-03
US201562255786P 2015-11-16 2015-11-16
US201662309216P 2016-03-16 2016-03-16
US201662350973P 2016-06-16 2016-06-16
PCT/US2016/050413 WO2017041100A2 (en) 2015-09-03 2016-09-06 Vaccine compositions having improved stability and immunogenicity

Publications (1)

Publication Number Publication Date
BR112018004242A2 true BR112018004242A2 (pt) 2018-09-25

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BR112018004242A BR112018004242A2 (pt) 2015-09-03 2016-09-06 composições de vacina que possuem estabilidade e imunogenicidade aumentadas

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US (4) US10426829B2 (pt)
EP (1) EP3344291A4 (pt)
JP (4) JP6670374B2 (pt)
KR (1) KR20180052124A (pt)
CN (4) CN108697790B (pt)
AU (2) AU2016315478B2 (pt)
BR (1) BR112018004242A2 (pt)
CA (1) CA2996007A1 (pt)
HK (1) HK1250136A1 (pt)
IL (2) IL257800B2 (pt)
MX (3) MX2018002728A (pt)
RU (1) RU2730625C2 (pt)
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