HK1250136A1 - 具有改善的穩定性和免疫原性之疫苗組合物 - Google Patents

具有改善的穩定性和免疫原性之疫苗組合物

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Publication number
HK1250136A1
HK1250136A1 HK18109416.7A HK18109416A HK1250136A1 HK 1250136 A1 HK1250136 A1 HK 1250136A1 HK 18109416 A HK18109416 A HK 18109416A HK 1250136 A1 HK1250136 A1 HK 1250136A1
Authority
HK
Hong Kong
Prior art keywords
immunogenicity
improved stability
vaccine compositions
vaccine
compositions
Prior art date
Application number
HK18109416.7A
Other languages
English (en)
Inventor
Gale Smith
Ye Liu
Jing-Hui Tian
Michael Massare
Sarathi Boddapati
Erica Shane
Cynthia Oliver
Gregory Glenn
Original Assignee
Novavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novavax Inc filed Critical Novavax Inc
Publication of HK1250136A1 publication Critical patent/HK1250136A1/zh

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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/385—Haptens or antigens, bound to carriers
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    • A61K39/12—Viral antigens
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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HK18109416.7A 2015-09-03 2018-07-20 具有改善的穩定性和免疫原性之疫苗組合物 HK1250136A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562213947P 2015-09-03 2015-09-03
US201562255786P 2015-11-16 2015-11-16
US201662309216P 2016-03-16 2016-03-16
US201662350973P 2016-06-16 2016-06-16
PCT/US2016/050413 WO2017041100A2 (en) 2015-09-03 2016-09-06 Vaccine compositions having improved stability and immunogenicity

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US (4) US10426829B2 (zh)
EP (1) EP3344291A4 (zh)
JP (4) JP6670374B2 (zh)
KR (1) KR20180052124A (zh)
CN (4) CN114699519A (zh)
AU (2) AU2016315478B2 (zh)
BR (1) BR112018004242A2 (zh)
CA (1) CA2996007A1 (zh)
HK (1) HK1250136A1 (zh)
IL (2) IL303336A (zh)
MX (3) MX2018002728A (zh)
RU (1) RU2730625C2 (zh)
SG (1) SG10201913145SA (zh)
WO (1) WO2017041100A2 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
HUE051666T2 (hu) 2008-12-09 2021-03-29 Novavax Inc Módosított RSV F fehérjék és alkalmazásuk módszerei
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
CN114699519A (zh) 2015-09-03 2022-07-05 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物
CA3003477A1 (en) 2015-11-01 2017-05-04 Glycobac, Llc Virus-free cell lines and methods for obtaining same
BR112019020661A2 (pt) 2017-04-04 2020-05-05 University Of Washington nanoestruturas de proteína de auto-montagem que exibem proteínas f de paramixovírus e/ou pneumovírus e seu uso
WO2019023196A1 (en) 2017-07-24 2019-01-31 Novavax, Inc. METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASE
CA3095216A1 (en) 2018-02-28 2019-09-06 University Of Washington Self-asssembling nanostructure vaccines
BR112020019108A2 (pt) 2018-03-19 2020-12-29 Novavax, Inc. Vacinas polivalentes de nanopartículas de influenza
US11495078B2 (en) * 2018-12-14 2022-11-08 Walmart Apollo, Llc Automated bakery kiosk with order customization
US20220096539A1 (en) * 2019-01-18 2022-03-31 University Of Georgia Research Foundation, Inc. Salt nanoparticles and compositions and methods of use thereof
JP2022521760A (ja) * 2019-02-28 2022-04-12 ノババックス，インコーポレイテッド Ｒｓｖ感染によって引き起こされる疾患又は障害を予防する方法
JP2023512648A (ja) * 2020-01-27 2023-03-28 ノババックス，インコーポレイテッド コロナウイルスワクチン製剤
US10953089B1 (en) 2020-01-27 2021-03-23 Novavax, Inc. Coronavirus vaccine formulations
US20210317170A1 (en) * 2020-04-14 2021-10-14 Ut-Battelle, Llc Compositions and methods for drug delivery and treating viral infections
WO2023069887A1 (en) * 2021-10-18 2023-04-27 Yang, Kejian Mucosal vaccine, methods of use and administration thereof
CN114533754B (zh) * 2022-02-23 2023-10-20 南京大学 一种广谱抗病毒纳米人工抗体及其制备方法和应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US5149650A (en) 1986-01-14 1992-09-22 University Of North Carolina At Chapel Hill Vaccines for human respiratory virus
DE3775783D1 (de) 1986-01-14 1992-02-20 Nederlanden Staat Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung.
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
FR2637324B1 (fr) 1988-10-04 1994-02-25 Peugeot Automobiles Dispositif de commande de securite pour electropompe
NL9002314A (nl) 1990-10-23 1992-05-18 Nederlanden Staat Immunogene complexen, in het bijzonder iscoms.
US6387373B1 (en) 1993-01-15 2002-05-14 Novavax, Inc. Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants
ES2370937T3 (es) 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
US5629021A (en) 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
US6846489B1 (en) 1995-04-25 2005-01-25 Smithkline Beecham Biologicals S.A. Vaccines containing a saponin and a sterol
SE9600647D0 (sv) 1996-02-21 1996-02-21 Bror Morein Ny användning
US6231859B1 (en) 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
AUPO517897A0 (en) 1997-02-19 1997-04-11 Csl Limited Chelating immunostimulating complexes
ITMI981138A1 (it) 1998-05-21 1999-11-21 Getters Spa Processo per la rimozione di acqua da camere evacuate o da gas
EP2204186B1 (en) 1999-02-17 2016-04-06 CSL Limited Immunogenic complexes and methods relating thereto
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
WO2001066137A1 (en) * 2000-03-07 2001-09-13 Merck & Co., Inc. Adenovirus formulations
CN101428006A (zh) * 2000-09-28 2009-05-13 诺华疫苗和诊断公司 微粒体组合物及其生产方法
CZ2003930A3 (cs) 2000-10-02 2003-08-13 Glaxosmithkline Biologicals S. A. Vakcinační prostředek obsahující štěpený virus s obalem
SE0202110D0 (sv) 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
CN1756562A (zh) * 2003-03-07 2006-04-05 麦克公司 流感病毒疫苗
US20050142148A1 (en) 2003-04-25 2005-06-30 Fouchier Ronaldus A.M. Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus
SE0301998D0 (sv) 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
WO2014124423A1 (en) 2013-02-11 2014-08-14 Smith Gale E Combination vaccine for respiratory syncytial virus and influenza
EP1713824A2 (en) 2003-12-10 2006-10-25 The Uab Research Foundation Recombinant viruses with heterologous envelope proteins
US8846607B2 (en) * 2004-10-29 2014-09-30 President And Fellows Of Harvard College Particles for treatment of pulmonary infection
WO2006060710A2 (en) 2004-12-02 2006-06-08 Becton, Dickinson And Company Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents
WO2006138145A1 (en) * 2005-06-14 2006-12-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
WO2008051245A2 (en) * 2005-12-02 2008-05-02 Novartis Ag Nanoparticles for use in immunogenic compositions
AU2007242572B2 (en) 2006-04-13 2011-11-24 Midatech Limited Nanoparticles containing three various ligands for providing immune responses against infectious agents
WO2007149490A1 (en) 2006-06-19 2007-12-27 Progenics Pharmaceuticals, Inc. Processes for recovering stabilized formulations of trimers of retroviral envelope (env) proteins
EP2089515A4 (en) 2006-11-16 2011-02-23 Novavax Inc VIRUSUAL PARTICLES OF RESPIRATORY SYNZYTIAL VIRUS
WO2008133663A2 (en) 2006-11-30 2008-11-06 Government Of The United States Of America, As Represented By The Secretary, Codon modified immunogenic compositions and methods of use
JP2010522540A (ja) 2007-03-21 2010-07-08 アイディー バイオメディカル コーポレイション オブ ケベック キメラ抗原
PT2540312E (pt) 2007-07-19 2015-08-31 Novavax Inc Vlps quiméricas de gripe aviária
WO2009061334A1 (en) * 2007-11-06 2009-05-14 Massachusetts Institute Of Technology Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate tissue repair
EP4219566A3 (en) 2007-12-24 2023-09-06 ID Biomedical Corporation of Quebec Recombinant rsv antigens
CN102014873A (zh) 2008-02-25 2011-04-13 诺瓦瓦克斯股份有限公司 糖玻璃化的病毒样颗粒
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
HUE051666T2 (hu) 2008-12-09 2021-03-29 Novavax Inc Módosított RSV F fehérjék és alkalmazásuk módszerei
AU2010254551B2 (en) * 2009-05-27 2016-10-20 Selecta Biosciences, Inc. Immunomodulatory agent-polymeric compounds
WO2011005183A1 (en) 2009-07-10 2011-01-13 Isconova Ab New composition
CN105214080A (zh) 2009-07-15 2016-01-06 诺华股份有限公司 Rsv f蛋白组合物和其制作方法
WO2011123495A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
WO2012011868A1 (en) 2010-07-23 2012-01-26 Osterhaus A D M E Influenza vaccine
MX354750B (es) * 2010-11-05 2018-03-20 Novavax Inc PARTÍCULAS PSEUDO-VIRALES (PPVs) QUE COMPRENDEN GLICOPROTEÍNAS DEL VIRUS DE LA RABIA.
CN102107003A (zh) * 2011-01-05 2011-06-29 重庆大学 一种猪繁殖与呼吸综合症病毒体疫苗及其制备方法
US11058762B2 (en) 2011-07-06 2021-07-13 Glaxosmithkline Biologicals Sa Immunogenic compositions and uses thereof
WO2013049342A1 (en) 2011-09-30 2013-04-04 Novavax, Inc. Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP6469081B2 (ja) * 2013-04-25 2019-02-13 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 安定化された可溶性融合前ｒｓｖｆポリペプチド
MX2016003419A (es) 2013-09-19 2016-10-10 Novavax Inc Metodos y composiciones para sindrome respiratorio coronavirus de oriente medio (mers-cov) inmunogenico.
AU2014100888A4 (en) 2014-08-07 2014-09-11 Novartis Ag Virus clearance and protein purification methods
CN114699519A (zh) 2015-09-03 2022-07-05 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物
BR112020019108A2 (pt) 2018-03-19 2020-12-29 Novavax, Inc. Vacinas polivalentes de nanopartículas de influenza

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