CN108368170B - 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 - Google Patents

抗pd-1抗体、可活化抗pd-1抗体及其使用方法 Download PDF

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CN108368170B
CN108368170B CN201680052368.XA CN201680052368A CN108368170B CN 108368170 B CN108368170 B CN 108368170B CN 201680052368 A CN201680052368 A CN 201680052368A CN 108368170 B CN108368170 B CN 108368170B
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seq
sequence
amino acid
acid sequence
activatable antibody
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CN108368170A (zh
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K.A.蒂普顿
J.W.韦斯特
C.M.陈
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Cytomx Therapeutics Inc
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Cytomx Therapeutics Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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CN201680052368.XA 2015-07-13 2016-07-13 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 Expired - Fee Related CN108368170B (zh)

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US201562191902P 2015-07-13 2015-07-13
US62/191902 2015-07-13
US201562205825P 2015-08-17 2015-08-17
US62/205825 2015-08-17
US201662295314P 2016-02-15 2016-02-15
US62/295314 2016-02-15
US201662323543P 2016-04-15 2016-04-15
US62/323543 2016-04-15
US201662333629P 2016-05-09 2016-05-09
US62/333629 2016-05-09
PCT/US2016/042141 WO2017011580A2 (en) 2015-07-13 2016-07-13 Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof

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