KR20180040138A - 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 - Google Patents

항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 Download PDF

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KR20180040138A
KR20180040138A KR1020187003863A KR20187003863A KR20180040138A KR 20180040138 A KR20180040138 A KR 20180040138A KR 1020187003863 A KR1020187003863 A KR 1020187003863A KR 20187003863 A KR20187003863 A KR 20187003863A KR 20180040138 A KR20180040138 A KR 20180040138A
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seq
sequence
amino acid
acid sequence
antibody
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Korean (ko)
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킴벌리 앤 팁톤
제임스 윌리엄 웨스트
산티 마리아테구 찬
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싸이톰스 테라퓨틱스, 인크.
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/54—F(ab')2
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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KR1020187003863A 2015-07-13 2016-07-13 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 Abandoned KR20180040138A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562191902P 2015-07-13 2015-07-13
US62/191,902 2015-07-13
US201562205825P 2015-08-17 2015-08-17
US62/205,825 2015-08-17
US201662295314P 2016-02-15 2016-02-15
US62/295,314 2016-02-15
US201662323543P 2016-04-15 2016-04-15
US62/323,543 2016-04-15
US201662333629P 2016-05-09 2016-05-09
US62/333,629 2016-05-09
PCT/US2016/042141 WO2017011580A2 (en) 2015-07-13 2016-07-13 Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof

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KR20180040138A true KR20180040138A (ko) 2018-04-19

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KR1020187003863A Abandoned KR20180040138A (ko) 2015-07-13 2016-07-13 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법

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US (2) US10513558B2 (enExample)
EP (1) EP3322732A2 (enExample)
JP (2) JP7014706B2 (enExample)
KR (1) KR20180040138A (enExample)
CN (2) CN108368170B (enExample)
AU (2) AU2016294440B2 (enExample)
BR (1) BR112018000768A2 (enExample)
CA (1) CA2991976A1 (enExample)
EA (1) EA201890285A1 (enExample)
HK (1) HK1250033A1 (enExample)
IL (1) IL256771B2 (enExample)
MA (1) MA42447A (enExample)
MX (2) MX383464B (enExample)
SG (1) SG10201913303XA (enExample)
WO (1) WO2017011580A2 (enExample)
ZA (1) ZA201800692B (enExample)

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Publication number Priority date Publication date Assignee Title
KR20180035728A (ko) * 2014-07-30 2018-04-06 립존 맙팜 아이엔씨. 항-pd-1 항체 및 이의 용도
WO2020246737A1 (ko) * 2019-06-04 2020-12-10 사회복지법인 삼성생명공익재단 콰시노이드를 포함하는 거세 저항성 전립선암 치료용 조성물
KR20210005617A (ko) * 2018-05-07 2021-01-14 젠맵 에이/에스 항-pd-1 항체와 항-조직 인자 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법
KR20220007118A (ko) * 2019-06-10 2022-01-18 샨동 보안 바이오테크놀로지 컴퍼니, 리미티드 PDL1 및 TGFβ에 대한 2기능성 융합 단백질 및 이의 용도

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IL291329B1 (en) 2013-09-25 2025-09-01 Cytomx Therapeutics Inc Polypeptides that can be determined in matrix metalloproteinases and uses thereof
EP3757130A1 (en) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
JOP20200094A1 (ar) * 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
CN106459153B (zh) * 2014-01-31 2021-12-21 西托姆克斯治疗公司 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法
ME03558B (me) 2014-03-14 2020-07-20 Novartis Ag Molekuli anti-lag-3 antiтela i njihove upotrebe
SG11201700496WA (en) 2014-07-22 2017-02-27 Cb Therapeutics Inc Anti-pd-1 antibodies
SG10201901057UA (en) 2014-08-05 2019-03-28 Cb Therapeutics Inc Anti-pd-l1 antibodies
KR20170060042A (ko) 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
MA41374A (fr) * 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
AU2016283344B2 (en) 2015-06-24 2022-08-04 Jcr Pharmaceuticals Co., Ltd. Fusion protein containing BDNF
EA039366B1 (ru) * 2015-06-24 2022-01-19 Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер
WO2017031242A1 (en) 2015-08-20 2017-02-23 Sutro Biopharma, Inc. Anti-tim-3 antibodies, compositions comprising anti-tim-3 antibodies and methods of making and using anti-tim-3 antibodies
HK1257840A1 (zh) 2015-09-01 2019-11-01 Agenus Inc. 抗-pd-1抗体及其使用方法
AU2016332725A1 (en) 2015-09-29 2018-03-22 Celgene Corporation PD-1 binding proteins and methods of use thereof
SI3370768T1 (sl) 2015-11-03 2022-04-29 Janssen Biotech, Inc. Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe
SI3394103T1 (sl) 2015-12-22 2023-10-30 Regeneron Pharmaceuticals, Inc. Kombinacija protiteles proti-PD-1 in bispecifičnih protiteles proti-CD20/proti-CD3 za zdravljenje raka
WO2017176651A1 (en) 2016-04-04 2017-10-12 True North Therapeutics, Inc. Anti-complement factor bb antibodies and uses thereof
TW202408578A (zh) 2016-05-13 2024-03-01 美商再生元醫藥公司 藉由投予pd-1抑制劑治療皮膚癌之方法
IL263616B2 (en) 2016-07-07 2025-01-01 Univ Leland Stanford Junior Antibody-adjuvant conjugates
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