CN104080811B - 在Fc结构域中具有突变的稳定异源二聚的抗体设计 - Google Patents
在Fc结构域中具有突变的稳定异源二聚的抗体设计 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
变体 | Tm℃ | 变体 | Tm℃ | 变体 | Tm℃ | 变体 Tm | ℃ |
野生型 | 81.5 | AZ42 | 70 | AZ73 | 71 | AZ91 | 91.5 |
对照1 | 69 | AZ44 | 71.5 | AZ74 | 71 | AZ92 | 71.5 |
对照2 | 69 | AZ46 | 70.5 | AZ75 | 70 | AZ93 | 71.5 |
AZ12 | >77 | AZ47 | 70.5 | AZ76 | 71.5 | AZ94 | 73.5 |
AZ14 | >77 | AZ48 | 70.5 | AZ77 | 71 | AZ95 | 72 |
AZ15 | 71.5 | AZ49 | 71 | AZ78 | 70 | AZ98 | 70 |
AZ17 | 71 | AZ63 | 71.5 | AZ79 | 70 | AZ100 | 71.5 |
AZ19 | 70.5 | AZ64 | 74 | AZ81 | 70.5 | AZ101 | 74 |
AZ20 | 70 | AZ65 | 73 | AZ82 | 71 | AZ106 | 74 |
AZ21 | 70 | AZ66 | 72.5 | AZ83 | 71 | AZ114 | 71 |
AZ25 | 70.5 | AZ67 | 72 | AZ84 | 71.5 | AZ115 | 70 |
AZ29 | 70 | AZ68 | 72 | AZ85 | 71.5 | AZ122 | 71 |
AZ30 | 71 | AZ69 | 71 | AZ86 | 72.5 | AZ123 | 70 |
AZ32 | 71.5 | AZ70 | 75.5 | AZ87 | 71 | AZ124 | 70 |
AZ33 | 74 | AZ71 | 71 | AZ88 | 72 | AZ129 | 70.5 |
AZ34 | 73.5 | AZ72 | 70.5 | AZ89 | 72.5 | AZ130 | 71 |
Claims (21)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201811302754.7A CN109897103A (zh) | 2011-11-04 | 2012-11-02 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
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US201161556090P | 2011-11-04 | 2011-11-04 | |
US61/556090 | 2011-11-04 | ||
US201161557262P | 2011-11-08 | 2011-11-08 | |
US61/557262 | 2011-11-08 | ||
US201261645547P | 2012-05-10 | 2012-05-10 | |
US61/645547 | 2012-05-10 | ||
PCT/CA2012/050780 WO2013063702A1 (en) | 2011-11-04 | 2012-11-02 | Stable heterodimeric antibody design with mutations in the fc domain |
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CN201811302754.7A Division CN109897103A (zh) | 2011-11-04 | 2012-11-02 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
Publications (2)
Publication Number | Publication Date |
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CN104080811A CN104080811A (zh) | 2014-10-01 |
CN104080811B true CN104080811B (zh) | 2019-09-27 |
Family
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CN201811302754.7A Pending CN109897103A (zh) | 2011-11-04 | 2012-11-02 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
CN201280057691.8A Active CN104080811B (zh) | 2011-11-04 | 2012-11-02 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
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CN201811302754.7A Pending CN109897103A (zh) | 2011-11-04 | 2012-11-02 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
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US (5) | US9574010B2 (zh) |
EP (1) | EP2773671B1 (zh) |
JP (1) | JP6326371B2 (zh) |
KR (1) | KR102052774B1 (zh) |
CN (2) | CN109897103A (zh) |
AU (2) | AU2012332021B8 (zh) |
BR (1) | BR112014010580B1 (zh) |
CA (1) | CA2854233C (zh) |
CY (1) | CY1124872T1 (zh) |
DK (1) | DK2773671T3 (zh) |
ES (1) | ES2899956T3 (zh) |
HK (1) | HK1200465A1 (zh) |
HR (1) | HRP20211773T1 (zh) |
HU (1) | HUE056462T2 (zh) |
MX (1) | MX358862B (zh) |
PL (1) | PL2773671T3 (zh) |
PT (1) | PT2773671T (zh) |
RS (1) | RS62689B1 (zh) |
RU (1) | RU2675319C2 (zh) |
WO (1) | WO2013063702A1 (zh) |
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