CN102667834B - 供应链管理系统 - Google Patents
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Abstract
公开一种用于从初始处至目的地追踪产品的系统。上述系统包括探针，探针包括两个板、电源和处理器。由处理器控制电源以在板处产生振荡输出。使用振荡电压，探针通过电容耦合来询问器件。器件包括控制单元、存储单元、以及与器件物理联接从而利用电容耦合来通信的第一材料和第二材料。与器件相关的信息分别通过第一材料和第二材料与第一板和第二板之间的电容耦合从器件传输至探针。
Description
相关申请的交叉引用
根据35 USC 119，该申请要求2009年11月4日提交的名称为“Method，Device andSystem for Supply Chain management of Ingestible Event Markers”、发明人为MarkZdeblick、系列号为No.61/258,182的美国临时申请的优先权，其内容并入本文中。
技术领域
本发明涉及使用电子器件追踪产品的方法和系统。更具体而言，本公开内容包括用于从源头至客户追踪医用产品的方法、器件、和系统。
背景技术
药物产品供应商担心从产品离开制造商起至产品送至最终用户时伪造品替代原产品。此外，有准确确定包装的数量和容纳物使得销售商能通过供应链来验明产品的需求。已知方法和系统使用近场通信，例如RFID(射频识别)。这些已知方法具有固有限制，例如缺乏数据完整性、保密性等。因此，需要一种用于询问产品以确保从制造商至最终用户或顾客的整个供应链中产品的有效性和来源的系统。
发明内容
公开一种在供应链环境中管理产品供应的系统。在各方面中，本发明包括电容板，电容板探测各种产品，得到产品有效或无效的指示。以这种方式，可实现各种供应链或其它追踪。
产品例如包括IV(静脉注射)袋、注射器、可吞食性事件标记器(IEM)以及类似的器件，如作为WO/2006/116718公开的系列号为no.PCT/US2006/016370的PCT申请；作为WO/2008/052136公开的系列号为no.PCT/US2007/082563的PCT申请；作为WO/2008/063626公开的系列号为no.PCT/US2007/024225的PCT申请；作为WO/2008/066617公开的系列号为no.PCT/US2007/022257的PCT申请；作为WO/2008/095183公开的系列号为no.PCT/US2008/052845的PCT申请；作为WO/2008/101107公开的系列号为no.PCT/US2008/053999的PCT申请；作为WO/2008/112577公开的系列号为no.PCT/US2008/056296的PCT申请；作为WO/2008/112578公开的系列号为no.PCT/US2008/056299的PCT申请；作为WO2009/042812公开的系列号为no.PCT/US2008/077753的PCT申请；系列号为no.PCT/US09/53721的PCT申请；作为WO 2008/008281公开的系列号为no.PCT/US2007/015547的PCT申请、以及系列号为No.61/142,849、No.61/142,861、No.61/177,611、No.61/173,564的美国临时申请所公开和描述的，以上各申请的全部内容通过引用并入本文中。这些产品通常可设计为包括导电性材料/部件。通过电容板来探测产品的导电性材料和部件的电容耦合的利用，可指示产品的导电性部件的正确配置的存在。替代地，当探测时通信耦合失败可指示产品不一致，例如一种或多种导电性材料缺失、不正确地配置等。
附图说明
图1A示出根据本发明一方面具有利用电容耦合能被询问的器件的药物产品。
图1B示出根据本发明另一方面具有利用电容耦合能被询问的器件的药物产品。
图1C示出根据本发明另一方面具有利用电容耦合能被询问的器件的药物产品。
图1D示出根据本发明又一方面利用电容耦合能被探测或询问的器件。
图1E示出根据本发明又一方面利用电容耦合用同轴式探针/板能被探测或询问的器件的药物产品。
图2示出根据本发明一方面的图1A-1D的器件的电路图。
图2A示出图2的器件中的二极管桥使用。
图2B示出通过板和导电材料与探针通信的图2的器件的逻辑单元，其与根据本发明的器件联接。
图2C示出根据本发明教示的利用电容耦合进行的电源传输循环和信息传输循环的有限时间段。
图3A示出根据本发明具有通过管状截面以确认产品真实性和器件操作性的器件的产品。
图3B是根据本发明在询问以确认产品的真实性期间通过两板之间的器件的具体示例。
图4A是根据本发明与产品联接的器件的俯视图。
图4B是根据本发明具有导电复合材料和器件的产品的侧视图。
图5示出根据本发明通过一对探针被询问的器件的侧视图。
具体实施方式
现参见图1A，示出位于诸如丸剂或片剂的药物产品12a内的器件10a，器件10a被完全包装并通过探针测试，如以下详述的。根据本发明的各方面，器件10a可位于产品12a内或固定到产品12a的表面，这些均涵盖在本发明的范围内。器件10a包括用于通信的控制模块和用于存储诸如身份等信息的存储器。执行对器件10a的探测以确保例如器件10a仍然在起作用。探测利用电容耦合途径，其中在第一探测电容板20a与位于器件10a一侧上的第一金属或材料14a以及第二探测电容板30a与位于器件10a另一侧上的第二金属或材料16a之间存在电容耦合。如对本领域技术人员显见的，板20a与板30a电绝缘，即使绝缘未特别示出也是如此。可实现利用电容耦合进行探测的多种方式，例如金属、金属垫等。根据本发明的一方面，例如，在材料14a与电容板20a以及材料16a与电容板30a之间存在电容耦合。板20a和30a是能通过电容耦合与器件10a通信的探针。板20a和30a电连接到能接受来自板20a和30a的信息以及处理这些信息的系统(未示出)。而且，根据本发明的各方面，产品可用非导电材料涂覆。
根据本发明的各方面，存在包括为器件10的部分的各种部件。例如，器件10可以是在吞食前能利用电容耦合读取以及在消耗后利用跨导(transconduction)通信的具有唯一身份的可吞食性事件标记器(IEM)。IEM的各方面在2009年9月21日提交的名称为“COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE”的美国专利申请12/564,017中公开，其全部公开内容通过引用并入本文中。
现参见图1B，根据本发明的一方面示出作为产品12b的部分的器件10b。器件10b包括沉积在器件10b表面上用于形成电容性连接的第一材料14b和第二材料16b。材料14b和16b与器件10b的控制模块通信。探针20b和30b分别与材料14b和16b电容耦合。因此，当用AC(交流)电压给探针20b和30b供电时，材料14b和16b与探针20b和30b电容耦合。因此，存储在器件10b的存储器中的与器件10b相关的信息能由器件10b的控制模块编码并利用电容耦合传送到探针。
现参见图1C，根据本发明示出器件10c固定至产品12c。器件10c包括绕器件10c的边缘(skirt)18c的周边沉积的第一材料14c和第二材料16c，且材料14c和16c的至少一部分沉积在边缘18c上。而且，材料14c和16c耦合至器件10c的控制模块，以容许与器件10c的控制模块通过电容耦合进行通信，从而通过探针20c和30c将器件10c的身份传送给系统。根据本发明的一方面，材料14c和16c是导电性油墨，例如可吞食性石墨或碳基油墨或胶剂。探针20c和30c由AC电源供电，并且当被带至靠近材料14c和16c时，探针20c和30c能利用电容耦合分别通过材料14c和16c与器件10c通信。而且，根据本发明的另一方面，探针22c和32c位于靠近材料14c和16c的不同位置处，从而使得可选择地定位器件10c或从而使得能从另一方向探测器件。一旦用AC电压给探针20c和30c供电且器件10c位于探针20c和30c附近，则材料14c和16c能用于通过电容耦合在器件10c和连接到探针20c和30c的系统之间传递信息。
现参见图1D，根据本发明的另一方面示出器件10d。导电材料14d沉积在与器件10d联接的材料19a的表面上。器件10d的材料19a和材料19b是不同的材料，并且形成用于器件10d的部分电源。例如，材料19a可以是CuCl以及材料19b可以是Mg。器件10d还包括连接处的晶体管19c，晶体管19c能够将复合材料14d电连接至V高或材料19b，材料19b与V低位于相同电势。器件10d包括复合材料16d，复合材料16d与器件10d物理联接且位于氧化层17d的顶部上。材料16d可以是镀金的CuCl。因此，当与图1A-1C中所示出的类似以及通过振荡或AC电压电源供电的探针或板被带至靠近器件10d时，在复合材料14d和复合材料16d与探针之间存在电容耦合。根据本发明的一方面，当电压电源隔离(isolate)时，传输至材料14d和材料16d的能量相应地变化并存储在器件10d上。当电压电源减少至零或静态(quiet)时，器件10d从接收能量切换成利用电容耦合发送能量至探针。为了产生振动能源，晶体管19c用于在材料19b(其代表V低)和V高之间连接和断开材料14d。当材料14d从V高到V低改变能级时，信息能传输至探针。因此，在循环的电源断开或静态时的部分中(如图2C所示)，器件10d能够传输能量至探针，其能量包括关于器件10d的信息。因此，利用电容耦合，信息可在器件10d和连接至器件10d附近的探针的系统之间传递。
现参见图1E，示出具有两个由绝缘材料25e分离的导电性探针/板20e和30e的同轴式探针。内部导电性探针或板20e由绝缘材料25e围绕，所述绝缘材料25e由外部导电性探针或板30e围绕。器件10e示出为药物产品12e的部分。器件10e包括沉积在与同轴式探针相对的一侧上的导电材料或油墨15e。当同轴式探针位于靠近产品12e处时，探针20e位于器件10e中心的上方，且探针30e位于器件10e外边缘的上方并靠近材料15e。因此，如上所述以及根据图2C，当电源隔离(isolate)时，能量从同轴式探针传输至器件10e，以及当电源切断或静态时，则能量从器件10e传输至与同轴式探针连接的系统。
现参见图2，诸如AC电压或其它隔离或交流电源40的电压电源以诸如1MHz等高频运行。电压电源连接探针或板。器件10包括控制模块50和焊盘(bonding pad)52，材料(例如，图1A的材料14和16)耦接至所述焊盘52。根据本发明的一方面，在器件10内的是二极管54和具有一些阻抗的开关56，二极管54例如为肖特基二极管(Schottky diode)或产生内部供电电压的其它类型的二极管，开关56的导通和断开改变器件10的阻抗。阻抗的变化用于传送有关器件10的身份的信息。阻抗的改变使得与器件10相关的信息被编码，以及利用电容耦合通过探针发送至系统，如由电容器58和60表示的。通过由电容器表示的与探针连接的系统来捕获信息，且该信息通过横跨标示为R样本的阻抗的取样放大器作为V输出读出。
一旦控制模块50通过板靠近或暴露于电压电源，则存在通过电容耦合进行的能量传输，并且器件10能产生能被检测的振荡信号。振荡信号含有信息，隔离信号能编码为例如1MHz信号或类似频率的信号，例如500KHz的信号，其可依赖于电容耦合的程度而定。将通过在图1的电容板或探针20和30与图1的材料14和16之间获得多少电容耦合，来确定电源40的电压。因此，在表示可能为5伏特的高频率下，在诸如探针20或30等探针与材料之间的电容值由电容器58和60表示。
现参见图2A和2B，根据本发明的另一方面，示出二极管桥，该二极管桥是在板20和30与器件10的材料14和16之间的相互作用的电路示图。在板20和30(标记为“板1”和“板2”)处存在的隔离电压导致对于器件10的呈高电压和低电压形式的能量传输。器件10包括作为处理器或逻辑单元的部分的控制模块。逻辑单元可以是处理器、微处理器、多模块式器件、或集成电路的任何形式。逻辑单元与导电性材料14和16以及板20和30(标记为“板1”和“板2”)通信。当用AC电源给板20和30供电时，逻辑单元存储能量以及以后利用该能量发送信息。
现参见图2C，电源循环示出具有有源期和静态期，以及器件10的传输循环示出为传输窗(transfer window)。根据本发明，有源期持续期间，能量从电源传输至器件10。然后在静态阶段，由器件10存储的能量用于从器件10传输能量至与探针连接的系统。以这种方式，与器件相关的信息能通过探针20和30从器件10传输至与探针连接的系统。根据本发明的各方面，在静态阶段中从器件10发送至探针20和30的系统的信息是基于在器件的存储器中存储的信息。因此，即使在传输窗期间或电源的静态阶段中示出为“1”，在电源的静态期间或阶段中传输的信息可能是“0”。
根据本发明的一方面，如果在电容板/探针与和器件10物理联接的材料之间有一微法拉的电容器，则表示较低电压的高隔离频率是电容耦合所必需的。根据本发明的另一方面，如本领域技术人员认识到的，如果存在一微微法拉的电容器，则可能需要更大的电压。实际通过的电流量将根据电容板/探针20和30之间所产生的电路之间的阻抗而定，例如如图1中所示的。因此，图1A-1C的短路电容板20和电容板30将导致显著的电流通过，这可由例如如图2中所示的取样放大器检测到。通过取样放大器输出，取样放大器实质上监测通过回路的电流以及控制模块50所引起的电流调制。
根据本发明的各方面，电容耦合可以在为DC(直流)电源器件的器件中使用，所述器件为了互操作性而改变，例如在适当位置具有整流器以在芯片上提供稳定电压的器件，其阻抗可调制。
现参见图3A和3B，根据本发明的各方面，电容板/探针和与电容板/探针连接的用于接收信息的系统可一体成型、或另外与多种结构部件和其它器件联接，例如，如图3A所示具有电容板20和30的管状结构60。为了说明，具有IEM或类似器件10的一种或多种药物制剂可被引入该结构内。器件10可被手动或通过自动化装置自动引入。当器件通过结构60时，由管60中的电容板20和30探测器件10。在各方面中，其它器件和/或部件可联接。在一个例子中，可编程的器件可与电容耦合器件以通信方式联接，以接收和/或发射通过电容耦合器件得到的数据和/或信息。继续以上说明，一旦产品10(其可以为丸剂)的数量的全部或部分被与探针/板20和30联接的电容耦合系统探测到或“读出”时，电容耦合系统能例如以无线、有线等方式与具有显示装置的数据库通信，用于进一步存储、显示、操纵等。以这种方式，单个数据、多个数据、大量数据等可为了各种目的而被处理。其中一个目的可以例如为在供应链应用中追踪药物制剂，例如在诸如片剂挤压或其它过程的制造过程中、在药房验证过程中、在药房开处方过程中等。各种过程可互补、相结合等。一个这样的例子是通过读出号码来确认。如果它是有效的，例如可读出的，则接受片剂。否则，则拒绝片剂。因此，使用具有振荡电源的简单手持式读取器，用户或保健提供者可用与其相关联的器件10来探测根据本发明一方面可为丸剂或片剂的产品，以及确认丸剂是否真实或为伪造产品。
现参见图4A和4B，根据本发明的另一方面，具有器件10的丸剂示出为具有涂层74，所述涂层74为非导电性或较强非渗透性的涂层，且丸剂自身包含非导电性医药粉末。区域72，例如如所示出的锥形区域，包括诸如与其它医药材料、赋形剂、安慰剂材料等混合的导电性材料形成的小颗粒或粒子等导电性材料70，使得区域72转变为导电区。例如，可使用石墨和其它导电性材料，例如十分之一份、十分之五份等，使得区域72可导电。其它材料和成分也是可能的，例如在其中具有导电性颗粒的凝胶或液体胶囊等。因此，在足够高的频率下，区域72中的导电性材料70的颗粒可一起短路。本领域技术人员将认识到，导电性材料70可包括多种材料以及形成因素及其组合，例如多种尺寸的颗粒、金属丝、金属膜、线等。本发明的范围不受区域72中使用的导电性材料70的类型或形状的限制。
根据本发明的另一方面，导电性材料70可通过多种方法和比例一体成型或形成。在一个例子中，器件10嵌入或以其它机械方式联接“面包圈状”粉末，且在其中形成的孔填充或以其它方式联接导电性颗粒等，以形成导电性区域。导电性区域的尺寸、面积、体积、位置或其它参数可改变，以可实现本文所述功能。
根据本发明另一方面和如图5所示，电容板或探针80和82耦合至用于接收数据的系统。探针80和82用于分别通过与材料84和86电容耦合来探测器件10。阻抗反馈系统可用于驱动它们相当接近彼此，一旦电流达到某个量值，则用此测量距离。使用足够大的阻抗，该系统可用于多种应用中，例如正确地操作制造环境以验证存在器件10等。
根据本发明的另一方面，电容耦合探针/板和器件10之间的紧密接近可便利于、提高等隐私方面。在某些方面，某些关联器件可包括例如具有与定时进行开、关、开始运行的CMOS(互补金属氧化物半导体)晶体管并联的肖特基二极管的电路等。其它电路设计和改变也是可以的。
Claims (17)
1.一种可吞食器件，所述可吞食器件构造成利用位于所述可吞食器件外部的探针对所述可吞食器件询问，所述可吞食器件包括：
基材，所述基材包括控制单元和用于存储信息的存储器；以及
第一可吞食板和第二可吞食板，所述第一可吞食板和第二可吞食板与所述基材物理联接，所述第一可吞食板构造成与位于所述可吞食器件外部的探针的第一探测板通信耦合，且所述第二可吞食板构造成与所述探针的第二探测板通信耦合，从而信息能够在所述第一可吞食板和所述探针的第一探测板之间、以及所述第二可吞食板和所述探针的第二探测板之间传输，并且
其中，所述可吞食器件构造成与药物产品物理联接；
其中，所述可吞食器件构造成被所述探针询问，以在从所述药物产品的制造商至用户的整个供应链中确认所述药物产品的有效性和来源；以及
其中，所述探针构造成通过所述第一探测板和所述第二探测板与对应的所述第一可吞食板和所述第二可吞食板的电容耦合，以给所述可吞食器件提供电，从而确认所述可吞食器件的功能性。
2.如权利要求1所述的可吞食器件，其中，所述第一可吞食板和第二可吞食板通信耦合至所述控制单元。
3.如权利要求1所述的可吞食器件，还包括与所述基材物理联接的导电材料区域。
4.如权利要求3所述的可吞食器件，其中，所述导电材料区域包括导电材料和至少一种其它材料所形成的颗粒的混合物。
5.如权利要求4所述的可吞食器件，其中，所述至少一种其它材料选自基本上由如下材料构成的组：至少一种医药材料、至少一种赋形剂、或者至少一种安慰剂材料。
6.如权利要求1所述的可吞食器件，其中，所述第一可吞食板和第二可吞食板各自包括彼此不同的材料。
7.如权利要求6所述的可吞食器件，其中，经过编码的信息能够由接收器远程探测到。
8.一种用于从来源至目的地追踪产品的系统，所述产品构造成利用位于所述产品外部的探针对所述产品询问，所述系统包括：
探针，所述探针包括：
电源；
耦合至所述电源的处理器，所述处理器构造成接收和发送信息；以及
第一探测板和第二探测板，所述第一探测板和第二探测板都耦合至所述处理器；
其中，所述电源构造成由所述处理器控制，以在所述第一探测板和第二探测板处产生输出；以及
可吞食器件，所述可吞食器件包括：
基材，所述基材包括控制单元和构造成存储信息的存储器；
第一可吞食板和第二可吞食板，所述第一可吞食板和第二可吞食板都与所述基材物理联接，
其中，所述可吞食器件构造成与所述探针的第一探测板和第二探测板通信耦合，从而信息能够在所述可吞食器件和所述探针之间传输；
其中，所述可吞食器件构造成与药物产品物理联接；
其中，所述可吞食器件构造成被所述探针询问，以在从所述药物产品的制造商至用户的整个供应链中确认所述药物产品的有效性和来源；以及
其中，所述探针构造成通过所述第一探测板和所述第二探测板与对应的所述第一可吞食板和所述第二可吞食板的电容耦合，以给所述可吞食器件提供电，以确认所述可吞食器件的功能性。
9.如权利要求8所述的系统，其中，所述第一探测板和第二探测板彼此面对并且限定分隔距离的间隙，使得当所述可吞食器件位于所述第一探测板和所述第二探测板之间的所述限定的间隙中时，所述可吞食器件与所述探针通信。
10.如权利要求8所述的系统，其中，所述第一探测板和第二探测板位于相同平面内并且并排定位，使得当所述可吞食器件被带至靠近所述探针时，所述可吞食器件与所述探针通信。
11.如权利要求8所述的系统，其中，所述探针还包括管，所述管具有容纳于所述管中的第一探测板和第二探测板。
12.如权利要求8所述的系统，其中，所述第一可吞食板和第二可吞食板与所述控制单元通信耦合。
13.如权利要求8所述的系统，还包括与所述基材物理联接的导电材料区域。
14.如权利要求13所述的系统，其中，所述导电材料区域包括导电材料和至少一种其它材料形成的颗粒的混合物。
15.如权利要求8所述的系统，其中所述第一可吞食板和第二可吞食板由导电性油墨制成。
16.如权利要求8所述的系统，还包括外部器件，其中所述可吞食器件构造成与所述外部器件通信。
17.如权利要求16所述的系统，其中，经过编码的信息能够由接收器远程探测到。
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- 2015-02-13 JP JP2015026812A patent/JP6005776B2/ja active Active
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2017
- 2017-03-16 IL IL251223A patent/IL251223B/en active IP Right Grant
- 2017-04-20 US US15/492,716 patent/US10305544B2/en active Active
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2019
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2020
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204764B1 (en) * | 1998-09-11 | 2001-03-20 | Key-Trak, Inc. | Object tracking system with non-contact object detection and identification |
| CN101522094A (zh) * | 2006-09-29 | 2009-09-02 | 皇家飞利浦电子股份有限公司 | 微型化阈值传感器 |
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