CN102124096B - 具有微通道的器官模仿装置及其使用和制造方法 - Google Patents

具有微通道的器官模仿装置及其使用和制造方法 Download PDF

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CN102124096B
CN102124096B CN200980132001.9A CN200980132001A CN102124096B CN 102124096 B CN102124096 B CN 102124096B CN 200980132001 A CN200980132001 A CN 200980132001A CN 102124096 B CN102124096 B CN 102124096B
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membrane
cells
microchannel
central
cell
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CN102124096A (zh
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唐纳德·E·英格贝尔
胡东恩
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Boston Childrens Hospital
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Boston Childrens Hospital
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Priority to CN201711113999.0A priority patent/CN107988072B/zh
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    • C12M23/00—Constructional details, e.g. recesses, hinges
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    • C12M23/16—Microfluidic devices; Capillary tubes
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CN200980132001.9A 2008-07-16 2009-07-16 具有微通道的器官模仿装置及其使用和制造方法 Active CN102124096B (zh)

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CN201410465085.0A CN104328050B (zh) 2008-07-16 2009-07-16 具有微通道的器官模仿装置及其使用和制造方法
CN201711113999.0A CN107988072B (zh) 2008-07-16 2009-07-16 具有微通道的器官模仿装置及其使用和制造方法

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US8108008P 2008-07-16 2008-07-16
US61/081,080 2008-07-16
PCT/US2009/050830 WO2010009307A2 (en) 2008-07-16 2009-07-16 Organ mimic device with microchannels and methods of use and manufacturing thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12157872B2 (en) 2018-07-19 2024-12-03 Stellular Bio, Inc. Stacked recirculating bioreactor

Families Citing this family (273)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US9157060B2 (en) 2005-06-09 2015-10-13 The United States Of America, As Represented By The Secretary Of The Navy Micro blood vessels and tissue ducts
ES2639183T3 (es) 2007-09-19 2017-10-25 The Charles Stark Draper Laboratory, Inc. Estructuras microfluídicas con sección transversal circular
KR102140055B1 (ko) 2008-07-16 2020-07-31 칠드런'즈 메디컬 센터 코포레이션 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법
US20110004304A1 (en) * 2009-03-20 2011-01-06 Tao Sarah L Culturing retinal cells and tissues
EP2284821A1 (en) * 2009-08-07 2011-02-16 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Method, device and computer program product for assessing the disintegration of a dosage form in the gastrointestinal tract
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
WO2012006320A1 (en) 2010-07-06 2012-01-12 President And Fellows Of Harvard College Photosensitive cardiac rhythm modulation systems
US9448195B2 (en) * 2010-07-16 2016-09-20 University Of Utah Research Foundation Electrophysiological recording system and methods of using same
EP2601524B1 (en) * 2010-08-05 2014-06-25 Koninklijke Philips N.V. Cardiomyocyte containing device, manufacturing method and measuring method
EP2622342A4 (en) * 2010-09-29 2016-12-14 Massachusetts Inst Technology DEVICE FOR THE INVESTIGATION OF CELLULAR INTERACTIONS WITH HIGH THROUGHPUT
CA2828110C (en) * 2011-02-28 2020-03-31 President And Fellows Of Harvard College Cell culture system
US20140158233A1 (en) * 2011-05-09 2014-06-12 President And Fellows Of Harvard College Aerosol delivery to a microfluidic device
EP2714892B1 (en) 2011-06-02 2018-02-21 President and Fellows of Harvard College Methods and uses for ex vivo tissue culture systems
JP2014516582A (ja) * 2011-06-15 2014-07-17 ザ チャールズ スターク ドレイパー ラボラトリー インク 生体模倣環境において細胞を培養するためのデバイスおよび方法
CA2839435C (en) 2011-06-15 2021-05-11 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
EP2560004A1 (de) * 2011-08-19 2013-02-20 DST Diagnostische Systeme & Technologien GmbH Neues PoC-Testsystem und Verfahren
DE102011112638B4 (de) * 2011-09-05 2013-11-14 Karlsruher Institut für Technologie Mikrofluidischer Chip mit mikrofluidischem Kanalsystem
JP2013111053A (ja) * 2011-11-30 2013-06-10 Kyoto Univ バイオマーカーの探索方法及びそれにより見出されたバイオマーカーを用いたがんの検出方法
US20140335496A1 (en) * 2011-12-05 2014-11-13 Research Triangle Institute Human conducting airway model comprising multiple fluidic pathways
WO2013086512A2 (en) * 2011-12-09 2013-06-13 President And Fellows Of Harvard College Muscle chips and methods of use thereof
WO2013086486A1 (en) * 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
WO2013086502A1 (en) * 2011-12-09 2013-06-13 President And Fellows Of Harvard College Organ chips and uses thereof
TWI454636B (zh) * 2011-12-26 2014-10-01 Ind Tech Res Inst 氣體驅動裝置及發光二極體模組
WO2013116834A2 (en) * 2012-02-03 2013-08-08 The Charles Stark Draper Laboratory, Inc. Microfluidic device for generating neural cells to simulate post-stroke conditions
CA2865795A1 (en) * 2012-03-02 2013-09-06 The Charles Stark Draper Laboratory, Inc. Porous structure with independently controlled surface patterns
US20150072413A1 (en) * 2012-03-29 2015-03-12 Arizona Board Of Regents On Behalf University Of Arizona Cell culture apparatus and culture methods using same
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US9658211B2 (en) * 2012-04-18 2017-05-23 Hemoshear, Llc In vitro model for pathological or physiologic conditions
US9081003B2 (en) * 2012-05-03 2015-07-14 Purdue Research Foundation Systems and methods for testing drugs and drug delivery systems
KR101480753B1 (ko) 2012-05-21 2015-01-09 한국과학기술원 미소입자 처리 장치
CN102723039A (zh) * 2012-06-25 2012-10-10 关真民 肿瘤血道扩散演示模型
WO2014039514A2 (en) * 2012-09-05 2014-03-13 President And Fellows Of Harvard College Removing bubbles in microfluidic systems
TWI454291B (zh) * 2012-10-26 2014-10-01 Univ Nat Taiwan 植入體以及製造其之方法
WO2014078790A1 (en) * 2012-11-16 2014-05-22 Lightstat Llc A micro-pillar array method and apparatus
WO2014133624A2 (en) 2012-12-10 2014-09-04 President And Fellows Of Harvard College Membrane-based fluid-flow control devices
CA2896997C (en) 2013-01-03 2023-10-03 Brigham And Women's Hospital, Inc. System and method for a biomimetic fluid processing
US9504780B2 (en) 2013-01-30 2016-11-29 The Charles Stark Draper Laboratory, Inc. Extracorporeal clearance of organophosphates from blood on an acoustic separation device
WO2014127250A1 (en) * 2013-02-14 2014-08-21 Cfd Research Corporation Cell culture device with an array of microfluidic networks
EP2767831A1 (de) 2013-02-19 2014-08-20 DST Diagnostische Systeme & Technologien GmbH Neues PoC-Testsystem und Verfahren
WO2014138739A1 (en) 2013-03-08 2014-09-12 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
US20140308207A1 (en) * 2013-04-16 2014-10-16 Christopher Janetopoulos Open microfluidic devices for chemotaxis, methods of using same, and applications of same
KR101663044B1 (ko) * 2013-05-28 2016-10-06 이화여자대학교 산학협력단 내분비 인자 스크리닝 장치, 및 이를 이용한 내분비 인자 스크리닝 방법
AU2014287013B2 (en) 2013-07-12 2020-01-23 President And Fellows Of Harvard College Systems and methods for cell culture device interconnection and fluidic device interconnection
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
US10066198B2 (en) 2013-09-05 2018-09-04 Universität Bern Device for in-vitro modelling in-vivo tissues of organs
US10959839B2 (en) * 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
JP6684706B2 (ja) 2013-10-21 2020-04-22 ヘモシアー・リミテッド・ライアビリティ・カンパニーＨｅｍｏＳｈｅａｒ， ＬＬＣ 腫瘍微細環境のための試験管内モデル
NL2011895C2 (en) * 2013-12-04 2015-06-08 Mikhail Alexandrovich Ponomarenko Fluidic device and perfusion system for in vitro tissue reconstruction.
GB2545287A (en) * 2013-12-20 2017-06-14 Harvard College Organomimetic devices and methods of use and manufacturing thereof
CA2934662C (en) * 2013-12-20 2024-02-20 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
EP2886644A1 (en) * 2013-12-20 2015-06-24 Kallistem Process for implementing in vitro spermatogenesis and associated device
WO2015116523A1 (en) 2014-01-31 2015-08-06 The Charles Stark Draper Laboratory, Inc. Multi-layered micro-channel electrode array with regenerative selectivity
US20150216682A1 (en) 2014-02-06 2015-08-06 The Charles Stark Draper Laboratory, Inc. Array of Microelectrodes for Interfacing to Neurons within Fascicles
WO2015178980A2 (en) 2014-02-18 2015-11-26 President And Fellows Of Harvard College Anisotropic muscular tissue devices with integrated electrical force readouts
US9631167B2 (en) * 2014-03-21 2017-04-25 Iontox, Llc Dynamic multi organ plate
CA2944314C (en) 2014-03-31 2023-09-19 Brigham And Women's Hospital, Inc. Systems and methods for biomimetic fluid processing
EP3132019A1 (en) 2014-04-16 2017-02-22 The Charles Stark Draper Laboratory, Inc. Microfluidic tissue model
WO2015176653A1 (zh) * 2014-05-22 2015-11-26 第三军医大学第三附属医院 一种适用于三维组织细胞灌注培养的生物反应器
GB2546424A (en) * 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US10099002B2 (en) 2014-07-31 2018-10-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
US10946133B2 (en) 2014-07-31 2021-03-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
WO2016042533A1 (en) * 2014-09-18 2016-03-24 Association For The Advancement Of Tissue Engineering And Cell Based Technologies And Therapies - A4Tec Multi-chambers bioreactor, methods and uses
KR101687291B1 (ko) 2014-09-19 2016-12-19 (주)세포바이오 3차원 세포배양 시스템 및 이를 이용한 세포 배양 방법
WO2016069142A2 (en) 2014-09-24 2016-05-06 President And Fellows Of Harvard College Contractile function measuring devices, systems, and methods of use thereof
EP3212757A4 (en) * 2014-10-27 2018-07-04 The Governing Council of the University of Toronto Microfluidic device for cell-based assays
GB2548740A (en) * 2014-11-25 2017-09-27 Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
WO2016100227A1 (en) * 2014-12-15 2016-06-23 The Regents Of The University Of California Multi-organ cell culture system and methods of use thereof
CN104524652B (zh) * 2015-01-29 2017-06-16 中国科学技术大学 一种人工肝体外工作平台
GB2555948A (en) * 2015-03-04 2018-05-16 Harvard College Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers
CA2980287C (en) * 2015-03-19 2022-08-16 President And Fellows Of Harvard College Incubating enclosure
AU2016235230A1 (en) * 2015-03-24 2017-11-09 The Trustees Of The University Of Pennsylvania Artificial placenta and methods of preparation
GB2554818A (en) * 2015-04-01 2018-04-11 Harvard College Respiration device for analysis of a response to shear stress and foreign agents on cells
EP3283610B1 (en) * 2015-04-14 2020-12-23 President and Fellows of Harvard College Method of removing cells from seeding channels within a microfluidic device
GB2554283B (en) * 2015-04-24 2021-06-16 Harvard College Devices for simulating a function of a tissue and methods of use and manufacturing thereof
US10961492B2 (en) * 2015-04-29 2021-03-30 Politecnico Di Milano Microfluidic devices and related methods for generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs
CN104849439B (zh) * 2015-04-30 2017-01-18 四川农业大学 一种高效检测纳米颗粒肾毒性的方法
CN104830683B (zh) * 2015-04-30 2017-06-30 大连医科大学附属第二医院 一种用于模拟体内肿瘤细胞及其转移微环境的仿生微流控芯片
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
GB2555319A (en) 2015-05-22 2018-04-25 Harvard College Methods, systems, and compositions for determining blood clot formation, and uses thereof
KR101744663B1 (ko) 2015-06-25 2017-06-08 홍익대학교 산학협력단 위-장-간 생체 모사 마이크로 칩
WO2017004516A1 (en) * 2015-07-01 2017-01-05 The Johns Hopkins University Device and method for analysis of tissue constructs
US11162859B2 (en) 2015-07-20 2021-11-02 Haemonetics Corporation System and method for measuring pressure of fluid flow
WO2017019542A1 (en) 2015-07-24 2017-02-02 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
CA2993943C (en) 2015-07-27 2024-01-16 The Trustees Of The University Of Pennsylvania Systems and methods for immobilizing extracellular matrix material on organ on chip, multilayer microfluidics microdevices, and three-dimensional cell culture systems
US10465155B2 (en) * 2015-08-10 2019-11-05 Board Of Regents, The University Of Texas System Non-linear flow path devices and methods for cell culture
EP3334531B1 (de) * 2015-08-12 2020-07-22 Meon Medical Solutions GmbH & Co. KG Vorrichtung und verfahren zur bestimmung der migrationsfähigkeit amöboid beweglicher zellen
JP2018525200A (ja) * 2015-08-14 2018-09-06 ザ ジェネラル ホスピタル コーポレイション 生体組織におけるコミュニケーションを提供する生体模倣構造を用いるためのシステムと方法
EP4026616B1 (en) 2015-08-26 2024-12-11 Emulate, Inc. Perfusion manifold assembly
WO2017044149A1 (en) * 2015-09-08 2017-03-16 Brigham And Women's Hospital, Inc. System and method for producing blood platelets
KR101750416B1 (ko) * 2015-10-16 2017-06-23 공주대학교 산학협력단 Het-cam 시험용 미세유체칩
CA3002399C (en) 2015-10-19 2024-06-11 Cedars-Sinai Medical Center Microfluidic model of the blood brain barrier
US12209253B2 (en) 2016-08-29 2025-01-28 EMULATE, Inc. Development of spinal cord on a microfluidic chip
US11066633B2 (en) 2015-10-22 2021-07-20 The Trustees Of The University Of Pennsylvania Systems and methods for producing micro-engineered models of the human cervix
EP3371295A1 (en) * 2015-11-04 2018-09-12 Northeastern University Systems for producing cellular immunotherapeutics and methods of use thereof
US11384328B2 (en) 2015-11-18 2022-07-12 President And Fellows Of Harvard College Cartridge-based system for long term culture of cell clusters
CA3003921A1 (en) 2015-11-20 2017-05-26 The Governing Council Of The University Of Toronto Devices and methods for quantification of male fertility
CN105420106A (zh) * 2015-11-23 2016-03-23 大连医科大学附属第一医院 仿生肾小球芯片以及由其组成的芯片组
WO2017096297A1 (en) * 2015-12-04 2017-06-08 EMULATE, Inc. Open-top microfluidic device with structural anchors
WO2017096282A1 (en) 2015-12-04 2017-06-08 EMULATE, Inc. Devices and methods for simulating a function of a liver tissue
GB2595081B (en) 2015-12-04 2022-02-23 Harvard College Open-top microfluidic devices and methods for simulating a function of a tissue
SG11201804710TA (en) * 2015-12-04 2018-07-30 Harvard College Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof
WO2017106727A1 (en) * 2015-12-16 2017-06-22 President And Fellows Of Harvard College Electrode integration into organs on chip devices
WO2017123806A1 (en) * 2016-01-12 2017-07-20 Cedars-Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
WO2017136462A2 (en) 2016-02-01 2017-08-10 EMULATE, Inc. Systems and methods for growth of intestinal cells in microfluidic devices
CA3013077A1 (en) 2016-02-16 2017-08-24 President And Fellows Of Harvard College Improved blood-brain barrier endothelial cells derived from pluripotent stem cells for blood-brain barrier models
EP3426319B1 (en) 2016-03-07 2022-10-26 The Regents of The University of California Bioartificial ultrafiltration device and methods related thereto
US10488394B2 (en) 2016-03-21 2019-11-26 Ontera Inc. Wafer-scale assembly of insulator-membrane-insulator devices for nanopore sensing
US11970680B2 (en) 2016-03-30 2024-04-30 EMULATE, Inc. Devices, systems and methods for inhibiting invasion and metasases of cancer
IL244922A0 (en) 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and method for sample preparation
FR3051252B1 (fr) 2016-05-11 2021-03-19 Univ Grenoble Alpes Methode de diagnostic de cancers urologiques
FR3051195B1 (fr) 2016-05-11 2018-05-18 Universite Grenoble Alpes Puce de co-culture cellulaire et son procede de fabrication
CN105925480B (zh) * 2016-05-12 2018-07-13 大连理工大学 用于血脑屏障药物通透性高通量筛选的微流控芯片及制备方法
CA3025353A1 (en) * 2016-05-27 2017-11-30 The Charles Stark Draper Laboratory, Inc. Biomimetic microfluidic device for high efficiency carbon dioxide removal from patients at low blood flow rates
RU2741806C2 (ru) * 2016-06-15 2021-01-28 Миметас Б.В. Устройство и способы для культивирования клеток
WO2018013654A1 (en) 2016-07-12 2018-01-18 EMULATE, Inc. Additive channels
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
SG11201901000XA (en) * 2016-07-12 2019-03-28 Emulate Inc Compositions and methods of cell attachment
US10335788B2 (en) * 2016-07-12 2019-07-02 EMULATE, Inc. Removing bubbles in a microfluidic device
GB2602935B (en) 2016-07-18 2022-10-12 Harvard College Human lymphoid tissue-on-chip
US12091650B2 (en) 2016-08-29 2024-09-17 EMULATE, Inc. Development of spinal cord on a microfluidic chip
USD838864S1 (en) * 2016-09-07 2019-01-22 EMULATE, Inc. Opaque microfluidic chip without pressure features for use with a fluid perfusion module
USD842493S1 (en) * 2016-09-07 2019-03-05 EMULATE, Inc. Microfluidic chip without pressure features for use with a fluid perfusion module
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
US12104174B2 (en) 2016-09-13 2024-10-01 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
US20180106784A1 (en) 2016-10-19 2018-04-19 R.J. Reynolds Tobacco Company Microfluidics Aerosol-Evaluation Apparatus
KR101774709B1 (ko) 2016-10-20 2017-09-04 연세대학교 산학협력단 세포 자극 장치
US11446133B2 (en) 2016-11-03 2022-09-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Stacked tissue encapsulation device systems with or without oxygen delivery
EP3534834A4 (en) 2016-11-03 2020-05-13 Arizona Board of Regents on behalf of the University of Arizona Encapsulation device systems with oxygen sensors with or without exogenous oxygen supply
CA3042712A1 (en) 2016-11-03 2018-08-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre- and post-transplantation
WO2018094003A1 (en) * 2016-11-16 2018-05-24 President And Fellows Of Harvard College Coupled organ-on-chip systems, devices, and methods of use for mimicking a de-coupled organ
EP3323882A1 (en) * 2016-11-18 2018-05-23 Ecole Polytechnique Fédérale de Lausanne Organoid tissue engineering
CN106754354B (zh) * 2016-11-19 2019-04-05 大连医科大学附属第一医院 主动脉夹层瘤血流剪切力诱发血管细胞释放炎症因子影响肺上皮细胞功能的微流控芯片装置
EP3545077A1 (en) * 2016-11-24 2019-10-02 AlveoliX AG Cell culturing system and method
GB2573427B (en) 2016-12-02 2020-12-09 Emulate Inc In vitro epithelial models comprising lamina propria-derived cells
EP3954757A1 (en) 2016-12-02 2022-02-16 Emulate, Inc. In vitro gastrointestinal model comprising lamina propria-derived cells
KR101916567B1 (ko) * 2017-01-04 2019-01-30 고려대학교 산학협력단 추간판 통증기전 연구용 추간판세포 공동배양장치
KR101970125B1 (ko) 2017-01-16 2019-04-18 한림대학교 산학협력단 신축 가능한 피부 칩
WO2018131829A1 (ko) * 2017-01-16 2018-07-19 한림대학교 산학협력단 신축 가능한 피부 칩
IT201700004017A1 (it) * 2017-01-16 2018-07-16 React4Life Srl Bioreattore e metodo di utilizzo di detto bioreattore
US11913022B2 (en) 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
WO2018208332A2 (en) 2017-02-17 2018-11-15 Koniku, Inc. Systems for detection
JP6663074B2 (ja) * 2017-02-22 2020-03-11 アルプスアルパイン株式会社 流路チップ及び流路チップの製造方法
CN110582561A (zh) * 2017-03-07 2019-12-17 血小板生源说股份有限公司 再循环生物反应器
BR102017004855A2 (pt) * 2017-03-10 2018-10-30 Soc Beneficente Israelita Brasileira Hospital Albert Einstein sistema de cultura celular dinâmico
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US11414648B2 (en) 2017-03-24 2022-08-16 Cedars-Sinai Medical Center Methods and compositions for production of fallopian tube epithelium
GB2608510B (en) * 2017-03-24 2023-04-05 Harvard College Bone marrow microfluidic devices and methods for preparing and using the same
WO2018201098A2 (en) * 2017-04-27 2018-11-01 Stc.Unm Enzymatically active high-flux selectively gas-permeable membranes for enhanced oil recovery and carbon capture
EP3398558A1 (en) * 2017-05-02 2018-11-07 Carlo Andretta In body perfusion system
EP3630957A4 (en) * 2017-05-23 2021-10-06 Emulate, Inc. ADVANCED PULMONARY MODELS
KR102274967B1 (ko) 2017-06-09 2021-07-07 후지필름 가부시키가이샤 마이크로 유로 디바이스
US20180356398A1 (en) * 2017-06-09 2018-12-13 Fujifilm Corporation Living tissue model device, vascular wall model, vascular wall model device and method of evaluating test substance
JP6869379B2 (ja) * 2017-06-09 2021-05-12 富士フイルム株式会社 血管モデル
GB2578989B (en) 2017-07-12 2021-06-16 Emulate Inc Surface functionalization
EP3431582A1 (en) * 2017-07-18 2019-01-23 Koninklijke Philips N.V. Cell culturing materials
KR101985311B1 (ko) * 2017-07-26 2019-06-03 강원대학교산학협력단 나노다공성 투과막이 부착된 3차원 세포배양용 마이크로 칩 및 그의 제조방법
US11649424B2 (en) 2017-07-28 2023-05-16 The Trustees Of Columbia University In The City Of New York Smart micro bioreactor platform for high throughput mechanical stimulation of cardiac microtissue
US11826757B2 (en) * 2017-08-02 2023-11-28 Wake Forest University Health Sciences Niches-on-a-chip
WO2019033096A1 (en) * 2017-08-11 2019-02-14 The Trustees Of The University Of Pennsylvania MEMBRANE INSERTS DERIVED FROM NATIVE EXTRACELLULAR MATRIX FOR CHIP ORGANS, MULTILAYER MICROFLUIDIC MICRODISPOSITIVES, AND THREE DIMENSIONAL CELL CULTURE SYSTEMS
US11373552B2 (en) * 2017-08-17 2022-06-28 Virginia Commonwealth University Anatomically accurate brain phantoms and methods for making and using the same
WO2019054287A1 (ja) * 2017-09-13 2019-03-21 国立研究開発法人産業技術総合研究所 細胞培養装置および細胞培養方法
CA3076500C (en) 2017-09-21 2025-07-08 Emulate Inc REOLOGICALLY BIOMIMITED FLUID SUBSTITUTE
WO2019060680A1 (en) * 2017-09-22 2019-03-28 The Regents Of The University Of Colorado, A Body Corporate MICROPHYSIOLOGICAL ORGAN-ON-CHIP SYSTEM
EP3473698A1 (en) 2017-10-19 2019-04-24 Koninklijke Philips N.V. Cell preservation or culturing arrangement
WO2019079681A1 (en) 2017-10-20 2019-04-25 President And Fellows Of Harvard College METHODS FOR PRODUCING MATURE ADIPOCYTES AND METHODS OF USE
US20210372995A1 (en) * 2017-10-22 2021-12-02 The Johns Hopkins University Biomimetic platforms to model vascular pathophysiology, diagnostics, and therapy
US10930380B2 (en) 2017-11-10 2021-02-23 Reliant Immune Diagnostics, Inc. Communication loop and record loop system for parallel/serial dual microfluidic chip
US11041185B2 (en) 2017-11-10 2021-06-22 Reliant Immune Diagnostics, Inc. Modular parallel/serial dual microfluidic chip
US11124821B2 (en) 2017-11-10 2021-09-21 Reliant Immune Diagnostics, Inc. Microfluidic testing system with cell capture/analysis regions for processing in a parallel and serial manner
WO2019094848A1 (en) * 2017-11-10 2019-05-16 Reliant Immune Diagnostics, Inc. Microfluidic testing system with cell capture/analysis regions for processing in a parallel and serial manner
US11200986B2 (en) 2017-11-10 2021-12-14 Reliant Immune Diagnostics, Inc. Database and machine learning in response to parallel serial dual microfluidic chip
US10930381B2 (en) 2017-11-10 2021-02-23 Reliant Immune Diagnostics, Inc. Microfluidic testing system for mobile veterinary applications
US11527324B2 (en) 2017-11-10 2022-12-13 Reliant Immune Diagnostics, Inc. Artificial intelligence response system based on testing with parallel/serial dual microfluidic chip
DE102017126629A1 (de) * 2017-11-13 2019-05-16 Fachhochschule Südwestfalen Einweg-Gehäuse mit Zellen und/oder Co-Kulturen zu In-situ-Testung
US20190261897A1 (en) * 2017-11-28 2019-08-29 Alan D. Kersey Apparatus and method for assessment of cancer margin
EP3728556A1 (fr) * 2017-12-21 2020-10-28 Nanobiose Puce micro-fluidique, laboratoire sur puce micro-fluidique, procédé de fabrication d'une telle puce et procédé d'analyse
EP3728553B1 (en) * 2017-12-22 2021-10-06 Institut Pasteur Hydrogel-based organ-on-chip microfluidic device
ES2882582T3 (es) * 2017-12-22 2021-12-02 Tissuse Gmbh Dispositivos microfluídicos que implementan el circuito de sangre y orina para emular el sistema microfisiológico homeostático
KR20190088354A (ko) 2018-01-18 2019-07-26 포항공과대학교 산학협력단 세포친화성 물질로 피복된 나노 섬유상 기저 막과 제조 방법
KR20190088337A (ko) 2018-01-18 2019-07-26 포항공과대학교 산학협력단 나노 섬유 기저 막을 생체 모사 조직 표면에 형성시키는 방법
AU2019215247A1 (en) 2018-02-05 2020-08-20 EMULATE, Inc. Stem cell-based lung-on-chip models
WO2019157136A2 (en) 2018-02-07 2019-08-15 EMULATE, Inc. Gas mixer and pressurizer apparatus
US11679546B2 (en) 2018-02-09 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate Bioprinter and methods of manufacturing an organomimetic device
GB2585302B (en) 2018-02-23 2023-03-22 Emulate Inc Organs-on-chips as a platform for epigenetics discovery
WO2019163551A1 (ja) * 2018-02-26 2019-08-29 富士フイルム株式会社 細胞培養デバイスの管理方法、及び細胞培養デバイスの管理システム
WO2019163925A1 (ja) 2018-02-26 2019-08-29 富士フイルム株式会社 流路デバイス
TW201938263A (zh) * 2018-03-02 2019-10-01 日商富士軟片股份有限公司 微流路裝置
GB2611641B (en) * 2018-03-14 2023-06-28 Emulate Inc Innervated intestine on-chip
US12161676B2 (en) 2018-03-23 2024-12-10 Cedars-Sinai Medical Center Methods of use of islet cells
WO2019191685A1 (en) 2018-03-30 2019-10-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Workstation for automated control of an in vitro system
PL425107A1 (pl) 2018-03-30 2019-10-07 Bacteromic Spółka Z Ograniczoną Odpowiedzialnością Segment inkubacyjny
GB2587142B (en) * 2018-04-02 2023-03-29 Harvard College Complex human gut microbiome cultured in an anaerobic human gut-on-a-chip
WO2019195338A1 (en) * 2018-04-03 2019-10-10 EMULATE, Inc. Microfluidic control
KR102064769B1 (ko) * 2018-04-03 2020-01-13 한국생산기술연구원 다공성 필름과 미세인공혈관 채널이 구비된 세포배양 플레이트, 이를 포함하는 세포배양 장치 및 세포배양 장치를 이용한 세포배양방법
WO2019195795A1 (en) * 2018-04-05 2019-10-10 University Of Virginia Patent Foundation 3d spatially patterned lymph node on a microfluidic device
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
EP3775161A4 (en) 2018-04-06 2022-04-06 Cedars-Sinai Medical Center NEURODEGENERATIVE DISEASE MODELS DERIVED FROM HUMAN PLURIPOTENTIC STEM CELLS ON A MICROFLUIDIC CHIP
US11443085B2 (en) * 2018-04-11 2022-09-13 University Of Central Florida Research Foundation, Inc. Model for fluid and mass transport in a recirculating microfluidic system
CN110373320A (zh) * 2018-04-12 2019-10-25 苏州天际创新纳米技术有限公司 细胞分离器及其分离方法
WO2019222871A1 (zh) * 2018-05-21 2019-11-28 深圳华大生命科学研究院 一种仿生肠-肝器官芯片及其制备方法和应用
US20190359927A1 (en) * 2018-05-22 2019-11-28 The Charles Stark Draper Laboratory, Inc. System and Method to Generate Progenitor Cells
US11480560B2 (en) 2018-06-11 2022-10-25 The Regents Of The University Of Colorado, A Body Corporate Delivery of aerosolized respiratory pathogens
WO2020023904A1 (en) * 2018-07-27 2020-01-30 The Trustees Of Columbia University In The City Of New York Human organ-on-chip models for predictive screening
WO2020026047A1 (en) * 2018-07-30 2020-02-06 Indian Institute Of Science A device and method for enhanced poration of biological cells
KR102054610B1 (ko) * 2019-01-02 2019-12-10 인제대학교 산학협력단 다양한 종류의 박막을 이용하여 압력의 변화에 일정한 민감도를 갖는 일회용 유속측정장치
US20210401564A1 (en) * 2018-09-24 2021-12-30 Arizona Board Regents On Behalf Of The University Of Arizona Methods and systems for implantable medical devices and vascularization membranes
WO2020072826A1 (en) 2018-10-03 2020-04-09 Oregon Health & Science University Microfluidic devices for dental applications
US20210341462A1 (en) * 2018-10-05 2021-11-04 The Trustees Of The University Of Pennsylvania Artificial human pulmonary airway and methods of preparation
TWI671399B (zh) 2018-10-22 2019-09-11 國立清華大學 細胞培養裝置及細胞培養系統
US20200123484A1 (en) * 2018-10-22 2020-04-23 National Tsing Hua University Integrated chip and method for sperm sorting, oocyte incubation, and in vitro fertilization
KR102233285B1 (ko) * 2018-11-08 2021-03-29 한국화학연구원 미세유체소자를 이용한 3차원 세포배양
US10864483B2 (en) * 2018-11-16 2020-12-15 Integrated Protein Technologies, Snc. Molecular weight filtration system and apparatus
NL2022085B1 (en) * 2018-11-28 2020-06-25 Mimetas B V Device for assessing mechanical strain induced in or by cells
CN109596837B (zh) * 2018-12-10 2022-02-08 中国农业科学院北京畜牧兽医研究所 一种猪饲料蛋白质消化率的仿生消化测定方法
CN111394245B (zh) * 2018-12-12 2024-05-14 中科芯瑞(苏州)生物科技有限公司 用于筛选对内皮糖萼相关疾病具有预防和治疗活性的化合物的方法和装置
CN109580427B (zh) * 2019-01-14 2021-07-23 内蒙古工业大学 一种模拟微通道阻塞的实验方法
US11725190B2 (en) 2019-02-22 2023-08-15 EMULATE, Inc. Microfluidic proximal tubule kidney-on-chip
KR102247512B1 (ko) * 2019-02-28 2021-04-30 인제대학교 산학협력단 뇌 혈관 장벽의 개폐 기능 조절이 가능한 3차원 생체 모사 구조체 및 이를 포함하는 약물 전달 실험 장치
CN109865540A (zh) * 2019-03-04 2019-06-11 中国科学院微电子研究所 基于化学改性的微流控肺泡芯片
WO2020223578A1 (en) * 2019-04-30 2020-11-05 Northeastern University Microfluidic chip for single cell pairing
CN113825831B (zh) * 2019-05-13 2024-09-17 纽索思创新有限公司 用于细胞培养的微流控装置和方法
CN110106081B (zh) * 2019-05-13 2022-10-14 大连医科大学附属第一医院 用于构建脑功能单元模型的微流控芯片及构建方法
AU2020294779A1 (en) * 2019-06-18 2021-12-23 3D Biolabs, Llc Systems and methods for fabricating a microchannel vascular network device and seeding a microchannel
GB2621762B (en) * 2019-06-27 2024-06-05 Emulate Inc Compound distribution in microfluidic devices
KR102354778B1 (ko) * 2019-09-30 2022-01-24 서울대학교병원 폐 조직 모사 미세유체 시스템
ES2966371T3 (es) * 2019-09-30 2024-04-22 Tolmar International Ltd Composiciones poliméricas líquidas y sistemas para el aporte prolongado de péptidos como ingredientes farmacéuticos activos
JP7689285B2 (ja) * 2019-10-02 2025-06-06 パナソニックＩｐマネジメント株式会社 細胞培養チップ、細胞培養装置、及び細胞培養方法
TWI708842B (zh) * 2019-10-02 2020-11-01 中原大學 仿生器官裝置以及其形成方法
WO2021079931A1 (ja) * 2019-10-25 2021-04-29 富士フイルム株式会社 細胞培養用基材及び細胞付き細胞培養用基材
CN114929856A (zh) * 2019-10-30 2022-08-19 总医院公司 Ipsc衍生的肺泡细胞的高通量培养
AU2020384282A1 (en) * 2019-11-11 2022-05-12 Case Western Reserve University Microfluidic device and uses thereof
CN114929875A (zh) 2019-11-15 2022-08-19 希望之城 包含用于腺相关病毒的强化产生的高密度细胞呼吸器的用于产生生物产物的系统、装置和方法
EP3825004A1 (en) * 2019-11-22 2021-05-26 Koninklijke Philips N.V. New multi-functional fluidic device for clamping biopsies
EP3854868A1 (en) 2020-01-24 2021-07-28 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Microfluidic device for analyzing a membrane
TWI728680B (zh) * 2020-02-04 2021-05-21 國立陽明交通大學 仿生系統
JP7469795B2 (ja) * 2020-03-27 2024-04-17 学校法人東海大学 細胞培養装置
GB202005154D0 (en) * 2020-04-07 2020-05-20 Univ Of Hertfordshire Higher Education Corporation Method and model
WO2021222724A1 (en) * 2020-05-01 2021-11-04 Cedars-Sinai Medical Center Multi-lineage cardiovascular microfluidic organ-chip
JP2021176290A (ja) * 2020-05-08 2021-11-11 パナソニックＩｐマネジメント株式会社 細胞培養チップ
CN111607516B (zh) * 2020-06-09 2021-07-09 苏州大学 面向突破发育阻滞的早期胚胎拟输卵管环境体外培养芯片
KR102403774B1 (ko) * 2020-06-23 2022-05-31 의료법인 성광의료재단 자궁 내막을 모사하기 위한 3차원 생체 모사 칩 및 이를 이용한 자궁 내막 모사 방법
WO2021262931A1 (en) * 2020-06-24 2021-12-30 The Methodist Hospital System Delivery devices
US20220062895A1 (en) * 2020-08-27 2022-03-03 Wisconsin Alumni Research Foundation Microfluidic Device And Method Of Assaying For Immune Cell Exhaustion Using Same
KR102475225B1 (ko) * 2020-08-27 2022-12-07 성균관대학교산학협력단 R2r 공정을 이용한 오가노이드 실시간 모니터링 장치 제조
CN111909838B (zh) * 2020-09-02 2025-08-26 安徽骆华生物科技有限公司 一种细胞功能检测的微流控芯片
EP3974516A1 (en) * 2020-09-24 2022-03-30 T.J. Smith and Nephew, Limited Physiological simulation device
JP2023545412A (ja) * 2020-10-07 2023-10-30 マサチューセッツ インスティテュート オブ テクノロジー マイクロ流体細胞培養デバイス
JP2022069109A (ja) * 2020-10-23 2022-05-11 住友ベークライト株式会社 流路デバイス及びその製造方法
CA3196876A1 (en) 2020-10-30 2022-05-05 Klearchos Papas Methods and systems for encapsulation devices for housing cells and agents
CN112452367B (zh) * 2020-12-10 2022-02-22 深圳先进技术研究院 一种双层微孔芯片、双层微孔芯片制备方法及生物装置
US11912967B2 (en) * 2020-12-22 2024-02-27 Upside Foods, Inc. Systems and methods for cultivating tissue on porous substrates
JPWO2022163827A1 (enExample) 2021-01-29 2022-08-04
IT202100004313A1 (it) * 2021-02-24 2022-08-24 Univ Degli Studi Genova Apparato biocompatibile e sistema biocompatibile per la creazione di colture cellulari in vitro
JPWO2022191222A1 (enExample) * 2021-03-10 2022-09-15
KR102515586B1 (ko) * 2021-03-25 2023-03-29 주식회사 바이오스페로 세포의 멀티 배양, 대량 배양 및 실시간 모니터링이 가능한 미세 생리학적 시스템
WO2022221522A1 (en) * 2021-04-14 2022-10-20 Cornell University Implantable cell encapsulation systems
WO2022250988A1 (en) * 2021-05-24 2022-12-01 Koniku Inc. System and methods for detection of compounds and metabolites
JP7717364B2 (ja) * 2021-06-23 2025-08-04 国立大学法人東京科学大学 生体機能チップ
WO2023275871A1 (en) * 2021-07-01 2023-01-05 Ramot At Tel Aviv University Ltd. Multi-layered modular organ-on-a-chip platform
WO2023283363A1 (en) * 2021-07-08 2023-01-12 The Texas A&M University System Microfluidic device mimicking tumor microenvironment
KR102678294B1 (ko) * 2021-07-23 2024-06-24 한림대학교 산학협력단 노화 피부 모델 및 그 제작 방법
US20230066039A1 (en) * 2021-09-01 2023-03-02 Global Life Sciences Solutions Usa Llc Perfusion filter membrane and method of use
US12241050B2 (en) 2021-09-01 2025-03-04 Global Life Sciences Solutions Usa, Llc Perfusion filter assembly for increased cross flow
CN114292751B (zh) * 2021-11-12 2023-04-25 中山大学 一种器官芯片及其应用
EP4198119A1 (en) * 2021-12-16 2023-06-21 Institute of Solid State Physics, University of Latvia A microfluidic device for simulating organ functions
CN115322902A (zh) * 2022-09-14 2022-11-11 大连民族大学 一种基于微流控芯片建立二型糖尿病体外模型的方法及其应用
CN115463698A (zh) * 2022-09-23 2022-12-13 浙江大学 一种干细胞变形性能检测用微流控芯片及其制备方法
EP4379041A1 (en) * 2022-12-02 2024-06-05 Fondazione Istituto Firc Di Oncologia Molecolare (IFOM) Mechanical stretching system for mimicking physiological environment
KR102754912B1 (ko) * 2023-04-05 2025-01-13 고려대학교 산학협력단 줄기세포 분화 제어 장치 및 그 제조방법
CN116474846B (zh) * 2023-04-26 2025-07-11 大连理工大学 一种精准模拟血糖波动和脉动剪应力协同作用的微流控芯片系统及方法
WO2024254436A2 (en) * 2023-06-07 2024-12-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Bio-engineered human prostate gland and disease model
WO2025017124A1 (en) 2023-07-18 2025-01-23 European Molecular Biology Laboratory A microfluidic device for investigating epithelial and/or endothelial barrier functions, such as in placental-like or breast duct-like 3d microvascular tissues

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1117707A (zh) * 1993-02-11 1996-02-28 马克·G·方特诺特 利用红外辐射导管检测组织通道
WO2003082145A2 (en) * 2002-03-25 2003-10-09 The General Hospital Corporation Fabrication of vascularized tissue using microfabricated two-dimensional molds
CN101278855A (zh) * 2007-04-04 2008-10-08 伊西康内外科公司 用于折叠和紧固胃组织的装置
CN101884573A (zh) * 2010-05-27 2010-11-17 清华大学 复杂器官前体三维受控成形机用多喷头喷射装置

Family Cites Families (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES16665A1 (es) 1894-12-01 1895-02-01 Faure Pierre Paulin Un nuevo procedimiento y aparato para la descortización de las plantas y hojas textiles, especialmente del ramio.
GB863707A (en) 1957-08-23 1961-03-22 Nat Res Dev Apparatus for culture of biological cells and tissues
FR1301897A (fr) 1961-07-10 1962-08-24 Procédé de sélection d'émulsions destinées à la préparation de produits cosmétiques et dermatologiques
US3313290A (en) 1963-08-14 1967-04-11 Research Corp Spectrofluorometer
FR1598245A (enExample) 1968-11-29 1970-07-06
US3722504A (en) 1969-12-23 1973-03-27 P Sawyer Method of screening substances for use in the treatment of circulatory system diseases
US3941662A (en) 1971-06-09 1976-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Apparatus for culturing cells
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
DE2431918A1 (de) 1974-07-03 1976-01-22 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur kontinuierlichen bestimmung und auswertung der humantoxizitaet von fluessigkeiten
DE2726313C3 (de) 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
CH651587A5 (de) 1980-11-18 1985-09-30 Chemap Ag Verfahren und vorrichtung zur submersen zuechtung von zellkulturen.
SE448881B (sv) 1981-03-12 1987-03-23 Erik Walum Apparat for genomforandet av perfusionsodling av en eller flera cellkulturer samt forfarande for perfusionsodling av en eller flera cellkulturer
US4436824A (en) 1981-06-09 1984-03-13 Ortho Diagnostic Systems, Inc. Leukocyte migration through antigen containing agaroses for immunocompetence testing
US4629686A (en) 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
US4537860A (en) 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
US4446229A (en) 1982-12-30 1984-05-01 Indech Robert B Method of tissue growth
US4734372A (en) 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
US4610878A (en) 1983-06-16 1986-09-09 Medical University Of South Carolina Use of in vitro assay techniques to measure parameters related to clinical applications of transfer factor therapy
US4649118A (en) * 1984-04-05 1987-03-10 The Virtis Company, Inc. Cell culturing apparatus with improved stirring and filter means
NL8401221A (nl) 1984-04-16 1985-11-18 Innovi Nv Analytische toepassing van fagocyt-cellijnen.
US4650766A (en) 1984-10-09 1987-03-17 Endotronics, Inc. Culturing apparatus
US4720462A (en) 1985-11-05 1988-01-19 Robert Rosenson Culture system for the culture of solid tissue masses and method of using the same
US4673650A (en) 1986-03-28 1987-06-16 Damon Biotech, Inc. Protein harvesting system
US5160490A (en) 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5316905A (en) 1986-09-29 1994-05-31 Suzuki Shokan Co., Ltd. Culture medium supplying method and culture system
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
US4839280A (en) 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
US5108926A (en) 1987-09-08 1992-04-28 Board Of Regents, The University Of Texas System Apparatus for the precise positioning of cells
US4929542A (en) 1987-10-30 1990-05-29 Cornell Research Foundation, Inc. In vitro screening test for mutagenicity and genotoxicity during spermatogenesis
US5043260A (en) 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
US4851354A (en) 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US4940853A (en) 1988-07-22 1990-07-10 Vandenburgh Herman H Method for growing tissue specimens in vitro
EP0394406B1 (en) 1988-10-21 1995-04-26 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
US5002890A (en) 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
DE69033032T2 (de) 1989-08-04 1999-11-11 Peter Grandics Integriertes zellkultur-proteinreinigungssystem zur automatisierten herstellung und reinigung von zellkulturprodukten
US5151362A (en) * 1989-08-25 1992-09-29 Hitachi, Ltd. Apparatus containing a septum which impedes cell permeation for cell culture and method of use
WO1991004483A1 (en) 1989-09-18 1991-04-04 Biostar Medical Products, Inc. Apparatus for detection of an immobilized analyte
WO1991018087A1 (en) 1990-05-16 1991-11-28 Baylor College Of Medicine A permanent human hepatocyte cell line and its use in a liver assist device (lad)
US5217899A (en) 1990-08-24 1993-06-08 The General Hospital Corporation Cell stretching apparatus
DE4116727C2 (de) 1991-05-17 1995-09-07 Uwe Dr Marx Verfahren und Vorrichtung zur gleichzeitigen Kultivierung unterschiedlicher Säugerzellen
WO1993011498A1 (en) 1991-11-25 1993-06-10 Cornell Research Foundation, Inc. Automated multicompartmental cell culture system
US5612188A (en) 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
AU677780B2 (en) 1992-05-01 1997-05-08 Trustees Of The University Of Pennsylvania, The Microfabricated detection structures
US5900160A (en) 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
JPH10508184A (ja) * 1994-07-14 1998-08-18 スミスクライン・ビーチャム・コーポレイション 輸送の研究のための拡散チャンバシステムおよび方法
US5695996A (en) 1994-09-23 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Artificial organ culture system
US7008634B2 (en) 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5820769A (en) 1995-05-24 1998-10-13 Regents Of The University Of Minnesota Method for making magnetic storage having discrete elements with quantized magnetic moments
US6087549A (en) * 1997-09-22 2000-07-11 Argentum International Multilayer laminate wound dressing
WO1997027318A1 (en) 1996-01-24 1997-07-31 Matsushita Electric Industrial Co., Ltd. Method for measuring physicochemical properties of tissues or cells, method for examining chemicals, and apparatus therefor
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
JP3163533B2 (ja) * 1996-12-02 2001-05-08 徹 武政 シリコンベルトを使った培養細胞用伸縮刺激負荷装置
CZ297165B6 (cs) 1997-04-21 2006-09-13 Randox Laboratories Ltd. A British Company Of Ardmore Zpusob výroby zarízení s pevnou fází k provádení multianalytních rozboru
CA2217266A1 (en) 1997-05-14 1998-11-14 The General Hospital Corporation Co-cultivation of cells in a micropatterned configuration
CA2307567C (en) * 1997-10-31 2009-01-20 Children's Medical Center Corporation Polymer matrix/cell construct for bladder reconstruction
US6048723A (en) 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6472202B1 (en) 1998-05-08 2002-10-29 Flexcell International Corporation Loading station assembly and method for tissue engineering
AT407047B (de) 1998-08-03 2000-11-27 Pfaller Walter Dr Zellkulturvorrichtung
US6645759B2 (en) 1998-12-04 2003-11-11 Flexcell International Corporation Apparatus for growing cells in culture under shear stress and/or strain
FR2786783B1 (fr) 1998-12-04 2002-12-06 Rtm Rech S Et Tech Modernes Poche comportant un textile poreux biocompatible pour l'expansion tridimensionnelle in vitro de cellules notamment a usage therapeutique
US6586235B1 (en) 1998-12-04 2003-07-01 Flexcell International Corporation Apparatus for growing cells in culture under shear stress and/or strain
US6562616B1 (en) 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
US6530370B1 (en) 1999-09-16 2003-03-11 Instrumentation Corp. Nebulizer apparatus
GR1003489B (el) * 1999-11-19 2000-11-30 Μεθοδος προσδιορισμου βιολογικων και χημικων παραγοντων μεσω της μετρησης των μεταβολων των ηλεκτρικων ιδιοτητων ακινητοποιημενων κυτταρων ή συστατικων αυτων (βιοηλεκτρικη μεθοδος αναγνωρισης)
AU3986501A (en) 2000-02-23 2001-09-03 Zyomyx Inc Chips having elevated sample surfaces
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM BASED ON A MICROFLUIDIC EQUIPMENT FOR ANALYTICAL EQUIPMENT
US6653124B1 (en) 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
WO2002046365A2 (en) * 2000-12-08 2002-06-13 Flexcell International Corporation Method and apparatus to grow and mechanically condition cell cultures
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US7314718B1 (en) 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US20040132166A1 (en) 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20070048727A1 (en) 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
US20070037277A1 (en) 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
US7288405B2 (en) 2001-04-25 2007-10-30 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
EP1820846A1 (en) 2001-04-25 2007-08-22 Cornell Research Foundation, Inc. Cell culture system
AU2002257289A1 (en) 2001-05-17 2002-11-25 The Board Of Trustees Of The Leland Stanford Junior University Device and method for three-dimensional spatial localization and functional interconnection of different types of cells
JP2005501011A (ja) 2001-06-08 2005-01-13 ユタ ベンチャー ザ セカンド リミテッド パートナーシップ 組織特異的内皮膜タンパク質
US7704728B2 (en) 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
TWI313609B (en) 2001-08-21 2009-08-21 Mitsubishi Tanabe Pharma Corp Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
US6630801B2 (en) 2001-10-22 2003-10-07 Lümileds USA Method and apparatus for sensing the color point of an RGB LED white luminary using photodiodes
EP1448247B1 (en) 2001-11-16 2011-02-16 Children's Medical Center Corporation Creation of tissue engineered female reproductive organs
US6921253B2 (en) 2001-12-21 2005-07-26 Cornell Research Foundation, Inc. Dual chamber micropump having checkvalves
AU2003205241A1 (en) 2002-01-22 2003-09-02 The Penn State Research Foundation Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems
WO2004006840A2 (en) 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
AU2003268202A1 (en) * 2002-08-27 2004-03-19 Vanderbilt University Bioreactors with an array of chambers and a common feed line
AU2003275140A1 (en) 2002-09-23 2004-04-08 Massachusetts Institute Of Technology Theree-dimensional construct for the design and fabrication of physiological fluidic networks
DE602004022508D1 (de) 2003-01-16 2009-09-24 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
WO2004076608A2 (en) * 2003-02-26 2004-09-10 Georgia Tech Research Corporation Bioreactor and methods for tissue growth and conditioning
US20060263336A1 (en) 2003-03-24 2006-11-23 Caplan Arnold I Cell targeting methods and compositions
WO2004094586A2 (en) 2003-04-18 2004-11-04 Carnegie Mellon University Three-dimentional, flexible cell growth substrate and related methods
CA2524496A1 (en) 2003-05-06 2004-11-25 Bellbrook Labs, Llc Three dimensional cell cultures in a microscale fluid handling system
WO2004101734A1 (ja) * 2003-05-19 2004-11-25 Japan Science And Technology Agency 細胞培養用マイクロチャンバー
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
HRP20060435T3 (en) 2003-07-16 2007-05-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg. A process for producing microfluidic arrangements from a plate-shaped composite structure
JP2005034069A (ja) * 2003-07-16 2005-02-10 Fuji Photo Film Co Ltd バイオリアクター及びそれを用いた細胞培養方法
US20050032205A1 (en) 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
US20050266393A1 (en) 2003-10-01 2005-12-01 Baxter Gregory T Circulating flow device for assays of cell cultures, cellular components and cell products
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
EP1718409B1 (de) * 2004-02-17 2018-12-26 ibidi GmbH Vorrichtung für mikrofluiduntersuchungen
US20050227350A1 (en) 2004-04-13 2005-10-13 Agency For Science, Technology And Research Device and method for studying cell migration and deformation
KR101164696B1 (ko) 2004-04-14 2012-07-11 셀진 코포레이션 골수이형성 증후군의 치료 및 관리를 위한 면역조절화합물의 사용 방법 및 상기 화합물을 포함하는 조성물
JP2007537759A (ja) 2004-05-19 2007-12-27 マサチューセッツ・インスティテュート・オブ・テクノロジー 灌流三次元細胞／組織疾患モデル
CA2500747A1 (en) 2004-06-14 2005-12-14 University Technologies International Inc. Microfluidic device with electrode structures
EP1793865A4 (en) 2004-08-05 2009-05-13 Baylor Res Inst GENETIC OR DRUG DELIVERY SYSTEM
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
WO2006047758A1 (en) 2004-10-27 2006-05-04 Massachusetts Institute Of Technology Novel technique to fabricate molded structures having a patterned porosity
WO2006052223A1 (en) 2004-11-11 2006-05-18 Agency For Science, Technology And Research Cell culture device
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
JP2008539787A (ja) 2005-05-18 2008-11-20 コーネル・リサーチ・ファンデーション・インコーポレイテッド 生物学的な障壁を有する薬物動態学ベース培養システム
AU2006249574B2 (en) 2005-05-25 2012-01-19 Novartis Ag Vibration systems and methods
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
EP1996013A4 (en) * 2005-09-21 2010-03-10 Dask Technologies Llc METHODS AND COMPOSITIONS FOR FUNCTIONALITY OF ORGANS AND TISSUES
US7790028B1 (en) 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
US9220831B2 (en) 2005-10-06 2015-12-29 Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
US20070090166A1 (en) 2005-10-18 2007-04-26 Shuichi Takayama Microfluidic cell culture device
US20070172943A1 (en) 2005-11-07 2007-07-26 Robert Freedman Devices and methods for culturing, preserving, transporting, storing, reconstituting and assaying cellular materials
US7964078B2 (en) 2005-11-07 2011-06-21 The Regents Of The University Of California Microfluidic device for cell and particle separation
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
RU2301677C1 (ru) 2005-12-09 2007-06-27 ЗАО "РеМеТэкс" Биотрансплантат для лечения дегенеративных и травматических заболеваний хрящевой ткани и способ его получения
US7802569B2 (en) 2005-12-22 2010-09-28 Kaer Biotherapeutics Corporation Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
KR20070077320A (ko) 2006-01-23 2007-07-26 삼성전자주식회사 세포 배양을 실시간으로 모니터링 가능한 세포 배양 칩 및그를 이용한 세포 배양 모니터링 방법
WO2008051265A2 (en) 2006-02-03 2008-05-02 President And Fellows Of Harvard College Engineered cell growth on polymeric films and biotechnological applications there of
EP1999247A4 (en) * 2006-03-14 2011-08-31 Univ Rochester CELL CULTURAL DEVICES WITH ULTRADOOR POROUS MEMBRANE AND APPLICATIONS THEREOF
US7622298B2 (en) 2006-03-24 2009-11-24 Norits, Inc. Method for creating perfusable microvessel systems
US9023642B2 (en) 2006-07-07 2015-05-05 The University Of Houston System Method and apparatus for a miniature bioreactor system for long-term cell culture
US20080064088A1 (en) 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
FR2905690B1 (fr) 2006-09-12 2008-10-17 Saint Gobain Procede de fabrication d'un dispositif microfluidique.
EP2069068A2 (en) 2006-09-28 2009-06-17 The University of Washington 3d micro-scale engineered tissue model systems
WO2008086477A1 (en) 2007-01-10 2008-07-17 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ, and related methods
US8343740B2 (en) 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
WO2008130618A1 (en) 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
US20080318334A1 (en) 2007-06-20 2008-12-25 Robotti Karla M Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material
KR20090030084A (ko) 2007-09-19 2009-03-24 삼성전자주식회사 미세유동장치
WO2009089189A2 (en) 2008-01-03 2009-07-16 Cellasic Cell culture array system for automated assays and methods of operation and manufacture thereof
US20100041128A1 (en) 2008-01-08 2010-02-18 Medtrain Technologies, Llc Microfluidic Device for Application of Shear Stress and Tensile Strain
CN101939644B (zh) 2008-01-10 2014-06-11 休雷尔公司 免疫系统模拟装置和方法
WO2009102751A2 (en) 2008-02-11 2009-08-20 The General Hospital Corporation System and method for in vitro blood vessel modeling
KR100952056B1 (ko) 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
DE102008018170B4 (de) 2008-04-03 2010-05-12 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Mikrofluidisches System und Verfahren zum Aufbau und zur anschließenden Kultivierung sowie nachfolgender Untersuchung von komplexen Zellanordnungen
CN102257124B (zh) 2008-06-04 2014-12-03 蒂斯由斯股份有限公司 芯片上器官装置
EP2294409B1 (en) 2008-06-17 2016-08-10 The Governing Council Of The University Of Toronto Device for investigation of a flow conduit
KR102140055B1 (ko) 2008-07-16 2020-07-31 칠드런'즈 메디컬 센터 코포레이션 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법
WO2010024779A1 (en) 2008-08-27 2010-03-04 Agency For Science, Technology And Research Microfluidic continuous flow device for culturing biological material
WO2010023497A1 (en) 2008-08-29 2010-03-04 Peking University A microfluidic chip for accurately controllable cell culture
US9243221B2 (en) 2008-11-26 2016-01-26 Hurel Corporation Compositions and methods of functionally enhanced in vitro cell culture system
US9156037B2 (en) 2009-01-15 2015-10-13 Children's Medical Center Corporation Microfluidic device and uses thereof
WO2010101708A2 (en) 2009-03-04 2010-09-10 University Of Maine System Board Of Trustees Microfluidic device and related methods
US20100294986A1 (en) 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US8748180B2 (en) 2009-07-29 2014-06-10 Cornell University Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof
PT2542663E (pt) 2010-08-06 2014-10-07 Tissuse Gmbh Sistema de circulação
WO2012034022A2 (en) 2010-09-10 2012-03-15 Solidus Biosciences, Inc. Microarray cell chip
CA2828110C (en) 2011-02-28 2020-03-31 President And Fellows Of Harvard College Cell culture system
US20140158233A1 (en) 2011-05-09 2014-06-12 President And Fellows Of Harvard College Aerosol delivery to a microfluidic device
US20140199764A1 (en) 2011-05-09 2014-07-17 President And Fellows Of Harvard College Microfluidic module and uses thereof
CA2839435C (en) 2011-06-15 2021-05-11 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
JP2014516582A (ja) 2011-06-15 2014-07-17 ザ チャールズ スターク ドレイパー ラボラトリー インク 生体模倣環境において細胞を培養するためのデバイスおよび方法
WO2013056019A1 (en) 2011-10-12 2013-04-18 The Trustees Of The University Of Pennsylvania In vitro microphysiological system for high throughput 3d tissue organization and biological function

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1117707A (zh) * 1993-02-11 1996-02-28 马克·G·方特诺特 利用红外辐射导管检测组织通道
WO2003082145A2 (en) * 2002-03-25 2003-10-09 The General Hospital Corporation Fabrication of vascularized tissue using microfabricated two-dimensional molds
CN101278855A (zh) * 2007-04-04 2008-10-08 伊西康内外科公司 用于折叠和紧固胃组织的装置
CN101884573A (zh) * 2010-05-27 2010-11-17 清华大学 复杂器官前体三维受控成形机用多喷头喷射装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YU CHANG KIM ET AL.Microfluidic biomechanical device for compressive cell stimulation and lysis.《SENSORS AND ACTUATORS B:CHEMICAL》.2007,第128卷108-116. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12157872B2 (en) 2018-07-19 2024-12-03 Stellular Bio, Inc. Stacked recirculating bioreactor

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