SG11201901000XA - Compositions and methods of cell attachment - Google Patents
Compositions and methods of cell attachmentInfo
- Publication number
- SG11201901000XA SG11201901000XA SG11201901000XA SG11201901000XA SG11201901000XA SG 11201901000X A SG11201901000X A SG 11201901000XA SG 11201901000X A SG11201901000X A SG 11201901000XA SG 11201901000X A SG11201901000X A SG 11201901000XA SG 11201901000X A SG11201901000X A SG 11201901000XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- street
- compositions
- methods
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5032—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2535/00—Supports or coatings for cell culture characterised by topography
- C12N2535/10—Patterned coating
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
- C12N2537/10—Cross-linking
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 January 2018 (18.01.2018) W I PO I PCT ill~~~~~~~~ 011101010VIIIOH olo omm offilm °nom° oimIE (10) International Publication Number WO 2018/013718 Al (51) International Patent Classification: C12M 1/12 (2006.01) G01N 33/50 (2006.01) C12N 5/07 (2010.01) (21) International Application Number: PCT/US2017/041762 (22) International Filing Date: 12 July 2017 (12.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/361,259 12 July 2016 (12.07.2016) US (71) Applicant: EMULATE, INC. [US/US]; 27 Drydock, Boston, MA 02210 (US). (72) Inventors: LEVNER, Daniel; 55 Sewall Avenue, 5C, Brookline, MA 02446 (US). HUH, Dongeun, Huh; 3411 Chestnut Street, #433, Philadelphia, PA 19104 (US). JANG, Kyung, Jin; 2 Greenmeadow Lane, Andover, MA 01810 (US). FRASER, Jacob; 19 Kingston Street, Apt. 2, Somerville, MA 02144 (US). KERNS, Jordan; 7 Her- itage Drive, Reading, MA 01867 (US). VARONE, Anto- nio; 4975 Washinton Street, Unit 118, West Roxbury, MA 02132 (US). (74) Agent: CARROLL, Peter, G. et al.; Medlen & Carroll, LLP, 1440 Broadway, Suite 1010, Oakland, CA 94612 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) = (54) Title: COMPOSITIONS AND METHODS OF CELL ATTACHMENT Sulfa-SAN PAH Suifosaccinintidyl e-14 . -aido-2'-riitrophonvlaminathexaaava PAW 492.40 1-1 Spacer Am 18,2 A cc FIGURE 1 N O (57) : Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in cc a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as O mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed. C
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662361259P | 2016-07-12 | 2016-07-12 | |
PCT/US2017/041762 WO2018013718A1 (en) | 2016-07-12 | 2017-07-12 | Compositions and methods of cell attachment |
Publications (1)
Publication Number | Publication Date |
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SG11201901000XA true SG11201901000XA (en) | 2019-03-28 |
Family
ID=59676739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201901000XA SG11201901000XA (en) | 2016-07-12 | 2017-07-12 | Compositions and methods of cell attachment |
Country Status (7)
Country | Link |
---|---|
US (7) | US11733234B2 (en) |
EP (1) | EP3484991A4 (en) |
AU (1) | AU2017297408A1 (en) |
CA (1) | CA3032997A1 (en) |
GB (2) | GB2558336B (en) |
SG (1) | SG11201901000XA (en) |
WO (1) | WO2018013718A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018013718A1 (en) * | 2016-07-12 | 2018-01-18 | EMULATE, Inc. | Compositions and methods of cell attachment |
CA3069742C (en) * | 2017-07-12 | 2021-06-22 | EMULATE, Inc. | Surface functionalization |
US11518971B2 (en) * | 2018-11-27 | 2022-12-06 | Research Triangle Institute | Method and apparatus for spatial control of cellular growth |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US7160687B1 (en) | 1997-05-29 | 2007-01-09 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
US7453486B2 (en) | 2000-12-13 | 2008-11-18 | Orbotech Ltd | Pulse light pattern writer |
US7157049B2 (en) * | 2001-11-20 | 2007-01-02 | Nagaoka & Co., Ltd. | Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto |
EP2495310A3 (en) * | 2005-05-24 | 2013-03-27 | The Regents Of the University of California | Microscale micropatterned engineered in vitro tissue |
JP2010537633A (en) * | 2007-08-30 | 2010-12-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Multi-well culture plate with compliant surface |
EP3778858A1 (en) | 2008-07-16 | 2021-02-17 | Children's Medical Center Corporation | Device with microchannels and method of use |
EP2321405A4 (en) * | 2008-08-08 | 2012-09-12 | Agency Science Tech & Res | Microfluidic continuous flow device |
US9040665B2 (en) | 2008-09-30 | 2015-05-26 | Case Western Reserve University | Controlled cross-linking processing of proteins |
FR2937050A1 (en) * | 2008-10-10 | 2010-04-16 | Inst Curie | CELL CULTURE DEVICE |
US20100135855A1 (en) * | 2008-11-26 | 2010-06-03 | Koninklijke Philips Electronics N.V. | Method for depositing substances on a support |
WO2010099310A1 (en) | 2009-02-26 | 2010-09-02 | Wake Forest University Health Sciences | Endothelial scaffolds |
US20120135446A1 (en) * | 2009-03-04 | 2012-05-31 | Maine Institute For Human Genetics & Health, Inc | Microfluidic Device and Related Methods |
WO2013086502A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Organ chips and uses thereof |
SE538193C2 (en) * | 2012-07-05 | 2016-03-29 | Scania Cv Ab | SCR system and procedure of an SCR system |
WO2014143998A1 (en) * | 2013-03-15 | 2014-09-18 | The Broad Institute | Systems and methods for culturing epithelial cells |
CN105658786B (en) * | 2013-08-28 | 2020-07-03 | 普罗米迪拉生物科学公司 | Method for producing adult liver progenitor cells |
CA2929172A1 (en) | 2013-10-30 | 2015-05-07 | Jason MIKLAS | Devices and methods for three-dimensional tissue culturing using contractile force |
EP3574985A1 (en) * | 2013-12-20 | 2019-12-04 | President And Fellows Of Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
JP2017504320A (en) | 2013-12-20 | 2017-02-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Low shear microfluidic device and methods of use and manufacture thereof |
WO2015108944A2 (en) * | 2014-01-14 | 2015-07-23 | Colorado State University Research Foundation | Stem cell-derived hepatocytes in co-culture and uses thereof |
WO2016004394A1 (en) | 2014-07-03 | 2016-01-07 | Texas Tech University System | Microfluidic cardiovascular system and method |
WO2016054288A1 (en) * | 2014-09-30 | 2016-04-07 | Taylor Lansing D | A human liver microphysiology platform and self assembly liver acinus model and methods of their use |
GB2556270B (en) * | 2015-07-27 | 2021-05-12 | Univ Pennsylvania | Lung disease models on a chip |
WO2017096192A1 (en) * | 2015-12-04 | 2017-06-08 | President And Fellows Of Harvard College | Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof |
WO2018013718A1 (en) * | 2016-07-12 | 2018-01-18 | EMULATE, Inc. | Compositions and methods of cell attachment |
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2017
- 2017-07-12 WO PCT/US2017/041762 patent/WO2018013718A1/en unknown
- 2017-07-12 US US15/648,339 patent/US11733234B2/en active Active
- 2017-07-12 SG SG11201901000XA patent/SG11201901000XA/en unknown
- 2017-07-12 EP EP17828406.3A patent/EP3484991A4/en active Pending
- 2017-07-12 US US15/648,319 patent/US11519903B2/en active Active
- 2017-07-12 US US15/648,293 patent/US11506652B2/en active Active
- 2017-07-12 AU AU2017297408A patent/AU2017297408A1/en not_active Abandoned
- 2017-07-12 US US15/648,213 patent/US11536714B2/en active Active
- 2017-07-12 GB GB1711206.1A patent/GB2558336B/en active Active
- 2017-07-12 US US15/648,306 patent/US11549937B2/en active Active
- 2017-07-12 US US15/648,352 patent/US11506653B2/en active Active
- 2017-07-12 GB GB2014449.9A patent/GB2584973B/en active Active
- 2017-07-12 CA CA3032997A patent/CA3032997A1/en active Pending
-
2023
- 2023-06-27 US US18/214,651 patent/US20230341378A1/en active Pending
Also Published As
Publication number | Publication date |
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GB201711206D0 (en) | 2017-08-23 |
US20180024118A1 (en) | 2018-01-25 |
US20180024116A1 (en) | 2018-01-25 |
US11536714B2 (en) | 2022-12-27 |
US11549937B2 (en) | 2023-01-10 |
US20230341378A1 (en) | 2023-10-26 |
US11506653B2 (en) | 2022-11-22 |
US11733234B2 (en) | 2023-08-22 |
GB2584973B (en) | 2021-04-14 |
CA3032997A1 (en) | 2018-01-18 |
AU2017297408A1 (en) | 2019-02-21 |
GB202014449D0 (en) | 2020-10-28 |
EP3484991A1 (en) | 2019-05-22 |
US20180024119A1 (en) | 2018-01-25 |
US20180024120A1 (en) | 2018-01-25 |
EP3484991A4 (en) | 2020-03-18 |
WO2018013718A1 (en) | 2018-01-18 |
US11506652B2 (en) | 2022-11-22 |
GB2558336B (en) | 2020-10-28 |
US11519903B2 (en) | 2022-12-06 |
US20180023050A1 (en) | 2018-01-25 |
GB2558336A (en) | 2018-07-11 |
US20180024117A1 (en) | 2018-01-25 |
GB2584973A (en) | 2020-12-23 |
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SG11201901621VA (en) | Development of spinal cord on a microfluidic chip | |
SG11201806988UA (en) | Improved differentiation method | |
SG11201909501TA (en) | Personalized 3d neural culture system for generating human oligodendrocytes and studying myelination in vitro | |
SG11201809913PA (en) | Methods for detecting target nucleic acids in a sample | |
SG11201810003UA (en) | Using programmable dna binding proteins to enhance targeted genome modification | |
SG11201804710TA (en) | Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof | |
SG11201407702XA (en) | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription | |
SG11201810171SA (en) | Kras g12c inhibitors | |
SG11201910173YA (en) | Device and method for microfluidics-based 3d bioprinting | |
SG11201805451TA (en) | Immune effector cell therapies with enhanced efficacy | |
SG11201908240YA (en) | Methods for evaluating tumor cell spheroids using 3d microfluidic cell culture device | |
SG11201811549UA (en) | Boronic acid derivatives and therapeutic uses thereof | |
SG11201803703UA (en) | Anti-complement factor c1q fab fragments and uses thereof | |
SG11201805420SA (en) | Antibodies and conjugates thereof | |
SG11201810780XA (en) | Single use bioreactor | |
SG11201809614VA (en) | Method for the fabrication of three-dimensional objects and apparatus for same | |
SG11201807538PA (en) | Crispr-cpf1-related methods, compositions and components for cancer immunotherapy | |
SG11201901000XA (en) | Compositions and methods of cell attachment | |
SG11201900057WA (en) | Biomatrix scaffolds for use in diagnosing and modeling cancer | |
SG11201807041PA (en) | Improved preparations of adult liver progenitor cells | |
SG11201808762XA (en) | Diagnostic methods for patient specific therapeutic decision making in cancer care | |
SG11201408405WA (en) | Engineered three-dimensional connective tissue constructs and methods of making the same | |
SG11201900081QA (en) | Removing bubbles in a microfluidic device | |
SG11201900058YA (en) | Method of generating mesenchymal stem cells and uses thereof |