CN101141980B - 针对人白介素-13的抗体及其用途 - Google Patents

针对人白介素-13的抗体及其用途 Download PDF

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CN101141980B
CN101141980B CN2005800191385A CN200580019138A CN101141980B CN 101141980 B CN101141980 B CN 101141980B CN 2005800191385 A CN2005800191385 A CN 2005800191385A CN 200580019138 A CN200580019138 A CN 200580019138A CN 101141980 B CN101141980 B CN 101141980B
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antibody
seq
fab
aminoacid sequence
light chain
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CN101141980A (zh
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M·T·卡塞安
L·奇斯提科娃
G·M·韦尔德曼
K·A·马凯特
X-Y·谭
D·D·唐纳森
L·L·林
T·沙内
A·S·塔姆
E·费凡特
N·L·伍德
L·J·菲茨
A·M·温德姆
K·D·帕里斯
S·J·戈尔德曼
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Wyeth LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
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  • Mycology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
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  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2005800191385A 2004-06-09 2005-06-09 针对人白介素-13的抗体及其用途 Expired - Fee Related CN101141980B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US57873604P 2004-06-09 2004-06-09
US57847304P 2004-06-09 2004-06-09
US60/578,736 2004-06-09
US60/578,473 2004-06-09
US58137504P 2004-06-22 2004-06-22
US60/581,375 2004-06-22
PCT/US2005/020160 WO2005123126A2 (en) 2004-06-09 2005-06-09 Antibodies against human interleukin-13 and uses therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2012102800731A Division CN102827280A (zh) 2004-06-09 2005-06-09 针对人白介素-13的抗体及其用途

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CN101141980A CN101141980A (zh) 2008-03-12
CN101141980B true CN101141980B (zh) 2012-10-31

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CN2005800191385A Expired - Fee Related CN101141980B (zh) 2004-06-09 2005-06-09 针对人白介素-13的抗体及其用途
CN2012102800731A Pending CN102827280A (zh) 2004-06-09 2005-06-09 针对人白介素-13的抗体及其用途

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US (2) US7615213B2 (cg-RX-API-DMAC7.html)
EP (3) EP1765401A4 (cg-RX-API-DMAC7.html)
JP (4) JP4970258B2 (cg-RX-API-DMAC7.html)
KR (3) KR101299073B1 (cg-RX-API-DMAC7.html)
CN (2) CN101141980B (cg-RX-API-DMAC7.html)
AR (2) AR049390A1 (cg-RX-API-DMAC7.html)
AU (2) AU2005253981B2 (cg-RX-API-DMAC7.html)
BR (2) BRPI0510881A (cg-RX-API-DMAC7.html)
CA (2) CA2567081A1 (cg-RX-API-DMAC7.html)
CR (2) CR8784A (cg-RX-API-DMAC7.html)
EC (2) ECSP067073A (cg-RX-API-DMAC7.html)
IL (2) IL179093A0 (cg-RX-API-DMAC7.html)
MX (2) MXPA06014298A (cg-RX-API-DMAC7.html)
NO (2) NO20070087L (cg-RX-API-DMAC7.html)
NZ (1) NZ582046A (cg-RX-API-DMAC7.html)
RU (2) RU2006140096A (cg-RX-API-DMAC7.html)
SG (2) SG155260A1 (cg-RX-API-DMAC7.html)
TW (1) TWI391133B (cg-RX-API-DMAC7.html)
WO (2) WO2005123126A2 (cg-RX-API-DMAC7.html)

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RU2427589C2 (ru) 2011-08-27
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