ATE549064T1 - Verfahren zur behandlung und prävention von kolitis, die il-13 und nk-t zellen betrifft - Google Patents

Verfahren zur behandlung und prävention von kolitis, die il-13 und nk-t zellen betrifft

Info

Publication number
ATE549064T1
ATE549064T1 AT10184017T AT10184017T ATE549064T1 AT E549064 T1 ATE549064 T1 AT E549064T1 AT 10184017 T AT10184017 T AT 10184017T AT 10184017 T AT10184017 T AT 10184017T AT E549064 T1 ATE549064 T1 AT E549064T1
Authority
AT
Austria
Prior art keywords
treating
cells
subject
antibody fragment
preventing
Prior art date
Application number
AT10184017T
Other languages
English (en)
Inventor
Warren Strober
Ivan J Fuss
Frank Heller
Richard Blumberg
Original Assignee
Us Gov Health & Human Serv
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Brigham & Womens Hospital filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE549064T1 publication Critical patent/ATE549064T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5437—IL-13

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT10184017T 2002-06-14 2002-06-14 Verfahren zur behandlung und prävention von kolitis, die il-13 und nk-t zellen betrifft ATE549064T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02742057A EP1552462B1 (de) 2002-06-14 2002-06-14 Verfahren zur behandlung und prävention von kolitis, an der il-13 und nk-t zellen beteiligt sind
PCT/US2002/018790 WO2004001655A1 (en) 2002-06-14 2002-06-14 Methods of treating and preventing colitis involving il-13 and nk-t cells

Publications (1)

Publication Number Publication Date
ATE549064T1 true ATE549064T1 (de) 2012-03-15

Family

ID=29998716

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02742057T ATE503233T1 (de) 2002-06-14 2002-06-14 Verfahren zur behandlung und prävention von kolitis, an der il-13 und nk-t zellen beteiligt sind
AT10184017T ATE549064T1 (de) 2002-06-14 2002-06-14 Verfahren zur behandlung und prävention von kolitis, die il-13 und nk-t zellen betrifft

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02742057T ATE503233T1 (de) 2002-06-14 2002-06-14 Verfahren zur behandlung und prävention von kolitis, an der il-13 und nk-t zellen beteiligt sind

Country Status (11)

Country Link
US (3) US7666411B2 (de)
EP (2) EP2273419B1 (de)
JP (1) JP4689268B2 (de)
AT (2) ATE503233T1 (de)
AU (1) AU2002315115B2 (de)
CA (1) CA2489540A1 (de)
DE (1) DE60239566D1 (de)
ES (2) ES2384439T3 (de)
HK (1) HK1079882B (de)
NZ (1) NZ537726A (de)
WO (1) WO2004001655A1 (de)

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DK2805728T3 (da) 2003-12-23 2020-04-20 Genentech Inc Hidtil ukendte anti-IL13-antistoffer og anvendelser deraf
US7501121B2 (en) * 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
US20090098142A1 (en) * 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
EP1812015B1 (de) 2004-11-02 2012-01-04 The Board of Trustees of Leland Stanford Junior University Verfahren zur hemmung von nkt-zellen
WO2006055638A2 (en) 2004-11-17 2006-05-26 Abgenix, Inc. Fully human monoclonal antibodies to il-13
EP1877074B1 (de) * 2005-04-15 2013-03-27 The Government of the United States of America, as represented by the Secretary of Health and Human Services Behandlung und prävention von entzündlicher darmerkrankung mit il-13 und nkt-zellen
WO2007140287A2 (en) * 2006-05-25 2007-12-06 Dr. Reddy's Laboratories, Inc. Use of biomarkers of inflammation as indicators of drug efficacy
KR101544108B1 (ko) * 2006-09-08 2015-08-13 애브비 바하마스 리미티드 인터루킨-13 결합 단백질
KR20090101924A (ko) * 2006-12-15 2009-09-29 센토코 오르토 바이오테크 인코포레이티드 Ｉｌ―４ 또는 ｉｌ―１３ 관련 섬유증과 관련된 병리증상을 치료하기 위한 방법 및 조성물
JP2010527916A (ja) * 2007-04-23 2010-08-19 ワイス・エルエルシー Ｉｌ−１３関連障害を治療する方法および組成物ならびにその治療をモニターする方法
HK1199405A1 (en) 2011-10-27 2015-07-03 Nkt治疗公司 Humanized antibodies to inkt
SG10201802525QA (en) 2013-09-13 2018-04-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
KR102332302B1 (ko) 2013-09-13 2021-12-01 제넨테크, 인크. 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법
US20190225683A1 (en) * 2015-11-13 2019-07-25 The Brigham And Women's Hospital, Inc. Targeting oxazole structures for therapy against inflammatory diseases
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies

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EP1877074B1 (de) * 2005-04-15 2013-03-27 The Government of the United States of America, as represented by the Secretary of Health and Human Services Behandlung und prävention von entzündlicher darmerkrankung mit il-13 und nkt-zellen

Also Published As

Publication number Publication date
ES2365210T3 (es) 2011-09-26
DE60239566D1 (de) 2011-05-05
EP2273419A1 (de) 2011-01-12
US8173123B2 (en) 2012-05-08
CA2489540A1 (en) 2003-12-31
US8821866B2 (en) 2014-09-02
US20060024306A1 (en) 2006-02-02
EP1552462B1 (de) 2011-03-23
ES2384439T3 (es) 2012-07-04
JP2005529974A (ja) 2005-10-06
US7666411B2 (en) 2010-02-23
AU2002315115A1 (en) 2004-01-06
US20100143339A1 (en) 2010-06-10
HK1079882B (en) 2011-11-25
EP1552462A1 (de) 2005-07-13
NZ537726A (en) 2008-06-30
US20120276113A1 (en) 2012-11-01
HK1079882A1 (en) 2006-04-13
ATE503233T1 (de) 2011-04-15
EP1552462A4 (de) 2006-09-20
WO2004001655A1 (en) 2003-12-31
EP2273419B1 (de) 2012-03-14
AU2002315115B2 (en) 2008-10-16
JP4689268B2 (ja) 2011-05-25
WO2004001655A8 (en) 2004-05-27

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