ATE198706T1 - Polyamin-verbindungen zur behandlung von proliferativer erkrankungen - Google Patents

Polyamin-verbindungen zur behandlung von proliferativer erkrankungen

Info

Publication number
ATE198706T1
ATE198706T1 AT95934421T AT95934421T ATE198706T1 AT E198706 T1 ATE198706 T1 AT E198706T1 AT 95934421 T AT95934421 T AT 95934421T AT 95934421 T AT95934421 T AT 95934421T AT E198706 T1 ATE198706 T1 AT E198706T1
Authority
AT
Austria
Prior art keywords
treatment
proliferative diseases
polyamine compounds
treating
useful
Prior art date
Application number
AT95934421T
Other languages
English (en)
Inventor
Donald Hupe
Joan Alexis Keiser
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE198706T1 publication Critical patent/ATE198706T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT95934421T 1994-10-25 1995-09-14 Polyamin-verbindungen zur behandlung von proliferativer erkrankungen ATE198706T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/329,588 US5516807A (en) 1994-10-25 1994-10-25 Method for treating vascular proliferative disorders following balloon angioplasty
PCT/US1995/011680 WO1996012480A1 (en) 1994-10-25 1995-09-14 Polyamine compounds for treating vascular proliferative disorders

Publications (1)

Publication Number Publication Date
ATE198706T1 true ATE198706T1 (de) 2001-02-15

Family

ID=23286110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95934421T ATE198706T1 (de) 1994-10-25 1995-09-14 Polyamin-verbindungen zur behandlung von proliferativer erkrankungen

Country Status (12)

Country Link
US (1) US5516807A (de)
EP (1) EP0786991B1 (de)
JP (1) JPH10507752A (de)
AT (1) ATE198706T1 (de)
CA (1) CA2198914A1 (de)
DE (1) DE69519937T2 (de)
DK (1) DK0786991T3 (de)
ES (1) ES2155531T3 (de)
GR (1) GR3035725T3 (de)
MX (1) MX9701838A (de)
PT (1) PT786991E (de)
WO (1) WO1996012480A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE377418T1 (de) 1995-06-07 2007-11-15 Poniard Pharmaceuticals Inc Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
JP3470901B2 (ja) * 1996-09-13 2003-11-25 ユニヴァーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド Ｅｌｆ５Ａ生合成の抑制方法
US6083991A (en) * 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
JP2002543163A (ja) * 1999-04-30 2002-12-17 スリル バイオメディカル コーポレイション 癌および前立腺疾患のための治療としての結合体
NZ515140A (en) * 1999-04-30 2003-07-25 Slil Biomedical Corp Conformationally restricted polyamine analogs as disease therapies for cancer, epilepsy, alzheimers, infections, grafts and others
WO2002038105A2 (en) * 2000-11-08 2002-05-16 Slil Biomedical Corporation Novel polyamine analog-amino acid conjugates useful as anticancer agents
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
AU2002364539A1 (en) * 2001-12-07 2003-06-23 Cellgate, Inc. Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
JP2004189714A (ja) * 2002-12-09 2004-07-08 Rasanen Tiina-Liisa すい臓炎の治療と予防ならびに肝臓再生機能の誘導のための薬剤
WO2006041805A1 (en) * 2004-10-04 2006-04-20 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS606348B2 (ja) * 1976-03-31 1985-02-18 三菱化学株式会社 新規ポリアミン類
JPS58135809A (ja) * 1982-02-05 1983-08-12 Fujisawa Pharmaceut Co Ltd 抗炎症・抗リウマチ剤
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
JPS606348A (ja) * 1983-06-09 1985-01-14 ケルベル・アクチエンゲゼルシヤフト 回転研削工具の支承装置
NZ212053A (en) * 1984-05-17 1988-02-29 Merrell Dow Pharma Polyamine containing pharmaceutical compositions for treating neoplasms
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
ZA88600B (en) * 1987-02-03 1988-07-28 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
ZA903804B (en) * 1989-05-23 1991-03-27 Merrell Dow Pharma A method of potentiating cell-mediated immunity utilizing polyamine derivatives

Also Published As

Publication number Publication date
US5516807A (en) 1996-05-14
JPH10507752A (ja) 1998-07-28
DE69519937D1 (de) 2001-02-22
EP0786991B1 (de) 2001-01-17
MX9701838A (es) 1997-06-28
DK0786991T3 (da) 2001-03-19
EP0786991A1 (de) 1997-08-06
DE69519937T2 (de) 2001-06-07
ES2155531T3 (es) 2001-05-16
CA2198914A1 (en) 1996-05-02
GR3035725T3 (en) 2001-07-31
WO1996012480A1 (en) 1996-05-02
PT786991E (pt) 2001-04-30

Similar Documents

Publication Publication Date Title
ATE198706T1 (de) Polyamin-verbindungen zur behandlung von proliferativer erkrankungen
ATE255896T1 (de) Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen
DE69826695D1 (de) Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen
DE60037394D1 (de) VERWENDUNG VON p53 INHIBITOREN ZUR BEHANDLUNG VON NEBENERSCHEINUNGEN BEI DER KREBSTHERAPIE
PL342078A1 (en) Inhibition of raf kinase using symmetrical and dissymmetrical substituted dimethylureas
DE69430309T2 (de) Dilatationskatheter und verfahren zur behandlung damit
ATE399553T1 (de) Pharmazeutische zusammensetzungen mit dextromethorphan und chinidin zur behandlung von neurologischen erkrankungen
PT971713E (pt) Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao
ATE269066T1 (de) Kombinationstherapie zur prophylaxe und/oder behandlung von gutartiger prostatischer hyperplasie
DE69805973D1 (de) Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin-abhängigen protein kinase
ATE411016T1 (de) Verfahren zur prophylaxis oder behandlung von östrogen-abhängigen krankheiten
DE69731652D1 (de) Verfahren zur behandlung von endothelialen verletzungen
DK1039912T3 (da) Angiostatiske midler og præparater til behandling af GLC1A-glaukom
DE69715000D1 (de) Verabreichung von gm-csf zur behandlung der gehirntumoren und verhütung deren wiederauftretens
DE69631478D1 (de) Verwendung von vitamin d4-derivaten zur behandlung von hauterkrankungen
ATE208384T1 (de) Verwendung von ascorbyl-gamma-linolenat und von ascorbyl-dihomo-gamma-linolenat zur behandlung von asthma, krebs, kardiovaskulären und inflammatorischen erkrankungen
ATE222491T1 (de) Melatonin-derivate zur verwendung in der behandlung von schlafstörungen
DE69432626D1 (de) Melatonin-Derivate zur Verwendung in der Behandlung von Desynchronisierungs-Erkankungen
DE69626816D1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
ATE251462T1 (de) Verfahren zur behandlung von narbengewebe
MX9304626A (es) Derivados heterociclicos utiles en el tratamiento de enfermedades cardiovasculares.
DE69014501T2 (de) Verfahren zur Behandlung von Titanlegierung und damit hergestelltes Stück.
DE69906701D1 (de) Topische verwendung von loperamid zur behandlung mikrobieller infektionen
ATE320263T1 (de) Verwendung von menschliche protein c zur herstellung eines arzneimittels zur behandlung von heparininduzierter thrombozytopenie
ATE225181T1 (de) Verwendung von heparinen niedrigeren molekulargewichtes zur behandlung von hirnödemen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee