ES2155531T3 - Compuestos de poliaminas para el tratamiento de desordenes vasculares proliferativos. - Google Patents

Compuestos de poliaminas para el tratamiento de desordenes vasculares proliferativos.

Info

Publication number
ES2155531T3
ES2155531T3 ES95934421T ES95934421T ES2155531T3 ES 2155531 T3 ES2155531 T3 ES 2155531T3 ES 95934421 T ES95934421 T ES 95934421T ES 95934421 T ES95934421 T ES 95934421T ES 2155531 T3 ES2155531 T3 ES 2155531T3
Authority
ES
Spain
Prior art keywords
treatment
vascular disorders
polyamine compounds
proliferative vascular
proliferative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95934421T
Other languages
English (en)
Inventor
Donald Hupe
Joan Alexis Keiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2155531T3 publication Critical patent/ES2155531T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LAS POLIAMINAS INHIBEN LA PROLIFERACION DE MUSCULO LISO VASCULAR Y POR TANTO SON UTILES PARA TRATAR Y PREVENIR ENFERMEDADES PROLIFERATIVAS VASCULARES COMO ES LA RESTENOSIS QUE SIGUE A LA ANGIOPLASTIA DE GLOBO
ES95934421T 1994-10-25 1995-09-14 Compuestos de poliaminas para el tratamiento de desordenes vasculares proliferativos. Expired - Lifetime ES2155531T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/329,588 US5516807A (en) 1994-10-25 1994-10-25 Method for treating vascular proliferative disorders following balloon angioplasty

Publications (1)

Publication Number Publication Date
ES2155531T3 true ES2155531T3 (es) 2001-05-16

Family

ID=23286110

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95934421T Expired - Lifetime ES2155531T3 (es) 1994-10-25 1995-09-14 Compuestos de poliaminas para el tratamiento de desordenes vasculares proliferativos.

Country Status (12)

Country Link
US (1) US5516807A (es)
EP (1) EP0786991B1 (es)
JP (1) JPH10507752A (es)
AT (1) ATE198706T1 (es)
CA (1) CA2198914A1 (es)
DE (1) DE69519937T2 (es)
DK (1) DK0786991T3 (es)
ES (1) ES2155531T3 (es)
GR (1) GR3035725T3 (es)
MX (1) MX9701838A (es)
PT (1) PT786991E (es)
WO (1) WO1996012480A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP0833624B1 (en) 1995-06-07 2007-11-07 Poniard Pharmaceuticals, Inc. Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
EP1459747A3 (en) * 1996-09-13 2004-12-15 University Of Florida Research Foundation, Inc. Method of inhibiting biosynthesis of Elf5A
US6083991A (en) * 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US7087648B1 (en) * 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6482943B1 (en) * 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
DE60029944T2 (de) 1999-04-30 2007-04-05 Cellgate, Inc., Redwood City Polyamine und ihre therapeutische verwendung
US7312244B2 (en) * 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
AU4678300A (en) * 1999-04-30 2000-11-17 Slil Biomedical Corporation Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
JP2005511734A (ja) * 2001-12-07 2005-04-28 スリル バイオメディカル コーポレイション 癌治療用のシクロアルキル置換ポリアミンおよびそれらの合成方法
JP2004189714A (ja) * 2002-12-09 2004-07-08 Rasanen Tiina-Liisa すい臓炎の治療と予防ならびに肝臓再生機能の誘導のための薬剤
WO2006041805A1 (en) * 2004-10-04 2006-04-20 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
US8709419B2 (en) * 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS606348B2 (ja) * 1976-03-31 1985-02-18 三菱化学株式会社 新規ポリアミン類
JPS58135809A (ja) * 1982-02-05 1983-08-12 Fujisawa Pharmaceut Co Ltd 抗炎症・抗リウマチ剤
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
JPS606348A (ja) * 1983-06-09 1985-01-14 ケルベル・アクチエンゲゼルシヤフト 回転研削工具の支承装置
NZ212053A (en) * 1984-05-17 1988-02-29 Merrell Dow Pharma Polyamine containing pharmaceutical compositions for treating neoplasms
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
CA1338764C (en) * 1987-02-03 1996-12-03 David M. Stemerick Polyamine derivatives
ZA903804B (en) * 1989-05-23 1991-03-27 Merrell Dow Pharma A method of potentiating cell-mediated immunity utilizing polyamine derivatives

Also Published As

Publication number Publication date
WO1996012480A1 (en) 1996-05-02
EP0786991A1 (en) 1997-08-06
MX9701838A (es) 1997-06-28
DK0786991T3 (da) 2001-03-19
EP0786991B1 (en) 2001-01-17
DE69519937T2 (de) 2001-06-07
US5516807A (en) 1996-05-14
ATE198706T1 (de) 2001-02-15
JPH10507752A (ja) 1998-07-28
CA2198914A1 (en) 1996-05-02
DE69519937D1 (de) 2001-02-22
GR3035725T3 (en) 2001-07-31
PT786991E (pt) 2001-04-30

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