CN100443499C - 高纯度白蛋白生产方法 - Google Patents

高纯度白蛋白生产方法 Download PDF

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Publication number
CN100443499C
CN100443499C CNB2006101006176A CN200610100617A CN100443499C CN 100443499 C CN100443499 C CN 100443499C CN B2006101006176 A CNB2006101006176 A CN B2006101006176A CN 200610100617 A CN200610100617 A CN 200610100617A CN 100443499 C CN100443499 C CN 100443499C
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China
Prior art keywords
albumin
solution
matrix
chromatography
ion
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Expired - Lifetime
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CNB2006101006176A
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English (en)
Chinese (zh)
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CN1880334A (zh
Inventor
安德鲁·R·古迪
达雷尔·斯利普
亨德里克·范厄克
斯蒂芬·贝雷曾科
约翰·R·伍德罗
理查德·A·约翰逊
帕特里夏·C·伍德
斯蒂芬·J·伯顿
艾伦·V·夸克
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Novozymes Biopharma DK AS
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Delta Biotechnology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CNB2006101006176A 1995-05-25 1996-02-29 高纯度白蛋白生产方法 Expired - Lifetime CN100443499C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/378,859 US5728553A (en) 1992-09-23 1995-05-25 High purity albumin and method of producing
US378,859 1995-05-25

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN03127743A Division CN100584857C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法

Publications (2)

Publication Number Publication Date
CN1880334A CN1880334A (zh) 2006-12-20
CN100443499C true CN100443499C (zh) 2008-12-17

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Family Applications (4)

Application Number Title Priority Date Filing Date
CNB2004100575838A Expired - Lifetime CN100455597C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法
CN03127743A Expired - Lifetime CN100584857C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法
CNB961958243A Expired - Lifetime CN1198844C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法
CNB2006101006176A Expired - Lifetime CN100443499C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CNB2004100575838A Expired - Lifetime CN100455597C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法
CN03127743A Expired - Lifetime CN100584857C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法
CNB961958243A Expired - Lifetime CN1198844C (zh) 1995-05-25 1996-02-29 高纯度白蛋白生产方法

Country Status (15)

Country Link
US (6) US5728553A (enExample)
EP (2) EP1031578B1 (enExample)
JP (4) JP4040088B2 (enExample)
KR (2) KR100566606B1 (enExample)
CN (4) CN100455597C (enExample)
AT (2) ATE198482T1 (enExample)
AU (1) AU698409B2 (enExample)
CA (1) CA2220923C (enExample)
DE (2) DE69611445T2 (enExample)
DK (2) DK0828759T3 (enExample)
ES (2) ES2219257T3 (enExample)
GR (1) GR3035651T3 (enExample)
MX (1) MX9709108A (enExample)
PT (2) PT828759E (enExample)
WO (1) WO1996037515A1 (enExample)

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