MX9709108A - Procedimiento para la produccion de albumina de alta pureza. - Google Patents
Procedimiento para la produccion de albumina de alta pureza.Info
- Publication number
- MX9709108A MX9709108A MX9709108A MX9709108A MX9709108A MX 9709108 A MX9709108 A MX 9709108A MX 9709108 A MX9709108 A MX 9709108A MX 9709108 A MX9709108 A MX 9709108A MX 9709108 A MX9709108 A MX 9709108A
- Authority
- MX
- Mexico
- Prior art keywords
- albumin
- affinity
- chromatography
- positive mode
- high purity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Se provee un procedimiento para preparar albumina que tiene niveles extremadamente bajos de colorantes, iones metálicos, proteínas humanas, proteínas de huésped, fragmentos de albumina, polímeros o agregados de albumina y virus, o que está esencialmente libre de ellos, y que está sustancialmente no glicada, tiene un contenido relativamente alto de tiol libre y con un extremo C intacto; el procedimiento comprende hacer parar albumina (de preferencia expresada y secretada mediante levadura transformada) a través cromatografía de cambio de cationes en modo positivo y luego de cambio de aniones en modo positivo; también se puede emplear otros pasos, por ejemplo, ultrafiltracion, cromatografía de permeacion de gel, cromatografía por afinidad, que une la albumina (por ejemplo, usando tintes azules) y contaminantes de aglutinacion de cromatografía por afinidad (por ejemplo, que utilizan resina de ácido aminofenilboronico); la elucion de la albumina con un compuesto que tiene afinidad para la albumina, a partir de un material que no tiene afinidad específica para la albumina también está descrita, así como la eliminacion de los iones amonio con un ion contrario.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/378,859 US5728553A (en) | 1992-09-23 | 1995-05-25 | High purity albumin and method of producing |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9709108A true MX9709108A (es) | 1998-06-30 |
Family
ID=23494845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9709108A MX9709108A (es) | 1995-05-25 | 1997-11-25 | Procedimiento para la produccion de albumina de alta pureza. |
Country Status (16)
Country | Link |
---|---|
US (6) | US5728553A (es) |
EP (2) | EP0828759B1 (es) |
JP (4) | JP4040088B2 (es) |
KR (2) | KR100566606B1 (es) |
CN (4) | CN100455597C (es) |
AT (2) | ATE265469T1 (es) |
AU (1) | AU698409B2 (es) |
CA (1) | CA2220923C (es) |
DE (2) | DE69632353T2 (es) |
DK (2) | DK0828759T3 (es) |
ES (2) | ES2156991T3 (es) |
GR (1) | GR3035651T3 (es) |
HK (2) | HK1009456A1 (es) |
MX (1) | MX9709108A (es) |
PT (2) | PT828759E (es) |
WO (1) | WO1996037515A1 (es) |
Families Citing this family (144)
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- 1996-02-29 AT AT96904190T patent/ATE198482T1/de active
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- 1996-02-29 AU AU48380/96A patent/AU698409B2/en not_active Ceased
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