CL2010000350A1 - Proceso para la preparacion de esteres boricos en un solvente de baja miscibilidad en agua. (divisional sol. n° 734-05). - Google Patents
Proceso para la preparacion de esteres boricos en un solvente de baja miscibilidad en agua. (divisional sol. n° 734-05).Info
- Publication number
- CL2010000350A1 CL2010000350A1 CL2010000350A CL2010000350A CL2010000350A1 CL 2010000350 A1 CL2010000350 A1 CL 2010000350A1 CL 2010000350 A CL2010000350 A CL 2010000350A CL 2010000350 A CL2010000350 A CL 2010000350A CL 2010000350 A1 CL2010000350 A1 CL 2010000350A1
- Authority
- CL
- Chile
- Prior art keywords
- formula
- divisional
- sun
- solvent
- preparation
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 1
- 239000002904 solvent Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- -1 ESTER COMPOUND Chemical class 0.000 abstract 2
- 239000002131 composite material Substances 0.000 abstract 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052796 boron Inorganic materials 0.000 abstract 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
UN PROCESO PARA PREPARAR UN COMPUESTO DE ÉSTER AMINOBÓRICO DE FÓRMULA (VII), O UNA SAL DE ADICIÓN DE ÁCIDOS DEL MISMO, QUE COMPRENDE LOS SIGUIENTES PASOS: (A) PROPORCIONAR UN COMPLEJO BORON"ATO" DE FÓRMULA (II), (B) PONER EN CONTACTO EL COMPLEJO BORONATO DE FÓRMULA (II) CON UN ÁCIDO DE LEWIS PARA DAR EL COMPUESTO DE ÉSTER BÓRICO DE FÓRMULA (1), (C) TRATAR EL COMPUESTO DE ÉSTER BÓRICO DE FÓRMULA (1) CON UN REACTIVO DE FÓRMULA M1-N(SI(R6)3)2, DONDE ML ES UN METAL ALCALINO Y CADA R6 INDEPENDIENTEMENTE SE SELECCIONA ENTRE EL GRUPO COMPUESTO POR ALQUILO, ARALQUILO, Y ARILO, PARA FORMAR UN SUBPRODUCTO DE FÓRMULA M1-R3 Y UN COMPUESTO DE FÓRMULA (VIII).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55753504P | 2004-03-30 | 2004-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2010000350A1 true CL2010000350A1 (es) | 2011-01-28 |
Family
ID=34968044
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2010000350A CL2010000350A1 (es) | 2004-03-30 | 2010-04-09 | Proceso para la preparacion de esteres boricos en un solvente de baja miscibilidad en agua. (divisional sol. n° 734-05). |
CL2014002252A CL2014002252A1 (es) | 2004-03-30 | 2014-08-25 | Proceso para preparar un compuesto de formula (xiv) o un anhidrido de acido borico del mismo. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014002252A CL2014002252A1 (es) | 2004-03-30 | 2014-08-25 | Proceso para preparar un compuesto de formula (xiv) o un anhidrido de acido borico del mismo. |
Country Status (41)
Country | Link |
---|---|
US (14) | US7714159B2 (es) |
EP (5) | EP2377869B1 (es) |
JP (4) | JP4558039B2 (es) |
KR (1) | KR100939598B1 (es) |
CN (5) | CN111925385B (es) |
AR (3) | AR049374A1 (es) |
AT (1) | ATE521612T1 (es) |
AU (1) | AU2005230930B2 (es) |
BR (1) | BRPI0509587A (es) |
CA (4) | CA2560886C (es) |
CL (2) | CL2010000350A1 (es) |
CR (1) | CR8653A (es) |
CY (3) | CY1112053T1 (es) |
DK (4) | DK3385267T3 (es) |
DO (1) | DOP2011000293A (es) |
EA (1) | EA012927B1 (es) |
EC (1) | ECSP066960A (es) |
ES (3) | ES2371652T3 (es) |
FI (1) | FI4008721T3 (es) |
HK (4) | HK1100004A1 (es) |
HR (4) | HRP20212002T1 (es) |
HU (1) | HUE056859T2 (es) |
IL (3) | IL178250A (es) |
LT (2) | LT4008721T (es) |
ME (1) | ME01975B (es) |
MX (1) | MX367324B (es) |
MY (1) | MY145427A (es) |
NL (3) | NL1028639C2 (es) |
NO (4) | NO338905B1 (es) |
NZ (3) | NZ550522A (es) |
PE (3) | PE20110075A1 (es) |
PL (4) | PL1756121T3 (es) |
PT (4) | PT2377869E (es) |
RS (4) | RS53259B (es) |
SG (5) | SG151322A1 (es) |
SI (3) | SI2377869T1 (es) |
TW (1) | TWI386212B (es) |
UA (1) | UA90108C2 (es) |
UY (3) | UY28830A1 (es) |
WO (1) | WO2005097809A2 (es) |
ZA (1) | ZA200608689B (es) |
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EA012927B1 (ru) * | 2004-03-30 | 2010-02-26 | Миллениум Фармасьютикалз, Инк. | Синтез эфиров бороновой кислоты и кислотных соединений |
WO2008075376A1 (en) * | 2006-12-18 | 2008-06-26 | Natco Pharma Limited | Polymorphic forms of bortezomib and process for their preparation |
WO2009004350A1 (en) * | 2007-07-03 | 2009-01-08 | Pliva Hrvatska D.O.O. | Methods for preparing bortezomib and intermediates used in its manufacture |
EA034601B1 (ru) * | 2007-08-06 | 2020-02-25 | Милленниум Фармасьютикалз, Инк. | Способ получения бороновых кислот |
MY161991A (en) * | 2007-08-06 | 2017-05-31 | Millennium Pharm Inc | Proteasome inhibitors |
AU2016253697A1 (en) * | 2007-08-06 | 2016-11-24 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
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MX2010013642A (es) * | 2008-06-17 | 2010-12-21 | Millennium Pharm Inc | Compuestos de ester boronato y composiciones farmaceuticas de los mismos. |
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CN105101970B (zh) | 2013-01-10 | 2018-11-20 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
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JPWO2003033506A1 (ja) * | 2001-10-12 | 2005-02-03 | 杏林製薬株式会社 | アミノボラン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
EA012927B1 (ru) | 2004-03-30 | 2010-02-26 | Миллениум Фармасьютикалз, Инк. | Синтез эфиров бороновой кислоты и кислотных соединений |
WO2009004350A1 (en) * | 2007-07-03 | 2009-01-08 | Pliva Hrvatska D.O.O. | Methods for preparing bortezomib and intermediates used in its manufacture |
US7838673B2 (en) * | 2007-10-16 | 2010-11-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
JP2012530116A (ja) * | 2009-06-19 | 2012-11-29 | レツク・フアーマシユーテイカルズ・デー・デー | 脱ハロゲン化なしにハロゲノアルケンを水素化する方法 |
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