IL219856A - Large scale process for forming a boronic derivative or anhydride thereof - Google Patents

Large scale process for forming a boronic derivative or anhydride thereof

Info

Publication number
IL219856A
IL219856A IL219856A IL21985612A IL219856A IL 219856 A IL219856 A IL 219856A IL 219856 A IL219856 A IL 219856A IL 21985612 A IL21985612 A IL 21985612A IL 219856 A IL219856 A IL 219856A
Authority
IL
Israel
Prior art keywords
anhydride
forming
large scale
scale process
boronic derivative
Prior art date
Application number
IL219856A
Other languages
Hebrew (he)
Other versions
IL219856A0 (en
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34968044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL219856(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of IL219856A0 publication Critical patent/IL219856A0/en
Publication of IL219856A publication Critical patent/IL219856A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL219856A 2004-03-30 2012-05-17 Large scale process for forming a boronic derivative or anhydride thereof IL219856A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55753504P 2004-03-30 2004-03-30
PCT/US2005/009774 WO2005097809A2 (en) 2004-03-30 2005-03-24 Synthesis of boronic ester and acid compounds

Publications (2)

Publication Number Publication Date
IL219856A0 IL219856A0 (en) 2012-06-28
IL219856A true IL219856A (en) 2015-05-31

Family

ID=34968044

Family Applications (3)

Application Number Title Priority Date Filing Date
IL178250A IL178250A (en) 2004-03-30 2006-09-21 Synthesis of boronic ester and acid compounds
IL219856A IL219856A (en) 2004-03-30 2012-05-17 Large scale process for forming a boronic derivative or anhydride thereof
IL219853A IL219853A (en) 2004-03-30 2012-05-17 Large scale process for forming a boronic derivative or anhydride thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL178250A IL178250A (en) 2004-03-30 2006-09-21 Synthesis of boronic ester and acid compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL219853A IL219853A (en) 2004-03-30 2012-05-17 Large scale process for forming a boronic derivative or anhydride thereof

Country Status (41)

Country Link
US (14) US7714159B2 (en)
EP (5) EP4008721B1 (en)
JP (4) JP4558039B2 (en)
KR (1) KR100939598B1 (en)
CN (5) CN103396427B (en)
AR (3) AR049374A1 (en)
AT (1) ATE521612T1 (en)
AU (1) AU2005230930B2 (en)
BR (1) BRPI0509587A (en)
CA (4) CA2859119A1 (en)
CL (2) CL2010000350A1 (en)
CR (1) CR8653A (en)
CY (3) CY1112053T1 (en)
DK (4) DK1756121T3 (en)
DO (1) DOP2011000293A (en)
EA (1) EA012927B1 (en)
EC (1) ECSP066960A (en)
ES (3) ES2371652T3 (en)
FI (1) FI4008721T3 (en)
HK (4) HK1100004A1 (en)
HR (3) HRP20212002T1 (en)
HU (1) HUE056859T2 (en)
IL (3) IL178250A (en)
LT (2) LT3385267T (en)
ME (1) ME01975B (en)
MX (1) MX367324B (en)
MY (1) MY145427A (en)
NL (3) NL1028639C2 (en)
NO (4) NO338905B1 (en)
NZ (3) NZ598172A (en)
PE (3) PE20060162A1 (en)
PL (3) PL3385267T3 (en)
PT (4) PT1756121E (en)
RS (4) RS62738B1 (en)
SG (5) SG10201600029PA (en)
SI (3) SI3385267T1 (en)
TW (1) TWI386212B (en)
UA (1) UA90108C2 (en)
UY (3) UY28830A1 (en)
WO (1) WO2005097809A2 (en)
ZA (1) ZA200608689B (en)

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EP2178888B1 (en) 2007-08-06 2012-07-04 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
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AU2016253697A1 (en) * 2007-08-06 2016-11-24 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
US20110118274A1 (en) * 2007-08-23 2011-05-19 Cornell Research Foundation, Inc. Proteasome inhibitors and their use in treating pathogen infection and cancer
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AU2013204896A1 (en) * 2008-09-29 2013-05-16 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclobutylethylboronic acid
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CN101899062B (en) * 2009-05-26 2015-04-15 上海威智医药科技有限公司 Synthesis technology of alpha-chiral boric acid and boric acid ester
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EP2280016A1 (en) 2009-07-27 2011-02-02 LEK Pharmaceuticals d.d. New synthetic route for the preparation of alpha-amino boronic esters via substituted alk-1-ynes
JP2012530115A (en) 2009-06-19 2012-11-29 レツク・フアーマシユーテイカルズ・デー・デー Novel synthetic route for the preparation of α-aminoboronic acid derivatives via substituted alk-1-ynes
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WO2011107912A1 (en) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Polymorphic forms of bortezomib
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
RU2529800C2 (en) * 2010-03-18 2014-09-27 ИННОФАРМА, Инк. Stable formulations of bortezomib
RU2012146101A (en) 2010-03-31 2014-05-10 Милленниум Фармасьютикалз, Инк. 1-AMINO-2-CYCLOPROPYLETHYL BORONIC ACID DERIVATIVES
CN101812026B (en) * 2010-04-12 2013-08-28 亚邦医药股份有限公司 Method for synthesizing bortezomib
EP3566719A1 (en) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
EP2627636B1 (en) 2010-10-14 2015-09-02 Synthon BV Process for making bortezomib and the intermediates for the process
TW201309303A (en) 2011-03-03 2013-03-01 Cephalon Inc Proteasome inhibitor for the treatment of lupus
CN102206188B (en) * 2011-04-08 2013-02-27 苏州二叶制药有限公司 Preparation method for N-(pyrazine-2-yl carbonyl)-L-phenylalanine
US8497374B2 (en) 2011-05-12 2013-07-30 Scinopharm Taiwan, Ltd. Process for preparing and purifying bortezomib
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CN102351890B (en) * 2011-09-30 2014-07-02 重庆泰濠制药有限公司 Method for synthesizing bortezomib
CN102492021B (en) * 2011-12-13 2013-10-23 重庆泰濠制药有限公司 Preparation process for bortezomib
US9688702B2 (en) * 2011-12-22 2017-06-27 Ares Trading Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
CN103374026A (en) * 2012-04-27 2013-10-30 重庆医药工业研究院有限责任公司 Preparation method of bortezomib midbody
CN103450331B (en) * 2012-06-05 2016-05-25 山东新时代药业有限公司 A kind of process for purification of bortezomib
BR112015005343A2 (en) * 2012-09-11 2017-07-04 Cipla Ltd process for the preparation of bortezomib, compound, bortezomib or its anhydride, and process for the preparation of a compound
WO2014072985A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Novel boronic acid derivatives as anti cancer agents
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Also Published As

Publication number Publication date
UY34969A (en) 2015-02-27
HK1164320A1 (en) 2012-10-19
SI3385267T1 (en) 2022-04-29
SG151322A1 (en) 2009-04-30
SI2377869T1 (en) 2014-05-30
JP5894952B2 (en) 2016-03-30
DK1756121T3 (en) 2012-01-09
CN1960996B (en) 2016-04-20
EP2377869B1 (en) 2014-01-29
AU2005230930A1 (en) 2005-10-20
US20190112334A1 (en) 2019-04-18
SG182998A1 (en) 2012-08-30
SG10201600029PA (en) 2016-02-26
CA2853272A1 (en) 2005-10-20
CN103396427A (en) 2013-11-20
EP3385267B1 (en) 2021-09-29
NO338905B1 (en) 2016-10-31
PT2377869E (en) 2014-04-15
CA2560886A1 (en) 2005-10-20
US8283467B2 (en) 2012-10-09
CN108329337B (en) 2021-06-25
AR049374A1 (en) 2006-07-26
AU2005230930B2 (en) 2011-09-29
CN107474062A (en) 2017-12-15
PE20060162A1 (en) 2006-04-07
US20050240047A1 (en) 2005-10-27
PE20142402A1 (en) 2015-02-04
JP2007530687A (en) 2007-11-01
KR100939598B1 (en) 2010-02-01
US20190330270A1 (en) 2019-10-31
NO20191065A1 (en) 2006-12-22
NZ586824A (en) 2012-03-30
HK1246300A1 (en) 2018-09-07
NL1028639A1 (en) 2005-10-20
SG10201800972PA (en) 2018-03-28
WO2005097809A3 (en) 2006-02-16
CA2738706C (en) 2014-10-14
TW200616646A (en) 2006-06-01
PL2377869T3 (en) 2014-07-31
AR097310A2 (en) 2016-03-02
US20100174072A1 (en) 2010-07-08
AR097309A2 (en) 2016-03-02
HK1100004A1 (en) 2007-08-31
US7714159B2 (en) 2010-05-11
ME01975B (en) 2015-05-20
SI1756121T1 (en) 2012-03-30
US20210171574A1 (en) 2021-06-10
IL219853A (en) 2015-05-31
FI4008721T3 (en) 2024-03-19
US20220204558A1 (en) 2022-06-30
HRP20212002T1 (en) 2022-04-01
PT4008721T (en) 2024-03-21
EP1756121B1 (en) 2011-08-24
ZA200608689B (en) 2007-09-26
EA012927B1 (en) 2010-02-26
SG182999A1 (en) 2012-08-30
ES2899606T3 (en) 2022-03-14
US20200369722A1 (en) 2020-11-26
US20180265546A1 (en) 2018-09-20
US20150038706A1 (en) 2015-02-05
ECSP066960A (en) 2006-12-20
EP3385267A1 (en) 2018-10-10
WO2005097809A2 (en) 2005-10-20
CY1115336T1 (en) 2017-01-04
BRPI0509587A (en) 2007-09-25
MX367324B (en) 2019-08-15
NO343966B1 (en) 2019-07-29
US20210395301A1 (en) 2021-12-23
PT3385267T (en) 2021-11-23
NO20064893L (en) 2006-12-22
DOP2011000293A (en) 2011-12-15
CN111925385B (en) 2023-11-21
JP2013100378A (en) 2013-05-23
CN111925385A (en) 2020-11-13
US20200157143A1 (en) 2020-05-21
CL2014002252A1 (en) 2014-12-05
JP2010241816A (en) 2010-10-28
JP4558039B2 (en) 2010-10-06
RS62738B1 (en) 2022-01-31
CN103396427B (en) 2018-04-13
IL219856A0 (en) 2012-06-28
PL3385267T3 (en) 2022-02-14
CY1112053T1 (en) 2015-11-04
HRP20110846T1 (en) 2011-12-31
JP5414625B2 (en) 2014-02-12
UY28830A1 (en) 2005-09-30
US10000529B2 (en) 2018-06-19
DK3385267T3 (en) 2021-11-01
EA200601795A1 (en) 2007-04-27
UA90108C2 (en) 2010-04-12
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US20160362449A1 (en) 2016-12-15
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US9862745B2 (en) 2018-01-09
EP1756121A2 (en) 2007-02-28
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IL178250A (en) 2012-06-28
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IL219853A0 (en) 2012-06-28
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