ECSP088679A - Proceso para la preparacion de compuestos de dibenzotiazepina - Google Patents

Proceso para la preparacion de compuestos de dibenzotiazepina

Info

Publication number
ECSP088679A
ECSP088679A EC2008008679A ECSP088679A ECSP088679A EC SP088679 A ECSP088679 A EC SP088679A EC 2008008679 A EC2008008679 A EC 2008008679A EC SP088679 A ECSP088679 A EC SP088679A EC SP088679 A ECSP088679 A EC SP088679A
Authority
EC
Ecuador
Prior art keywords
compound
carboxy
diphenylsulfide
appropriately prepared
dibenzotiazepine
Prior art date
Application number
EC2008008679A
Other languages
English (en)
Inventor
Paul Michael Murray
Luis-Manuel Vaz
Debra Ainge
Katsumasa Harada
Shigeyoshi Nishino
Kiyotaka Yoshii
Original Assignee
Astrazeneca Uk Ltd
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd, Ube Industries filed Critical Astrazeneca Uk Ltd
Publication of ECSP088679A publication Critical patent/ECSP088679A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Un compuesto de di-benzotiazepina se prepara apropiadamente sometiendo un compuesto de 2-amino-2'-carboxi-difenilsulfuroide a reacción de deshidratación-condensación en la presencia de un catalizador ácido; el compuesto de 2-amino-2'-carboxi-difenilsulfuro se prepara apropiadamente reduciendo el compuesto de 2-nitro-2'-carboxi-difenilsulfuro en un solvente más bajo de éster alifático; y el compuesto de 2-nitro-2'-carboxi-difenilsulfuro se prepara apropiadamente reaccionando un compuesto de nitrobenceno con un compuesto de ácido tiosalicílico en una mezcla de un alcohol alifático inferior y agua.
EC2008008679A 2006-02-22 2008-08-13 Proceso para la preparacion de compuestos de dibenzotiazepina ECSP088679A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77548306P 2006-02-22 2006-02-22

Publications (1)

Publication Number Publication Date
ECSP088679A true ECSP088679A (es) 2008-09-29

Family

ID=38220043

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008679A ECSP088679A (es) 2006-02-22 2008-08-13 Proceso para la preparacion de compuestos de dibenzotiazepina

Country Status (17)

Country Link
US (1) US7671195B2 (es)
EP (1) EP1996568A2 (es)
JP (1) JP2009527458A (es)
KR (1) KR20080108468A (es)
CN (1) CN101389615A (es)
AR (1) AR059613A1 (es)
AU (1) AU2007223597A1 (es)
BR (1) BRPI0708096A2 (es)
CA (1) CA2642659A1 (es)
EC (1) ECSP088679A (es)
IL (1) IL193264A0 (es)
NO (1) NO20083544L (es)
RU (1) RU2008137615A (es)
TW (1) TW200811119A (es)
UY (1) UY30170A1 (es)
WO (1) WO2007102352A2 (es)
ZA (1) ZA200806903B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL164155A0 (en) * 2002-03-20 2005-12-18 Teva Pharma Crystalline forms of quetiapine hemifumarate
CA2603795A1 (en) * 2005-04-14 2006-10-26 Teva Pharmaceutical Industries Ltd. Process for preparing quetiapine fumarate
JP2009529062A (ja) * 2007-03-29 2009-08-13 テバ ファーマシューティカル インダストリーズ リミティド フマル酸クエチアピンを調製するための改良法
CN104177311B (zh) * 2013-05-27 2016-09-14 许昌恒生制药有限公司 一种喹硫平中间体的制备方法
CN103772319A (zh) * 2014-01-02 2014-05-07 成都医路康医学技术服务有限公司 一种硫氮杂卓类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301061B6 (cs) 1999-07-09 2009-10-29 Astrazeneca Uk Limited Zpusob prípravy dibenzothiazepinových derivátu
KR100707050B1 (ko) 2002-11-28 2007-04-13 에스케이 주식회사 10Ｈ-디벤조[ｂ,ｆ][1,4]티아제핀-11-온의 제조방법
PL195728B1 (pl) 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
PL1682537T3 (pl) * 2003-11-05 2012-09-28 Sarcode Bioscience Inc Modulatory adhezji komórkowej

Also Published As

Publication number Publication date
UY30170A1 (es) 2007-09-28
AU2007223597A8 (en) 2008-09-11
AR059613A1 (es) 2008-04-16
NO20083544L (no) 2008-09-16
RU2008137615A (ru) 2010-03-27
AU2007223597A1 (en) 2007-09-13
ZA200806903B (en) 2010-10-27
WO2007102352A3 (en) 2008-01-10
KR20080108468A (ko) 2008-12-15
BRPI0708096A2 (pt) 2011-05-17
US20070203336A1 (en) 2007-08-30
JP2009527458A (ja) 2009-07-30
CA2642659A1 (en) 2007-09-13
CN101389615A (zh) 2009-03-18
IL193264A0 (en) 2009-02-11
US7671195B2 (en) 2010-03-02
TW200811119A (en) 2008-03-01
WO2007102352A2 (en) 2007-09-13
EP1996568A2 (en) 2008-12-03

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