WO2008093205A3 - A method for the purification of rosuvastatin intermediate - Google Patents

A method for the purification of rosuvastatin intermediate Download PDF

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Publication number
WO2008093205A3
WO2008093205A3 PCT/IB2008/000189 IB2008000189W WO2008093205A3 WO 2008093205 A3 WO2008093205 A3 WO 2008093205A3 IB 2008000189 W IB2008000189 W IB 2008000189W WO 2008093205 A3 WO2008093205 A3 WO 2008093205A3
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WO
WIPO (PCT)
Prior art keywords
purification
formula
under stirring
addition
organic solvent
Prior art date
Application number
PCT/IB2008/000189
Other languages
French (fr)
Other versions
WO2008093205A2 (en
Inventor
Upparapalli Sampath Kumar
Subramaniyan Mannathan
Natarajan Sabrinathan
Anand Sivadas
Senthilnathan Palanivel
Siripragada Mahender Rao
Original Assignee
Orchid Chemicals & Pharm Ltd
Upparapalli Sampath Kumar
Subramaniyan Mannathan
Natarajan Sabrinathan
Anand Sivadas
Senthilnathan Palanivel
Siripragada Mahender Rao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Upparapalli Sampath Kumar, Subramaniyan Mannathan, Natarajan Sabrinathan, Anand Sivadas, Senthilnathan Palanivel, Siripragada Mahender Rao filed Critical Orchid Chemicals & Pharm Ltd
Publication of WO2008093205A2 publication Critical patent/WO2008093205A2/en
Publication of WO2008093205A3 publication Critical patent/WO2008093205A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Abstract

The present invention relates to a method for the purification of an intermediate of formula (1), which is useful for the preparation of Rosuvastatin and its pharmaceutically acceptable salts thereof, more particularly purification method comprises the addition of aqueous organic acid such as acetic acid under stirring conditions in presence of an organic solvent such as isopropyl ether or alternatively the purification method comprises the addition of aqueous alcohol such as methanol under stirring conditions in presence of an organic solvent such as isopropyl ether (Formula I)
PCT/IB2008/000189 2007-01-31 2008-01-29 A method for the purification of rosuvastatin intermediate WO2008093205A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN220CH2007 2007-01-31
IN220/CHE/2007 2007-01-31

Publications (2)

Publication Number Publication Date
WO2008093205A2 WO2008093205A2 (en) 2008-08-07
WO2008093205A3 true WO2008093205A3 (en) 2009-02-26

Family

ID=39674562

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/000189 WO2008093205A2 (en) 2007-01-31 2008-01-29 A method for the purification of rosuvastatin intermediate

Country Status (1)

Country Link
WO (1) WO2008093205A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
EP2032587A2 (en) 2007-04-18 2009-03-11 Teva Pharmaceutical Industries Ltd. Rosuvastatin intermediates and process for the preparation of rosuvastatin
CN102967683B (en) * 2012-11-16 2014-10-08 峨眉山天梁星制药有限公司 High-performance liquid chromatography method for methyl(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphos phoranylidenehexanoate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin

Also Published As

Publication number Publication date
WO2008093205A2 (en) 2008-08-07

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