WO2007069266A3 - A novel process for the synthesis of bisodprolol and its intermediate - Google Patents

A novel process for the synthesis of bisodprolol and its intermediate Download PDF

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Publication number
WO2007069266A3
WO2007069266A3 PCT/IN2006/000358 IN2006000358W WO2007069266A3 WO 2007069266 A3 WO2007069266 A3 WO 2007069266A3 IN 2006000358 W IN2006000358 W IN 2006000358W WO 2007069266 A3 WO2007069266 A3 WO 2007069266A3
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WO
WIPO (PCT)
Prior art keywords
bisodprolol
synthesis
novel process
isopropoxyethoxy
bisoprolol
Prior art date
Application number
PCT/IN2006/000358
Other languages
French (fr)
Other versions
WO2007069266A2 (en
Inventor
Arul Ramakrishnan
Dayalji Chauhan Ajay
Harshnath Pathak Rajesh
Agarwal Ruchi
Original Assignee
Unichem Lab Ltd
Arul Ramakrishnan
Dayalji Chauhan Ajay
Harshnath Pathak Rajesh
Agarwal Ruchi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unichem Lab Ltd, Arul Ramakrishnan, Dayalji Chauhan Ajay, Harshnath Pathak Rajesh, Agarwal Ruchi filed Critical Unichem Lab Ltd
Publication of WO2007069266A2 publication Critical patent/WO2007069266A2/en
Publication of WO2007069266A3 publication Critical patent/WO2007069266A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/09—Preparation of ethers by dehydration of compounds containing hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

This invention relates to a manufacturing process for the preparation of bisoprolol and its pharmaceutically acceptable salt as well as its intermediates. The intermediate 4-[(2-isopropoxyethoxy)methyl]phenol is prepared by reaction of 4-hydroxybenzyl alcohol with 2-isopropoxy ethanol in presence of Amberlyst 15 in high yield with high purity.
PCT/IN2006/000358 2005-12-12 2006-09-12 A novel process for the synthesis of bisodprolol and its intermediate WO2007069266A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1533MU2005 2005-12-12
IN1533/MUM/2005 2005-12-12

Publications (2)

Publication Number Publication Date
WO2007069266A2 WO2007069266A2 (en) 2007-06-21
WO2007069266A3 true WO2007069266A3 (en) 2007-08-09

Family

ID=38163335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000358 WO2007069266A2 (en) 2005-12-12 2006-09-12 A novel process for the synthesis of bisodprolol and its intermediate

Country Status (1)

Country Link
WO (1) WO2007069266A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IES20090901A2 (en) * 2008-11-28 2010-07-07 Corden Pharma Ip Ltd Manufacture of beta blockers
CN102557891B (en) * 2012-01-10 2014-02-19 济南久创化学有限责任公司 Preparation method for 4-isopropoxy ethyoxyl methyl phenol
CN102964258B (en) * 2012-12-11 2014-01-29 上海奥博生物医药技术有限公司 Preparation method of related substance J of metoprolol
EP2886656A1 (en) 2013-12-18 2015-06-24 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzyme and method for preparing 4-hydroxyl benzyl alcohol and derivatives thereof
WO2016135616A1 (en) * 2015-02-27 2016-09-01 Piramal Enterprises Limited An improved process for the preparation of bisoprolol and its intermediate
CN104876806A (en) * 2015-05-26 2015-09-02 济南大学 Novel method for synthesizing bisoprolol importance intermediate
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4434823A1 (en) * 1994-09-29 1996-04-04 Merck Patent Gmbh Continuous prodn. of hydroxy-benzyl alkyl ether
CN1590366A (en) * 2002-07-12 2005-03-09 北京四环医药科技股份有限公司 Improved method of preparing bisolol and its salt

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4434823A1 (en) * 1994-09-29 1996-04-04 Merck Patent Gmbh Continuous prodn. of hydroxy-benzyl alkyl ether
CN1590366A (en) * 2002-07-12 2005-03-09 北京四环医药科技股份有限公司 Improved method of preparing bisolol and its salt

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] SOLOVIEV D.V. ET AL.: "Asymmetric synthesis and preliminary evaluation of (R)- and (S)-[11C]bisoprolol, a putative ?1-selective adrenoreceptor radioligand", accession no. STN Database accession no. (2001:80291) *
NEUROCHEMISTRY INTERNATIONAL, vol. 38, no. 2, 2001, pages 169 - 180 *

Also Published As

Publication number Publication date
WO2007069266A2 (en) 2007-06-21

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