WO2009072139A8 - Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof - Google Patents

Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof Download PDF

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Publication number
WO2009072139A8
WO2009072139A8 PCT/IN2008/000231 IN2008000231W WO2009072139A8 WO 2009072139 A8 WO2009072139 A8 WO 2009072139A8 IN 2008000231 W IN2008000231 W IN 2008000231W WO 2009072139 A8 WO2009072139 A8 WO 2009072139A8
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WO
WIPO (PCT)
Prior art keywords
methyl
methylbenzoyl
pyrrol
salt
producing
Prior art date
Application number
PCT/IN2008/000231
Other languages
French (fr)
Other versions
WO2009072139A1 (en
Inventor
Nageswara Rao Karusala
Bhausaheb Chavhan
Jebaraj Rathinapandian
Muneendra Kumar Veeranki
Purna Chandra Ray
Om Dutt Tyagi
Original Assignee
Matrix Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Limited filed Critical Matrix Laboratories Limited
Publication of WO2009072139A1 publication Critical patent/WO2009072139A1/en
Publication of WO2009072139A8 publication Critical patent/WO2009072139A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel process for the preparation of tolmetin sodium, by employing easily available starting material and suitable reaction conditions. This invention is further related to novel crystalline forms of tolmetin methyl ester, tolmetin and tolmetin sodium and their process for the preparation.
PCT/IN2008/000231 2007-12-07 2008-04-08 Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof WO2009072139A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2930CH2007 2007-12-07
IN2930/CHE/2007 2007-12-07

Publications (2)

Publication Number Publication Date
WO2009072139A1 WO2009072139A1 (en) 2009-06-11
WO2009072139A8 true WO2009072139A8 (en) 2009-10-22

Family

ID=39737091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000231 WO2009072139A1 (en) 2007-12-07 2008-04-08 Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof

Country Status (1)

Country Link
WO (1) WO2009072139A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508511A1 (en) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
CN103435527B (en) * 2013-09-03 2015-09-23 张家港市信谊化工有限公司 A kind of preparation method of non-steroidal antiphlogiston tolmetin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US3846447A (en) * 1972-08-03 1974-11-05 Mcneilab Inc Preparation of 5-aroyl-pyrroles and intermediates therefor
US4187230A (en) * 1975-05-27 1980-02-05 Ethyl Corporation Preparation of 5-aroyl-pyrrole compounds
US4213905A (en) * 1979-06-25 1980-07-22 Mcneilab, Inc. Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid salts
IT1320770B1 (en) * 2000-07-21 2003-12-10 Zambon Spa METHYL ESTER SYNTHESIS PROCESS OF 1-METHYL-5- (4-METHYLBENZOYL) -PYRROL-2-ACETIC ACID.

Also Published As

Publication number Publication date
WO2009072139A1 (en) 2009-06-11

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