WO2011024192A3 - Novel polymorphs of raltegravir - Google Patents

Novel polymorphs of raltegravir Download PDF

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Publication number
WO2011024192A3
WO2011024192A3 PCT/IN2010/000490 IN2010000490W WO2011024192A3 WO 2011024192 A3 WO2011024192 A3 WO 2011024192A3 IN 2010000490 W IN2010000490 W IN 2010000490W WO 2011024192 A3 WO2011024192 A3 WO 2011024192A3
Authority
WO
WIPO (PCT)
Prior art keywords
raltegravir
novel polymorphs
preparation
present
novel
Prior art date
Application number
PCT/IN2010/000490
Other languages
French (fr)
Other versions
WO2011024192A2 (en
Inventor
Ramakoteswara Rao Jetti
Madhavi Jonnalagadda
Chetan Kanaiyalal Raval
Debashish Datta
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2011024192A2 publication Critical patent/WO2011024192A2/en
Publication of WO2011024192A3 publication Critical patent/WO2011024192A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to novel polymorphic forms of Raltegravir and processes for its preparation thereof. The present invention further relates to an improved process for preparation of amorphous and crystalline Form 1, Form 2 and Form 3 of Raltegravir Potassium salt.
PCT/IN2010/000490 2009-07-27 2010-07-26 Novel polymorphs of raltegravir WO2011024192A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1765/CHE/2009 2009-07-27
IN1765CH2009 2009-07-27

Publications (2)

Publication Number Publication Date
WO2011024192A2 WO2011024192A2 (en) 2011-03-03
WO2011024192A3 true WO2011024192A3 (en) 2011-04-21

Family

ID=43384549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000490 WO2011024192A2 (en) 2009-07-27 2010-07-26 Novel polymorphs of raltegravir

Country Status (1)

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WO (1) WO2011024192A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2549387T3 (en) 2009-06-02 2015-10-27 Hetero Research Foundation Preparation procedure for amorphous potassium raltegravir
EP2796458B1 (en) 2010-04-01 2018-01-10 Teva Pharmaceutical Industries Ltd. Crystalline raltegravir sodium salts
WO2012103105A1 (en) 2011-01-24 2012-08-02 Assia Chemical Industries Ltd. Processes for preparing raltegravir and intermediates in the processes
AU2012241050B2 (en) 2011-04-06 2016-05-19 Lupin Limited Novel salts of raltegravir
AU2012245524A1 (en) * 2011-04-22 2013-10-24 Merck Sharp & Dohme Corp. Taste-masked formulations of raltegravir
EP2755968A1 (en) 2011-09-16 2014-07-23 Hexal AG Novel polymorphic form of raltegravir potassium
BR112014018247A8 (en) * 2012-01-25 2017-07-11 Lupin Ltd AMORPHOUS AND STABLE RALTEGRAVIR POTASSIUM PREMIX; PROCESS; PHARMACEUTICAL FORMULATION; AND METHOD
ES2713686T3 (en) 2014-02-03 2019-05-23 Mylan Laboratories Ltd Procedure for the preparation of Raltegravir intermediates
WO2015140765A1 (en) * 2014-03-21 2015-09-24 Mylan Laboratories Ltd. A premix of crystalline raltegravir potassium salt and a process for the preparation thereof
EP3512854A1 (en) 2016-09-15 2019-07-24 Lupin Limited Process for the preparation of pure and stable crystalline raltegravir potassium form 3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04003932A (en) 2001-10-26 2004-06-18 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase.
UA87884C2 (en) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Potassium salt of an hiv integrase inhibitor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUMMA VINCENZO ET AL: "Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.", JOURNAL OF MEDICINAL CHEMISTRY 25 SEP 2008 LNKD- PUBMED:18763751, vol. 51, no. 18, 25 September 2008 (2008-09-25), pages 5843 - 5855, XP002615638, ISSN: 1520-4804 *

Also Published As

Publication number Publication date
WO2011024192A2 (en) 2011-03-03

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