WO2010122575A3 - Process for the preparation of pure paliperidone - Google Patents

Process for the preparation of pure paliperidone Download PDF

Info

Publication number
WO2010122575A3
WO2010122575A3 PCT/IN2010/000244 IN2010000244W WO2010122575A3 WO 2010122575 A3 WO2010122575 A3 WO 2010122575A3 IN 2010000244 W IN2010000244 W IN 2010000244W WO 2010122575 A3 WO2010122575 A3 WO 2010122575A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pure paliperidone
paliperidone
pure
less
Prior art date
Application number
PCT/IN2010/000244
Other languages
French (fr)
Other versions
WO2010122575A2 (en
Inventor
Siva Rama Prasad Vellanki
Arabinda Sahu
Naveen Kumar Phaduri
Debashish Datta
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2010122575A2 publication Critical patent/WO2010122575A2/en
Publication of WO2010122575A3 publication Critical patent/WO2010122575A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

The present invention provides pure Paliperidone comprising less than about 0.1%, preferably less than about 0.05% of PLP keto impurity as well as purification processes for preparing thereof.
PCT/IN2010/000244 2009-04-20 2010-04-16 Process for the preparation of pure paliperidone WO2010122575A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN903/CHE/2009 2009-04-20
IN903CH2009 2009-04-20

Publications (2)

Publication Number Publication Date
WO2010122575A2 WO2010122575A2 (en) 2010-10-28
WO2010122575A3 true WO2010122575A3 (en) 2011-01-06

Family

ID=42628959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000244 WO2010122575A2 (en) 2009-04-20 2010-04-16 Process for the preparation of pure paliperidone

Country Status (1)

Country Link
WO (1) WO2010122575A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120165527A1 (en) * 2009-08-04 2012-06-28 Orchid Chemicals & Pharmaceuticals Ltd. process for the preparation of pure paliperidone
CN102584818A (en) * 2012-01-11 2012-07-18 吉林三善恩科技开发有限公司 Novel paliperidone medicinal eutectic and preparation method thereof
CN104140423B (en) * 2013-05-10 2017-12-08 江苏豪森药业集团有限公司 The process for purification of 9-hydroxy-risperidone
CN106220622A (en) * 2016-06-30 2016-12-14 广州仁恒医药科技有限公司 A kind of preparation method of Palmic acid 9-hydroxy-risperidone

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008021342A2 (en) * 2006-08-14 2008-02-21 Teva Pharmaceutical Industries Ltd. Amorphous and crystalline forms of 9-hydroxy-risperidone ( paliperidone )
US20080281100A1 (en) * 2007-05-10 2008-11-13 Santiago Ini Pure paliperidone and processes for preparing thereof
US20090048272A1 (en) * 2007-08-16 2009-02-19 Pratap Reddy Padi Preparation of paliperidone
WO2009044413A2 (en) * 2007-10-05 2009-04-09 Matrix Laboratories Limited Improved process for preparing paliperidone, novel polymorphic forms of the same and process thereof
WO2009118655A2 (en) * 2008-03-27 2009-10-01 Actavis Group Ptc Ehf Highly pure paliperidone or a pharmaceutically acceptable salt thereof substantially free of keto impurity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158952A (en) 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008021342A2 (en) * 2006-08-14 2008-02-21 Teva Pharmaceutical Industries Ltd. Amorphous and crystalline forms of 9-hydroxy-risperidone ( paliperidone )
US20080281100A1 (en) * 2007-05-10 2008-11-13 Santiago Ini Pure paliperidone and processes for preparing thereof
US20090048272A1 (en) * 2007-08-16 2009-02-19 Pratap Reddy Padi Preparation of paliperidone
WO2009044413A2 (en) * 2007-10-05 2009-04-09 Matrix Laboratories Limited Improved process for preparing paliperidone, novel polymorphic forms of the same and process thereof
WO2009118655A2 (en) * 2008-03-27 2009-10-01 Actavis Group Ptc Ehf Highly pure paliperidone or a pharmaceutically acceptable salt thereof substantially free of keto impurity

Also Published As

Publication number Publication date
WO2010122575A2 (en) 2010-10-28

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