AR080863A1 - Derivados del acido1-amino-2-ciclopropiletilboronico, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer. - Google Patents

Derivados del acido1-amino-2-ciclopropiletilboronico, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer.

Info

Publication number
AR080863A1
AR080863A1 ARP110101066A ARP110101066A AR080863A1 AR 080863 A1 AR080863 A1 AR 080863A1 AR P110101066 A ARP110101066 A AR P110101066A AR P110101066 A ARP110101066 A AR P110101066A AR 080863 A1 AR080863 A1 AR 080863A1
Authority
AR
Argentina
Prior art keywords
independently
substituted
unsubstituted
aliphatic
aryl
Prior art date
Application number
ARP110101066A
Other languages
English (en)
Inventor
Jing Li
Paul E Fleming
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR080863(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of AR080863A1 publication Critical patent/AR080863A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Reivindicacion 1: Compuesto de la formula (1) o una sal farmacéuticamente aceptable o anhídrido de ácido boronico del mismo, caracterizado porque: A es 0, 1 o 2; P es hidrogeno o un radical de bloqueo de grupo amino; cada Ra2 independientemente hidrogeno, alifático C1-6, fluoroalifático C1-6, (CH2)m-CH2-Rb, (CH2)m-CH2-NHC(=NR4)NH-Y, (CH2)m-CH2-CON(R4)2, -(CH2)m-CH2-N(R4)CON(R4)2, -(CH2)m-CH(R6)N(R4)2, -(CH2)m-CH(R5) OR5 o -(CH2)m-CH(R5)-SR5 cada Y es independientemente hidrogeno, -CN, -NO2 o -S(O)2-R10; cada RB es independientemente un sistema de anillo mono o bicíclico sustituido o insustituido; cada R4 es independientemente hidrogeno o un grupo arilo, heteroarilo o heterociclilo alifático sustituido o insustituido; o dos R4 en el mismo átomo de nitrogeno, tomados juntos con el átomo de nitrogeno, forman un anillo heterociclilo sustituido o insustituido de 4 a 8 miembros que tiene, además del átomo de nitrogeno, 0-2 heteroátomos de anillo seleccionados independientemente de N, O y S; cada R5 es independientemente hidrogeno o un grupo alifático arilo, heteroarilo o heterociclilo sustituido o insustituido; cada R6 es independientemente un grupo arilo o heteroarilo alifático sustituido o insustituido; cada R10 es independientemente alifático C1-6, arilo C1-10 o -N(R4)2; m es 0, 1 o 2; Z1 y Z2 son cada uno independientemente hidroxi, alcoxi, ariloxi; o aralcoxi; o Z1 y Z2 forman juntos un radical derivado de un agente de acomplejamiento de ácido boronico.
ARP110101066A 2010-03-31 2011-03-30 Derivados del acido1-amino-2-ciclopropiletilboronico, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer. AR080863A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31946410P 2010-03-31 2010-03-31

Publications (1)

Publication Number Publication Date
AR080863A1 true AR080863A1 (es) 2012-05-16

Family

ID=44710349

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101066A AR080863A1 (es) 2010-03-31 2011-03-30 Derivados del acido1-amino-2-ciclopropiletilboronico, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer.

Country Status (25)

Country Link
US (3) US8513218B2 (es)
EP (1) EP2552216B1 (es)
JP (1) JP5933523B2 (es)
KR (1) KR20130036228A (es)
CN (3) CN106008570A (es)
AR (1) AR080863A1 (es)
AU (1) AU2011235227B2 (es)
CA (1) CA2794334C (es)
CL (1) CL2012002733A1 (es)
CO (1) CO6630162A2 (es)
CR (1) CR20120529A (es)
DO (1) DOP2012000257A (es)
EA (1) EA029521B1 (es)
EC (1) ECSP12012249A (es)
MA (1) MA34169B1 (es)
MX (1) MX2012011298A (es)
NZ (1) NZ602622A (es)
PE (1) PE20130383A1 (es)
RU (1) RU2012146101A (es)
SG (1) SG184222A1 (es)
TN (1) TN2012000465A1 (es)
UA (1) UA110612C2 (es)
UY (1) UY33314A (es)
WO (1) WO2011123502A1 (es)
ZA (2) ZA201207406B (es)

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Also Published As

Publication number Publication date
WO2011123502A1 (en) 2011-10-06
AU2011235227B2 (en) 2016-09-08
CA2794334A1 (en) 2011-10-06
TN2012000465A1 (en) 2014-01-30
US9023832B2 (en) 2015-05-05
JP5933523B2 (ja) 2016-06-08
US20110245203A1 (en) 2011-10-06
UY33314A (es) 2011-10-31
CN106008570A (zh) 2016-10-12
NZ602622A (en) 2015-01-30
CO6630162A2 (es) 2013-03-01
ZA201207406B (en) 2014-01-29
UA110612C2 (uk) 2016-01-25
US8703743B2 (en) 2014-04-22
US20140011998A1 (en) 2014-01-09
CR20120529A (es) 2013-01-11
EA029521B1 (ru) 2018-04-30
ECSP12012249A (es) 2012-11-30
CN107266485A (zh) 2017-10-20
SG184222A1 (en) 2012-10-30
MA34169B1 (fr) 2013-04-03
DOP2012000257A (es) 2012-11-15
EP2552216B1 (en) 2018-01-24
RU2012146101A (ru) 2014-05-10
AU2011235227A1 (en) 2012-10-18
MX2012011298A (es) 2012-11-06
CA2794334C (en) 2018-06-12
CL2012002733A1 (es) 2013-01-25
US8513218B2 (en) 2013-08-20
EP2552216A4 (en) 2013-07-31
EP2552216A1 (en) 2013-02-06
PE20130383A1 (es) 2013-04-24
JP2013523760A (ja) 2013-06-17
EA201290980A1 (ru) 2013-03-29
KR20130036228A (ko) 2013-04-11
CN102892291A (zh) 2013-01-23
ZA201308086B (en) 2015-03-25
US20140179631A1 (en) 2014-06-26

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