BR112014000563A2 - composto, composição farmacêutica, e, uso do composto - Google Patents

composto, composição farmacêutica, e, uso do composto

Info

Publication number
BR112014000563A2
BR112014000563A2 BR112014000563-0A BR112014000563A BR112014000563A2 BR 112014000563 A2 BR112014000563 A2 BR 112014000563A2 BR 112014000563 A BR112014000563 A BR 112014000563A BR 112014000563 A2 BR112014000563 A2 BR 112014000563A2
Authority
BR
Brazil
Prior art keywords
compound
compounds
pharmaceutical composition
hepatitis
disease
Prior art date
Application number
BR112014000563-0A
Other languages
English (en)
Inventor
Zhang Jiancun
Zhang Yingjun
Xie Hongming
Ren Qingyun
Luo Huichao
Yu Tianzhu
Tan Yumei
Original Assignee
Sunshine Lake Pharma Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunshine Lake Pharma Co., Ltd filed Critical Sunshine Lake Pharma Co., Ltd
Publication of BR112014000563A2 publication Critical patent/BR112014000563A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

composto, composição farmacêutica, e, uso do composto são divulgados os compostos de espiro da fórmula (i), ou estereoisômeros, isômeros geométricos, tautômeros, óxidos de nitrogênio, hidratos, solvatos, metabólitos, sais farmaceuticamente aceitáveis ou prómedicamentos do mesmo. os compostos podem ser usados para a infecção pelo vírus da hepatite c (hcv) ou doença pela hepatite c. além disso são divulgadas composições farmacêuticas contendo os compostos e o método de usar os compostos ou composições farmacêuticas no tratamento da infecção pelo hcv ou doença pela hepatite c.
BR112014000563-0A 2011-07-09 2012-07-09 composto, composição farmacêutica, e, uso do composto BR112014000563A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201110195113 2011-07-09
CN201110195113.8 2011-07-09
PCT/CN2012/000945 WO2013007106A1 (zh) 2011-07-09 2012-07-09 作为丙型肝炎病毒抑制剂的螺环化合物

Publications (1)

Publication Number Publication Date
BR112014000563A2 true BR112014000563A2 (pt) 2019-12-10

Family

ID=47442590

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000563-0A BR112014000563A2 (pt) 2011-07-09 2012-07-09 composto, composição farmacêutica, e, uso do composto

Country Status (11)

Country Link
US (1) US9303061B2 (pt)
EP (1) EP2730572B1 (pt)
JP (1) JP2014520822A (pt)
KR (1) KR20140053166A (pt)
CN (1) CN102863428B (pt)
AU (1) AU2012283609B2 (pt)
BR (1) BR112014000563A2 (pt)
CA (1) CA2841095A1 (pt)
HK (1) HK1191935A1 (pt)
TW (1) TWI482766B (pt)
WO (1) WO2013007106A1 (pt)

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TW201412709A (zh) * 2012-09-28 2014-04-01 Sunshine Lake Pharma Co Ltd 作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用
TWI585082B (zh) * 2012-11-29 2017-06-01 廣東東陽光藥業有限公司 作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們的用途
TW201439060A (zh) * 2013-02-27 2014-10-16 Sunshine Lake Pharma Co Ltd 作爲丙型肝炎抑制劑的橋環化合物及其藥物組合物和用途
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CN116120272A (zh) * 2022-12-31 2023-05-16 淮北师范大学 一种合成咯菌腈中间体2,2-二氟-1,3-苯并二噁茂-4-甲醛的方法

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Also Published As

Publication number Publication date
KR20140053166A (ko) 2014-05-07
HK1191935A1 (en) 2014-08-08
CN102863428B (zh) 2014-12-24
CN102863428A (zh) 2013-01-09
TW201302731A (zh) 2013-01-16
EP2730572A4 (en) 2014-12-10
TWI482766B (zh) 2015-05-01
AU2012283609A1 (en) 2014-02-20
US20140147412A1 (en) 2014-05-29
US9303061B2 (en) 2016-04-05
EP2730572B1 (en) 2015-09-16
CA2841095A1 (en) 2013-01-17
JP2014520822A (ja) 2014-08-25
EP2730572A1 (en) 2014-05-14
AU2012283609B2 (en) 2016-09-29
WO2013007106A1 (zh) 2013-01-17

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