MA34169B1 - Dérivés d'acide 1-amino-2-cyclopropyléthylboronique - Google Patents

Dérivés d'acide 1-amino-2-cyclopropyléthylboronique

Info

Publication number
MA34169B1
MA34169B1 MA35323A MA35323A MA34169B1 MA 34169 B1 MA34169 B1 MA 34169B1 MA 35323 A MA35323 A MA 35323A MA 35323 A MA35323 A MA 35323A MA 34169 B1 MA34169 B1 MA 34169B1
Authority
MA
Morocco
Prior art keywords
cyclopropylethylboronic
amino
acid derivatives
relates
compositions
Prior art date
Application number
MA35323A
Other languages
English (en)
Inventor
Paul E Fleming
Jing Li
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34169(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of MA34169B1 publication Critical patent/MA34169B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Abstract

La présente invention concerne des nouveaux composés utiles comme inhibiteurs du protéasome. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention et des procédés employant les compositions dans le traitement de diverses maladies.
MA35323A 2010-03-31 2011-03-30 Dérivés d'acide 1-amino-2-cyclopropyléthylboronique MA34169B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31946410P 2010-03-31 2010-03-31
PCT/US2011/030455 WO2011123502A1 (fr) 2010-03-31 2011-03-30 Dérivés d'acide 1-amino-2-cyclopropyléthylboronique

Publications (1)

Publication Number Publication Date
MA34169B1 true MA34169B1 (fr) 2013-04-03

Family

ID=44710349

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35323A MA34169B1 (fr) 2010-03-31 2011-03-30 Dérivés d'acide 1-amino-2-cyclopropyléthylboronique

Country Status (25)

Country Link
US (3) US8513218B2 (fr)
EP (1) EP2552216B1 (fr)
JP (1) JP5933523B2 (fr)
KR (1) KR20130036228A (fr)
CN (3) CN102892291A (fr)
AR (1) AR080863A1 (fr)
AU (1) AU2011235227B2 (fr)
CA (1) CA2794334C (fr)
CL (1) CL2012002733A1 (fr)
CO (1) CO6630162A2 (fr)
CR (1) CR20120529A (fr)
DO (1) DOP2012000257A (fr)
EA (1) EA029521B1 (fr)
EC (1) ECSP12012249A (fr)
MA (1) MA34169B1 (fr)
MX (1) MX2012011298A (fr)
NZ (1) NZ602622A (fr)
PE (1) PE20130383A1 (fr)
RU (1) RU2012146101A (fr)
SG (1) SG184222A1 (fr)
TN (1) TN2012000465A1 (fr)
UA (1) UA110612C2 (fr)
UY (1) UY33314A (fr)
WO (1) WO2011123502A1 (fr)
ZA (2) ZA201207406B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1948678E (pt) 2005-11-09 2013-07-16 Onyx Therapeutics Inc Compostos para inibição de enzimas
US7691852B2 (en) 2006-06-19 2010-04-06 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
KR20170040374A (ko) 2007-10-04 2017-04-12 오닉스 세라퓨틱스, 인크. 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
DK2730581T3 (en) 2008-06-17 2016-08-15 Millennium Pharm Inc Boronate Ester Compounds and Pharmaceutical Compositions thereof.
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
MX2011004225A (es) 2008-10-21 2011-06-21 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (fr) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Utilisation de peptides epoxycetones pour la suppression de la metastase
MA34133B1 (fr) 2010-03-01 2013-04-03 Onyx Therapeutics Inc Composes pour inhibiteurs de l'immunoproteasome
CN102892291A (zh) 2010-03-31 2013-01-23 米伦纽姆医药公司 1-氨基-2-环丙基乙硼酸衍生物
CN103180328B (zh) 2010-08-10 2016-10-26 莱姆派克斯制药公司 环硼酸酯衍生物及其治疗用途
WO2013071142A1 (fr) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarqueurs de la sensibilité à des inhibiteurs du protéasome
JP6286358B2 (ja) 2011-11-11 2018-02-28 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤に応答するバイオマーカー
BR112014015363A2 (pt) * 2011-12-22 2017-06-13 Ares Trading Sa derivados de ácido alfa-amino borônico, inibidores de imunoproteassoma seletivos
JP6215235B2 (ja) 2012-01-24 2017-10-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌の治療方法
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
CN103570806B (zh) * 2012-07-26 2020-04-07 圣特莱国际公司 多肽环氧酮化合物
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EA201591003A1 (ru) 2013-01-04 2015-12-30 Ремпекс Фармасьютикалз, Инк. Производные бороновой кислоты и их терапевтическое применение
MX2016003979A (es) 2013-10-03 2016-06-15 Millennium Pharm Inc Metodo para profilaxis o tratamiento de lupus eritematoso sistemico y/o nefritis lupica.
US9988421B2 (en) 2014-01-10 2018-06-05 Cornell University Dipeptides as inhibitors of human immunoproteasomes
WO2015171398A1 (fr) 2014-05-05 2015-11-12 Rempex Pharmaceuticals, Inc. Sels et polymorphes de dérivés cycliques d'ester d'acide boronique, et leurs utilisations thérapeutiques
HUE046836T2 (hu) 2014-05-05 2020-03-30 Rempex Pharmaceuticals Inc Boronát sók szintézise és alkalmazásuk
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
AU2015264272A1 (en) 2014-05-20 2016-11-24 Millennium Pharmaceuticals, Inc. Boron-containing proteasome inhibitors for use after primary cancer therapy
AU2015284307A1 (en) * 2014-07-01 2017-02-02 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3177292B1 (fr) 2014-08-07 2020-11-25 Mayo Foundation for Medical Education and Research Composés et méthodes de traitement du cancer
US11202817B2 (en) 2014-08-18 2021-12-21 Cornell University Dipeptidomimetics as inhibitors of human immunoproteasomes
WO2016081297A1 (fr) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Dérivés d'esters d'acide boronique cycliques et leurs utilisations thérapeutiques
WO2016149393A1 (fr) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Dérivés d'acide boronique et leurs utilisations thérapeutiques
EP3362754B1 (fr) 2015-10-15 2021-12-22 Cornell University Inhibiteurs des protéasomes et leurs utilisations
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
WO2018160717A1 (fr) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Composés et méthodes de traitement du cancer
JP7377545B2 (ja) 2017-10-11 2023-11-10 キューペックス バイオファーマ， インコーポレイテッド ボロン酸誘導体およびその合成
US11203613B2 (en) 2017-10-11 2021-12-21 Cornell University Peptidomimetic proteasome inhibitors
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ203706A (en) 1982-04-22 1986-03-14 Squibb & Sons Inc Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (fr) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Inhibiteurs de la rénine
US5159060A (en) 1988-05-27 1992-10-27 Mayo Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
US5106948A (en) 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
DE3827340A1 (de) 1988-08-12 1990-02-15 Hoechst Ag Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen
ATE149563T1 (de) 1992-08-14 1997-03-15 Procter & Gamble Alpha-aminoborsäurehaltige flüssige waschmittel
US5492900A (en) 1993-09-10 1996-02-20 Neutron Technology Corporation Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA)
US6060462A (en) 1993-10-20 2000-05-09 Dupont Pharmaceuticals Company Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
US5574017A (en) 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
AU741802B2 (en) 1997-02-15 2001-12-13 Millennium Pharmaceuticals, Inc. Treatment of infarcts through inhibition of NF-kappaB
JP2001517631A (ja) 1997-09-25 2001-10-09 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症疾患および自己免疫疾患を治療するためのプロテアソーム阻害剤、ユビキチン経路阻害剤、またはユビキチンプロテアソーム経路を介したＮＦ−κＢの活性化に干渉する剤
CA2314259A1 (fr) 1997-12-16 1999-06-24 Robert Siman Inhibiteurs de protease multicatalytique, utiles en tant qu'agents antitumoraux
US6169076B1 (en) 1999-03-31 2001-01-02 Glcosyn Pharmaceuticals, Inc. P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols
CA2376965A1 (fr) 1999-07-07 2001-01-11 Timothy Patrick Forsyth Inhibiteurs de la protease du virus de l'hepatite c a base d'acide boronique peptide
US7122627B2 (en) * 1999-07-26 2006-10-17 Bristol-Myers Squibb Company Lactam inhibitors of Hepatitis C virus NS3 protease
BRPI0108435B8 (pt) 2000-02-29 2021-05-25 Bristol Myers Squibb Co formulação e uso de entecavir de baixa dose
US6846806B2 (en) 2000-10-23 2005-01-25 Bristol-Myers Squibb Company Peptide inhibitors of Hepatitis C virus NS3 protein
EP3078667B1 (fr) 2001-01-25 2018-11-21 The United States of America, represented by the Secretary, Department of Health and Human Services Formulation de composés d'acide boronique
WO2003033507A1 (fr) 2001-10-12 2003-04-24 Kyorin Pharmaceutical Co., Ltd. Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant
EP1463719A2 (fr) 2002-01-08 2004-10-06 Eisai Co., Ltd Analogues d'eponemycine et d'epoxomicine et leurs utilisations
US20060084592A1 (en) 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
TW200418791A (en) * 2003-01-23 2004-10-01 Bristol Myers Squibb Co Pharmaceutical compositions for inhibiting proteasome
UA88771C2 (ru) * 2003-08-14 2009-11-25 Сефалон, Инк. Ингибиторы протеасомы и способ их применения (варианты)
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
DK3385267T3 (da) 2004-03-30 2021-11-01 Millennium Pharm Inc Syntese af boronestere og syreforbindelser
KR20080030079A (ko) 2005-07-05 2008-04-03 트러스티즈 오브 터프츠 칼리지 섬유아세포 활성 단백질 알파의 억제제
EP2029153A2 (fr) 2006-01-27 2009-03-04 Phenomix Corporation Inhibiteurs de la sérine protéase de l'hépatite c et leurs utilisations
WO2009006473A2 (fr) 2007-07-05 2009-01-08 Trustees Of Tufts College Inhibiteurs promedicaments doux de proteasome polypeptidique et methodes d'utilisation associees
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
GEP20125599B (en) 2007-08-06 2012-08-10 Millennium Pharm Inc Proteasome inhibitors
DK2730581T3 (en) * 2008-06-17 2016-08-15 Millennium Pharm Inc Boronate Ester Compounds and Pharmaceutical Compositions thereof.
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
CN102892291A (zh) 2010-03-31 2013-01-23 米伦纽姆医药公司 1-氨基-2-环丙基乙硼酸衍生物

Also Published As

Publication number Publication date
CN106008570A (zh) 2016-10-12
US20110245203A1 (en) 2011-10-06
US20140011998A1 (en) 2014-01-09
DOP2012000257A (es) 2012-11-15
CL2012002733A1 (es) 2013-01-25
AU2011235227B2 (en) 2016-09-08
US8513218B2 (en) 2013-08-20
CN107266485A (zh) 2017-10-20
CR20120529A (es) 2013-01-11
PE20130383A1 (es) 2013-04-24
WO2011123502A1 (fr) 2011-10-06
MX2012011298A (es) 2012-11-06
AR080863A1 (es) 2012-05-16
TN2012000465A1 (en) 2014-01-30
ECSP12012249A (es) 2012-11-30
ZA201308086B (en) 2015-03-25
JP5933523B2 (ja) 2016-06-08
SG184222A1 (en) 2012-10-30
KR20130036228A (ko) 2013-04-11
UY33314A (es) 2011-10-31
UA110612C2 (uk) 2016-01-25
EP2552216A4 (fr) 2013-07-31
CA2794334C (fr) 2018-06-12
US20140179631A1 (en) 2014-06-26
AU2011235227A1 (en) 2012-10-18
RU2012146101A (ru) 2014-05-10
EA029521B1 (ru) 2018-04-30
NZ602622A (en) 2015-01-30
US9023832B2 (en) 2015-05-05
ZA201207406B (en) 2014-01-29
CO6630162A2 (es) 2013-03-01
CN102892291A (zh) 2013-01-23
US8703743B2 (en) 2014-04-22
EP2552216B1 (fr) 2018-01-24
JP2013523760A (ja) 2013-06-17
EP2552216A1 (fr) 2013-02-06
EA201290980A1 (ru) 2013-03-29
CA2794334A1 (fr) 2011-10-06

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