CA2660286A1 - Organ-specific proteins and methods of their use - Google Patents
Organ-specific proteins and methods of their use Download PDFInfo
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- CA2660286A1 CA2660286A1 CA002660286A CA2660286A CA2660286A1 CA 2660286 A1 CA2660286 A1 CA 2660286A1 CA 002660286 A CA002660286 A CA 002660286A CA 2660286 A CA2660286 A CA 2660286A CA 2660286 A1 CA2660286 A1 CA 2660286A1
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- organ
- specific proteins
- specific
- disease
- detection reagents
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Families Citing this family (375)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| EP1831370A4 (en) | 2004-12-13 | 2009-08-12 | Alethia Biotherapeutics Inc | POLYNUCLEOTIDES AND POLYPEPTIDE SEQUENCES INVOLVED IN BONE RESOLUTION |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| CA2822302A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| ES2444695T3 (es) * | 2006-06-23 | 2014-02-26 | Alethia Biotherapeutics Inc. | Polinucleótidos y polipéptidos implicados en el cáncer |
| US20120128661A1 (en) * | 2006-06-23 | 2012-05-24 | Alethia Biotherapeutics Inc. | Polynucleotide and polypeptide sequences involved in cancer |
| AU2007284651B2 (en) * | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| EP2069793B9 (en) | 2006-08-29 | 2017-08-16 | Oxford BioTherapeutics Ltd | Identification of protein associated with hepatocellular carcinoma, glioblastoma and lung cancer |
| WO2008057795A2 (en) * | 2006-10-27 | 2008-05-15 | Temple University - Of The Commonwealth System Of Higher Education | Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera |
| US20100143949A1 (en) * | 2006-10-31 | 2010-06-10 | George Mason Intellectual Properties, Inc. | Biomarkers for colorectal cancer |
| EP2450368A1 (en) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| WO2008104803A2 (en) | 2007-02-26 | 2008-09-04 | Oxford Genome Sciences (Uk) Limited | Proteins |
| US20090062144A1 (en) * | 2007-04-03 | 2009-03-05 | Nancy Lan Guo | Gene signature for prognosis and diagnosis of lung cancer |
| WO2008128161A2 (en) * | 2007-04-13 | 2008-10-23 | University Of Florida Research Foundation Inc. | Identification of cardiac specific myosin light chain kinase |
| US8664359B2 (en) | 2007-06-03 | 2014-03-04 | Oncotx, Inc. | Cancer related isoforms of components of transcription factor complexes as biomarkers and drug targets |
| FR2919061B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal. |
| JP5715817B2 (ja) | 2007-07-19 | 2015-05-13 | ビオメリューBiomerieux | 結腸直腸癌のインビトロ診断のための肝臓脂肪酸結合タンパク質、ceaおよびca19−9のアッセイのための方法 |
| FR2919063B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal. |
| FR2919060B1 (fr) | 2007-07-19 | 2012-11-30 | Biomerieux Sa | Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal. |
| FR2919062B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'aminoacylase 1 pour le diagnostic in vitro du cancer colorectal. |
| FR2919064B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine all pour le diagnostic in vitro du cancer colorectal |
| FR2919065B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal |
| CA2694112A1 (en) * | 2007-07-20 | 2009-01-29 | The University Of Utah Research Foundation | Identification and quantification of biomarkers for evaluating the risk of preterm birth |
| DE102007036678B4 (de) * | 2007-08-03 | 2015-05-21 | Sirs-Lab Gmbh | Verwendung von Polynukleotiden zur Erfassung von Genaktivitäten für die Unterscheidung zwischen lokaler und systemischer Infektion |
| CN102099055A (zh) * | 2007-10-04 | 2011-06-15 | 津莫吉尼蒂克斯公司 | B7家族成员zB7H6及相关的组合物和方法 |
| US9808506B2 (en) | 2007-10-19 | 2017-11-07 | Rappaport Family Institute For Research In The Medical Sciences | Compositions comprising semaphorins for the treatment of cancer and methods of selection thereof |
| EP2781223B1 (en) * | 2007-10-19 | 2017-02-22 | Rappaport Family Institute for Research in the Medical Sciences | Compositions comprising semaphorins for use in the treatment of cancer |
| AU2008316319A1 (en) * | 2007-10-23 | 2009-04-30 | Clinical Genomics Pty. Ltd. | A method of diagnosing neoplasms |
| US9404932B2 (en) * | 2007-11-05 | 2016-08-02 | Nordic Bioscience A/S | Pathology biomarker assay |
| EP2235189A1 (en) * | 2008-01-14 | 2010-10-06 | Genentech, Inc. | Methods for inhibiting angiogenesis using egfl8 antagonists |
| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| BRPI0909044B8 (pt) | 2008-03-14 | 2021-05-25 | Transgene Sa | anticorpo que se liga especificamente ao csf-1r humano,composição farmacêutica e uso dos mesmos |
| EP2279414A4 (en) * | 2008-04-21 | 2011-06-29 | Merck Sharp & Dohme | PANCREATIC BETA CELL MASSE BIOMARKERS |
| US8173369B2 (en) * | 2008-05-15 | 2012-05-08 | The Regents Of The University Of California | Peripheral gene expression biomarkers for autism |
| JP5428527B2 (ja) * | 2008-06-03 | 2014-02-26 | 住友化学株式会社 | 化学物質が有する発生毒性の予測方法 |
| FR2933773B1 (fr) * | 2008-07-10 | 2013-02-15 | Biomerieux Sa | Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal |
| JP2011529453A (ja) * | 2008-07-31 | 2011-12-08 | ホスピタル クリニク アイ プロビンシアル デ バルセロナ | 健康な腎臓のバイオマーカ |
| EP2161031A1 (en) * | 2008-09-05 | 2010-03-10 | SuppreMol GmbH | Fc gamma receptor for the treatment of B cell mediated multiple sclerosis |
| CA2740900C (en) | 2008-11-03 | 2019-09-24 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| US8465980B2 (en) | 2009-01-28 | 2013-06-18 | Industrial Technology Research Institute | Urine and serum biomarkers associated with diabetic nephropathy |
| PT2391653E (pt) | 2009-01-28 | 2015-02-13 | Ind Tech Res Inst | Biomarcadores associados a nefropatia |
| EP2524928A1 (en) * | 2011-05-18 | 2012-11-21 | Atlas Antibodies AB | RBM3 in bladder cancer |
| EP2221066A1 (en) | 2009-02-18 | 2010-08-25 | Sanofi-Aventis | Use of VgII3 activity modulator for the modulation of adipogenesis |
| EP2403864B1 (en) | 2009-02-27 | 2015-08-12 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| CN102341412B (zh) | 2009-03-05 | 2018-01-05 | 梅达雷克斯有限责任公司 | 特异于cadm1 的全人抗体 |
| GB0904382D0 (en) * | 2009-03-13 | 2009-04-29 | Univ Dundee | Treatment of cell proliferation and differentiation disorders |
| AU2010226726B8 (en) | 2009-03-16 | 2014-08-14 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities |
| US20100310576A1 (en) | 2009-03-31 | 2010-12-09 | Adams Ryan A | COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES |
| US8399663B2 (en) | 2009-04-03 | 2013-03-19 | Astellas Pharma Inc. | Salt of 1,3,5-triazine-2,4,6-triamine derivative |
| WO2010115286A1 (en) * | 2009-04-09 | 2010-10-14 | Centre For Addiction And Mental Health | Dopamine d2 receptor-disc1 interaction, compositions and methods for modulating same |
| EP2438170A4 (en) * | 2009-06-05 | 2012-12-26 | Univ North Carolina | SOGA POLYNUCLEOTIDES AND POLYPEPTIDES AND ITS USES |
| WO2011006119A2 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| CN102695716B (zh) * | 2009-07-14 | 2016-03-02 | 独立行政法人产业技术综合研究所 | 肝病病情指标糖链标记物 |
| CA2768042C (en) * | 2009-07-24 | 2017-11-21 | Universite De Montreal | Bret-based biosensors and methods for monitoring raf dimerization |
| US9410965B2 (en) * | 2009-09-17 | 2016-08-09 | Battelle Energy Alliance, Llc | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual |
| WO2011039289A1 (de) * | 2009-09-29 | 2011-04-07 | Protagen Ag | Markersequenzen für pankreaskrebserkrankungen, pankreaskarzinom und deren verwendung |
| JP5695384B2 (ja) | 2009-10-05 | 2015-04-01 | 花王株式会社 | 毛髪形状感受性遺伝子 |
| JP5695383B2 (ja) | 2009-10-05 | 2015-04-01 | 花王株式会社 | 毛髪形状感受性遺伝子 |
| JP5695385B2 (ja) | 2009-10-05 | 2015-04-01 | 花王株式会社 | 毛髪形状感受性遺伝子 |
| US10288617B2 (en) | 2009-10-26 | 2019-05-14 | Externautics Spa | Ovary tumor markers and methods of use thereof |
| US8921058B2 (en) | 2009-10-26 | 2014-12-30 | Externautics Spa | Prostate tumor markers and methods of use thereof |
| US9588121B2 (en) | 2009-11-06 | 2017-03-07 | Go Therapeutics, Inc. | Method for early detection of cancer |
| EA034462B1 (ru) | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| PH12012500982A1 (en) | 2009-11-30 | 2019-07-10 | Genentech Inc | Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211=seqid2) |
| EP2507255A1 (en) * | 2009-12-01 | 2012-10-10 | Universita' Degli Studi Di Modena E Reggio Emilia | Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer |
| US9127268B2 (en) | 2009-12-11 | 2015-09-08 | Atyr Pharma, Inc. | Aminoacyl tRNA synthetases for modulating inflammation |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| WO2011100472A1 (en) * | 2010-02-10 | 2011-08-18 | The Regents Of The University Of California | Salivary transcriptomic and proteomic biomarkers for breast cancer detection |
| TWI622402B (zh) | 2010-02-24 | 2018-05-01 | 免疫遺傳股份有限公司 | 葉酸受體1抗體類和免疫共軛物類及彼等之用途 |
| EP2548888B1 (en) * | 2010-03-17 | 2017-11-01 | Kagoshima University | Periodontal-disease-specific peptide, and treatment and diagnosis of periodontal disease using same |
| SG184345A1 (en) * | 2010-03-31 | 2012-11-29 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| CA2797093C (en) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| AU2011248521B2 (en) | 2010-04-27 | 2017-03-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl tRNA synthetases |
| EP2563381B1 (en) | 2010-04-27 | 2017-08-09 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| EP2563383B1 (en) | 2010-04-29 | 2017-03-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| WO2011139387A1 (en) * | 2010-05-03 | 2011-11-10 | Opko Curna, Llc | Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt) |
| ES2668207T3 (es) | 2010-05-03 | 2018-05-17 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas |
| EP2566516B1 (en) | 2010-05-03 | 2019-07-03 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| AU2011248227B2 (en) | 2010-05-03 | 2016-12-01 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
| US8759298B2 (en) | 2010-05-03 | 2014-06-24 | Scott & White Healthcare | Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN103096909A (zh) | 2010-05-04 | 2013-05-08 | Atyr医药公司 | 与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| EP2568996B1 (en) | 2010-05-14 | 2017-10-04 | aTyr Pharma, Inc. | Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| GB201008541D0 (en) * | 2010-05-21 | 2010-07-07 | Univ Geneve | Diagnostic methods |
| CN103096913B (zh) | 2010-05-27 | 2017-07-18 | Atyr 医药公司 | 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| EP2577316B1 (en) | 2010-05-31 | 2017-02-08 | University Hospital of Basel | Method for assaying lower respiratory tract infection or inflammation |
| CA2800281C (en) | 2010-06-01 | 2021-01-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| EP2577315B1 (en) | 2010-06-03 | 2017-04-12 | Idexx Laboratories, Inc. | Markers for renal disease |
| AU2015230872B2 (en) * | 2010-06-03 | 2017-05-11 | Idexx Laboratories, Inc. | Markers for renal disease |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| KR20130102534A (ko) | 2010-07-12 | 2013-09-17 | 에이티와이알 파마, 인코포레이티드 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| KR20180059575A (ko) | 2010-07-12 | 2018-06-04 | 에이티와이알 파마, 인코포레이티드 | 아스파르틸trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| WO2012021887A2 (en) | 2010-08-13 | 2012-02-16 | Arizona Borad Of Regents, A Body Corporate Acting For And On Behalf Of Arizona State University | Biomarkers for the early detection of breast cancer |
| EP2618147A4 (en) * | 2010-08-16 | 2014-11-26 | Univ Kyushu Nat Univ Corp | REAGENT FOR TUMOR TESTS AND PHARMACEUTICAL COMPOSITION FOR TUMOR PREVENTION |
| CN103108650A (zh) | 2010-08-25 | 2013-05-15 | Atyr医药公司 | 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2012031082A2 (en) * | 2010-09-02 | 2012-03-08 | University Of The Sciences In Philadelphia | System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry |
| WO2012035066A1 (en) * | 2010-09-14 | 2012-03-22 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschften E.V. | Hot1 and uses thereof |
| WO2012038503A1 (en) * | 2010-09-23 | 2012-03-29 | Qiagen Gmbh | Method for detecting and/or quantifying human dna |
| CN103118696B (zh) | 2010-10-06 | 2020-02-14 | Atyr 医药公司 | 与色氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物 |
| FR2968560A1 (fr) * | 2010-12-13 | 2012-06-15 | Oreal | Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu |
| CN103403187A (zh) * | 2011-01-18 | 2013-11-20 | 艾沃锐斯特基因有限公司 | 结肠直肠癌复发的预后特征 |
| US9364414B2 (en) | 2011-02-01 | 2016-06-14 | Isp Investments Inc. | Method to protect skin from ultraviolet radiation using novel peptides involved in the improvement of microparasol organization in keratinocytes |
| FR2970968A1 (fr) * | 2011-02-01 | 2012-08-03 | Isp Investments Inc | Nouveaux peptides intervenant dans la voie de signalisation scf c-kit et compositions les comprenant |
| WO2012106175A1 (en) * | 2011-02-02 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Trrap and grin2a mutations and use thereof for the diagnosis and treatment of melanoma |
| WO2012118988A1 (en) * | 2011-03-01 | 2012-09-07 | The Scripps Research Institute | Direct reprogramming of human fibroblasts to functional neurons under defined conditions |
| JP2012197258A (ja) * | 2011-03-23 | 2012-10-18 | Tohoku Univ | 個別化治療診断のためのマーカータンパク質絶対量の定量方法 |
| CA2831074A1 (en) * | 2011-03-26 | 2012-10-04 | Oregon Health And Science University | Gene expression predictors of cancer prognosis |
| JP5800180B2 (ja) * | 2011-03-28 | 2015-10-28 | 国立大学法人 長崎大学 | 日焼けの原因遺伝子 |
| SI3173427T1 (sl) | 2011-03-31 | 2019-08-30 | ADC Therapeutics SA, | Protitelesa proti antigenu 1, povezanemu z ledvicami, in antigen vezavni fragmenti le-tega |
| BR112013025415B1 (pt) | 2011-04-01 | 2021-03-16 | Immunogen, Inc | uso de um imunoconjugado antirreceptor de folato 1 (folr1) |
| EP3351641A1 (en) | 2011-04-08 | 2018-07-25 | Tufts Medical Center, Inc. | Pepducin design and use |
| NZ713461A (en) * | 2011-04-15 | 2017-02-24 | Compugen Ltd | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| EP2697653B1 (en) | 2011-04-15 | 2016-03-30 | Children's Medical Center Corporation | Diagnostic markers and therapeutic targets of kawasaki disease |
| US9611292B2 (en) * | 2011-04-27 | 2017-04-04 | The Board Of Regents Of The University Of Texas System | Peptide inhibitors of serotonin 5-HT2c receptors:PTEN interaction |
| CA2835806A1 (en) * | 2011-05-13 | 2012-11-22 | King's College London | Methods and compositions relating to platelet sensitivity |
| BR112013030381B1 (pt) | 2011-05-27 | 2021-10-26 | University Of Washington Through Its Center For Commercialization | Produto de cuidado oral |
| US8455624B2 (en) * | 2011-06-03 | 2013-06-04 | University Of South Alabama | Methods and compositions for detecting endometrial or ovarian cancer |
| EP2738250B1 (en) * | 2011-07-26 | 2017-11-15 | National Institute of Advanced Industrial Science And Technology | Anti-beta1,6-N-acetylglucosaminyltransferase 5B antibody for detecting epithelial ovarian cancer and method for diagnosing epithelial ovarian cancer |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
| CN102337285A (zh) * | 2011-10-25 | 2012-02-01 | 上海交通大学医学院附属仁济医院 | 一种含HIhh的逆转录病毒载体和病毒颗粒及其应用 |
| EP2780472A4 (en) * | 2011-11-15 | 2015-10-28 | Oncocyte Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF BUBBLE CANCER |
| WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| EP2794645A1 (en) * | 2011-12-21 | 2014-10-29 | Regents of the University of Minnesota | Cationic peptides and use of such peptides for inhibiting exotoxin production |
| CA2858613A1 (en) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
| KR102102239B1 (ko) | 2012-01-09 | 2020-04-21 | 에이디씨 테라퓨틱스 에스에이 | 유방암을 치료하기 위한 방법 |
| JP6266347B2 (ja) | 2012-01-16 | 2018-01-24 | ライオン株式会社 | メタボリックシンドローム罹患リスク判定用マーカーペプチドおよびその用途 |
| DE102012100781B4 (de) | 2012-01-31 | 2013-08-14 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Forensisches Verfahren |
| EP2814514B1 (en) | 2012-02-16 | 2017-09-13 | Atyr Pharma, Inc. | Histidyl-trna synthetases for treating autoimmune and inflammatory diseases |
| WO2013126402A1 (en) * | 2012-02-20 | 2013-08-29 | University Of Virginia Patent Foundation | Composition and methods for treating melanoma |
| US9822170B2 (en) | 2012-02-22 | 2017-11-21 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer |
| CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| WO2013135836A1 (en) * | 2012-03-14 | 2013-09-19 | Centre Hospitalier Universitaire Pontchaillou | Itih5 as a diagnostic marker of uterine development and functional defects |
| WO2013151665A2 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| WO2013155567A1 (en) * | 2012-04-20 | 2013-10-24 | Mat Malta Advanced Technologies Limited | Sex determination genes |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| JP6441215B2 (ja) * | 2012-05-16 | 2018-12-19 | エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. | 肺組織像を細分類するためのsrm/mrm分析 |
| EP2852399B1 (en) * | 2012-05-21 | 2020-02-19 | The Regents of The University of Colorado, A Body Corporate | Ledgf peptides and formulations thereof for treatment of degenerative disorders |
| WO2013184482A1 (en) * | 2012-06-04 | 2013-12-12 | Yale University | Method of treating and preventing ocular angiogenesis |
| EP3202419A1 (en) * | 2012-06-06 | 2017-08-09 | OncoMed Pharmaceuticals, Inc. | Pvrig binding agents that modulate the hippo pathway and uses thereof |
| CA2877721A1 (en) | 2012-06-27 | 2014-01-03 | Berg Llc | Use of markers in the diagnosis and treatment of prostate cancer |
| WO2014003580A1 (en) * | 2012-06-28 | 2014-01-03 | Caldera Health Ltd | Targeted rna-seq methods and materials for the diagnosis of prostate cancer |
| HK1210192A1 (en) | 2012-07-19 | 2016-04-15 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| US9200073B2 (en) | 2012-08-31 | 2015-12-01 | Immunogen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| US9120841B2 (en) | 2012-09-28 | 2015-09-01 | Agency For Science, Technology And Research | Amphiphilic linear peptidepeptoid and hydrogel comprising the same |
| WO2014066392A2 (en) * | 2012-10-22 | 2014-05-01 | Gaston Benjamin M | Compositions and methods for regulating arterial tone |
| US11230589B2 (en) | 2012-11-05 | 2022-01-25 | Foundation Medicine, Inc. | Fusion molecules and uses thereof |
| EP2914621B1 (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
| EP2918600B1 (en) * | 2012-11-06 | 2019-04-24 | University of Miyazaki | Novel peptide and use thereof |
| JP6196034B2 (ja) * | 2012-12-20 | 2017-09-13 | ライオン株式会社 | 高血糖リスク判定用マーカーペプチドおよびその用途 |
| CN105492023A (zh) * | 2012-12-21 | 2016-04-13 | 加利福尼亚大学董事会 | Tspan 33是用于治疗b细胞霍奇金淋巴瘤的抗体靶向疗法的候选物 |
| SG2012096699A (en) * | 2012-12-31 | 2014-07-30 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| CA3150658A1 (en) | 2013-01-18 | 2014-07-24 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| EP2966087B1 (en) | 2013-03-08 | 2020-05-06 | Osaka University | Antibody against peptide encoded by exon-21 of periostin, and pharmaceutical composition for preventing or treating inflammation-associated diseases containing the same |
| US20160039877A1 (en) | 2013-03-15 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| ES2708565T3 (es) | 2013-03-15 | 2019-04-10 | Atyr Pharma Inc | Conjugados de Fc-histidil-ARNt sintetasa |
| TWI522367B (zh) * | 2013-04-12 | 2016-02-21 | 長庚大學 | Urine biomarkers are used to predict bladder and kidney cancer |
| JP6498114B2 (ja) * | 2013-04-25 | 2019-04-10 | 国立大学法人 宮崎大学 | 成人t細胞白血病の診断方法および成人t細胞白血病の治療薬のスクリーニング方法 |
| US20160097100A1 (en) * | 2013-05-17 | 2016-04-07 | Jeffrey Trent | Genetic test to predict patient response to bone morphogenetic protein in arthrodesis |
| GB2529585A (en) * | 2013-05-30 | 2016-02-24 | Memorial University Of Newfoundland | Methods and compositions for detecting progressive hearing loss |
| CN103319571B (zh) * | 2013-05-30 | 2015-04-08 | 北京正旦国际科技有限责任公司 | 一种鼻咽癌放疗敏感性多肽标志物spg03及其elisa试剂盒 |
| GB201310203D0 (en) * | 2013-06-07 | 2013-07-24 | Electrophoretics Ltd | Materials and methods relating to Alzheimer's disease |
| WO2014199780A1 (ja) * | 2013-06-12 | 2014-12-18 | マルハニチロ株式会社 | ジペプチジルペプチダーゼiv(dppiv)阻害ペプチド化合物、それを含有する組成物、及びその製造方法 |
| EP3013332A4 (en) * | 2013-06-24 | 2017-05-31 | Duke University | Cancer treatment |
| WO2014205507A1 (en) * | 2013-06-28 | 2014-12-31 | Newsouth Innovations Pty Limited | Diagnostic method |
| KR102758333B1 (ko) | 2013-08-28 | 2025-01-23 | 벡톤 디킨슨 앤드 컴퍼니 | 대량의 동시 단일 세포 분석 |
| CN113150145B (zh) | 2013-08-30 | 2025-02-14 | 伊缪诺金公司 | 用于检测叶酸受体1的抗体和测定 |
| LT3052628T (lt) | 2013-10-04 | 2020-09-10 | Alnylam Pharmaceuticals, Inc. | Kompozicijos ir būdai alas1 geno raiškai nuslopinti |
| CN105745224B (zh) | 2013-10-11 | 2019-11-05 | 牛津生物疗法有限公司 | 用于治疗癌症的针对ly75的偶联抗体 |
| ES2730429T3 (es) | 2013-10-18 | 2019-11-11 | Univ Do Minho | Composición peptídica y usos de la misma |
| IL229134A0 (en) * | 2013-10-29 | 2014-03-31 | Omrix Biopharmaceuticals Ltd | Compounds and methods for stabilizing thrombin activity |
| EP3083946B1 (en) | 2013-12-16 | 2024-08-07 | The University of North Carolina at Chapel Hill | Depletion of plasmacytoid dendritic cells |
| US10035848B2 (en) | 2014-01-08 | 2018-07-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody targeting cell surface deposited complement protein C3d and use thereof |
| CN103756984B (zh) * | 2014-02-18 | 2015-10-14 | 吉林大学 | 高活力谷胱甘肽过氧化物酶gpx2突变体及其制备方法 |
| JP6825910B2 (ja) * | 2014-03-26 | 2021-02-03 | ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) | Flattop(Fltp)はβ細胞成熟についての新規のバイオマーカーである |
| US10344285B2 (en) | 2014-04-09 | 2019-07-09 | Dna2.0, Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
| JP6721571B2 (ja) * | 2014-04-18 | 2020-07-15 | ▲煙▼台聚▲傑▼生物工程有限公司 | 15種類の男性生殖関連タンパク質またはその組み合わせの使用 |
| BR122021009041B1 (pt) | 2014-05-06 | 2022-11-29 | Genentech, Inc | Métodos para a preparação de uma proteína heteromultimérica |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| GB201409519D0 (en) * | 2014-05-29 | 2014-07-16 | Univ Leicester | Senescent cell biomarkers |
| WO2015187992A2 (en) * | 2014-06-05 | 2015-12-10 | The Regents Of The University Of Colorado, A Body Corporate | Map44 polypeptides and constructs based on natural antibodies and uses thereof |
| CN105879053A (zh) * | 2014-09-26 | 2016-08-24 | 北京大学 | Cmtm1-v5基因及其编码蛋白的应用 |
| WO2016054075A1 (en) * | 2014-09-29 | 2016-04-07 | University Of Rochester | U2af65 variants and uses thereof |
| WO2016054114A1 (en) | 2014-09-29 | 2016-04-07 | The Regents Of The University Of California | Compositions for expanding regulatory t cells (treg), and treating autoimmune and inflammatory diseases and conditions |
| ES2568702B1 (es) * | 2014-10-01 | 2017-02-13 | Servizo Galego De Saude (Sergas) | Método para el diagnóstico de artrosis |
| WO2016049770A1 (en) * | 2014-10-01 | 2016-04-07 | Centre For Addiction And Mental Health | Markers for mood disorders |
| CN104225088A (zh) * | 2014-10-06 | 2014-12-24 | 李先强 | 治疗慢性肺心病的混合中药 |
| US10539566B2 (en) | 2014-12-08 | 2020-01-21 | Berg Llc | Use of markers including filamin A in the diagnosis and treatment of prostate cancer |
| CA2969659A1 (en) * | 2014-12-09 | 2016-06-16 | Sapporo Medical University | Tumor antigen peptide |
| US10485846B2 (en) * | 2014-12-12 | 2019-11-26 | Tufts University | Collagenase-derived peptides promote tissue regeneration and wound healing |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| MA49156A (fr) | 2014-12-23 | 2020-03-25 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
| CN104673762B (zh) * | 2015-01-19 | 2017-10-20 | 江苏大学 | 抗泛素连接酶Nedd4‑1的特异性抗体及其应用 |
| CN105985423A (zh) * | 2015-01-30 | 2016-10-05 | 天津奥维亚生物技术有限公司 | 一种人c1qb多肽及其抗体制备方法 |
| US20180002692A1 (en) * | 2015-01-30 | 2018-01-04 | Anushree Chatterjee | Sequence Specific and Organism Specific Antimicrobials and Related Materials and Methods |
| EP3259283B1 (en) * | 2015-02-17 | 2021-06-09 | Santonico, Elena | Hybrid protein for the identification of neddylated substrates |
| DK3653221T5 (da) | 2015-02-19 | 2024-08-26 | Compugen Ltd | Anti-pvrig-antistoffer og anvendelsesfremgangsmåder |
| US10550173B2 (en) | 2015-02-19 | 2020-02-04 | Compugen, Ltd. | PVRIG polypeptides and methods of treatment |
| WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| LT3388075T (lt) | 2015-03-27 | 2023-11-10 | Immatics Biotechnologies Gmbh | Nauji peptidai ir peptidų deriniai, skirti naudoti imunoterapijai prieš įvairius navikus (seq id 25 - mrax5-003) |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| MX2017012426A (es) | 2015-04-03 | 2018-01-26 | Ionis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de tmprss6. |
| EP4582556A3 (en) | 2015-04-23 | 2025-10-08 | Becton, Dickinson and Company | Methods and compositions for whole transcriptome amplification |
| GB201507030D0 (en) * | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
| CN114085283A (zh) * | 2015-05-19 | 2022-02-25 | 拉·约拉过敏反应及免疫医学研究所 | 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途 |
| WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
| EP3304084B1 (en) | 2015-06-08 | 2022-03-23 | Arquer Diagnostics Limited | Methods and kits |
| JP6854246B2 (ja) | 2015-06-08 | 2021-04-07 | アーケア ダイアグノスティクス リミテッド | 尿サンプルの分析方法 |
| HK1254818A1 (zh) | 2015-06-26 | 2019-07-26 | The Regents Of The University Of California | 抗原肽及其用於诊断和治疗自闭症的用途 |
| EP3115058A1 (fr) * | 2015-07-09 | 2017-01-11 | Institut Gustave Roussy | Peptides immunogenes de preprocalcitonine |
| US11254744B2 (en) | 2015-08-07 | 2022-02-22 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| EP3130680A1 (en) | 2015-08-11 | 2017-02-15 | Universitat de Girona | Method for the detection, follow up and/or classification of intestinal diseases |
| CA2994929A1 (en) * | 2015-08-12 | 2017-02-16 | Oncotherapy Science, Inc. | Depdc1-derived peptide and vaccine containing same |
| WO2017031342A1 (en) * | 2015-08-20 | 2017-02-23 | Rhode Island Hospital | Circulating biomarker for brugada syndrome |
| JP6757924B2 (ja) * | 2015-08-24 | 2020-09-23 | 国立大学法人 東京大学 | オキシトシン感受性予測マーカー |
| JP6940484B2 (ja) | 2015-09-11 | 2021-09-29 | セルラー リサーチ, インコーポレイテッド | ライブラリー正規化のための方法および組成物 |
| CN116440279B (zh) | 2015-09-17 | 2026-02-24 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| EP3359210B1 (en) * | 2015-10-08 | 2021-04-14 | Université de Genève | Periostin fragments and use thereof |
| CA3001312A1 (en) | 2015-10-08 | 2017-04-13 | Dna2.0, Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
| CN108779181A (zh) * | 2015-10-16 | 2018-11-09 | 国立输血研究院 | 生产红细胞蛋白质的方法 |
| KR20180100302A (ko) | 2015-10-23 | 2018-09-10 | 우니베르지태트 트벤테 | 인테그린 결합 펩티드 및 그의 용도 |
| EP3373950B1 (en) | 2015-11-11 | 2024-05-01 | Serimmune Inc. | Methods and compositions for assessing antibody specificities |
| WO2017083618A1 (en) | 2015-11-13 | 2017-05-18 | Oasis Pharmaceuticals, LLC | Protease-activated receptor-2 modulators |
| KR102877920B1 (ko) | 2015-11-16 | 2025-10-30 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 티틴-기반 근증 및 다른 티틴성병증의 치료를 위한 물질 및 방법 |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520542D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| GB201607534D0 (en) * | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| PE20230343A1 (es) | 2015-12-11 | 2023-03-01 | Immatics Biotechnologies Gmbh | Peptidos que estimulan respuestas inmunitarias antitumorales |
| GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| CN109072219B (zh) * | 2015-12-28 | 2024-02-27 | 北海道公立大学法人札幌医科大学 | 肿瘤抗原肽 |
| CN105622742B (zh) * | 2016-02-22 | 2019-01-18 | 西安交通大学 | 一种孤独症血清多肽标志物fabp1-a及其应用 |
| EP4299586A3 (en) | 2016-03-02 | 2024-04-03 | Idexx Laboratories, Inc. | Methods and compositions for the detection and diagnosis of renal disease and periodontal disease |
| CN109071605A (zh) | 2016-04-06 | 2018-12-21 | 伊玛提克斯生物技术有限公司 | 用于aml和其他癌症免疫治疗的新型肽和肽组合物 |
| LT3442600T (lt) | 2016-04-15 | 2024-05-27 | Research Institute At Nationwide Children's Hospital | Su adeno virusu susijusio viruso vektoriaus iš β-sarkoglikano ir mikro- rnr-29 pristatymas ir raumenų distrofijos gydymas |
| JP7129343B2 (ja) | 2016-05-02 | 2022-09-01 | ベクトン・ディキンソン・アンド・カンパニー | 正確な分子バーコーディング |
| WO2017190218A1 (en) * | 2016-05-06 | 2017-11-09 | University Health Network | Liquid-biopsy signatures for prostate cancer |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| CA2971303C (en) | 2016-06-21 | 2026-03-03 | Bamboo Therapeutics, Inc. | Optimized mini-dystrophin genes and expression cassettes and their use |
| TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
| US20240002459A1 (en) * | 2016-07-14 | 2024-01-04 | Emory University | Granulin Compositions and Uses Related Thereto |
| IL317989A (en) | 2016-08-17 | 2025-02-01 | Compugen Ltd | Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof |
| TWI796299B (zh) | 2016-08-26 | 2023-03-21 | 德商英麥提克生物技術股份有限公司 | 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架 |
| MY199468A (en) | 2016-09-23 | 2023-10-31 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
| CN109791157B (zh) | 2016-09-26 | 2022-06-07 | 贝克顿迪金森公司 | 使用具有条形码化的寡核苷酸序列的试剂测量蛋白质表达 |
| JP2020503840A (ja) * | 2016-10-07 | 2020-02-06 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | Hla拘束性vgll1ペプチドおよびその使用 |
| US11981943B2 (en) | 2016-10-11 | 2024-05-14 | University Of Iowa Research Foundation | Methods and composition for detecting CAPN5 |
| EP3450453A4 (en) * | 2016-12-27 | 2019-05-01 | Zhejiang University | LEG1 PROTEIN, LEG1 GEN, APPLICATIONS OF LEG1 PROTEIN AND LEG1 GENE AND MEDICAMENTS |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| ES2999550T3 (en) * | 2017-03-31 | 2025-02-26 | Alexion Pharma Inc | Method for simultaneous quantification of alxn1210 and eculizumab in human serum or urine |
| CA3060514A1 (en) | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| WO2018195416A1 (en) * | 2017-04-21 | 2018-10-25 | Mayo Foundation For Medical Education And Research | Polypeptide-antibody complexes and uses thereof |
| KR102606810B1 (ko) | 2017-05-05 | 2023-11-27 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 오토펄린을 발현시키기 위한 조성물 및 방법 |
| JP7348072B2 (ja) | 2017-06-01 | 2023-09-20 | コンピュジェン リミテッド | 三重併用抗体療法 |
| CN110719959B (zh) | 2017-06-05 | 2021-08-06 | 贝克顿迪金森公司 | 针对单细胞的样品索引 |
| WO2018225830A1 (ja) * | 2017-06-08 | 2018-12-13 | 国立大学法人宮崎大学 | 肺がんの検出方法 |
| WO2019006022A1 (en) * | 2017-06-27 | 2019-01-03 | The Broad Institute, Inc. | SYSTEMS AND METHODS FOR PREDICTING MHC CLASS II EPITOPE |
| CN107326090B (zh) * | 2017-08-23 | 2020-05-26 | 武汉大学 | 用于非小细胞肺癌诊断的血小板LncRNA的定量检测方法 |
| ES2702617B2 (es) * | 2017-09-04 | 2019-11-18 | Univ Rovira I Virgili | Hidrolizados de garras de patas de pollo, sus péptidos y usos de los mismos |
| KR102034929B1 (ko) * | 2017-09-27 | 2019-10-22 | 한양대학교 산학협력단 | Nckap1 단백질 또는 상기 단백질을 암호화하는 유전자를 포함하는 신경계 퇴행성질환의 예방 또는 치료용 약학적 조성물 |
| WO2019071116A1 (en) | 2017-10-05 | 2019-04-11 | Epivax, Inc. | T REGULATORY LYMPHOCYTE EPITOPES |
| CN107641626B (zh) * | 2017-11-23 | 2018-06-01 | 黄志清 | 912位点发生突变的RanBP9突变基因及其应用 |
| WO2019117690A1 (ko) * | 2017-12-15 | 2019-06-20 | 경북대학교 산학협력단 | Pd-l1에 결합하는 펩타이드 및 이의 용도 |
| EP3728636B1 (en) | 2017-12-19 | 2024-09-11 | Becton, Dickinson and Company | Particles associated with oligonucleotides |
| EP3731876A4 (en) * | 2017-12-28 | 2022-04-06 | Gritstone bio, Inc. | ANTIGEN-BINDING PROTEINS TARGETING SHARED ANTIGENS |
| AU2019209770B2 (en) | 2018-01-16 | 2025-07-31 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity |
| CN108409851B (zh) * | 2018-01-29 | 2020-12-08 | 上海交通大学 | 肾细胞癌中高水平表达的蛋白及其应用 |
| AR114350A1 (es) | 2018-01-31 | 2020-08-26 | Res Institute At Nationwide ChildrenS Hospital | Terapia genética para la distrofia muscular de cinturas del tipo 2c |
| US20210238690A1 (en) * | 2018-04-26 | 2021-08-05 | Intellexon Gmbh | Hla-j and medical/diagnostic uses thereof |
| CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
| JP7358388B2 (ja) | 2018-05-03 | 2023-10-10 | ベクトン・ディキンソン・アンド・カンパニー | 反対側の転写物末端における分子バーコーディング |
| TW202016131A (zh) * | 2018-05-16 | 2020-05-01 | 德商英麥提克生物技術股份有限公司 | 用於抗癌免疫治療的肽 |
| KR20210028162A (ko) | 2018-06-29 | 2021-03-11 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 지대근 이영양증 2a형을 치료하기 위한 재조합 아데노 연관 바이러스 생성물 및 방법 |
| JP2021534196A (ja) | 2018-08-23 | 2021-12-09 | シージェン インコーポレイテッド | 抗tigit抗体 |
| US11712410B2 (en) | 2018-09-05 | 2023-08-01 | K18, Inc. | Composition for improving hair health |
| ES2992135T3 (es) | 2018-10-01 | 2024-12-09 | Becton Dickinson Co | Determinar secuencias de transcripción 5 |
| EP3861018A4 (en) | 2018-10-05 | 2022-10-26 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | NEWBORN SCREENING FOR PRIMARY IMMUNODEFICIENCY CYSTINosis AND WILSON'S DISEASE |
| WO2020093018A1 (en) | 2018-11-01 | 2020-05-07 | University Of Florida Research Foundation, Incorporated | A codon optimized otoferlin aav dual vector gene therapy |
| US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
| AU2019380606B2 (en) | 2018-11-15 | 2026-04-23 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
| CN109456968B (zh) * | 2018-12-29 | 2022-10-04 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物 |
| CN109651500B (zh) * | 2019-01-15 | 2021-08-13 | 南京蜂瑞生物科技有限公司 | 一种具有抑制白血病细胞增殖作用的多肽 |
| US11371076B2 (en) | 2019-01-16 | 2022-06-28 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| ES2945227T3 (es) | 2019-01-23 | 2023-06-29 | Becton Dickinson Co | Oligonucleótidos asociados con anticuerpos |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| EP3695883A1 (en) * | 2019-02-13 | 2020-08-19 | Alytas Therapeutics GmbH | Means for specifically eliminating perilipin-1 fragment presenting adipocytes |
| WO2020167920A1 (en) | 2019-02-14 | 2020-08-20 | Cellular Research, Inc. | Hybrid targeted and whole transcriptome amplification |
| AU2020225319B2 (en) * | 2019-02-19 | 2025-05-29 | Medizinische Universität Wien | New recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine |
| AU2020229340A1 (en) | 2019-02-26 | 2021-09-16 | Research Institute At Nationwide Children's Hospital | Adeno-associated virus vector delivery of B-sarcoglycan and the treatment of muscular dystrophy |
| EP3947700A4 (en) | 2019-04-01 | 2023-01-04 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| CN110045130B (zh) * | 2019-04-17 | 2022-03-29 | 中山大学附属第一医院 | 一种与IgA肾病相关的多肽的免疫分析检测试剂盒 |
| ES2948620T3 (es) | 2019-07-10 | 2023-09-14 | Masonic Medical Res Laboratory | Vgll4 con elemento regulador CIS de UCP-1 y método de uso del mismo |
| US20220291220A1 (en) * | 2019-07-15 | 2022-09-15 | Oncocyte Corporation | Methods and compositions for detection and treatment of lung cancer |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| RS65421B1 (sr) | 2019-08-21 | 2024-05-31 | Res Inst Nationwide Childrens Hospital | Isporuka adeno-asociranog virusnog vektora alfa-sarkoglikana i lečenje mišićne distrofije |
| WO2021050510A1 (en) * | 2019-09-09 | 2021-03-18 | The Wistar Institute Of Anatomy And Biology | Engineered peptide and peptide mimetic compositions and methods |
| CN110706749B (zh) * | 2019-09-10 | 2022-06-10 | 至本医疗科技(上海)有限公司 | 一种基于组织器官分化层次关系的癌症类型预测系统和方法 |
| EP4038086A4 (en) * | 2019-10-03 | 2023-11-01 | Board of Regents, The University of Texas System | VCX/Y PEPTIDES AND THEIR USE |
| KR20220130093A (ko) | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
| CN110669104B (zh) * | 2019-10-30 | 2021-11-05 | 上海交通大学 | 一组来源于人外周血单核细胞的标志物及其应用 |
| IL292628A (en) | 2019-11-01 | 2022-07-01 | Magenta Therapeutics Inc | Anti-cd45 antibody and conjugates accordingly |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
| WO2021146219A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Cell capture using du-containing oligonucleotides |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| CN115003692B (zh) * | 2020-01-19 | 2024-09-03 | 北京生命科学研究所 | 乙型肝炎病毒感染的特异性宿主因子及其应用 |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| US20230065917A1 (en) * | 2020-01-31 | 2023-03-02 | Venn Biosciences Corporation | Biomarkers for diagnosing ovarian cancer |
| EP3868884A1 (en) * | 2020-02-19 | 2021-08-25 | Aarhus Universitet | Method for subtyping bladder cancer using aptamers |
| WO2021173719A1 (en) | 2020-02-25 | 2021-09-02 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| KR20210121585A (ko) * | 2020-03-30 | 2021-10-08 | 한국세라믹기술원 | 반응성 및 안정성 그리고 항체회수가 향상된 z-도메인 및 칼시퀘스트린 융합단백질 및 이를 이용한 항체의 분리 및 정제 방법 |
| JP2023519969A (ja) | 2020-03-31 | 2023-05-15 | シアトル・チルドレンズ・ホスピタル・ドゥーイング/ビジネス/アズ・シアトル・チルドレンズ・リサーチ・インスティテュート | リソソーム蓄積症に関するプロテオミクススクリーニング |
| CN115666658A (zh) | 2020-04-01 | 2023-01-31 | 佛罗里达州大学研究基金会 | 具有提高的治疗ush1b的安全性的双aav-myo7a载体 |
| US12523662B2 (en) | 2020-04-02 | 2026-01-13 | Seattle Children's Hospital | Antibodies that specifically bind peptides associated with the primary immunodeficiencies: Wiskott-Aldrich syndrome and x-linked agammaglobulinemia |
| IT202000006973A1 (it) * | 2020-04-02 | 2021-10-02 | Istituto Naz Tumori Irccs Fondazione G Pascale | Antigeni herv tumore-specifici e loro uso nella immunoterapia del cancro |
| US20230158108A1 (en) * | 2020-05-04 | 2023-05-25 | University Of Utah Research Foundation | Immunothrombosis in covid-19 acute respiratory distress syndrome |
| US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| EP4143579A2 (en) * | 2020-05-20 | 2023-03-08 | Quantum-si Incorporated | Methods and compositions for protein sequencing |
| AU2021275239A1 (en) | 2020-05-21 | 2022-12-15 | Board Of Regents, The University Of Texas System | T cell receptors with VGLL1 specificity and uses thereof |
| WO2021247487A1 (en) * | 2020-06-01 | 2021-12-09 | Medical University Of South Carolina | Recombinant fusion proteins targeting p-selectin, and methods of use thereof for treating diseases and disorders |
| US12157913B2 (en) | 2020-06-02 | 2024-12-03 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| TW202216111A (zh) * | 2020-07-03 | 2022-05-01 | 米尼奧大學 | 香氛釋放機制、方法及其用途 |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| US12391940B2 (en) | 2020-07-31 | 2025-08-19 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| WO2022031733A2 (en) * | 2020-08-03 | 2022-02-10 | Cornell University | Keratinolytic polypeptides and methods of use |
| MX2023003805A (es) * | 2020-10-01 | 2023-04-12 | Genzyme Corp | Casete de expresion de pah humana para el tratamiento de la pku mediante terapia de reemplazo genico dirigida al higado. |
| US11781156B2 (en) * | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
| BR112023006305A2 (pt) | 2020-10-09 | 2023-05-09 | Tenaya Therapeutics Inc | Métodos e composições de terapia gênica com placofilina-2 |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| EP4247967A1 (en) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profiling of highly expressed and lowly expressed proteins |
| WO2022106666A1 (en) * | 2020-11-20 | 2022-05-27 | Universitätsklinikum Knappschaftskrankenhaus Bochum Gmbh | Use of mature mitochondrial transcription factor a (tfam) for diagnosing organ dysfunctions |
| CN116685850A (zh) | 2020-12-15 | 2023-09-01 | 贝克顿迪金森公司 | 单细胞分泌组分析 |
| CN112552394B (zh) * | 2020-12-30 | 2023-03-21 | 青海瑞肽生物科技有限公司 | 一种牦牛降压肽及其制备方法 |
| CA3210492A1 (en) * | 2021-02-05 | 2022-08-11 | Dharmacon, Inc. | Fusion proteins for crispr-based transcriptional repression |
| CN113061176B (zh) * | 2021-03-12 | 2022-08-16 | 华中农业大学 | 一种草鱼抗菌蛋白lect2及其制备方法和应用 |
| US20240336659A1 (en) * | 2021-04-15 | 2024-10-10 | Onecuregen Co., Ltd. | Cell-penetrating peptide, anti-cancer peptide, and pharmaceutical composition for preventing or treating cancer, comprising same |
| EP4337699A4 (en) * | 2021-05-12 | 2025-07-23 | Biolegend Inc | ANTI-CCR8 ANTIBODIES, ANTIGEN-BINDING FRAGMENTS THEREOF, AND AGENTS AND COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME |
| CA3226615A1 (en) * | 2021-07-23 | 2023-03-30 | Ian Pike | Blood-based diagnostic assays for alzheimer's disease |
| TWI800922B (zh) * | 2021-09-14 | 2023-05-01 | 東海大學 | 短胜肽、含有該短胜肽之水解物及其用於預防或/及治療神經損傷相關疾病之用途 |
| TWI838648B (zh) * | 2021-09-28 | 2024-04-11 | 臺北醫學大學 | 用於檢測大腸直腸癌的組合物的用途與方法 |
| US20250102522A1 (en) * | 2021-10-07 | 2025-03-27 | Hepatx Corporation | Methods of tracking donor cells in a recipient |
| EP4219726A1 (en) | 2021-10-15 | 2023-08-02 | Research Institute at Nationwide Children's Hospital | Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy |
| CN114195884B (zh) * | 2021-10-27 | 2024-03-29 | 禾美生物科技(浙江)有限公司 | 一种重组人源胶原蛋白及其制备方法 |
| GB2621640A (en) * | 2021-11-10 | 2024-02-21 | Univ South China Tech | Active polypeptide for inhibiting growth of liver cancer cells, and preparation method therefor and use thereof |
| CN113845571B (zh) * | 2021-11-10 | 2023-08-15 | 华南理工大学 | 一种抑制肝癌细胞生长的活性多肽及其制备方法和应用 |
| WO2023092057A1 (en) * | 2021-11-18 | 2023-05-25 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating progranulin expression |
| AU2022399828A1 (en) * | 2021-11-30 | 2024-05-23 | Venn Biosciences Corporation | Diagnosis of pancreatic cancer using targeted quantification of site-specific protein glycosylation |
| WO2023196898A1 (en) * | 2022-04-07 | 2023-10-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Beta globin mimetic peptides and their use |
| TWI845024B (zh) * | 2022-11-15 | 2024-06-11 | 長庚大學 | 用以診斷和預斷大腸直腸癌的方法 |
| WO2024115743A1 (en) * | 2022-12-02 | 2024-06-06 | Cézanne S.A.S. | Protein biomarkers for use in methods for the diagnosis or prognosis of chronic airflow limitation (cal) and chronic obstructive pulmonary disease (copd) |
| CN115894623B (zh) * | 2022-12-20 | 2025-05-13 | 中国科学院昆明动物研究所 | 一种具有双重调节dbh和ddc酶活性功能的多肽nr6及其应用 |
| CN116891523B (zh) * | 2023-05-24 | 2024-05-17 | 深圳晶蛋生物医药科技有限公司 | 一种trpm3截短体、包含其的细胞系及其用途 |
| WO2025003457A1 (en) * | 2023-06-29 | 2025-01-02 | University Of Fribourg | Targeted proteomics for monitoring autophagy |
| KR20250031017A (ko) * | 2023-08-23 | 2025-03-06 | 재단법인 아산사회복지재단 | Pibf1 또는 이를 코딩하는 유전자를 포함하는 벡터를 포함하는 태반 또는 태아 심혈관 이상과 관련된 임신 합병증의 예방 또는 치료용 약학 조성물 |
| US20250076313A1 (en) * | 2023-09-01 | 2025-03-06 | Nordic Bioscience A/S | Anastellin Biomarker |
| CN119899273B (zh) * | 2025-01-15 | 2025-10-31 | 中国人民解放军空军军医大学 | 一种人pgk1第131位赖氨酸乳酸化修饰的抗体制备方法与应用 |
| CN121248719B (zh) * | 2025-11-25 | 2026-04-24 | 北京榕树堂生物科技有限公司 | 一种燕窝肽的制备方法及其应用 |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US493495A (en) | 1893-03-14 | Lantern | ||
| US197506A (en) | 1877-11-27 | Improvement in hernia-trusses | ||
| US604823A (en) | 1898-05-31 | Op stratiidon | ||
| US4437975A (en) | 1977-07-20 | 1984-03-20 | Mobil Oil Corporation | Manufacture of lube base stock oil |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4690715A (en) | 1982-06-18 | 1987-09-01 | American Telephone And Telegraph Company, At&T Bell Laboratories | Modification of the properties of metals |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| WO1984003506A1 (en) | 1983-03-08 | 1984-09-13 | Commw Serum Lab Commission | Antigenically active amino acid sequences |
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US4483105A (en) | 1983-03-11 | 1984-11-20 | Maschinenfabrik Gehring, Gesellschaft Mit Beschrankter Haftung & Co. Kommanditgesellschaft | Device to hold workpieces for the honing of their axial center bore |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4644545A (en) | 1983-05-16 | 1987-02-17 | Data General Corporation | Digital encoding and decoding apparatus |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5333675C1 (en) | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE229046T1 (de) | 1985-03-30 | 1987-12-17 | Marc Genf/Geneve Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
| US4886743A (en) * | 1985-04-24 | 1989-12-12 | California Institute Of Technology | Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof |
| US5045995A (en) | 1985-06-24 | 1991-09-03 | Vicom Systems, Inc. | Selective operation of processing elements in a single instruction multiple data stream (SIMD) computer system |
| US4965108A (en) | 1985-09-11 | 1990-10-23 | First Brands Corporation | Low temperature impact and puncture resistant thermoplastic films and bags therefrom |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| US4833195A (en) | 1987-07-20 | 1989-05-23 | Bp Performance Polymers, Inc. | High flow drapable polymer compositions |
| WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| DE3850542T2 (de) | 1987-09-23 | 1994-11-24 | Bristol Myers Squibb Co | Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen. |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| JP2650159B2 (ja) | 1988-02-24 | 1997-09-03 | アクゾ・ノベル・エヌ・ベー | 核酸増幅方法 |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5571689A (en) | 1988-06-16 | 1996-11-05 | Washington University | Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| CA2005589C (en) | 1988-12-16 | 2001-02-06 | Akzo Nobel Nv | Self-sustained, sequence replication system |
| US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
| US5081584A (en) | 1989-03-13 | 1992-01-14 | United States Of America | Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| WO1991001384A1 (en) | 1989-07-11 | 1991-02-07 | Gen-Probe, Incorporated | Nucleic acid sequence amplification methods utilizing a transcription complex |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5498538A (en) | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| JPH06500471A (ja) | 1990-08-24 | 1994-01-20 | ザ・ユニバーシティ・オブ・テネシー・リサーチ・コーポレーション | Dna増幅フィンガープリント法 |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| US5770434A (en) | 1990-09-28 | 1998-06-23 | Ixsys Incorporated | Soluble peptides having constrained, secondary conformation in solution and method of making same |
| CA2027434C (en) * | 1990-10-12 | 1999-01-05 | George Jackowski | Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof |
| WO1992007095A1 (en) | 1990-10-15 | 1992-04-30 | Stratagene | Arbitrarily primed polymerase chain reaction method for fingerprinting genomes |
| AU668347B2 (en) | 1990-11-21 | 1996-05-02 | Torrey Pines Institute For Molecular Studies | Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5550215A (en) | 1991-11-22 | 1996-08-27 | Holmes; Christopher P. | Polymer reversal on solid surfaces |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| CA2124087C (en) | 1991-11-22 | 2002-10-01 | James L. Winkler | Combinatorial strategies for polymer synthesis |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| IT1252624B (it) | 1991-12-05 | 1995-06-19 | Cons Ric Microelettronica | Dispositivo semiconduttore incapsulato in resina e elettricamente isolato di migliorate caratteristiche di isolamento,e relativo processo di fabbricazione |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
| CA2064683A1 (en) | 1992-03-26 | 1993-09-27 | Krishna Mohan Rao Kallury | Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| GB9208733D0 (en) | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| FR2703359B1 (fr) | 1993-03-31 | 1995-06-23 | Cis Bio Int | Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation . |
| US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
| US5312790A (en) | 1993-06-09 | 1994-05-17 | The United States Of America As Represented By The Secretary Of The Army | Ceramic ferroelectric material |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| DE69431719T2 (de) | 1993-06-25 | 2003-09-18 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Hybridisierung und sequenzierung von nukleinsäuren |
| DE69429038T2 (de) | 1993-07-28 | 2002-03-21 | Pe Corporation (Ny), Norwalk | Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5429708A (en) | 1993-12-22 | 1995-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Molecular layers covalently bonded to silicon surfaces |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| JP3552264B2 (ja) | 1994-03-04 | 2004-08-11 | ヤマハ株式会社 | 自動演奏装置 |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| EP0758403B1 (en) | 1994-05-05 | 1998-06-24 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| AU7104294A (en) | 1994-06-10 | 1996-01-05 | Symbiotech, Inc. | Method of detecting compounds utilizing genetically modified lambdoid bacteriophage |
| US5403464A (en) | 1994-06-15 | 1995-04-04 | Modern Controls, Inc. | High permeability rate oxygen sensor |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5627024A (en) | 1994-08-05 | 1997-05-06 | The Scripps Research Institute | Lambdoid bacteriophage vectors for expression and display of foreign proteins |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US6013445A (en) | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US5545539A (en) | 1994-10-18 | 1996-08-13 | Genzyme Corporation | Method for nucleotide sequence amplification |
| US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US5688642A (en) | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
| AU4289496A (en) | 1994-12-02 | 1996-06-19 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
| NO179986C (no) | 1994-12-08 | 1997-01-22 | Norske Stats Oljeselskap | Fremgangsmåte og system for fremstilling av flytendegjort naturgass til havs |
| US6270962B1 (en) | 1995-01-30 | 2001-08-07 | The Regents Of The University Of California | Methods for the elimination of DNA sequencing artifacts |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| WO1996038726A1 (en) | 1995-05-30 | 1996-12-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Covalently immobilized phospholipid bilayers on solid surfaces |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
| US5671894A (en) | 1995-08-11 | 1997-09-30 | Alliedsignal Inc. | Retractor with load limiting spool with decoupled pretensioner |
| EP0854933B1 (en) | 1995-09-07 | 2003-05-07 | Novozymes A/S | Phage display for detergent enzyme activity |
| US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
| WO1997014028A2 (en) | 1995-10-11 | 1997-04-17 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and method |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
| US6063026A (en) * | 1995-12-07 | 2000-05-16 | Carbon Based Corporation | Medical diagnostic analysis system |
| US6147205A (en) | 1995-12-15 | 2000-11-14 | Affymetrix, Inc. | Photocleavable protecting groups and methods for their use |
| NZ331866A (en) * | 1996-03-15 | 2000-05-26 | Corixa Corp | Compounds for immunotherapy and immunodiagnosis of prostate cancer |
| WO1997035196A1 (en) | 1996-03-20 | 1997-09-25 | Dyax Corp. | Engineering affinity ligands for macromolecules |
| US6114122A (en) | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
| EP0902885A4 (en) | 1996-05-16 | 2006-09-27 | Affymetrix Inc | SYSTEMS AND METHODS FOR DETECTION OF BRANDED PRODUCTS |
| KR20000016414A (ko) | 1996-06-06 | 2000-03-25 | 와이즈먼 앤드루 | Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법 |
| JP2880453B2 (ja) | 1996-06-07 | 1999-04-12 | 三桜工業株式会社 | 配管用継手装置のリテーナ |
| AU735015B2 (en) | 1996-06-10 | 2001-06-28 | Scripps Research Institute, The | Use of substrate subtraction libraries to distinguish enzyme specificities |
| US5766905A (en) | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| JP2000514307A (ja) | 1996-07-16 | 2000-10-31 | ジェン―プローブ・インコーポレーテッド | 増加した標的特異的t▲下m▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法 |
| WO1998014277A1 (en) | 1996-10-04 | 1998-04-09 | Whatman, Inc. | Device and method for simultaneous multiple chemical syntheses |
| DK0934526T3 (da) | 1996-10-08 | 2003-05-05 | Bisys B V U | Fremgangsmåder og midler til udvælgelse af peptider og proteiner, der har specifik affinitet til et mål |
| WO1998020036A1 (en) | 1996-11-06 | 1998-05-14 | Genentech, Inc. | Constrained helical peptides and methods of making same |
| DE69735112T2 (de) | 1996-11-06 | 2006-09-07 | Sequenom, Inc., San Diego | Verfahren zur Analyse und Vorrichtung |
| IL119587A (en) | 1996-11-07 | 2000-12-06 | Univ Ramot | Method of preparing and for obtaining bimolecular interactions |
| IL119586A (en) | 1996-11-07 | 2001-09-13 | Univ Ramot | Discontinuous library of a single biological unit and a method for its preparation |
| US6025681A (en) | 1997-02-05 | 2000-02-15 | Duly Research Inc. | Dielectric supported radio-frequency cavities |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| DE69833758T2 (de) | 1997-06-13 | 2006-08-31 | Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara | Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips |
| US6333179B1 (en) | 1997-06-20 | 2001-12-25 | Affymetrix, Inc. | Methods and compositions for multiplex amplification of nucleic acids |
| US6172211B1 (en) * | 1997-07-11 | 2001-01-09 | Boehringer Ingelheim International Gmbh | Nucleic acid encoding tag7 polypeptide |
| US6188783B1 (en) | 1997-07-25 | 2001-02-13 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
| US6420108B2 (en) | 1998-02-09 | 2002-07-16 | Affymetrix, Inc. | Computer-aided display for comparative gene expression |
| US5878832A (en) | 1997-08-13 | 1999-03-09 | General Motors Corporation | Steering apparatus for motor vehicle |
| US6223127B1 (en) | 1997-08-15 | 2001-04-24 | Affymetrix, Inc. | Polymorphism detection utilizing clustering analysis |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| DE69829402T2 (de) | 1997-10-31 | 2006-04-13 | Affymetrix, Inc. (a Delaware Corp.), Santa Clara | Expressionsprofile in adulten und fötalen organen |
| US6013449A (en) | 1997-11-26 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
| US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
| US6428752B1 (en) | 1998-05-14 | 2002-08-06 | Affymetrix, Inc. | Cleaning deposit devices that form microarrays and the like |
| US6201639B1 (en) | 1998-03-20 | 2001-03-13 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US6185030B1 (en) | 1998-03-20 | 2001-02-06 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| US5936324A (en) | 1998-03-30 | 1999-08-10 | Genetic Microsystems Inc. | Moving magnet scanner |
| US6525185B1 (en) | 1998-05-07 | 2003-02-25 | Affymetrix, Inc. | Polymorphisms associated with hypertension |
| US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6171239B1 (en) | 1998-08-17 | 2001-01-09 | Emory University | Systems, methods, and devices for controlling external devices by signals derived directly from the nervous system |
| US6185561B1 (en) | 1998-09-17 | 2001-02-06 | Affymetrix, Inc. | Method and apparatus for providing and expression data mining database |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6262216B1 (en) | 1998-10-13 | 2001-07-17 | Affymetrix, Inc. | Functionalized silicon compounds and methods for their synthesis and use |
| CA2345441A1 (en) | 1998-10-27 | 2000-05-04 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
| US6252743B1 (en) | 1998-11-02 | 2001-06-26 | Read-Rite Corporation | Read/write positioning arm with interspaced amplifier chips |
| EP1020534B2 (en) | 1998-11-09 | 2011-01-05 | Eiken Kagaku Kabushiki Kaisha | Process for synthesizing nucleic acid |
| CA2355215A1 (en) | 1998-12-28 | 2000-07-06 | Jim Wells | Identifying small organic molecule ligands for binding |
| US6470305B1 (en) | 1998-12-31 | 2002-10-22 | Ajay N. Jain | Chemical analysis by morphological similarity |
| US20060134637A1 (en) | 1999-01-06 | 2006-06-22 | Chondrogene Limited | Method for the detection of cancer related gene transcripts in blood |
| US6492505B1 (en) * | 1999-02-01 | 2002-12-10 | Incyte Genomics, Inc. | Composition for detection of genes encoding membrane-associated proteins |
| US6177248B1 (en) | 1999-02-24 | 2001-01-23 | Affymetrix, Inc. | Downstream genes of tumor suppressor WT1 |
| JP2002539849A (ja) | 1999-03-26 | 2002-11-26 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | ユニバーサルアレイ |
| US6268141B1 (en) | 1999-05-12 | 2001-07-31 | Beckman Coulter, Inc. | Immobilization of unmodified biopolymers to acyl fluoride activated substrates |
| US6026601A (en) | 1999-05-25 | 2000-02-22 | Kiel; Walter J. | Ironing board adapted to vertical surface |
| US6218803B1 (en) | 1999-06-04 | 2001-04-17 | Genetic Microsystems, Inc. | Position sensing with variable capacitance transducers |
| US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
| AU7537200A (en) | 1999-09-29 | 2001-04-30 | Solexa Ltd. | Polynucleotide sequencing |
| US6958225B2 (en) | 1999-10-27 | 2005-10-25 | Affymetrix, Inc. | Complexity management of genomic DNA |
| DE19957827C2 (de) | 1999-11-25 | 2003-06-12 | Epigenomics Ag | Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche |
| PT1244705E (pt) | 1999-12-06 | 2010-05-04 | Agensys Inc | Antigénios transmembranares em serpentina expressos em cancros da próstata humanos e suas utilizações |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| US20030097222A1 (en) | 2000-01-25 | 2003-05-22 | Craford David M. | Method, system, and computer software for providing a genomic web portal |
| JP3490368B2 (ja) | 2000-02-07 | 2004-01-26 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 信号出力装置、ドライバ回路、信号伝送システム、および信号伝送方法 |
| US6267152B1 (en) | 2000-02-18 | 2001-07-31 | Wisconsin Label Corporation | Hang tag and method of applying hang tag to an elongated object |
| US6696620B2 (en) | 2000-05-02 | 2004-02-24 | Epicyte Pharmaceutical, Inc. | Immunoglobulin binding protein arrays in eukaryotic cells |
| US6593425B2 (en) | 2000-05-31 | 2003-07-15 | General Electric Company | Data storage media containing transparent polycarbonate blends |
| US6531283B1 (en) | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
| US20060166227A1 (en) | 2000-06-20 | 2006-07-27 | Stephen Kingsmore | Protein expression profiling |
| US6386749B1 (en) | 2000-06-26 | 2002-05-14 | Affymetrix, Inc. | Systems and methods for heating and mixing fluids |
| US6323009B1 (en) | 2000-06-28 | 2001-11-27 | Molecular Staging, Inc. | Multiply-primed amplification of nucleic acid sequences |
| US7567870B1 (en) * | 2000-07-31 | 2009-07-28 | Institute For Systems Biology | Multiparameter analysis for predictive medicine |
| JP2002071687A (ja) | 2000-08-31 | 2002-03-12 | Canon Inc | 変異遺伝子のスクリーニング方法 |
| US6897023B2 (en) | 2000-09-27 | 2005-05-24 | The Molecular Sciences Institute, Inc. | Method for determining relative abundance of nucleic acid sequences |
| ATE362107T1 (de) * | 2000-11-20 | 2007-06-15 | Eastern Virginia Med School | Verfahren und vorrichtungen zum quantitativen nachweis eines prostata-spezifischen membranantigens und anderer prostatamarker |
| US6391592B1 (en) | 2000-12-14 | 2002-05-21 | Affymetrix, Inc. | Blocker-aided target amplification of nucleic acids |
| US6448387B1 (en) | 2000-12-18 | 2002-09-10 | Monsanto Technology, Llc | Polymeric arrays adapted for high expressing polynucleotides |
| US6405783B1 (en) | 2000-12-23 | 2002-06-18 | Advanced Innovations, Llc. | Horizontal window blind apparatus |
| US20020183936A1 (en) | 2001-01-24 | 2002-12-05 | Affymetrix, Inc. | Method, system, and computer software for providing a genomic web portal |
| US20030120432A1 (en) | 2001-01-29 | 2003-06-26 | Affymetrix, Inc. | Method, system and computer software for online ordering of custom probe arrays |
| US6689568B2 (en) | 2001-02-01 | 2004-02-10 | Agilent Technologies, Inc. | Capture arrays using polypeptide capture agents |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| WO2002084252A2 (en) | 2001-04-17 | 2002-10-24 | Xenoport, Inc. | Epitope-captured antibody display |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| US20030100995A1 (en) | 2001-07-16 | 2003-05-29 | Affymetrix, Inc. | Method, system and computer software for variant information via a web portal |
| US6632611B2 (en) | 2001-07-20 | 2003-10-14 | Affymetrix, Inc. | Method of target enrichment and amplification |
| US6872529B2 (en) | 2001-07-25 | 2005-03-29 | Affymetrix, Inc. | Complexity management of genomic DNA |
| US7343247B2 (en) | 2001-07-30 | 2008-03-11 | The Institute For Systems Biology | Methods of classifying drug responsiveness using multiparameter analysis |
| US7229774B2 (en) * | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US20030044320A1 (en) | 2001-08-31 | 2003-03-06 | Shun Luo | High throughput screening micro array platform |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| EP1463818A2 (en) * | 2001-12-14 | 2004-10-06 | Incyte Genomics, Inc. | Transporters and ion channels |
| US20040002818A1 (en) | 2001-12-21 | 2004-01-01 | Affymetrix, Inc. | Method, system and computer software for providing microarray probe data |
| US7011945B2 (en) | 2001-12-21 | 2006-03-14 | Eastman Kodak Company | Random array of micro-spheres for the analysis of nucleic acids |
| US20030219801A1 (en) | 2002-03-06 | 2003-11-27 | Affymetrix, Inc. | Aptamer base technique for ligand identification |
| JP2004003989A (ja) | 2002-03-15 | 2004-01-08 | Affymetrix Inc | 生物学的物質の走査のためのシステム、方法、および製品 |
| US20040126840A1 (en) | 2002-12-23 | 2004-07-01 | Affymetrix, Inc. | Method, system and computer software for providing genomic ontological data |
| US20040049354A1 (en) | 2002-04-26 | 2004-03-11 | Affymetrix, Inc. | Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants |
| US20070065816A1 (en) | 2002-05-17 | 2007-03-22 | Affymetrix, Inc. | Methods for genotyping |
| JP4638225B2 (ja) | 2002-05-30 | 2011-02-23 | ザ スクリプス リサーチ インスティテュート | 銅を触媒とするアジドとアセチレンのライゲーション |
| EP1514107B1 (en) | 2002-06-03 | 2013-05-15 | The Institute for Systems Biology | Methods for quantitative proteome analysis of glycoproteins |
| US20040072217A1 (en) | 2002-06-17 | 2004-04-15 | Affymetrix, Inc. | Methods of analysis of linkage disequilibrium |
| US7011949B2 (en) | 2002-09-30 | 2006-03-14 | Agilent Technologies, Inc. | Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| EP1578994A2 (en) | 2002-11-11 | 2005-09-28 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| JP2006526140A (ja) * | 2002-12-24 | 2006-11-16 | バイオサイト インコーポレイテッド | 鑑別診断のためのマーカーおよびその使用方法 |
| US20040146883A1 (en) | 2003-01-28 | 2004-07-29 | Affymetrix, Inc. | Methods for prenatal diagnosis |
| US7028629B2 (en) | 2003-02-03 | 2006-04-18 | Richard Walcome | Self-sealing port light assembly |
| AU2004264948A1 (en) * | 2003-08-15 | 2005-02-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Multifactorial assay for cancer detection |
| US20060094064A1 (en) | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
| AU2005241003B2 (en) | 2004-04-14 | 2011-05-19 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
| EP1607898A3 (en) | 2004-05-18 | 2006-03-29 | Neal E. Solomon | A bioinformatics system for functional proteomics modelling |
| US20060141528A1 (en) * | 2004-05-21 | 2006-06-29 | Aebersold Rudolf H | Compositions and methods for quantification of serum glycoproteins |
| JP5139058B2 (ja) * | 2004-06-02 | 2013-02-06 | シドニー キンメル キャンサー センター | 新形成または新生脈管構造の検出、画像化および処置のための血管標的 |
| US7883858B2 (en) * | 2005-01-27 | 2011-02-08 | Institute For Systems Biology | Methods for identifying and monitoring drug side effects |
| US9002652B1 (en) * | 2005-01-27 | 2015-04-07 | Institute For Systems Biology | Methods for identifying and using organ-specific proteins in blood |
| EP1938104A2 (en) * | 2005-10-17 | 2008-07-02 | Institute for Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
| AU2007284651B2 (en) * | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| US8632982B2 (en) * | 2009-05-21 | 2014-01-21 | Institute For Systems Biology | Biomarkers for liver injury |
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2007
- 2007-08-09 AU AU2007284651A patent/AU2007284651B2/en not_active Ceased
- 2007-08-09 EP EP07836742A patent/EP2057465A4/en not_active Ceased
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- 2007-08-09 EP EP12174646A patent/EP2520935A3/en not_active Ceased
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- 2007-08-09 JP JP2009523868A patent/JP5244103B2/ja not_active Expired - Fee Related
- 2007-08-09 CA CA002660286A patent/CA2660286A1/en not_active Abandoned
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|---|---|
| EP2057465A2 (en) | 2009-05-13 |
| WO2008021290A3 (en) | 2008-11-13 |
| WO2008021290A2 (en) | 2008-02-21 |
| AU2007284651B2 (en) | 2014-03-20 |
| EP2520935A2 (en) | 2012-11-07 |
| JP2010500568A (ja) | 2010-01-07 |
| US20120087862A1 (en) | 2012-04-12 |
| AU2007284651A1 (en) | 2008-02-21 |
| JP5244103B2 (ja) | 2013-07-24 |
| WO2008021290A8 (en) | 2008-04-17 |
| EP2520935A3 (en) | 2013-02-13 |
| US8586006B2 (en) | 2013-11-19 |
| US20140106981A1 (en) | 2014-04-17 |
| WO2008021290A9 (en) | 2009-04-16 |
| EP2057465A4 (en) | 2010-04-21 |
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