BR112019005900A2 - medição de expressão de proteínas usando reagentes com sequências de oligonucleotídeos com código de barras - Google Patents

medição de expressão de proteínas usando reagentes com sequências de oligonucleotídeos com código de barras

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Publication number
BR112019005900A2
BR112019005900A2 BR112019005900A BR112019005900A BR112019005900A2 BR 112019005900 A2 BR112019005900 A2 BR 112019005900A2 BR 112019005900 A BR112019005900 A BR 112019005900A BR 112019005900 A BR112019005900 A BR 112019005900A BR 112019005900 A2 BR112019005900 A2 BR 112019005900A2
Authority
BR
Brazil
Prior art keywords
protein
reagents
protein expression
oligonucleotide sequences
binding reagent
Prior art date
Application number
BR112019005900A
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English (en)
Inventor
Gaylord Brent
Chang Christina
Fan Christina
Shum Eleen
Jensen Eric
Ghadiali James
G Vidal Jason
martin Jody
Rohrer Jurg
Bansal Nidhanjali
Zoellner Olaf
Gretchen Lam Yinbon
Original Assignee
Becton Dickinson Co
Cellular Res Inc
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Publication date
Application filed by Becton Dickinson Co, Cellular Res Inc filed Critical Becton Dickinson Co
Publication of BR112019005900A2 publication Critical patent/BR112019005900A2/pt

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Abstract

algumas modalidades divulgadas aqui proporcional uma pluralidade de composições compreendendo cada uma um reagente de ligação a proteínas conjugado com um oligonucleotídeo. o oligonucleotídeo compreende um identificador único para o reagente de ligação a proteínas com o qual está conjugado e o reagente de ligação a proteínas é capaz de se ligar especificamente a um alvo de proteínas. são adicionalmente divulgados métodos e estojos para análise quantitativa de uma pluralidade de alvos de proteínas em uma amostra e para análise quantitativa simultânea de alvos de proteínas e ácidos nucleicos em uma amostra. são também divulgados aqui sistemas e métodos para preparação de um reagente de biomolécula etiquetado, incluindo um agente de biomolécula etiquetado compreendendo um reagente de ligação a proteínas conjugado com um oligonucleotídeo.
BR112019005900A 2016-09-26 2017-09-25 medição de expressão de proteínas usando reagentes com sequências de oligonucleotídeos com código de barras BR112019005900A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662399795P 2016-09-26 2016-09-26
US201762464279P 2017-02-27 2017-02-27
US201762515952P 2017-06-06 2017-06-06
PCT/US2017/053331 WO2018058073A2 (en) 2016-09-26 2017-09-25 Measurement of protein expression using reagents with barcoded oligonucleotide sequences

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BR112019005900A2 true BR112019005900A2 (pt) 2019-06-11

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US (7) US11460468B2 (pt)
EP (2) EP4300099A3 (pt)
JP (3) JP7091348B2 (pt)
KR (3) KR102522023B1 (pt)
CN (2) CN115060911A (pt)
AU (2) AU2017331459B2 (pt)
BR (1) BR112019005900A2 (pt)
CA (1) CA3034924A1 (pt)
ES (1) ES2961743T3 (pt)
IL (1) IL265478B1 (pt)
SG (1) SG11201901733PA (pt)
WO (1) WO2018058073A2 (pt)

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