BG96978A - Производни и аналози на 2-дезокси-2,3-дидехидро-n- ацетилнеураминовата киселина и използването им като противовирусни средства - Google Patents
Производни и аналози на 2-дезокси-2,3-дидехидро-n- ацетилнеураминовата киселина и използването им като противовирусни средства Download PDFInfo
- Publication number
- BG96978A BG96978A BG096978A BG9697892A BG96978A BG 96978 A BG96978 A BG 96978A BG 096978 A BG096978 A BG 096978A BG 9697892 A BG9697892 A BG 9697892A BG 96978 A BG96978 A BG 96978A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- hydrogen
- derivatives
- desoxy
- didehydro
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001409 amidines Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Изобретението се отнася до нов клас съединения на база производни на N-ацетилнеуралинова киселина, по-специално до съединение с формула в която R3b e (алк)хNR6bR7b, CN или N3, където алк е незаместена или заместен метилен, х има стойност 0 или 1, R6b e водород, C1-6 алкил, арил, аралкил, амидин, NR7bR8b или незаместен, или заместен пръстен, съдържащ един или повече хетероатома, избрани от групата, състояща се от азот, кислород или сяра, R7b е водород, C1-6 алкил или арил, R8b е водород или C1-6 алкил; R4b означава NHCOR9b, където R9b е водород, незаместен или заместен C1-4 алкил или арил. Изобретението се отнася още до фармацевтично приемлива сол или производно на тези съединения. 17 претенции
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ980090 | 1990-04-24 | ||
AUPK289690 | 1990-10-19 | ||
AUPK453791 | 1991-02-11 | ||
PCT/AU1991/000161 WO1991016320A1 (en) | 1990-04-24 | 1991-04-24 | Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents |
Publications (2)
Publication Number | Publication Date |
---|---|
BG96978A true BG96978A (bg) | 1993-12-24 |
BG62092B1 BG62092B1 (bg) | 1999-02-26 |
Family
ID=27157556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG96978A BG62092B1 (bg) | 1990-04-24 | 1992-10-14 | Производни и аналози на2-дезокси-2,3-дидехидро-n-ацетилнеураминовата киселина иизползването им като противовирусни средства |
Country Status (37)
Country | Link |
---|---|
US (2) | US5360817A (bg) |
EP (2) | EP0786458B1 (bg) |
JP (1) | JP2944750B2 (bg) |
KR (1) | KR0169496B1 (bg) |
CN (3) | CN1143853C (bg) |
AP (1) | AP249A (bg) |
AT (2) | ATE406358T1 (bg) |
AU (2) | AU7533891A (bg) |
BG (1) | BG62092B1 (bg) |
CA (2) | CA2291994C (bg) |
CY (1) | CY2186B1 (bg) |
CZ (1) | CZ288492B6 (bg) |
DE (3) | DE69133604D1 (bg) |
DK (1) | DK0526543T3 (bg) |
ES (2) | ES2313730T3 (bg) |
FI (2) | FI105478B (bg) |
GR (1) | GR3026225T3 (bg) |
HK (2) | HK1003834A1 (bg) |
HU (2) | HU219355B (bg) |
IE (2) | IE980526A1 (bg) |
IL (1) | IL97936A (bg) |
LU (1) | LU90468I2 (bg) |
MY (1) | MY107843A (bg) |
NL (1) | NL990030I2 (bg) |
NO (3) | NO302751B1 (bg) |
NZ (1) | NZ237936A (bg) |
OA (1) | OA09679A (bg) |
PL (3) | PL166918B1 (bg) |
PT (1) | PT97460B (bg) |
RU (1) | RU2119487C1 (bg) |
SG (1) | SG43170A1 (bg) |
SI (1) | SI9110745B (bg) |
SK (1) | SK282950B6 (bg) |
UA (1) | UA41252C2 (bg) |
WO (1) | WO1991016320A1 (bg) |
YU (1) | YU48741B (bg) |
ZA (1) | ZA913086B (bg) |
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